Gonzalez-Franquesa A

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MiPsociety
COST Action CA15203 MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping


 

Gonzalez-Franquesa A


MitoPedia topics: EAGLE 

COST: ECI COST WG1: WG1 COST WG2: WG2


Name Gonzalez-Franquesa Alba, Postdoctoral Research Fellow
Institution The Novo Nordisk Center for Basic Metabolic Research,

Section for Integrative Physiology,

Københavns Universitet, DK

Address Blegdamsvej 3B, 7.7, 2200
City Copenhagen
State/Province
Country Denmark
Email albagf@sund.ku.dk
Weblink
O2k-Network Lab ES Barcelona Garcia-Roves PM


Labels:



Publications

 PublishedReference
Doerrier 2019 MitoFit Preprint Arch EA2019Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0009.
Gnaiger 2019 MitoFit Preprint Arch2019Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6.
Pardo 2018 FASEB J2018Pardo R, Vilà M, Cervela L, de Marco M, Gama-Pérez P, González-Franquesa A, Statuto L, Vilallonga R, Simó R, Garcia-Roves PM, Villena JA (2018) Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue. FASEB J 33:2343-58.
Ejaz 2016 Diabetes2016Ejaz A, Martinez-Guino L, Goldfine AB, Ribas-Aulinas F, De Nigris V, Ribó S, Gonzalez-Franquesa A, Garcia-Roves PM, Li E, Dreyfuss JM, Gall W, Kim JK, Bottiglieri T, Villarroya F, Gerszten RE, Patti ME, Lerin C (2016) Dietary betaine supplementation increases Fgf21 levels to improve glucose homeostasis and reduce hepatic lipid accumulation in mice. Diabetes 65:902-12.
Torres 2016 Redox Biol2016Torres S, Matías N, Baulies A, Nuñez S, Alarcon-Vila C, Martinez L, Nuño N, Fernandez A, Caballeria J, Levade T, Gonzalez-Franquesa A, Garcia-Rovés P, Balboa E, Zanlungo S, Fabrías G, Casas J, Enrich C, Garcia-Ruiz C, Fernández-Checa JC (2016) Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 11:60-72.
Errea 2015 J Neuroinflammation2015Errea O, Moreno B, Gonzalez-Franquesa A, Garcia-Roves PM, Villoslada P (2015) The disruption of mitochondrial axonal transport is an early event in neuroinflammation. J Neuroinflammation 12:152.
Schneeberger 2013 Cell2013Schneeberger M, Dietrich MO, Sebastián D, Imbernón M, Castaño C, Garcia A, Esteban Y, Gonzalez-Franquesa A, Rodríguez IC, Bortolozzi A, Garcia-Roves PM, Gomis R, Nogueiras R, Horvath TL, Zorzano A, Claret M (2013) Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell 155:172-87.

Abstracts

 PublishedReference
Doerrier 2019 MiP20192019
Carolina Doerrier
Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers.
Dahdah 2019 MiP20192019
Norma Dahdah
Approaches to assess mitochondrial respiration in white adipose tissue.
Doerrier 2018 MiP2018c2018
Carolina Doerrier
Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation.
Villena 2017 MiP20172017
MiPsociety
PGC-1 co-activators mediate calorie restriction-induced mitochondrial biogenesis in white adipose tissue: implications on glucose homeostasis.
Garcia-Roves 2016a Abstract MitoFit Science Camp 20162016Design and implementation of systems biology approaches to integrate heterogenic data in biomedical research.
Garcia-Roves 2016b Abstract MitoFit Science Camp 20162016Technical perspective of high-resolution respirometry in permeabilized skinned muscle fibers from different mouse models.
Garcia-Roves 2013 Abstract MiP20132013Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08.

MitoEAGLE Short-Term Scientific Mission

Work Plan summary
Aim and motivation
A collaboration already exist between the two partners involved in this STSM. This collaboration includes two main projects: the study of mitochondrial function in white adipose tissue (WAT) in order to understand its role and importance in the hallmark of type 2 diabetes; and the implication of both parts in the WG2 and WG3.
Proposed contribution
This STSM will be a first step into the assessment of most used protocol for the study of mitochondrial respiration in white adipose tissue preparations (not isolated mitochondria), given the lack of standardized protocols comparisons and the aims of the COST Action.
Techniques
Oroboros O2k will be used for measuring mitochondrial respiration in different type of white adipose tissue sample preparation (e.g. whole WAT homogenate, adipocyte after SVF removal, and permeabilized WAT depot after gentle centrifugation to remove lipid layer)
Planning
1 day for study design and clarifying all the variables involved for a proper experimental performance
4 days for experimental performance
1 day for data analysis
4 days for data discussion, along with WG2 and WG3 results discussion


Participated at


  • Mitochondrial dysfunction in insulin-dependent tissues such as liver, skeletal muscle and adipose tissue