Alencar 2022 BEC

From Bioblast

Bioenergetics Communications        
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Gnaiger 2020 BEC MitoPathways
Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1.
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Bioenergetics Communications
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Alencar MB, Ramos EV, Silber AM, ZΓ­kovΓ‘ A, Oliveira MF (2022) The extraordinary energy metabolism of the bloodstream Trypanosoma brucei forms: a critical review and hypothesis. Bioenerg Commun 2022.17.

Β» Bioenerg Commun 2022.17. Open Access pdf
published online 2022-12-05

Alencar Mayke Bezerra, Ramos Emily V, Silber Ariel M, Zikova Alena, Oliveira Marcus F (2022) Bioenerg Commun

Abstract: BEC.png
The parasite Trypanosoma brucei is the causative agent of sleeping sickness and involves an insect vector and a mammalian host through its complex life cycle. T. brucei mammalian bloodstream forms (BSF) exhibits unique metabolic features including: (1) reduced expression and activity of mitochondrial enzymes; (2) respiration mediated by the glycerol phosphate shuttle (GPSh) and the Trypanosome alternative oxidase (TAO) that is intrinsically uncoupled from generation of mitochondrial protonmotive force; (3) maintenance of mitochondrial membrane potential by ATP hydrolysis through the reversal of F1FO-ATP synthase activity; (4) strong reliance on glycolysis to meet their energy demands; (5) high susceptibility to oxidants. Here, we critically review the main metabolic features of BSF and provide a hypothesis to explain the unusual metabolic network and its biological significance for this parasite form. We postulate that intrinsically uncoupled respiration provided by the GPSh-TAO system acts as a preventive antioxidant defense by limiting mitochondrial superoxide production and complementing the NADPH-dependent scavenging antioxidant defenses to maintain redox balance. Given the uncoupled nature of the GPSh-TAO system, BSF avoids cell death processes by maintaining mitochondrial protonmotive force through the reversal of ATP synthase activity using the ATP generated by glycolysis. This unique β€œmetabolic design” in BSF has no biological parallel outside of trypanosomatids and highlights the enormous diversity of the parasite mitochondrial processes to adapt to distinct environments.
β€’ Keywords: Alternative oxidase; glycerol phosphate; reactive oxygen species; cell death; Trypanosoma brucei; mitophagy; antioxidant β€’ Bioblast editor: Tindle-Solomon L β€’ O2k-Network Lab: BR Sao Paulo Silber AM, BR Rio de Janeiro Oliveira MF

ORCID: ORCID.png Alencar MB, ORCID.png Silber Ariel M, ORCID.png Zikova Alena, ORCID.png Oliveira Marcus F

MitoFit Preprint

Β» Alencar 2022 MitoFit


Organism: Protists 

Pathway: Gp 

AOX, Trypanosoma brucei, glycerophosphate shuttle, BEC 

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