State 3: Difference between revisions
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Whereas [[OXPHOS capacity]] is measured at saturating concentrations of ADP and Pi, State 3 is defined as ADP stimulated respiration in the presence of high ADP and Pi concentrations (Chance and Williams, 1955) which are not necessarily saturating. For instance, non-saturating ADP concentrations are applied in State 3 in pulse titrations to determine the [[P/O ratio]] in State 3→4 (D→T) transitions, when saturating ADP concentrations would deplete the oxygen concentration in the closed oxygraph chamber before [[State 4]] is obtained (Gnaiger et al 2000; Puchowicz et al 2004). | {{MitoPedia | ||
= | |abbr=''P'' | ||
|description=Whereas [[OXPHOS capacity]] is measured at saturating concentrations of ADP and Pi, '''State 3''' is defined as ADP stimulated respiration in the presence of high ADP and Pi concentrations [[(Chance_1955_JBC-III|Chance and Williams, 1955]]) which are not necessarily saturating. For instance, non-saturating ADP concentrations are applied in State 3 in pulse titrations to determine the [[P/O ratio]] in State 3→4 (D→T) transitions, when saturating ADP concentrations would deplete the oxygen concentration in the closed oxygraph chamber before [[State 4]] is obtained ([[Gnaiger_2000_PNAS|Gnaiger et al 2000]]; [[Puchowicz_2004_Mitochondrion|(Puchowicz et al 2004]]). | |||
|info=MiPNet12.15, Chance_1955_JBC-III | |||
|type=Respiration | |||
}} | |||
{{Labeling | |||
|discipline=Mitochondrial Physiology | |||
|topics=Respiration; OXPHOS; ETS Capacity, ATP; ADP; AMP; PCr | |||
}} | |||
Revision as of 08:47, 16 September 2010
- high-resolution terminology - matching measurements at high-resolution
State 3
Description
Whereas OXPHOS capacity is measured at saturating concentrations of ADP and Pi, State 3 is defined as ADP stimulated respiration in the presence of high ADP and Pi concentrations Chance and Williams, 1955) which are not necessarily saturating. For instance, non-saturating ADP concentrations are applied in State 3 in pulse titrations to determine the P/O ratio in State 3→4 (D→T) transitions, when saturating ADP concentrations would deplete the oxygen concentration in the closed oxygraph chamber before State 4 is obtained (Gnaiger et al 2000; (Puchowicz et al 2004).
Abbreviation: P
Reference: MiPNet12.15, Chance_1955_JBC-III
Labels:
Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., ATP; ADP; AMP; PCr"ATP; ADP; AMP; PCr" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
