NS e-input: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|description='''CI&II e-input''' is electron input though Complexes [[CI]] | |description='''CI&II e-input''' is electron input though Complexes [[CI]] and [[CII]] simultaneously into the [[Q-junction]] corresponding to [[TCA cycle]] function ''in vivo'', with [[convergent electron flow]] through the [[ETS]]. In [[Mitochondrial preparations|mt-preparations]], CI&II e-input requires addition not only of CI-linked substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant stimulation of CII-linked respiration. For more details, see: [[Additive effect of convergent CI&II electron flow]]. | ||
|info=[http://www.oroboros.at/?Gnaiger_2012_MitoPathways Gnaiger 2012 MitoPathways], [[Gnaiger 2009 Int J Biochem Cell Biol]] | |info=[http://www.oroboros.at/?Gnaiger_2012_MitoPathways Gnaiger 2012 MitoPathways], [[Gnaiger 2009 Int J Biochem Cell Biol]] | ||
|type=Transport | |type=Transport | ||
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|type=Transport | |type=Transport | ||
}} | }} | ||
{{MitoPedia topics|type=Transport | {{MitoPedia topics | ||
|mitopedia topic=Substrate and metabolite | |||
|type=Transport | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
|enzymes=Complex I, Complex II; Succinate Dehydrogenase | |enzymes=Complex I, Complex II; Succinate Dehydrogenase | ||
}} | }} | ||
Revision as of 09:40, 21 August 2014
- high-resolution terminology - matching measurements at high-resolution
NS e-input
Description
CI&II e-input is electron input though Complexes CI and CII simultaneously into the Q-junction corresponding to TCA cycle function in vivo, with convergent electron flow through the ETS. In mt-preparations, CI&II e-input requires addition not only of CI-linked substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since metabolite depletion in the absence of succinate prevents a significant stimulation of CII-linked respiration. For more details, see: Additive effect of convergent CI&II electron flow.
Reference: Gnaiger 2012 MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol
MitoPedia methods:
Respirometry
MitoPedia topics:
Substrate and metabolite
Labels:
Enzyme: Complex I, Complex II; Succinate Dehydrogenase"Complex II; Succinate Dehydrogenase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property.
