From Bioblast
- high-resolution terminology - matching measurements at high-resolution
Etomoxir
Description
Etomoxir (Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of carnitine palmitoyltransferase I (CPT-I) on the outer face of the mitochondrial inner membrane. Eto inhibits fatty acid oxidation by blocking the formation of acyl carnitines from long-chain fatty acids which require the carnitine shuttle for transport into mitochondria. In contrast to long-chain fatty acids, the transport of short- and medium-chain fatty acids is carnitine-independent.
Abbreviation: Eto
Application in HRR
- Eto (Etomoxir): ((+)-Etomoxir sodium salt hydrate); Sigma Aldrich; E-1905; storage: 2-8 °C; M = 338.76 g·mol-1
- Caution: Store tightly sealed, protected from exposure to light. Acute toxicity (oral, dermal, inhalation). Dust mask or eyeshields, faceshields and gloves are recommended by the preparation.
- Preparation of 10 mM stock solution (dissolved in H2O): The commercially available white compound is soluble in water.
- Weigh 5 mg etomoxir.
- Add 1.476 mL dt H2O.
- Divide into 500 µL portions.
- Store frozen at -20 °C.
MitoPedia topics: Inhibitor
Labels:
MitoPedia:FAT4BRAIN
