Electron leak

From Bioblast

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Electron leak


Electrons that escape the electron transfer pathway without completing the reduction of oxygen to water at cytochrome c oxidase, causing the production of ROS. The rate of electron leak depends on the topology of the complex, the redox state of the moiety responsible of electron leakiness and usually on the protonmotive force (Ξ”p). In some cases, the Ξ”p dependance relies more on the βˆ†pH component than in the βˆ†Ξ¨.


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  1. Jastroch M, Divakaruni AS, MookerjeecS, Treberg JR, Brand MD (2010) Mitochondrial proton and electron leaks. Essays Biochemistry 47: 53–67 pp.

MitoPedia concepts: MiP concept 

MitoPedia methods: Respirometry, Fluorometry 

MitoPedia topics: EAGLE 

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