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Brown RA, Sarkar A (2020) Vitamin D deficiency: a factor in COVID-19, progression, severity and mortality? – An urgent call for research.

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Vitamin D deficiency: a factor in COVID-19 progression severity and mortality? An urgent call for research - 2020-02-29 Published without peer-review in »Modern Ghana«

Brown Robert Andrew, Sarkar Amrita (2020) MitoFit Preprint Arch

Abstract: Version 1 (v1) 2020-03-24 doi:10.26124/mitofit:200001

The COVID-19 virus emerged in 2019. Mortality rates as at 20th March 2020 are much higher in southern than northern Europe. The elderly, and those with pre-existing conditions, are at greatest risk. It is hypothesised, vitamin D deficiency may significantly compromise, respiratory immune response function, thus greatly increasing risk of COVID-19 hospitalisation, severity and mortality. Winter vitamin D levels: based on; limited data, including; historical measured regional vitamin D deficiency rates (<25 nmol/L), intakes, and plasma vitamin D levels; fortification and supplementation policies; and public vitamin D awareness: appear to be significantly lower in southern, than northern Europe. In respiratory system conditions, such as influenza, vitamin D has wide-ranging and fundamental roles, including through: gene transcription via COVID-19 relevant VDR (Vitamin D Receptor) pathways; ACE1 and ACE2 pathways; wider immune function; airway epithelial cell tight-junction function and integrity; and mitochondrial related, energetics, apoptosis and inflammation, management. Studies suggest vitamin D supplementation may be protective against respiratory conditions, in ‘D’ deficient persons. Would vitamin D supplementation of the deficient, mitigate the severity of the current COVID-19 outbreak; and reduce future, likely upcoming, seasonal amplification effects? Keywords: COVID-19, Vitamin D deficiency, 25 hydroxy D, Vitamin D Receptor, VDR Receptor, Obesity, Influenza, ACE, Angiotensin, Tight Junctions. Bioblast editor: Iglesias-Gonzalez J


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Minor corrections

  • First author: Brown RA
  • Table 1 needs sorting.
  • Reference is to table 2 although wrongly called Table 1.

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