R/E control ratio: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=''R/E'' | |abbr=''R/E'' | ||
|description=[[Image:R over E.jpg|50 px|ROUTINE control ratio]] The '''ROUTINE control ratio''' (''R/E'' coupling control ratio) is the ratio of (partially coupled) [[ROUTINE respiration]] and (noncoupled) [[ | |description=[[Image:R over E.jpg|50 px|ROUTINE control ratio]] The '''ROUTINE control ratio''' (''R/E'' coupling control ratio) is the ratio of (partially coupled) [[ROUTINE respiration]] and (noncoupled) [[ET capacity]].ย The ''R/E'' control ratio is an expression of how close ROUTINE respiration operates to ET capacity. | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
}} | }} | ||
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== Boundaries of the ROUTINE control ratio == | == Boundaries of the ROUTINE control ratio == | ||
:::: ''R/E'' increases due to (i) high ATP demand and ADP-stimulated ROUTINE respiration, (ii) partial uncoupling, and (iii) limitation of oxidative capacity by defects of substrate oxidation and complexes of the | :::: ''R/E'' increases due to (i) high ATP demand and ADP-stimulated ROUTINE respiration, (ii) partial uncoupling, and (iii) limitation of oxidative capacity by defects of substrate oxidation and complexes of the ET-pathway. The corresponding inverse ratio is the uncoupling control ratio, UCR, which can be seen as an index of apparent ET-pathway excess capacity. The lower boundary of ''R/E'' is the ''[[L/E]]'' flux control ratio, whereas the upper boundary is set by the ''[[P/E]]'' flux control ratio (OXPHOS/ET capacity). | ||
== Biochemical coupling efficiency: from 0 to <1 == | == Biochemical coupling efficiency: from 0 to <1 == | ||
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== List of publications: ROUTINE and | == List of publications: ROUTINE and ET-pathway == | ||
{{#ask:[[Category:Publications]] [[Coupling states::ROUTINE]] [[Coupling states::ETS]] | {{#ask:[[Category:Publications]] [[Coupling states::ROUTINE]] [[Coupling states::ETS]] | ||
|?Was published in year=Year | |||
|?Has title=Reference | |||
|?Mammal and model | |||
|?Tissue and cell | |||
|?Stress | |||
|?Diseases | |||
|format=broadtable | |||
|limit=5000 | |||
|offset=0 | |||
|sort=Was published in year | |||
|order=descending | |||
}} | |||
{{#ask:[[Category:Publications]] [[Coupling states::ROUTINE]] [[Coupling states::ET-pathway]] | |||
|?Was published in year=Year | |?Was published in year=Year | ||
|?Has title=Reference | |?Has title=Reference |
Revision as of 09:49, 20 October 2017
Description
The ROUTINE control ratio (R/E coupling control ratio) is the ratio of (partially coupled) ROUTINE respiration and (noncoupled) ET capacity. The R/E control ratio is an expression of how close ROUTINE respiration operates to ET capacity.
Abbreviation: R/E
Reference: Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory control ratio
Boundaries of the ROUTINE control ratio
- R/E increases due to (i) high ATP demand and ADP-stimulated ROUTINE respiration, (ii) partial uncoupling, and (iii) limitation of oxidative capacity by defects of substrate oxidation and complexes of the ET-pathway. The corresponding inverse ratio is the uncoupling control ratio, UCR, which can be seen as an index of apparent ET-pathway excess capacity. The lower boundary of R/E is the L/E flux control ratio, whereas the upper boundary is set by the P/E flux control ratio (OXPHOS/ET capacity).
Biochemical coupling efficiency: from 0 to <1
- More details: ยปBiochemical coupling efficiency
- Compare:
- Excess E-R capacity factor, jExR = (E-R)/E = 1-R/E
- ROUTINE coupling efficiency, jโR = โR/R = (R-L)/R = 1-L/R
- NetROUTINE control ratio, โR/E = (R-L)/E