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Residual oxygen consumption

From Bioblast


high-resolution terminology - matching measurements at high-resolution


Residual oxygen consumption

Description

ROX.jpg Residual oxygen consumption Rox — respiration in the ROX state — is due to oxidative side reactions remaining after inhibition of the electron transfer pathway (ET pathway) in mitochondrial preparations or cells, or in mt-preparations incubated without addition of fuel substrates (in the presence of ADP following a stimulation of the consumption of endogenous fuel substrates: State 2). Different conditions designated as ROX states (different combinations of inhibitors of CI, CII, CIII and CIV; or respiration of mt-preparations without addition of fuel substrates) may result in consistent or significantly different levels of oxygen consumption. Hence the best quantitative estimate of Rox has to be carefully evaluated. Mitochondrial respiration is frequently corrected for Rox as the baseline state. Then total ROUTINE, LEAK respiration, OXPHOS or ET (R, L, P and E) respiration are distinguished from the corresponding Rox-corrected, mitochondrial (ET-pathway linked) fluxes: R(mt), L(mt), P(mt) and E(mt). Alternatively, R, L, P and E are defined as Rox-corrected rates, in contrast to total rates R´, L´, P´ and E´. When expressing Rox as a fraction of ET capacity (flux control ratio), total flux E´ (not corrected for Rox), should be taken as the reference. Rox may be related to, but is of course different from ROS production.

Abbreviation: ROX, Rox

Reference: BEC 2020.1, Electron-transfer-pathway state, Gnaiger 2020 BEC MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol

Residual oxygen consumption: a baseline correction of mitochondrial respiration

Publications in the MiPMap
Gnaiger E (2020) Residual oxygen consumption: a baseline correction of mitochondrial respiration. Mitochondr Physiol Network (2016-01-28) last update 2020-11-11.


Oroboros (2020) MiPNet

Abstract: ROX.jpg Residual oxygen consumption (Rox) is sometimes referred to as 'non-mitochondrial respiration'. This may be correct to a large extent, but is not entirely accurate. In a preparation of purified isolated mitochondria, a small but significant Rox is observed after appropriate correction for instrumental background oxygen flux. In this case, Rox is 'mitochondrial non-ET pathway' rather than ‘non-mitochondrial’ respiration. In permeabilized and living cells, Rox may be higher than in isolated mitochondria, and this increased part then would be a measurement of non-mitochondrial respiration. Keilin (1926) introduced and accurately defined the term residual respiration.


O2k-Network Lab: AT Innsbruck Gnaiger E


Abbreviations

  • Previous editions (including Gnaiger 2020 BEC MitoPathways): ROX-corrected ROUTINE, LEAK respiration, OXPHOS or ET pathway (R, L, P and E) is distinguished from the corresponding apparent fluxes that are not corrected for ROX. Apparent fluxes (not corrected for ROX; R´, L´, P´ and E´) places the terminology into the conceptual context of physical chemistry (including kinetics), where e.g. apparent equilibrium constants, Keq´ (apparent Michaelis-Menten kinetic constants, Km´) are carefully distinguished from the less accessible (or inaccessible) 'true' constants, Keq (Km).
  • Mitochondrial physiology nomenclature: Despite the fact that the previously used system of abbreviations is linked to a conceptually consistent framework of physical chemistry, generalized applicability may gain from a shift to a pragmatic emphasis of the experimental context of mitochondrial physiology. Rox correction is a baseline correction, which may be evaluated by a direct measurement within an experimental assay, or by independent test experiments for critical evaluation of the best estimate for a particular Rox correction. The Rox correction, therefore, may be emphasized by labelling the Rox-corrected values as mitochondrial (mt) fluxes: R(mt), L(mt), P(mt) and E(mt). Unfortunately, the total R, L, P and E values in this mitochondrial physiology system carry opposite meanings to the physical chemistry system of terminology. Confusion may be avoided in this context by explicit abbreviations, R(total), L(total), P(total) and E(total). Such lengthy abbreviations are not really practical.
  • Agreement is required for paving the way towards consistent data reporting and managing a meaningful database (but agreement is not even reached in hot debates on caloric units [J versus cal] or frozen debates on commonly used temperature scales [°C versus Faraday]. Unfortunately, the two systems of abbreviations for Rox correction are not compatible. It is of practical importance to use short and well defined symbols. As a practical guideline, therefore, the simplest solution is to define in a given context, if data (and symbols used) refer to total or Rox-corrected results, and then use the simple symbols R, L, P and E in such a defined context.


Keilin 1929: Residual respiration

'KCN, H2S and CO combine with some of the components of oxidase forming an inactive compound, with the result that cytochrome, or at least its components a’ and c’, as well as paraphenylenediamine added to the cells, are not oxidised. The respiratory process can be still carried out through the medium of some autoxidisable carriers such as haemochromogens, haematins, the component b’ of cytochrome, or some as yet unknown autoxidisable substances. This residual respiration, according to the nature of the cell, may represent a larger or smaller fraction of the total respiration of the cell.'
Keilin D (1929) Cytochrome and respiratory enzymes. Proc R Soc London Ser B 104:206-52.


Experimental tests on Rox

Is the preparation fully permeabilized?

Rox may be estimated in mitochondrial preparations in SUIT protocols which start at a respiratory state without added CHO substrates and without inhibitors, such that continuation of the SUIT protocol is possible for OXPHOS analysis. Some critical questions arise for evaluation, if this respiratory 'ROX state' represents a valid condition for estimation of Rox, and for comparison with Rox measured at the end of a SUIT protocol after titration of substrates and inhibitors of key elements of the electron transfer pathway (e.g. Rotenone, Malonate and Antimycin A as inhibitors of CI, CII and CIII). For evaluation of such an initial estimate of Rox, the following considerations are suggested.
  1. A preparation of permeabilized tissue or cells, Ptic, may contain a fraction of living, non-permeabilized cells. Non-permeabilized cells have ROUTINE respiration that
    1. is higher than Rox;
    2. is not stimulated by addition of ADP;
    3. is not diminished over prolonged periods of time due to the presence of cellular endogenous substrates;
    4. can be stimulated by uncoupler titration;
    5. can be inhibited by Rot (CI) and Ama (CIII), etc.
  2. Respiration of permeabilized tissue or cells incubated in a medium with significant concentrations of mitochondrial substrates
    1. is higher than Rox;
    2. is stimulated by addition of ADP (compare 1.2);
    3. is not diminished over prolonged periods of time due to the presence of exogenous substrates in the medium;
    4. can be stimulated by uncoupler titration,
    5. can be inhibited by Rot (CI) and Ama (CIII), etc.
  3. In contrast, the acutal level of Rox of fully permeabilized cells responds to such tests as
    1. Rox is obtained after gradual depletion of mitochondrial internal substrates (gradual decline of oxygen consumption);
    2. ADP or uncoupler titrations accelerate this decline;
    3. Rot and Ama do not inhibit Rox;
    4. uncoupler titration does not stimulate Rox.

Keywords


Questions.jpg


Click to expand or collaps
Bioblast links: Coupling control - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

1. Mitochondrial and cellular respiratory rates in coupling-control states

OXPHOS-coupled energy cycles. Source: The Blue Book
» Baseline state
Respiratory rate Defining relations Icon
OXPHOS capacity P = -Rox P.jpg mt-preparations
ROUTINE respiration R = -Rox R.jpg living cells
ET capacity E = -Rox E.jpg » Level flow
» Noncoupled respiration - Uncoupler
LEAK respiration L = -Rox L.jpg » Static head
» LEAK state with ATP
» LEAK state with oligomycin
» LEAK state without adenylates
Residual oxygen consumption Rox L = -Rox ROX.jpg
  • Chance and Williams nomenclature: respiratory states
» State 1 —» State 2 —» State 3 —» State 4 —» State 5

2. Flux control ratios related to coupling in mt-preparations and living cells

» Flux control ratio
» Coupling-control ratio
» Coupling-control protocol
FCR Definition Icon
L/P coupling-control ratio L/P L/P coupling-control ratio » Respiratory acceptor control ratio, RCR = P/L
L/R coupling-control ratio L/R L/R coupling-control ratio
L/E coupling-control ratio L/E L/E coupling-control ratio » Uncoupling-control ratio, UCR = E/L (ambiguous)
P/E control ratio P/E P/E control ratio
R/E control ratio R/E R/E control ratio » Uncoupling-control ratio, UCR = E/L
net P/E control ratio (P-L)/E net P/E control ratio
net R/E control ratio (R-L)/E net R/E control ratio

3. Net, excess, and reserve capacities of respiration

Respiratory net rate Definition Icon
P-L net OXPHOS capacity P-L P-L net OXPHOS capacity
R-L net ROUTINE capacity R-L R-L net ROUTINE capacity
E-L net ET capacity E-L E-L net ET capacity
E-P excess capacity E-P E-P excess capacity
E-R reserve capacity E-R E-R reserve capacity

4. Flux control efficiencies related to coupling-control ratios

» Flux control efficiency jZ-Y
» Background state
» Reference state
» Metabolic control variable
Coupling-control efficiency Definition Icon Canonical term
P-L control efficiency jP-L = (P-L)/P = 1-L/P P-L control efficiency P-L OXPHOS-flux control efficiency
R-L control efficiency jR-L = (R-L)/R = 1-L/R R-L control efficiency R-L ROUTINE-flux control efficiency
E-L coupling efficiency jE-L = (E-L)/E = 1-L/E E-L coupling efficiency E-L ET-coupling efficiency » Biochemical coupling efficiency
E-P control efficiency jE-P = (E-P)/E = 1-P/E E-P control efficiency E-P ET-excess flux control efficiency
E-R control efficiency jE-R = (E-R)/E = 1-R/E E-R control efficiency E-R ET-reserve flux control efficiency

5. General

» Basal respiration
» Cell ergometry
» Dyscoupled respiration
» Dyscoupling
» Electron leak
» Electron-transfer-pathway state
» Hyphenation
» Oxidative phosphorylation
» Oxygen flow
» Oxygen flux
» Permeabilized cells
» Phosphorylation system
» Proton leak
» Proton slip
» Respiratory state
» Uncoupling


References

Bioblast linkReferenceYear
Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. https://doi.org/10.1016/j.biocel.2009.03.0132009
Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. https://doi.org/10.26124/bec:2020-0002BEC 2020.2
Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. https://doi.org/10.26124/bec:2020-0001.v1BEC 2020.1
Keilin D (1929) Cytochrome and respiratory enzymes. Proc R Soc London Ser B 104:206-52.1929
Publications in the MiPMap


» List of publications: Residual oxygen consumption
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 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Karavyraki 2022 BECBEC 2022.11Karavyraki M, Gnaiger E, Porter RK (2022) Bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells https://doi.org/10.26124/bec:2022-0011LEAK
ROUTINE
ET
S
ROX
Permeabilized cellsHuman
Serna 2022 BECBEC 2022.07Serna JDC, Ramos VM, Cabral-Costa JV, Vilas-Boas EA, Amaral AG, Ohya G, da Silva CCC, Kowaltowski AJ (2022) Measuring mitochondrial Ca2+ efflux in isolated mitochondria and permeabilized cells. https://doi.org/10.26124/bec:2022-0007LEAK
OXPHOS
S
ROX
Permeabilized cells
Isolated mitochondria
Human
Mouse
Liver
Other cell lines
Heimler 2022 BECBEC 2022.02Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina AJA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older adult women. https://doi.org/10.26124/bec:2022-0002OXPHOS
ET
F
N
S
Gp
ROX
Permeabilized cellsHumanBlood cells
Cardoso 2021 BEC MgGBEC 2021.1Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. https://doi.org/10.26124/bec:2021-0001LEAK
OXPHOS
ET
N
S
ROX
Isolated mitochondriaMouseHeart
Gnaiger 2020 BEC MitoPathwaysBEC 2020.2Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. https://doi.org/10.26124/bec:2020-0002LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Intact cells
Human
Mouse
Heart
Skeletal muscle
Fibroblast
BEC 2020.1 doi10.26124bec2020-0001.v1BEC 2020.1Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. https://doi.org/10.26124/bec:2020-0001.v1LEAK
OXPHOS
ET
F
N
S
Gp
DQ
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Karavyraki 2022 MitoFit2022-06-02Karavyraki M, Gnaiger E, Porter RK (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. https://doi.org/10.26124/mitofit:2022-00222022-11-11 published in Bioenerg Commun 2022.11.LEAK
ROUTINE
ET
S
ROX
Permeabilized cellsHuman
Serna 2022 MitoFit2022-05-24Serna JDC, Ramos VM, Cabral-Costa JV, Vilas-Boas EA, Amaral AG, Ohya G, da Silva CCC, Kowaltowski AJ (2022) Measuring mitochondrial Ca2+ efflux in isolated mitochondria and permeabilized cells. https://doi.org/10.26124/mitofit:2022-00212022-07-28 published in Bioenerg Commun 2022.7.LEAK
OXPHOS
S
ROX
Permeabilized cells
Isolated mitochondria
Human
Mouse
Liver
Other cell lines
Heimler 2022 MitoFit2022-04-12Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina AJA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older women. https://doi.org/10.26124/mitofit:2022-00072022-06-28 published in Bioenerg Commun 2022.2.ET
OXPHOS
ROX
F
N
S
Gp
Permeabilized cellsHumanBlood cells
Torres-Quesada 2022 MitoFit2022-04-01Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Human Plasma-Like Media fine-tune mitochondrial function and alter drug sensitivity in cancer cell lines. https://doi.org/10.26124/mitofit:2022-00082022-08-13 published in https://doi.org/10.3390/cancers14163917ROUTINE
LEAK
ET
ROXIntact cellsHumanOther cell lines
Pallag 2022 MitoFit Proline2022-03-07Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation leading to high electron flow through reduction of ubiquinone supports ATP production by F1FO-ATPase in mitochondria with inhibited Complex I. https://doi.org/10.26124/mitofit:2022-0001.v32022-05-04 published in https://doi.org/10.3390/ijms23095111LEAK
OXPHOS
N
S
NS
Other combinations
ROX
Isolated mitochondriaMouseHeart
Kidney
Liver
Nervous system
Ilha 2022 Cell Biol Int2022Ilha M, Meira Martins LA, da Silveira Moraes K, Dias CK, Thomé MP, Petry F, Rohden F, Borojevic R, Trindade VMT, Klamt F, Barbé-Tuana F, Lenz G, Guma FCR (2022) Caveolin-1 influences mitochondrial plasticity and function in hepatic stellate cell activation. https://doi.org/10.1002/cbin.11876LEAK
ROUTINE
ET
ROXIntact cellsMouseLiver
Soares 2022 Geroscience2022Soares RN, Ramirez-Perez FI, Cabral-Amador FJ, Morales-Quinones M, Foote CA, Ghiarone T, Sharma N, Power G, Smith JA, Rector RS, Martinez-Lemus LA, Padilla J, Manrique-Acevedo C (2022) SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice. https://doi.org/10.1007/s11357-022-00563-xLEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseEndothelial;epithelial;mesothelial cell
Nadeu 2022 Nat Med2022Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, Duran-Ferrer M, Dawson KJ, Kulis M, Diaz-Navarro A, Villamor N, Melero JL, Chapaprieta V, Dueso-Barroso A, Delgado J, Moia R, Ruiz-Gil S, Marchese D, Giró A, Verdaguer-Dot N, Romo M, Clot G, Rozman M, Frigola G, Rivas-Delgado A, Baumann T, Alcoceba M, González M, Climent F, Abrisqueta P, Castellví J, Bosch F, Aymerich M, Enjuanes A, Ruiz-Gaspà S, López-Guillermo A, Jares P, Beà S, Capella-Gutierrez S, Gelpí JL, López-Bigas N, Torrents D, Campbell PJ, Gut I, Rossi D, Gaidano G, Puente XS, Garcia-Roves PM, Colomer D, Heyn H, Maura F, Martín-Subero JI, Campo E (2022) Detection of early seeding of Richter transformation in chronic lymphocytic leukemia. https://doi.org/10.1038/s41591-022-01927-8LEAK
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ET
ROXIntact cellsHumanLymphocyte
Blood cells
Babylon 2022 Int J Mol Sci2022Babylon L, Schmitt F, Franke Y, Hubert T, Eckert GP (2022) Effects of combining biofactors on bioenergetic parameters, Aβ levels and survival in Alzheimer model organisms. https://doi.org/10.3390/ijms23158670LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanNeuroblastoma
Tepp 2022 Biochem Biophys Rep2022Tepp K, Aid-Vanakova J, Puurand M, Timohhina N, Reinsalu L, Tein K, Plaas M, Shevchuk I, Terasmaa A, Kaambre T (2022) Wolframin deficiency is accompanied with metabolic inflexibility in rat striated muscles. Biochem Biophys Rep 30:101250.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized tissueRatSkeletal muscle
Roy 2022 Am J Pathol2022Roy N, Alencastro F, Roseman BA, Wilson SR, Delgado ER, May MC, Bhushan B, Bello FM, Jurczak MJ, Shiva S, Locker J, Gingras S, Duncan AW (2022) Dysregulation of lipid and glucose homeostasis in hepatocyte-specific SLC25A34 knockout mice. https://doi.org/10.1016/j.ajpath.2022.06.002LEAK
OXPHOS
ET
N
NS
ROX
HomogenateMouseLiver
Melin 2022 JHEP Rep2022Melin N, Yarahmadov T, Sanchez-Taltavull D, Birrer FE, Brodie TM, Petit B, Felser A, Nuoffer JM, Montani M, Vozenin MC, Herrmann E, Candinas D, Aebersold DM, Stroka D (2022) A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus. https://doi.org/10.1016/j.jhepr.2022.100508LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsMouseLiver
Wu 2022 Antioxidants (Basel)2022Wu YL, Chang JC, Chao YC, Chan H, Hsieh M, Liu CS (2022) In vitro efficacy and molecular mechanism of curcumin analog in pathological regulation of spinocerebellar ataxia type 3. https://doi.org/10.3390/antiox11071389LEAK
OXPHOS
ET
N
S
NS
ROX
Intact cellsHumanNeuroblastoma
Zhang 2022 Int J Mol Sci2022Zhang A, Gupte AA, Chatterjee S, Li S, Ayala AG, Miles BJ, Hamilton DJ (2022) Enhanced succinate oxidation with mitochondrial complex II reactive oxygen species generation in human prostate cancer. https://doi.org/10.3390/ijms232012168LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanGenital
Wang 2022 Redox Biol2022Wang P, Cui Y, Liu Y, Li Z, Bai H, Zhao Y, Chang YZ (2022) Mitochondrial ferritin alleviates apoptosis by enhancing mitochondrial bioenergetics and stimulating glucose metabolism in cerebral ischemia reperfusion. https://doi.org/10.1016/j.redox.2022.102475LEAK
OXPHOS
ET
N
ROX
HomogenateMouseNervous system
Guo 2022 Sci Adv2022Guo Q, Xu Z, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z (2022) Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4. https://doi.org/10.1126/sciadv.abo0340LEAK
OXPHOS
N
S
ROX
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Fat
Torres-Quesada 2022 Cancers (Basel)2022Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Physiological cell culture media tune mitochondrial bioenergetics and drug sensitivity in cancer cell models. https://doi.org/10.3390/cancers14163917LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
Peugnet 2022 Antioxidants (Basel)2022Peugnet V, Chwastyniak M, Mulder P, Lancel S, Bultot L, Fourny N, Renguet E, Bugger H, Beseme O, Loyens A, Heyse W, Richard V, Amouyel P, Bertrand L, Pinet F, Dubois-Deruy E (2022) Mitochondrial-targeted therapies require mitophagy to prevent oxidative stress induced by SOD2 inactivation in hypertrophied cardiomyocytes. https://doi.org/10.3390/antiox11040723LEAK
ROUTINE
ET
ROXIntact cellsRatHeart
Cano-Sanchez 2022 PLoS Negl Trop Dis2022Cano-Sanchez M, Ben-Hassen K, Louis OP, Dantin F, Gueye P, Roques F, Mehdaoui H, Resiere D, Neviere R (2022) Bothrops lanceolatus snake venom impairs mitochondrial respiration and induces DNA release in human heart preparation. https://doi.org/10.1371/journal.pntd.0010523LEAK
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ET
N
S
CIV
NS
ROX
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Ceja-Galicia 2022 Antioxidants (Basel)2022Ceja-Galicia ZA, García-Arroyo FE, Aparicio-Trejo OE, El-Hafidi M, Gonzaga-Sánchez G, León-Contreras JC, Hernández-Pando R, Guevara-Cruz M, Tovar AR, Rojas-Morales P, Aranda-Rivera AK, Sánchez-Lozada LG, Tapia E, Pedraza-Chaverri J (2022) Therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia: association with the improvement of renal mitochondrial β-oxidation and lipid metabolism in kidney and liver. https://doi.org/10.3390/antiox11112195LEAK
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F
N
ROX
Isolated mitochondriaRatKidney
Pallag 2022 Int J Mol Sci2022Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. https://doi.org/10.3390/ijms23095111LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
Other combinations
ROX
Isolated mitochondriaMouseLiver
Kidney
Quast 2022 Basic Res Cardiol2022Quast C, Kober F, Becker K, Zweck E, Hoffe J, Jacoby C, Flocke V, Gyamfi-Poku I, Keyser F, Piayda K, Erkens R, Niepmann S, Adam M, Baldus S, Zimmer S, Nickenig G, Grandoch M, Bönner F, Kelm M, Flögel U (2022) Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis. https://doi.org/10.1007/s00395-022-00936-5LEAK
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ET
F
N
S
NS
ROX
Permeabilized tissueMouseHeart
Jelenik 2022 Pharmacol Res2022Jelenik T, Kodde A, Pesta D, Phielix E, Oosting A, Rohbeck E, Dewidar B, Mastrototaro L, Trenkamp S, Keijer J, van der Beek EM, Roden M (2022) Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming. https://doi.org/10.1016/j.phrs.2022.106193LEAK
OXPHOS
ET
N
NS
ROX
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Petry 2022 Antioxidants (Basel)2022Petry SF, Römer A, Rawat D, Brunner L, Lerch N, Zhou M, Grewal R, Sharifpanah F, Sauer H, Eckert GP, Linn T (2022) Loss and recovery of glutaredoxin 5 is inducible by diet in a murine model of diabesity and mediated by free fatty acids in vitro. https://doi.org/10.3390/antiox11040788LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsMouseIslet cell;pancreas;thymus
Mandic 2022 J Comp Physiol B2022Mandic M, Frazier AJ, Naslund AW, Todgham AE (2022) A comparative and ontogenetic examination of mitochondrial function in antarctic notothenioid species. https://doi.org/10.1007/s00360-022-01461-6LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueFishesHeart
Dieter 2022 Int J Mol Sci2022Dieter F, Esselun C, Eckert GP (2022) Redox active α-lipoic acid differentially improves mitochondrial dysfunction in a cellular model of Alzheimer and its control cells. https://doi.org/10.3390/ijms23169186LEAK
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ET
N
S
CIV
NS
ROX
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Crowder 2022 Islets2022Crowder JJ, Zeng Z, Novak AN, Alves NJ, Linnemann AK (2022) Stabilization protects islet integrity during respirometry in the Oroboros Oxygraph-2K analyzer. Islets 14:128-38.LEAK
ROUTINE
ET
ROXIntact cellsMouseIslet cell;pancreas;thymus
Bresciani 2022 J Hepatol2022Bresciani N, Demagny H, Lemos V, Pontanari F, Li X, Sun Y, Li H, Perino A, Auwerx J, Schoonjans K (2022) The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. https://doi.org/10.1016/j.jhep.2022.05.040LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaMouseLiver
Kluckova 2022 Hemasphere2022Kluckova K, Clear AJ, D'Avola A, Rassenti LZ, Kipps TJ, Gribben JG, Riches JC (2022) B-cell receptor signaling induced metabolic alterations in chronic lymphocytic leukemia can be partially bypassed by TP53 abnormalities. https://doi.org/10.1097/hs9.0000000000000722LEAK
ET
ROXIntact cellsBlood cells
Meza-Buendia 2022 PLoS One2022Meza-Buendia AK, Aparicio-Trejo OE, Díaz F, Caamal-Monsreal C, Pedraza-Chaverri J, Álvarez-Delgado C, Paschke K, Rosas C (2022) High resolution respirometry of isolated mitochondria from adult Octopus maya (Class: Cephalopoda) systemic heart. https://doi.org/10.1371/journal.pone.0273554LEAK
OXPHOS
ROXIsolated mitochondriaMolluscsHeart
Meszaros 2022 EBioMedicine2022Meszaros AT, Hofmann J, Buch ML , Cardini B, Dunzendorfer-Matt T, Nardin F, Blumer MJ, Fodor M, Hermann M, Zelger B, Otarashvili G, Schartner M, Weissenbacher A, Oberhuber R, Resch T, Troppmair J, Öfner D, Zoller H, Tilg H, Gnaiger E, Hautz T, Schneeberger S (2022) Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome. https://doi.org/10.1016/j.ebiom.2022.104311OXPHOS
ET
LEAK
F
N
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HomogenateHumanLiver
Zdrazilova 2022 PLOS ONE2022Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. https://doi.org/10.1371/journal.pone.0264496LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Fuertes-Agudo 2022 Antioxidants (Basel)2022Fuertes-Agudo M, Luque-Tévar M, Cucarella C, Brea R, Boscá L, Quintana-Cabrera R, Martín-Sanz P, Casado M (2022) COX-2 expression in hepatocytes improves mitochondrial function after hepatic ischemia-reperfusion injury.OXPHOS
ET
F
N
Gp
CIV
NS
Other combinations
ROX
Isolated mitochondriaMouseLiver
Deng 2022 Cell Mol Life Sci2022Deng H, Gao Y, Trappetti V, Hertig D, Karatkevich D, Losmanova T, Urzi C, Ge H, Geest GA, Bruggmann R, Djonov V, Nuoffer JM, Vermathen P, Zamboni N, Riether C, Ochsenbein A, Peng RW, Kocher GJ, Schmid RA, Dorn P, Marti TM (2022) Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. https://doi.org/10.1007/s00018-022-04453-5LEAKROX
N
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CIV
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Smith 2022 J Pineal Res2022Smith KLM, Swiderska A, Lock MC, Graham L, Iswari W, Choudhary T, Thomas D, Kowash HM, Desforges M, Cottrell EC, Trafford AW, Giussani DA, Galli GLJ (2022) Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex-dependent manner. https://doi.org/10.1111/jpi.12821LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateRatHeart
Siewiera 2022 Int J Mol Sci2022Siewiera K, Labieniec-Watala M, Kassassir H, Wolska N, Polak D, Watala C (2022) Potential role of mitochondria as modulators of blood platelet activation and reactivity in diabetes and effect of metformin on blood platelet bioenergetics and platelet activation. https://doi.org/10.3390/ijms23073666LEAK
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ET
N
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Permeabilized cells
Intact cells
RatPlatelet
Zhang 2022 Ecotoxicol Environ Saf2022Zhang Y, Yuan F, Li P, Gu J, Han J, Ni Z, Liu F (2022) Resveratrol inhibits HeLa cell proliferation by regulating mitochondrial function. https://doi.org/10.1016/j.ecoenv.2022.113788LEAK
ROUTINE
ET
ROXIntact cellsHumanHeLa
Schober 2022 Hum Mol Genet2022Schober FA, Tang JX, Sergeant K, Moedas MF, Zierz CM, Moore D, Smith C, Lewis D, Guha N, Hopton S, Falkous G, Lam A, Pyle A, Poulton J, Gorman GS, Taylor RW, Freyer C, Wredenberg A (2022) Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease. https://doi.org/10.1093/hmg/ddac002LEAK
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N
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CIV
NS
ROX
Permeabilized cells
Intact cells
Mouse
Drosophila
Fibroblast
Zhang 2022 Nat Metab2022Zhang CS, Li M, Wang Y, Li X, Zong Y, Long S, Zhang M, Feng JW, Wei X, Liu YH, Zhang B, Wu J, Zhang C, Lian W, Ma T, Tian X, Qu Q, Yu Y, Xiong J, Liu DT, Wu Z, Zhu M, Xie C, Wu Y, Xu Z, Yang C, Chen J, Huang G, He Q, Huang X, Zhang L, Sun X, Liu Q, Ghafoor A, Gui F, Zheng K, Wang W, Wang ZC, Yu Y, Zhao Q, Lin SY, Wang ZX, Piao HL, Deng X, Lin SC (2022) The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. https://doi.org/10.1038/s42255-022-00640-7LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized tissueMouseSkeletal muscle
Graham 2022 Physiol Rep2022Graham ZA, DeBerry JJ, Cardozo CP, Bamman MM (2022) SS-31 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice. https://doi.org/10.14814/phy2.15266LEAK
OXPHOS
ET
N
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Permeabilized tissueMouseSkeletal muscle
Salmon 2022 Geroscience2022Salmón P, Millet C, Selman C, Monaghan P, Dawson NJ (2022) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. https://doi.org/10.1007/s11357-022-00624-1LEAK
OXPHOS
N
CIV
NS
ROX
HomogenateBirdsSkeletal muscle
Liver
Hansen 2022 Magn Reson Med2022Hansen K, Hansen ESS, Jespersen NRV, Bøtker HE, Pedersen M, Wang T, Laustsen C (2022) Hyperpolarized 13C MRI reveals large changes in pyruvate metabolism during digestion in snakes. https://doi.org/10.1002/mrm.29239LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaReptilesLiver
Liu 2022 Adv Sci (Weinh)2022Liu H, Liu Y, Wang H, Zhao Q, Zhang T, Xie SA, Liu Y, Tang Y, Peng Q, Pang W, Yao W, Zhou J (2022) Geometric constraints regulate energy metabolism and cellular contractility in vascular smooth muscle cells by coordinating mitochondrial DNA methylation. https://doi.org/10.1002/advs.202203995LEAK
OXPHOS
N
S
CIV
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Permeabilized cellsHumanOther cell lines
Pochakom 2022 Brain Sci2022Pochakom A, Mu C, Rho JM, Tompkins TA, Mayengbam S, Shearer J (2022) Selective probiotic treatment positively modulates the microbiota-gut-brain axis in the BTBR mouse model of autism. https://doi.org/10.3390/brainsci12060781LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseNervous system
Spagnuolo 2022 Mol Neurobiol2022Spagnuolo MS, Mazzoli A, Nazzaro M, Troise AD, Gatto C, Tonini C, Colardo M, Segatto M, Scaloni A, Pallottini V, Iossa S, Cigliano L (2022) Long-lasting Impact of sugar intake on neurotrophins and neurotransmitters from adolescence to young adulthood in rat frontal cortex. https://doi.org/10.1007/s12035-022-03115-8LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
O'Hanlon 2022 Neurobiol Dis2022O'Hanlon ME, Tweedy C, Scialo F, Bass R, Sanz A, Smulders-Srinivasan TK (2022) Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model. https://doi.org/10.1016/j.nbd.2022.105803LEAK
OXPHOS
N
Gp
CIV
ROX
HomogenateDrosophila
Brown 2022 Redox Biol2022Brown JL, Peelor FF 3rd, Georgescu C, Wren JD, Kinter M, Tyrrell VJ, O'Donnell VB, Miller BF, Van Remmen H (2022) Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. https://doi.org/10.1016/j.redox.2022.102518LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Molinie 2022 Biochim Biophys Acta Bioenerg2022Molinié T, Cougouilles E, David C, Cahoreau E, Portais JC, Mourier A (2022) MDH2 produced OAA is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle. Biochim Biophys Acta Bioenerg 1863:148532.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Liver
Saraiva 2022 Pathogens2022Saraiva FMS, Cosentino-Gomes D, Inacio JDF, Almeida-Amaral EE, Louzada-Neto O, Rossini A, Nogueira NP, Meyer-Fernandes JR, Paes MC (2022) Hypoxia effects on Trypanosoma cruzi epimastigotes proliferation, differentiation, and energy metabolism. https://doi.org/10.3390/pathogens11080897LEAK
OXPHOS
S
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Permeabilized cellsProtists
Thapa 2022 Physiol Rep2022Thapa D, Bugga P, Mushala BAS, Manning JR, Stoner MW, McMahon B, Zeng X, Cantrell PS, Yates N, Xie B, Edmunds LR, Jurczak MJ, Scott I (2022) GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation. https://doi.org/10.14814/phy2.15415LEAK
OXPHOS
ET
N
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MouseHeart
Long 2022 Cell Commun Signal2022Long C, Guo R, Han R, Li K, Wan Y, Xu J, Gong X, Zhao Y, Yao X, Liu J (2022) Effects of macrophages on the proliferation and cardiac differentiation of human induced pluripotent stem cells. https://doi.org/10.1186/s12964-022-00916-1LEAK
ROUTINE
ET
ROXIntact cellsHumanMacrophage-derived
Salazar-Petres 2022 Biol Reprod2022Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J, Sferruzzi-Perri AN (2022) Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice†. https://doi.org/10.1093/biolre/ioac056LEAK
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ET
F
N
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Permeabilized tissueMouseGenital
Sarabhai 2022 Diabetologia2022Sarabhai T, Mastrototaro L, Kahl S, Bönhof GJ, Jonuscheit M, Bobrov P, Katsuyama H, Guthoff R, Wolkersdorfer M, Herder C, Meuth SG, Dreyer S, Roden M (2022) Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial. https://doi.org/10.1007/s00125-022-05797-0LEAK
OXPHOS
ET
N
NS
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Permeabilized tissueHumanSkeletal muscle
Fat
De Goede 2022 FASEB J2022de Goede P, Wüst RCI, Schomakers BV, Denis S, Vaz FM, Pras-Raves ML, van Weeghel M, Yi CX, Kalsbeek A, Houtkooper RH (2022) Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle. FASEB J 36:e22133.LEAK
OXPHOS
ET
N
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Permeabilized tissueRatSkeletal muscle
Neupane 2022 Commun Biol2022Neupane N, Rajendran J, Kvist J, Harjuhaahto S, Hu B, Kinnunen V, Yang Y, Nieminen AI, Tyynismaa H (2022) Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle. https://doi.org/10.1038/s42003-022-04034-zOXPHOS
ET
N
NS
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Isolated mitochondriaMouseSkeletal muscle
Scrima 2022 Stem Cell Res Ther2022Scrima R, Agriesti F, Pacelli C, Piccoli C, Pucci P, Amoresano A, Cela O, Nappi L, Tataranni T, Mori G, Formisano P, Capitanio N (2022) Myoglobin expression by alternative transcript in different mesenchymal stem cells compartments. https://doi.org/10.1186/s13287-022-02880-6ROUTINEROXIntact cellsHumanStem cells
Hadjihambi 2022 J Hepatol2022Hadjihambi A, Konstantinou C, Klohs J, Monsorno K, Le Guennec A, Donnelly C, Cox J, Kusumbe A, Hosford PS, Soffientini U, Lecca S, Mameli M, Jalan R, Paolicelli RC, Pellerin L (2022) Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction. https://doi.org/10.1016/j.jhep.2022.08.008LEAK
OXPHOS
ET
N
S
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Permeabilized tissue
Homogenate
MouseNervous system
Della Noce 2022 J Biol Chem2022Della Noce B, Martins da Silva R, de Carvalho Uhl MV, Konnai S, Ohashi K, Calixto C, Arcanjo A, de Abreu LA, de Carvalho SS, da Silva Vaz I Jr, Logullo C (2022) Redox imbalance induces remodeling of glucose metabolism in Rhipicephalus microplus embryonic cell line. https://doi.org/10.1016/j.jbc.2022.101599LEAK
ROUTINE
ET
ROXIntact cellsCheliceratesOther cell lines
Paulus 2022 Basic Res Cardiol2022Paulus MG, Renner K, Nickel AG, Brochhausen C, Limm K, Zügner E, Baier MJ, Pabel S, Wallner S, Birner C, Luchner A, Magnes C, Oefner PJ, Stark KJ, Wagner S, Maack C, Maier LS, Streckfuss-Bömeke K, Sossalla S, Dietl A (2022) Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions. https://doi.org/10.1007/s00395-022-00949-0OXPHOS
ET
NS
F
ROX
Permeabilized tissue
Isolated mitochondria
RabbitHeart
Tilokani 2022 Sci Adv2022Tilokani L, Russell FM, Hamilton S, Virga DM, Segawa M, Paupe V, Gruszczyk AV, Protasoni M, Tabara LC, Johnson M, Anand H, Murphy MP, Hardie DG, Polleux F, Prudent J (2022) AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology. https://doi.org/10.1126/sciadv.abo7956LEAK
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ET
ROXIntact cellsHumanOther cell lines
Brun 2022 Plant Direct2022Brun A, Smokvarska M, Wei L, Chay S, Curie C, Mari S (2022) MCO1 and MCO3, two putative ascorbate oxidases with ferroxidase activity, new candidates for the regulation of apoplastic iron excess in Arabidopsis. https://doi.org/10.1002/pld3.463ROXIntact organism
Intact cells
Saccharomyces cerevisiae
Adant 2022 Mol Metab2022Adant I, Bird M, Decru B, Windmolders P, Wallays M, de Witte P, Rymen D, Witters P, Vermeersch P, Cassiman D, Ghesquière B (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. https://doi.org/10.1016/j.molmet.2022.101537LEAK
OXPHOS
ET
N
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Permeabilized cellsHumanFibroblast
Leibold 2022 PLoS One2022Leibold S, Bagivalu Lakshminarasimha A, Gremse F, Hammerschmidt M, Michel M (2022) Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish. https://doi.org/10.1371/journal.pone.0267933LEAK
OXPHOS
ET
N
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Isolated mitochondriaZebrafish
Gonzalez-Franquesa 2022 Redox Biol2022Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM (2022) Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. https://doi.org/10.1016/j.redox.2022.102353LEAK
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ET
N
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NS
ROX
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Nervous system
Liver
Fat
Felix 2022 Chemosphere2022Félix L, Carreira P, Peixoto F (2022) Effects of chronic exposure of naturally weathered microplastics on oxidative stress level, behaviour, and mitochondrial function of adult zebrafish (Danio rerio). https://doi.org/10.1016/j.chemosphere.2022.136895LEAK
OXPHOS
N
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CIV
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HomogenateZebrafishNervous system
Liver
Nath 2022 Cell Rep2022Nath AS, Parsons BD, Makdissi S, Chilvers RL, Mu Y, Weaver CM, Euodia I, Fitze KA, Long J, Scur M, Mackenzie DP, Makrigiannis AP, Pichaud N, Boudreau LH, Simmonds AJ, Webber CA, Derfalvi B, Hammon Y, Rachubinski RA, Di Cara F (2022) Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses . Cell Rep 38:110433.LEAK
ROUTINE
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ET
N
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CIV
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Permeabilized cells
Intact cells
De Paula Nascimento-Castro 2022 Biomedicines2022de Paula Nascimento-Castro C, Winkelmann-Duarte EC, Mancini G, Welter PG, Plácido E, Farina M, Gil-Mohapel J, Rodrigues ALS, de Bem AF, Brocardo PS (2022) Temporal characterization of behavioral and hippocampal dysfunction in the YAC128 mouse model of Huntington's disease. https://doi.org/10.3390/biomedicines10061433LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Laehteenmaeki 2022 Physiol Rep2022Lähteenmäki EI, Koski M, Koskela I, Lehtonen E, Kankaanpää A, Kainulainen H, Walker S, Lehti M (2022) Resistance exercise with different workloads have distinct effects on cellular respiration of peripheral blood mononuclear cells. https://doi.org/10.14814/phy2.15394LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Starr 2022 Curr Res Physiol2022Starr VJ, Dzialowski EM (2022) Developing chicken cardiac muscle mitochondria are resistant to variations in incubation oxygen levels. https://doi.org/10.1016/j.crphys.2022.03.001LEAK
OXPHOS
N
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CIV
NS
ROX
Permeabilized tissueChickenHeart
Cherix 2022 Mol Psychiatry2022Cherix A, Poitry-Yamate C, Lanz B, Zanoletti O, Grosse J, Sandi C, Gruetter R, Cardinaux JR (2022) Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior. https://doi.org/10.1038/s41380-022-01791-5LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Fernandez-Vizarra 2022 Cell Metab2022Fernández-Vizarra E, López-Calcerrada S, Sierra-Magro A, Pérez-Pérez R, Formosa LE, Hock DH, Illescas M, Peñas A, Brischigliaro M, Ding S, Fearnley IM, Tzoulis C, Pitceathly RDS, Arenas J, Martín MA, Stroud DA, Zeviani M, Ryan MT, Ugalde C (2022) Two independent respiratory chains adapt OXPHOS performance to glycolytic switch. https://doi.org/10.1016/j.cmet.2022.09.005LEAK
ET
N
S
Gp
NS
ROX
Permeabilized cells
Intact cells
HumanHEK
Goudie 2022 Sci Rep2022Goudie L, Mancini NL, Shutt TE, Holloway GP, Mu C, Wang A, McKay DM, Shearer J (2022) Impact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells. https://doi.org/10.1038/s41598-022-11123-wLEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized cellsMouseEndothelial;epithelial;mesothelial cell
Garcia-Roche 2022 J Dairy Sci2022García-Roche M, Talmón D, Cañibe G, Astessiano AL, Mendoza A, Quijano C, Cassina A, Carriquiry M (2022) Differential hepatic mitochondrial function and gluconeogenic gene expression in 2 Holstein strains in a pasture-based system. https://doi.org/10.3168/jds.2021-21358LEAK
OXPHOS
ET
N
S
NS
ROX
Intact cellsBovinesLiver
Hong 2022 Cell Stem Cell2022Hong X, Isern J, Campanario S, Perdiguero E, Ramírez-Pardo I, Segalés J, Hernansanz-Agustín P, Curtabbi A, Deryagin O, Pollán A, González-Reyes JA, Villalba JM, Sandri M, Serrano AL, Enríquez JA, Muñoz-Cánoves P (2022) Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy. https://doi.org/10.1016/j.stem.2022.07.009LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized cellsMouseSkeletal muscle
Yin 2022 J Exp Med2022Yin Y, Xu D, Mao Y, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z (2022) FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. https://doi.org/10.1084/jem.20212491LEAK
OXPHOS
F
N
S
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Permeabilized cellsMouseFat
Li 2022 Mol Med2022Li X, Zhou X, Liu X, Li X, Jiang X, Shi B, Wang S (2022) Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway. https://doi.org/10.1186/s10020-022-00533-1LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanBlood cells
Gutierrez 2022 Cell Rep Med2022Gutierrez AD, Gao Z, Hamidi V, Zhu L, Saint Andre KB, Riggs K, Ruscheinsky M, Wang H, Yu Y, Miller C 3rd, Vasquez H, Taegtmeyer H, Kolonin MG (2022) Anti-diabetic effects of GLP1 analogs are mediated by thermogenic interleukin-6 signaling in adipocytes. https://doi.org/10.1016/j.xcrm.2022.100813LEAKS
ROX
MouseFat
Ahn 2022 Aging Cell2022Ahn B, Ranjit R, Kneis P, Xu H, Piekarz KM, Freeman WM, Kinter M, Richardson A, Ran Q, Brooks SV, Van Remmen H (2022) Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia. Aging Cell 21:e13569.LEAK
OXPHOS
N
S
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Dias 2022 Free Radic Biol Med2022Dias C, Lourenço CF, Laranjinha J, Ledo A (2022) Modulation of oxidative neurometabolism in ischemia/reperfusion by nitrite. https://doi.org/10.1016/j.freeradbiomed.2022.11.021ROUTINE
OXPHOS
ET
N
S
ROX
Permeabilized tissue
Intact cells
RatNervous system
Pileggi 2022 EBioMedicine2022Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O'Dwyer C, Thrush AB, Fullerton MD, Bennett SAL, Doucet É, Haman F, Cuperlovic-Culf M, McPherson R, Dent RRM, Harper ME (2022) Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity. https://doi.org/10.1016/j.ebiom.2022.104192LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Tremmel 2022 Sci Rep2022Tremmel DM, Sackett SD, Feeney AK, Mitchell SA, Schaid MD, Polyak E, Chlebeck PJ, Gupta S, Kimple ME, Fernandez LA, Odorico JS (2022) A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment. https://doi.org/10.1038/s41598-022-11085-zLEAK
ROUTINE
ET
ROXIntact cellsHumanIslet cell;pancreas;thymus
Vizuete 2022 J Neuroinflammation2022Vizuete AFK, Fróes F, Seady M, Zanotto C, Bobermin LD, Roginski AC, Wajner M, Quincozes-Santos A, Gonçalves CA (2022) Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway. https://doi.org/10.1186/s12974-022-02612-wLEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Fischer 2022 Metabolites2022Fischer C, Valente de Souza L, Komlódi T, Garcia-Souza LF, Volani C, Tymoszuk P, Demetz E, Seifert M, Auer K, Hilbe R, Brigo N, Petzer V, Asshoff M, Gnaiger E, Weiss G (2022) Mitochondrial respiration in response to iron deficiency anemia. Comparison of peripheral blood mononuclear cells and liver. https://doi.org/10.3390/metabo12030270LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Other combinations
ROX
Permeabilized cells
Homogenate
RatLiver
Blood cells
Risiglione 2022 Life (Basel)2022Risiglione P, Cubisino SAM, Lipari CLR, De Pinto V, Messina A, Magrì A (2022) α-Synuclein A53T promotes mitochondrial proton gradient dissipation and depletion of the organelle respiratory reserve in a neuroblastoma cell line. https://doi.org/10.3390/life12060894LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanNeuroblastoma
Trewin 2022 BMC Biol2022Trewin AJ, Silver J, Dillon HT, Della Gatta PA, Parker L, Hiam DS, Lee YP, Richardson M, Wadley GD, Lamon S (2022) Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle. https://doi.org/10.1186/s12915-022-01366-4LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseSkeletal muscle
Xu 2022 Sci Adv2022Xu H, Ahn B, Van Remmen H (2022) Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation. https://doi.org/10.1126/sciadv.add7377LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Quemeneur 2022 Sci Rep2022Quéméneur JB, Danion M, Cabon J, Collet S, Zambonino-Infante JL, Salin K (2022) The relationships between growth rate and mitochondrial metabolism varies over time. https://doi.org/10.1038/s41598-022-20428-9LEAK
OXPHOS
N
CIV
NS
ROX
HomogenateFishesSkeletal muscle
Broome 2022 Redox Biol2022Broome SC, Pham T, Braakhuis AJ, Narang R, Wang HW, Hickey AJR, Mitchell CJ, Merry TL (2022) MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men. https://doi.org/10.1016/j.redox.2022.102341LEAK
OXPHOS
ET
N
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Leggio 2022 Adv Healthc Mater2022Leggio L, L'Episcopo F, Magrì A, Ulloa-Navas MJ, Paternò G, Vivarelli S, Bastos CAP, Tirolo C, Testa N, Caniglia S, Risiglione P, Pappalardo F, Serra A, García-Tárraga P, Faria N, Powell JJ, Peruzzotti-Jametti L, Pluchino S, García-Verdugo JM, Messina A, Marchetti B, Iraci N (2022) Small extracellular vesicles secreted by nigrostriatal astrocytes rescue cell death and preserve mitochondrial function in Parkinson's disease. https://doi.org/10.1002/adhm.202201203LEAK
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Intact cells
HumanNeuroblastoma
Bina 2022 Mol Cell Biochem2022Bînă AM, Aburel OM, Avram VF, Lelcu T, Lința AV, Chiriac DV, Mocanu AG, Bernad E, Borza C, Craina ML, Popa ZL, Muntean DM, Crețu OM (2022) Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies. https://doi.org/10.1007/s11010-022-04415-2LEAK
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Isolated mitochondria
Intact cells
HumanGenital
Platelet
Zhu 2022 Metabolism2022Zhu JY, Chen M, Mu WJ, Luo HY, Guo L (2022) Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice. https://doi.org/10.1016/j.metabol.2022.155241LEAK
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ROXIntact cellsMouseLiver
Fedorov 2022 Naunyn Schmiedebergs Arch Pharmacol2022Fedorov A, Lehto A, Klein J (2022) Inhibition of mitochondrial respiration by general anesthetic drugs. https://doi.org/10.1007/s00210-022-02338-9LEAK
OXPHOS
ET
N
S
CIV
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Isolated mitochondriaMouseNervous system
Gnaiger 2021 MitoFit BCA2021-09-21Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. https://doi.org/10.26124/mitofit:2021-0008LEAK
OXPHOS
ET
ROXIntact cellsHumanFibroblast
Zdrazilova 2021 MitoFit ace-sce2021-09-21Zdrazilova L, Hansikova H, Gnaiger E (2021) Comparable respiratory activity in attached and suspended human fibroblasts. https://doi.org/10.26124/mitofit:2021-00072022-03-03 published in PLOS ONE 17:e0264496LEAK
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ROXIntact cellsHumanFibroblast
Lei 2021 Ecotoxicol Environ Saf2021Lei C, Liao J, Li Q, Shi J, Zhang H, Guo J, Han Q, Hu L, Li Y, Pan J, Tang Z (2021) Copper induces mitochondria-mediated apoptosis via AMPK-mTOR pathway in hypothalamus of pigs. Ecotoxicol Environ Saf 220:112395.LEAK
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ET
N
S
ROX
PigNervous system
Riguet 2021 Nat Commun2021Riguet N, Mahul-Mellier AL, Maharjan N, Burtscher J, Croisier M, Knott G, Hastings J, Patin A, Reiterer V, Farhan H, Nasarov S, Lashuel HA (2021) Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties. Nat Commun 12:6579.LEAK
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ET
N
S
NS
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Permeabilized cells
Intact cells
HumanHEK
Giordano 2021 Gene Ther2021Giordano L, Aneja MK, Sommer N, Alebrahimdehkordi N, Seraji A, Weissmann N, Rudolph C, Plank C, Jacobs HT, Szibor M (2021) Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. Gene Ther [Epub ahead of print].LEAK
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N
S
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ROX
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Intact cells
MouseFibroblast
Bouche 2021 PLoS One2021Bouche L, Kamel R, Tamareille S, Garcia G, Villedieu C, Pillot B, Gueguen N, Chehaitly A, Chao de la Barca JM, Beaumont J, Baetz D, Ovize M, Sesaki H, Henrion D, Reynier P, Lenaers G, Prunier F, Mirebeau-Prunier D (2021) DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries. PLoS One 16:0248554.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
F
Permeabilized tissueMouseHeart
Schumann 2021 Commun Biol2021Schumann T, Koenig J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL (2021) Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol 4:826.LEAK
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ET
F
N
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Intact cellsMouseLiver
Marrocco 2021 J Immunol2021Marrocco A, Frawley K, Pearce LL, Peterson J, O'Brien JP, Mullett SJ, Wendell SG, St Croix CM, Mischler SE, Ortiz LA (2021) Metabolic adaptation of macrophages as mechanism of defense against crystalline silica. J Immunol 207:1627-40.LEAK
OXPHOS
ET
N
ROX
MouseMacrophage-derived
Sanchez-de-Diego 2021 Redox Biol2021Sánchez-de-Diego C, Pedrazza L, Pimenta-Lopes C, Martinez-Martinez A, Dahdah N, Valer JA, Garcia-Roves P, Rosa JL, Ventura F (2021) NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression. Redox Biol 40:101845.LEAK
ROUTINE
ET
ROXIntact cellsMouseOther cell lines
Apostolopoulou 2021 Sci Adv2021Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straßburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Müssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. https://doi.org/10.1126/sciadv.abi9551LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kaspar 2021 Sci Adv2021Kaspar S, Oertlin C, Szczepanowska K, Kukat A, Senft K, Lucas C, Brodesser S, Hatzoglou M, Larsson O, Topisirovic I, Trifunovic A (2021) Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Sci Adv 7:0971.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Assis-de-Lemos 2021 Biosci Rep2021Assis-de-Lemos G, Monteiro J, Oliveira-Valença VM, Melo GA, Reis RAM, Rehen SK, Silveira MS, Galina A (2021) Dopamine signaling impairs ROS modulation by mitochondrial hexokinase in human neural progenitor cells. https://doi.org/10.1042/bsr20211191LEAK
ROUTINE
ET
ROXIntact cellsHumanNervous system
Thoral 2021 Biol Lett2021Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759.LEAK
OXPHOS
N
CIV
NS
ROX
HomogenateFishesSkeletal muscle
Herraez 2021 Pharmaceutics2021Herraez R, Quesada R, Dahdah N, Vinas M, Vinuesa T (2021) Tambjamines and prodiginines: Biocidal activity against Trypanosoma cruzi. Pharmaceutics 13:705.ROUTINEROXIntact cellsProtists
Willis 2021 Sci Rep2021Willis JR, Hickey AJR, Devaux JBL (2021) Thermally tolerant intertidal triplefin fish (Tripterygiidae) sustain ATP dynamics better than subtidal species under acute heat stress. Sci Rep 11:11074.LEAK
OXPHOS
ET
ROUTINE
N
ROX
NS
HomogenateFishesNervous system
Hoppel 2021 Cells2021Hoppel F, Garcia-Souza LF, Kantner-Rumplmair W, Burtscher M, Gnaiger E, Pesta D, Calabria E (2021) Human platelet mitochondrial function reflects systemic mitochondrial alterations: a protocol for application in field studies. https://doi.org/10.3390/cells10082088LEAK
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ET
N
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NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Kladnicka 2021 Biomolecules2021Kladnicka I, Cedikova M, Jedlicka J, Kohoutova M, Muller L, Plavinova I, Kripnerova M, Bludovska M, Kuncova J, Mullerova D (2021) Chronic DDE exposure modifies mitochondrial respiration during differentiation of human adipose-derived mesenchymal stem cells into mature adipocytes. Biomolecules 11:1068.LEAK
ROUTINE
ET
ROXIntact cellsHumanFat
Sighel 2021 Cell Rep2021Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A (2021) Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep 35:109024.ROUTINE
OXPHOS
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanNervous system
Stem cells
Akinbiyi 2021 Sci Rep2021Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, Hanover JA, Mears JA (2021) Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Sci Rep 11:22106.LEAK
OXPHOS
ET
F
N
S
DQ
CIV
NS
ROX
Permeabilized cells
MacCannell 2021 Int J Obes (Lond)2021MacCannell ADV, Futers TS, Whitehead A, Moran A, Witte KK, Roberts LD (2021) Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity. Int J Obes (Lond) 45:1773-81.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseFat
Kumar 2021 JCI Insight2021Kumar A, Welch N, Mishra S, Bellar A, Silva RN, Li L, Singh SS, Sharkoff M, Kerr A, Chelluboyina AK, Sekar J, Attaway AH, Hoppel C, Willard B, Davuluri G, Dasarathy S (2021) Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence. JCI Insight 6:e154089.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
Intact cells
Mouse
Rat
Skeletal muscle
Valera-Alberni 2021 Cell Rep2021Valera-Alberni M, Joffraud M, Miro-Blanch J, Capellades J, Junza A, Dayon L, Núñez Galindo A, Sanchez-Garcia JL, Valsesia A, Cercillieux A, Söllner F, Ladurner AG, Yanes O, Cantó C (2021) Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation. Cell Rep 36:109565.LEAK
OXPHOS
ET
N
S
NS
ROX
Homogenate
Isolated mitochondria
MouseLiver
Fat
Cheng 2021 Comp Biochem Physiol B Biochem Mol Biol2021Cheng H, Munro D, Huynh K, Pamenter ME (2021) Naked mole-rat skeletal muscle mitochondria exhibit minimal functional plasticity in acute or chronic hypoxia. Comp Biochem Physiol B Biochem Mol Biol 255:110596.OXPHOS
ET
LEAK
F
N
S
CIV
NS
ROX
Isolated mitochondriaOther mammalsSkeletal muscle
Hoene 2021 Mol Metab2021Hoene M, Kappler L, Kollipara L, Hu C, Irmler M, Bleher D, Hoffmann C, Beckers J, Hrabě de Angelis M, Häring HU, Birkenfeld AL, Peter A, Sickmann A, Xu G, Lehmann R, Weigert C (2021) Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability. Mol Metab 54:101359.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaMouseLiver
Zhang 2021 PLOS ONE2021Zhang X, Yuan T, Keijer J, de Boer VCJ (2021) OCRbayes: a Bayesian hierarchical modeling framework for Seahorse extracellular flux oxygen consumption rate data analysis. PLOS ONE 16:e0253926.LEAK
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ET
ROXFibroblast
Holody 2021 Mitochondrion2021Holody C, Anfray A, Mast H, Lessard M, Han WH, Carpenter R, Bourque S, Sauvé Y, Lemieux H (2021) Differences in relative capacities of oxidative phosphorylation pathways may explain sex- and tissue-specific susceptibility to vision defects due to mitochondrial dysfunction. Mitochondrion 56:102-10.LEAK
OXPHOS
N
S
CIV
NS
ROX
HomogenateRatNervous system
Sladowska 2021 PLoS Biol2021Sladowska M, Turek M, Kim MJ, Drabikowski K, Mussulini BHM, Mohanraj K, Serwa RA, Topf U, Chacinska A (2021) Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. PLoS Biol 19:3001302.OXPHOSN
S
CIV
ROX
Isolated mitochondriaCaenorhabditis elegans
Weiss 2021 Crit Care Explor2021Weiss SL, Bittinger K, Lee JJ, Friedman ES, Mattei LM, Graham K, Zhang D, Bush J, Balamuth F, McGowan FX Jr, Bushman FD, Baldassano RN, Wu GD, Wallace DC, Collman RG (2021) Decreased intestinal microbiome diversity in pediatric sepsis: a conceptual framework for intestinal dysbiosis to influence immunometabolic function. Crit Care Explor 3:0360.LEAK
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ET
ROXIntact cellsHumanLymphocyte
Wall 2021 Dis Model Mech2021Wall JM, Basu A, Zunica ERM, Dubuisson OS, Pergola K, Broussard JP, Kirwan JP, Axelrod CL, Johnson AE (2021) CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Dis Model Mech 14:dmm048603.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized tissueDrosophilaSkeletal muscle
Zunica 2021 Cancer Metab2021Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab 9:36.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
F
DQ
Permeabilized cells
Homogenate
Human
Mouse
Endothelial;epithelial;mesothelial cell
Chowdhury 2021 Cancers (Basel)2021Chowdhury SR, Peltier C, Hou S, Singh A, Johnston JB, Gibson SB, Marshall A, Banerji V (2021) Ex vivo mitochondrial respiration parallels biochemical response to ibrutinib in CLL cells. Cancers (Basel) 13:E354.LEAK
ROUTINE
ET
ROXIntact cellsHumanLymphocyte
Tallosy 2021 Sci Rep2021Tallósy SP, Poles MZ, Rutai A, Fejes R, Juhász L, Burián K, Sóki J, Szabó A, Boros M, Kaszaki J (2021) The microbial composition of the initial insult can predict the prognosis of experimental sepsis. Sci Rep 11:22772.LEAK
OXPHOS
S
ROX
HomogenateRatLiver
Furihata 2021 Commun Biol2021Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Avram 2021 Life (Basel)2021Avram VF, Bina AM, Sima A, Aburel OM, Sturza A, Burlacu O, Timar RZ, Muntean DM, Elmer E, Cretu OM (2021) Improvement of platelet respiration by cell-permeable succinate in diabetic patients treated with statins. Life (Basel) 11:288.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Terwilliger 2021 Vasc Med2021Terwilliger ZS, Ryan TE, Goldberg EJ, Schmidt CA, Yamaguchi DJ, Karnekar R, Brophy P, Green TD, Zeczycki TN, Mac Gabhann F, Annex BH, McClung JM (2021) Racial differences in the limb skeletal muscle transcriptional programs of patients with critical limb ischemia. Vasc Med 26:247-58.OXPHOS
LEAK
N
S
CIV
ROX
NS
Permeabilized tissueHumanSkeletal muscle
King 2021 J Biol Chem2021King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cellsMouseSkeletal muscle
Dos Santos Escaliante 2021 Int J Biol Macromol2021Dos Santos Escaliante LA, Busato B, de Oliveira Petkowicz CL, Suter Correia Cadena SM, Rodrigues Noleto G (2021) Cytotoxic effect of xyloglucan and oxovanadium (IV/V) xyloglucan complex in HepG2 cells. Int J Biol Macromol 185:40-48.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsHumanLiver
Scheffer 2021 Brain Commun2021Scheffer DDL, Freitas FC, Aguiar AS Jr, Ward C, Guglielmo LGA, Prediger RD, Cronin SJF, Walz R, Andrews NA, Latini A (2021) Impaired dopamine metabolism is linked to fatigability in mice and fatigue in Parkinson's disease patients. Brain Commun 3:fcab116.LEAK
ROUTINE
ET
ROXIntact cellsRatSkeletal muscle
Nedel 2021 Intensive Care Med Exp2021Nedel WL, Kopczynski A, Rodolphi MS, Strogulski NR, De Bastiani M, Montes THM, Abruzzi J Jr, Galina A, Horvath TL, Portela LV (2021) Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study. Intensive Care Med Exp 9:39.LEAK
OXPHOS
N
NS
ROX
Permeabilized cellsHumanLymphocyte
Antico 2021 Sci Adv2021Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK (2021) Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Sci Adv 7:eabj0722.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Intact cellsMouseNervous system
Klepinina 2021 PLoS One2021Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348.LEAK
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OXPHOS
ET
N
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Styles 2021 Cell Death Dis2021Styles FL, Al-Owais MM, Scragg JL, Chuntharpursat-Bon E, Hettiarachchi NT, Lippiat JD, Minard A, Bon RS, Porter K, Sukumar P, Peers C, Roberts LD (2021) Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism. Cell Death Dis 12:372.LEAK
ROUTINE
ET
CIV
ROX
Intact cellsHumanHEK
Bastos Sant'Anna Silva 2021 Cancers (Basel)2021Bastos Sant'Anna Silva AC, Perez Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. https://doi.org/10.3390/cancers13071727LEAK
ROUTINE
OXPHOS
S
ROX
Permeabilized cells
Intact cells
HumanGenital
Hansen 2021 Physiol Rep2021Hansen C, Olsen K, Pilegaard H, Bangsbo J, Gliemann L, Hellsten Y (2021) High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells. Physiol Rep 9:e14855.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
RatSkeletal muscle
Endothelial;epithelial;mesothelial cell
Liu 2021 FASEB J2021Liu Z, Chaillou T, Santos Alves E, Mader T, Jude B, Ferreira DMS, Hynynen H, Cheng AJ, Jonsson WO, Pironti G, Andersson DC, Kenne E, Ruas JL, Tavi P, Lanner JT (2021) Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force. FASEB J 35:e22010.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Su 2021 Chin J Physiol2021Su Y, Wang Y, Xu P, Sun Y, Ping Z, Huang H, Cao X (2021) Study on the time-effectiveness of exercise preconditioning on heart protection in exhausted rats. Chin J Physiol 64:97-105.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueRatHeart
Theall 2021 Physiol Rep2021Theall B, Stampley J, Cho E, Granger J, Johannsen NM, Irving BA, Spielmann G (2021) Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults. Physiol Rep 9:e15147.LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Baldini 2021 Life Sci2021Baldini F, Fabbri R, Eberhagen C, Voci A, Portincasa P, Zischka H, Vergani L (2021) Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity. Life Sci 265:118812.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseFibroblast
Kruse 2021 Life (Basel)2021Kruse CJ, Stern D, Mouithys-Mickalad A, Niesten A, Art T, Lemieux H, Votion DM (2021) In vitro assays for the assessment of impaired mitochondrial bioenergetics in equine atypical myopathy. Life (Basel) 11:719.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Intact cells
Permeabilized cells
HorseSkeletal muscle
Mazzoli 2021 Antioxidants (Basel)2021Mazzoli A, Spagnuolo MS, Nazzaro M, Gatto C, Iossa S, Cigliano L (2021) Fructose removal from the diet reverses inflammation, mitochondrial dysfunction, and oxidative stress in hippocampus. Antioxidants (Basel) 10:487.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Axelrod 2021 EMBO Mol Med2021Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088.ROUTINE
OXPHOS
ET
LEAK
F
N
S
NS
ROX
DQ
Intact cells
Permeabilized tissue
MouseSkeletal muscle
Conceicao 2021 Sci Rep2021Conceição CC, da Silva JN, Arcanjo A, Nogueira CL, de Abreu LA, de Oliveira PL, Gondim KC, Moraes B, de Carvalho SS, da Silva RM, da Silva Vaz I Jr, Moreira LA, Logullo C (2021) Aedes fluviatilis cell lines as new tools to study metabolic and immune interactions in mosquito-Wolbachia symbiosis. Sci Rep 11:19202.LEAK
ROUTINE
ET
ROXIntact cellsMolluscs
Taylor 2021 Int J Mol Sci2021Taylor OJ, Thatcher MO, Carr ST, Gibbs JL, Trumbull AM, Harrison ME, Winden DR, Pearson MJ, Tippetts TS, Holland WL, Reynolds PR, Bikman BT (2021) High-mobility group box 1 disrupts metabolic function with cigarette smoke exposure in a ceramide-dependent manner. Int J Mol Sci 18:1099.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cells
Permeabilized tissue
MouseSkeletal muscle
Wigner 2021 Sci Rep2021Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Sci Rep 11:4544.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
Mukherjee 2021 JCI Insight2021Mukherjee S, Mo J, Paolella LM, Perry CE, Toth J, Hugo MM, Chu Q, Tong Q, Chellappa K, Baur JA (2021) SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside. JCI Insight 6:e14719.OXPHOSN
S
CIV
ROX
F
Isolated mitochondriaMouseLiver
Cannon 2021 Respir Physiol Neurobiol2021Cannon DT, Nogueira L, Gutierrez-Gonzalez AK, Gilmore NK, Bigby TD, Breen EC (2021) Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension. Respir Physiol Neurobiol 295:103783.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Seefeldt 2021 Sci Rep2021Seefeldt JM, Lassen TR, Vognstoft Hjortbak M, Jespersen NR, Kvist F, Hansen J, Boetker HE (2021) Cardioprotective effects of empagliflozin after ischemia and reperfusion in rats. Sci Rep 11:9544.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized tissueRatHeart
Gvozdjakova 2021 PLoS One2021Gvozdjáková A, Sumbalová Z, Kucharská J, Szamosová M, Čápová L, Rausová Z, Vančová O, Mojto V, Langsjoen P, Palacka P (2021) Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases. PLoS ONE 16:e0256135.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Basse 2021 Mol Metab2021Basse AL, Agerholm M, Farup J, Dalbram E, Nielsen J, Oertenblad N, Altıntas A, Ehrlich AM, Krag T, Bruzzone S, Dall M, de Guia RM, Jensen JB, Moeller AB, Karlsen A, Kjaer M, Barres R, Vissing J, Larsen S, Jessen N, Treebak JT (2021) Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity. Mol Metab 53:101271.LEAK
OXPHOS
N
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Meng 2021 FEBS Open Bio2021Meng L, Chen D, Meng G, Lu L, Han C (2021) Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. FEBS Open Bio 11:921-31.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanKidney
Pamenter 2021 Biol Lett2021Pamenter ME, Gomez CR, Richards JG, Milsom WK (2021) Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biol Lett 12:20150797.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized cellsReptilesNervous system
Rossetti 2021 Sci Adv2021Rossetti G, Ermer JA, Stentenbach M, Siira SJ, Richman TR, Milenkovic D, Perks KL, Hughes LA, Jamieson E, Xiafukaiti G, Ward NC, Takahashi S, Gray N, Viola HM, Hool LC, Rackham O, Filipovska A (2021) A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv 7:eabi7514.LEAK
OXPHOS
ET
F
N
S
ROX
Isolated mitochondriaMouseLiver
Jimenez-Uribe 2021 Free Radic Biol Med2021Jimenez-Uribe AP, Bellido B, Aparicio-Trejo OE, Tapia E, Sanchez-Lozada LG, Hernandez-Santos JA, Fernandez-Valverde F, Hernandez-Cruz EY, Orozco-Ibarra M, Pedraza-Chaverri J (2021) Temporal characterization of mitochondrial impairment in the unilateral ureteral obstruction model in rats. Free Radic Biol Med 172:358-71.LEAK
OXPHOS
N
S
ROX
Isolated mitochondriaRatKidney
Liepinsh 2021 Free Radic Biol Med2021Liepinsh E, Kuka J, Vilks K, Svalbe B, Stelfa G, Vilskersts R, Sevostjanovs E, Goldins NR, Groma V, Grinberga S, Plaas M, Makrecka-Kuka M, Dambrova M (2021) Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage. Free Radic Biol Med 177:370-80.LEAK
OXPHOS
F
N
S
NS
ROX
Permeabilized tissueMouseHeart
Avram 2021 Int J Mol Sci2021Avram VF, Chamkha I, Åsander-Frostner E, Ehinger JK, Timar RZ, Hansson MJ, Muntean DM, Elmér E (2021) Cell-permeable succinate rescues mitochondrial respiration in cellular models of statin toxicity. Int J Mol Sci 22:424.ROUTINE
ET
LEAK
ROXIntact cellsHumanPlatelet
Tungtur 2021 Sci Rep2021Tungtur SK, Wilkins HM, Rogers RS, Badawi Y, Sage JM, Agbas A, Jawdat O, Barohn RJ, Swerdlow RH, Nishimune H (2021) Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord. Sci Rep 11:11051.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaMouseNervous system
Zanou 2021 Nat Commun2021Zanou N, Dridi H, Reiken S, Imamura de Lima T, Donnelly C, De Marchi U, Ferrini M, Vidal J, Sittenfeld L, Feige JN, Garcia-Roves PM, Lopez-Mejia IC, Marks AR, Auwerx J, Kayser B, Place N (2021) Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity. Nat Commun 12:7219.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseSkeletal muscle
Vidimce 2021 Front Pharmacol2021Vidimce J, Pillay J, Shrestha N, Dong LF, Neuzil J, Wagner KH, Holland OJ, Bulmer AC (2021) Mitochondrial function, fatty acid metabolism, and body composition in the hyperbilirubinemic gunn rat. Front Pharmacol 12:586715.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Homogenate
RatSkeletal muscle
Liver
Mazzoli 2021 Nutrients2021Mazzoli A, Gatto C, Crescenzo R, Cigliano L, Iossa S (2021) Prolonged changes in hepatic mitochondrial activity and insulin sensitivity by high fructose intake in adolescent rats. Nutrients 13:1370.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatLiver
Mendham 2021 Diabetologia2021Mendham AE, Goedecke JH, Zeng Y, Larsen S, George C, Hauksson J, Fortuin-de Smidt MC, Chibalin AV, Olsson T, Chorell E (2021) Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity. Diabetologia 64:1642-59.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Intact cellsHumanSkeletal muscle
Leo 2021 Conserv Physiol2021Leo E, Dahlke FT, Storch D, Poertner HO, Mark FC (2021) Impact of ocean acidification and warming on the bioenergetics of developing eggs of atlantic herring Clupea harengus. Conserv Physiol 6:50.ETN
ROX
NS
Intact organismFishes
Branco Haas 2021 Thesis2021Branco Haas C (2021) Insulin signaling and microglia in the young and aged brain. PhD Thesis 135.LEAK
OXPHOS
ET
N
ROX
Intact cells
Prieto-Carrasco 2021 Biology (Basel)2021Prieto-Carrasco R, Silva-Palacios A, Rojas-Morales P, Aparicio-Trejo OE, Medina-Reyes EI, Hernandez-Cruz EY, Sanchez-Garibay C, Salinas-Lara C, Pavon N, Roldan FJ, Zazueta C, Tapia E, Pedraza-Chaverri J (2021) Unilateral ureteral obstruction for 28 days in rats is not associated with changes in cardiac function or alterations in mitochondrial function. Biology (Basel) 10:671.LEAK
OXPHOS
ET
N
S
ROX
Isolated mitochondriaRatHeart
Flouda 2021 Free Radic Biol Med2021Flouda K, Mercer J, Davies MJ, Hawkins CL (2021) Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage. Free Radic Biol Med 166:165-77.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
Cretin 2021 EMBO Mol Med2021Cretin E, Lopes P, Vimont E, Tatsuta T, Langer T, Gazi A, Sachse M, Yu-Wai-Man P, Reynier P, Wai T (2021) High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts. EMBO Mol Med 13:13579.LEAK
ROUTINE
ET
ROXIntact cellsMouseFibroblast
Iadarola 2021 J Biol Chem2021Iadarola DM, Joshi A, Caldwell CB, Gohil VM (2021) Choline restores respiration in Psd1-deficient yeast by replenishing mitochondrial phosphatidylethanolamine. J Biol Chem 296:100539.ET
ROUTINE
ROXIntact cells
Intact organism
Saccharomyces cerevisiae
Liang 2021 Biomed Pharmacother2021Liang L, Zhang G, Cheng C, Li H, Jin T, Su C, Xiao Y, Bradley J, Peberdy MA, Ornato JP, Mangino MJ, Tang W (2021) High-resolution respirometry for evaluation of mitochondrial function on brain and heart homogenates in a rat model of cardiac arrest and cardiopulmonary resuscitation. Biomed Pharmacother 142:111935.LEAK
OXPHOS
ROUTINE
N
S
CIV
ROX
HomogenateRatHeart
Nervous system
Giovarelli 2021 Pharmacol Res2021Giovarelli M, Zecchini S, Catarinella G, Moscheni C, Sartori P, Barbieri C, Roux-Biejat P, Napoli A, Vantaggiato C, Cervia D, Perrotta C, Clementi E, Latella L, De Palma C (2021) Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy. Pharmacol Res 170:105751.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Alves 2021 Eur J Nutr2021Alves BL, Araújo TDR, Guimarães DSPSF, Zoppi CC, Figueiredo MS, Carneiro EM (2021) Amino acid restriction alters survival mechanisms in pancreatic beta cells: possible role of the PI3K/Akt pathway. Eur J Nutr 60:3947-57.LEAK
ROUTINE
ET
ROXIntact cellsRatIslet cell;pancreas;thymus
Babylon 2021 Antioxidants (Basel)2021Babylon L, Grewal R, Stahr PL, Eckert RW, Keck CM, Eckert GP (2021) Hesperetin nanocrystals improve mitochondrial function in a cell model of early Alzheimer disease. Antioxidants (Basel) 10:1003.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanNeuroblastoma
Young 2021 J Biol Chem2021Young MP, Schug ZT, Booth DM, Yule DI, Mikoshiba K, Hajnóczky G, Joseph SK (2021) Metabolic adaptation to the chronic loss of Ca2+ signaling induced by knockout of IP 3 receptors or the mitochondrial Ca2+ uniporter. J Biol Chem 298:101436.LEAK
ROUTINE
ET
ROXIntact cellsHumanHEK
HeLa
Schmidt 2021 Cancer Metab2021Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3.LEAK
OXPHOS
ET
N
S
Gp
CIV
ROX
Isolated mitochondriaHumanLiver
Villanueva 2021 Transplant Direct2021Villanueva JE, Chew HC, Gao L, Doyle A, Scheuer SE, Hicks M, Jabbour A, Dhital KK, Macdonald PS (2021) The effect of increasing donor age on myocardial ischemic tolerance in a rodent model of donation after circulatory death. Transplant Direct 7:699.LEAK
OXPHOS
ET
F
N
NS
ROX
S
Permeabilized tissueRatHeart
Wuest 2021 Int J Mol Sci2021Wüst RCI, Coolen BF, Held NM, Daal MRR, Alizadeh Tazehkandi V, Baks-Te Bulte L, Wiersma M, Kuster DWD, Brundel BJJM, van Weeghel M, Strijkers GJ, Houtkooper RH (2021) The antibiotic doxycycline impairs cardiac mitochondrial and contractile function. Int J Mol Sci 22:4100.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseHeart
Oemer 2021 J Lipid Res2021Oemer G, Edenhofer ML, Wohlfarter Y, Lackner K, Leman G, Koch J, Cardoso LHD, Lindner HH, Gnaiger E, Dubrac S, Zschocke J, Keller MA (2021) Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells. https://doi.org/10.1016/j.jlr.2021.100111LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanHeLa
Burska 2021 Biochim Biophys Acta Mol Basis Dis2021Burska D, Stiburek L, Krizova J, Vanisova M, Martinek V, Sladkova J, Zamecnik J, Honzik T, Zeman J, Hansikova H, Tesarova M (2021) Homozygous missense mutation in UQCRC2 associated with severe encephalomyopathy, mitochondrial complex III assembly defect and activation of mitochondrial protein quality control. Biochim Biophys Acta Mol Basis Dis 1867:166147.LEAK
OXPHOS
ET
CIV
NS
ROX
N
S
Permeabilized cellsHumanFibroblast
Gupta 2021 Sci Rep2021Gupta MK, Sahu A, Sun Y, Mohan ML, Kumar A, Zalavadia A, Wang X, Martelli EE, Stenson K, Witherow CP, Drazba J, Dasarathy S, Naga Prasad SV (2021) Cardiac expression of microRNA-7 is associated with adverse cardiac remodeling. Sci Rep 11:22018.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMouseHeart
James 2021 Nat Commun2021James OJ, Vandereyken M, Marchingo JM, Singh F, Bray SE, Wilson J, Love AG, Swamy M (2021) IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes. Nat Commun 12:4290.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
MouseLymphocyte
Palzur 2021 Int J Mol Sci2021Palzur E, Edelman D, Sakas R, Soustiel JF (2021) Etifoxine restores mitochondrial oxidative phosphorylation and improves cognitive recovery following traumatic brain injury. Int J Mol Sci 22:12881. doi: 10.3390/ijms222312881LEAK
OXPHOS
N
S
ROX
Isolated mitochondriaRatNervous system
Goldberg 2021 Biochem J2021Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2021) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37.LEAK
OXPHOS
ET
N
S
NS
ROX
F
Isolated mitochondriaMouseHeart
Skeletal muscle
Liver
Brodnanova 2021 Eur J Pharmacol2021Brodnanova M, Hatokova Z, Evinova A, Cibulka M, Racay P (2021) Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells. Eur J Pharmacol 902:174073.LEAK
ROUTINE
ET
N
S
ROX
Permeabilized cells
Intact cells
HumanNeuroblastoma
Gomez-Valades 2021 Cell Metab2021Gómez-Valadés AG, Pozo M, Varela L, Boudjadja MB, Ramírez S, Chivite I, Eyre E, Haddad-Tóvolli R, Obri A, Milà-Guasch M, Altirriba J, Schneeberger M, Imbernón M, Garcia-Rendueles AR, Gama-Perez P, Rojo-Ruiz J, Rácz B, Alonso MT, Gomis R, Zorzano A, D'Agostino G, Alvarez CV, Nogueiras R, Garcia-Roves PM, Horvath TL, Claret M (2021) Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis . Cell Metab 33:1820-35.e9.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Homogenate
MouseNervous system
Elliehausen 2021 Exp Gerontol2021Elliehausen CJ, Minton DM, Nichol AD, Konopka AR (2021) Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin. https://doi.org/10.1016/j.exger.2021.111579LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueGuinea pigSkeletal muscle
Peruzzotti-Jametti 2021 PLoS Biol2021Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel A, Beninca C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021) Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 19:3001166.LEAK
OXPHOS
N
S
Gp
CIV
ROX
Permeabilized cellsMouseNervous system
Stem cells
Vernerova 2021 Biomedicines2021Vernerova A, Garcia-Souza LF, Soucek O, Kostal M, Rehacek V, Krcmova LK, Gnaiger E, Sobotka O (2021) Mitochondrial respiration of platelets: comparison of isolation methods. https://doi.org/10.3390/biomedicines9121859LEAK
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ET
ROXIntact cellsHumanPlatelet
Hoppel 2021 Front Physiol2021Hoppel F, Calabria E, Pesta DH, Kantner-Rumplmair W, Gnaiger E, Burtscher M (2021) Effects of ultramarathon running on mitochondrial function of platelets and oxidative stress parameters: a pilot study. https://doi.org/10.3389/fphys.2021.632664LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Dunn 2021 Arterioscler Thromb Vasc Biol2021Dunn LL, Kong SMY, Tumanov S, Chen W, Cantley J, Ayer A, Maghzal GJ, Midwinter RG, Chan KH, Ng MKC, Stocker R (2021) Hmox1 (heme oxygenase-1) protects against ischemia-mediated injury via stabilization of HIF-1α (hypoxia-inducible factor-1α). Arterioscler Thromb Vasc Biol 41:317-30.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Ko 2021 Biomolecules2021Ko HJ, Tsai CY, Chiou SJ, Lai YL, Wang CH, Cheng JT, Chuang TH, Huang CF, Kwan AL, Loh JK, Hong YR (2021) The phosphorylation status of Drp1-Ser637 by PKA in mitochondrial fission modulates mitophagy via PINK1/Parkin to exert multipolar spindles assembly during mitosis. Biomolecules 11:424.LEAK
ROUTINE
ET
ROXIntact cellsHumanHeLa
Liu 2021 Basic Res Cardiol2021Liu N, Kataoka M, Wang Y, Pu L, Dong X, Fu X, Zhang F, Gao F, Liang T, Pei J, Xiao C, Qiu Q, Hong T, Chen Q, Zhao J, Zhu L, He J, Hu X, Nie Y, Zhu W, Yu H, Cowan DB, Hu X, Wang J, Wang DZ, Chen J (2021) LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway. Basic Res Cardiol 116:48.OXPHOSF
N
S
CIV
ROX
Permeabilized tissueMouseHeart
Saura-Esteller 2021 Int J Mol Sci2021Saura-Esteller J, Sánchez-Vera I, Núñez-Vázquez S, Cosialls AM, Gama-Pérez P, Bhosale G, Mendive-Tapia L, Lavilla R, Pons G, Garcia-Roves PM, Duchen MR, Iglesias-Serret D, Gil J (2021) Activation of the integrated stress response and ER stress protect from fluorizoline-induced apoptosis in HEK293T and U2OS cell lines. Int J Mol Sci 22:6117.LEAK
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ET
ROXIntact cellsHumanLymphocyte
McKenna 2021 Redox Biol2021McKenna HT, O'Brien KA, Fernandez BO, Minnion M, Tod A, McNally BD, West JA, Griffin JL, Grocott MP, Mythen MG, Feelisch M, Murray AJ, Martin DS (2021) Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness. Redox Biol 41:101907.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Dorigatti 2021 Geroscience2021Dorigatti JD, Thyne KM, Ginsburg BC, Salmon AB (2021) Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice. Geroscience 43:1497-511.LEAK
OXPHOS
ET
N
S
NS
ROX
F
Permeabilized tissueMouseSkeletal muscle
Fischer 2021 Antioxidants2021Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and Hfe-/- related hemochromatosis alter hepatic mitochondrial function. https://doi.org/10.3390/antiox10111818LEAK
OXPHOS
ET
ROX
N
S
Gp
MouseLiver
Yardeni 2021 Proc Natl Acad Sci U S A2021Yardeni T, Cristancho AG, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC (2021) An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes. Proc Natl Acad Sci U S A 118:e2021429118.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Zhang 2021 Pharmaceutics2021Zhang H, Zhang A, Gupte AA, Hamilton DJ (2021) Plumbagin elicits cell-specific cytotoxic effects and metabolic responses in melanoma cells. Pharmaceutics 13:706.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Kripnerova 2021 J Clin Med2021Kripnerová M, Parmar HS, Šána J, Kopková A, Radová L, Sopper S, Biernacki K, Jedlička J, Kohoutová M, Kuncová J, Peychl J, Rudolf E, Červinka M, Houdek Z, Dvořák P, Houfková K, Pešta M, Tůma Z, Dolejšová M, Tichánek F, Babuška V, Leba M, Slabý O, Hatina J (2021) Complex interplay of genes underlies invasiveness in fibrosarcoma progression model. J Clin Med 10:2297.LEAK
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ET
ROXIntact cellsMouseFibroblast
Garcia 2021 J Steroid Biochem Mol Biol2021Garcia AM, Bishop EL, Li D, Jeffery LE, Garten A, Thakker A, Certo M, Mauro C, Tennant DA, Dimeloe S, Evelo CT, Coort SL, Hewison M (2021) Tolerogenic effects of 1,25-dihydroxyvitamin D on dendritic cells involve induction of fatty acid synthesis. J Steroid Biochem Mol Biol 211:105891.LEAK
ET
ROXIntact cellsHumanNervous system
Zuccarelli 2021 J Physiol2021Zuccarelli L, Baldassarre G, Magnesa B, Degano C, Comelli M, Gasparini M, Manferdelli G, Marzorati M, Mavelli I, Pilotto A, Porcelli S, Rasica L, Šimunič B, Pišot R, Narici M, Grassi B (2021) Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration. J Physiol 599:4813-29.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Schroeder 2021 Cell Rep2021Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Mueller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Uecal M, Schaefer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Toelle RC, Sotonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Racz B, Kiechl S, Eisenberg T, Madeo F (2021) Dietary spermidine improves cognitive function. Cell Rep 35:108985.LEAK
OXPHOS
ET
N
NS
ROX
S
HomogenateMouse
Drosophila
Nervous system
Ferreira 2021 Redox Biol2021Ferreira JJ, Cassina A, Irigoyen P, Ford M, Pietroroia S, Peramsetty N, Radi R, Santi CM, Sapiro R (2021) Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation . Redox Biol [Epub ahead of print].LEAK
ROUTINE
ET
ROXIntact cellsMouseGenital
Watt 2021 Nat Commun2021Watt KI, Henstridge DC, Ziemann M, Sim CB, Montgomery MK, Samocha-Bonet D, Parker BL, Dodd GT, Bond ST, Salmi TM, Lee RS, Thomson RE, Hagg A, Davey JR, Qian H, Koopman R, El-Osta A, Greenfield JR, Watt MJ, Febbraio MA, Drew BG, Cox AG, Porrello ER, Harvey KF, Gregorevic P (2021) Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nat Commun 12:2887.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Galli 2021 Front Physiol2021Galli GLJ, Ruhr IM, Crossley J, Crossley DA 2nd (2021) The long-term effects of developmental hypoxia on cardiac mitochondrial function in snapping turtles. Front Physiol 12:689684. doi: 10.3389/fphys.2021.689684LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaReptilesHeart
MiPNet21.17 BloodCellsIsolation2020-10-22
O2k-Protocols
O2k-Protocols: Isolation of blood cells for HRR.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Hassan 2020 MitoFit Preprint Arch2020-04-30Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. https://doi.org/10.26124/mitofit:200003LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHuman
Cornelissen 2020 Hum Mol Genet2020Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanFibroblast
Makrecka-Kuka 2020 Cardiovasc Drugs Ther2020Makrecka-Kuka Marina, Korzh Stanislava, Videja Melita, Vilks Karlis, Cirule Helena, Kuka Janis, Dambrova Maija, Liepinsh Edgars (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther 34:791-97.OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseHeart
Lensu 2020 Nutrients2020Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Lindén J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides ameliorate high-fat-diet-induced hepatic steatosis in rats . Nutrients 12:E3225.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatLiver
Zhang 2020 Chemosphere2020Zhang Y, Li Y, Feng Q, Shao M, Yuan F, Liu F (2020) Polydatin attenuates cadmium-induced oxidative stress via stimulating SOD activity and regulating mitochondrial function in Musca domestica larvae. Chemosphere 248:126009.LEAK
OXPHOS
N
S
ROX
Isolated mitochondriaHexapods
Edmunds 2020 Mol Metab2020Edmunds LR, Xie B, Mills AM, Huckestein BR, Undamatla R, Murali A, Pangburn MM, Martin J, Sipula I, Kaufman BA, Scott I, Jurczak MJ (2020) Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab 41:101051.LEAK
OXPHOS
ET
F
N
ROX
HomogenateMouseLiver
Cipullo 2020 Nucleic Acids Res2020Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J (2020) Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly. Nucleic Acids Res 49:354-70.LEAK
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OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanHEK
Jaber 2020 BM Exp Neurol2020Jaber SM, Yadava N, Polster BM (2020) Mapping mitochondrial respiratory chain deficiencies by respirometry: beyond the Mito Stress Test. BM Exp Neurol 328:113282.LEAK
ROUTINE
ET
ROXIntact cellsNervous system
Close 2020 Cells2020Close AF, Dadheech N, Lemieux H, Wang Q, Buteau J (2020) Disruption of beta-cell mitochondrial networks by the orphan nuclear receptor Nor1/Nr4a3. Cells 9:E168.LEAK
ROUTINE
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
RatIslet cell;pancreas;thymus
Kanellopoulos 2020 Cell2020Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, Smit AB, Abrahams BS, Fiala A, Achsel T, Bagni C (2020) Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits. Cell 180:1178-97.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateDrosophilaNervous system
Other cell lines
Guo 2020 Hum Gene Ther2020Guo Y, Zhang K, Gao X, Zhou Z, Liu Z, Yang K, Huang K, Yang Q, Long Q (2020) Sustained oligomycin sensitivity conferring protein expression in cardiomyocytes protects against cardiac hypertrophy induced by pressure-overload via improving mitochondrial function. Hum Gene Ther 31:1178-89.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseHeart
Musi 2020 Aging Cell2020Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2020) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Coppin 2020 Cell Death Dis2020Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanIslet cell;pancreas;thymus
Endothelial;epithelial;mesothelial cell
Wei 2020 Cell Rep2020Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaRatKidney
Residual oxygen consumption2020Gnaiger E (2020) Residual oxygen consumption: a baseline correction of mitochondrial respiration. Mitochondr Physiol Network (2016-01-28) last update 2020-11-11.ROX
Brand 2020 J Clin Med2020Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.LEAK
OXPHOS
ET
N
CIV
ROX
Permeabilized cellsHumanLymphocyte
Dawid 2020 Biochim Biophys Acta Bioenerg2020Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg 1861:148251.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
NS
ROX
Permeabilized cells
Isolated mitochondria
Intact cells
Human
Mouse
Nervous system
HEK
Battaglia 2020 Cell Death Dis2020Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM (2020) Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Intact cellsRatNervous system
Hayes 2020 Nutrients2020Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
ROX
Permeabilized cells
Intact cells
HumanHeLa
Zhang 2020 Acta Pharmacol Sin2020Zhang L, Wang YN, Ju JM, Shabanova A, Li Y, Fang RN, Sun JB, Guo YY, Jin TZ, Liu YY, Li TY, Shan HL, Liang HH, Yang BF (2020) Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation. Acta Pharmacol Sin 42:691-700.LEAK
ROUTINE
ET
ROXIntact cellsMouseHeart
Al-Azab 2020 FEBS J2020Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J 287:3088-104.LEAK
ROUTINE
OXPHOS
ET
N
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
Briones-Herrera 2020 Free Radic Biol Med2020Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70.LEAK
OXPHOS
F
N
S
NS
ROX
Isolated mitochondriaRatKidney
Ost 2020 EMBO Rep2020Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Szibor 2020 J Biol Chem2020Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, Leßmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem 295:4383-97.LEAK
OXPHOS
N
S
Gp
CIV
NS
ROX
Isolated mitochondria
Intact cells
MouseNervous system
Rondot 2020 Thesis2020Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (Bombus impatiens). Master's Thesis 41.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized tissueHexapodsSkeletal muscle
Palavicini 2020 JCI Insight2020Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseNervous system
Locatelli 2020 FASEB J2020Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM (2020) Mitophagy contributes to endothelial adaptation to simulated microgravity. FASEB J 34:1833-45.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondria
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Yurre 2020 Arq Bras Cardiol2020Yurre AR, Silva JDFD, Torres MKDS, Martins EL, Ramos IP, Silva WSFLD, Sarpa JDS, Guedes CCDS, Napoleão TH, Coelho LCBB, Paiva PMG, Medei E (2020) Evaluation of the cardiac effects of a water-soluble lectin (Wsmol) from Moringa oleifera seeds. Arq Bras Cardiol 114:1029-37.LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseHeart
Parker 2020 Thesis2020Parker EP (2020) The effect of isoleucine supplementation of peripheral blood mononuclear cell metabolism in subjects with type 2 diabetes. URS Thesis 31.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Esselun 2020 Neuromolecular Med2020Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP (2020) A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med 23:140-60.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMouseNervous system
Piel 2020 PLoS One2020Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
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Permeabilized cells
Intact cells
HumanLiver
Platelet
Chang 2020 J Biol Chem2020Chang L, Liu X, Diggle CP, Boyle JP, Hopkins PM, Shaw MA, Allen PD (2020) Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia. J Biol Chem 295:15226-35.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Kuffner 2020 Cells2020Kuffner K, Triebelhorn J, Meindl K, Benner C, Manook A, Sudria-Lopez D, Siebert R, Nothdurfter C, Baghai TC, Drexler K, Berneburg M, Rupprecht R, Milenkovic VM, Wetzel CH (2020) Major depressive disorder is associated with impaired mitochondrial function in skin fibroblasts. Cells 9:884. doi: 10.3390/cells9040884LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Franco 2020 bioRxiv2020Franco JLM, Genoula M, Corral D, Duette G, Ferreyra M, Maio M, Dolotowicz MB, Aparicio-Trejo OE, Patiño-Martínez E, Fuentes F, Soldan V, Moraña EJ, Palmero D, Ostrowski M, Schierloh P, Sánchez-Torres C, Hernández-Pando R, Pedraza-Chaverri J, Rombouts Y, Layre E, Hudrisier D, Vérollet C, Neyrolles O, Sasiain MC, Lugo-Villarino G, Balboa L (2020) Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity. bioRxiv doi: https://doi.org/10.1101/2020.03.23.001818 .LEAK
ROUTINE
N
S
CIV
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Intact cellsHumanMacrophage-derived
Alahmad 2020 EMBO Mol Med2020Alahmad A, Nasca A, Heidler J, Thompson K, Oláhová M, Legati A, Lamantea E, Meisterknecht J, Spagnolo M, He L, Alameer S, Hakami F, Almehdar A, Ardissone A, Alston CL, McFarland R, Wittig I, Ghezzi D, Taylor RW (2020) Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I. EMBO Mol Med 12:e12619.LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Doig 2020 Skelet Muscle2020Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Fecker 2020 Biomolecules2020Fecker R, Buda V, Alexa E, Avram S, Pavel IZ, Muntean D, Cocan I, Watz C, Minda D, Dehelean CA, Soica C, Danciu C (2020) Phytochemical and biological screening of Oenothera biennis L. hydroalcoholic extract. Biomolecules 10:E818.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Hroudova 2020 Mol Neurobiol2020Hroudová J, Nováková T, Korábečný J, Maliňák D, Górecki L, Fišar Z (2020) Effects of novel tacrine derivatives on mitochondrial energy metabolism and monoamine oxidase activity-in vitro study. Mol Neurobiol 58:1102-13.OXPHOSN
S
ROX
Isolated mitochondriaPigNervous system
Karabatsiakis 2020 Transl Psychiatry2020Karabatsiakis DA, Schönfeldt-Lecuona PDC (2020) Depression, mitochondrial bioenergetics, and electroconvulsive therapy: a new approach towards personalized medicine in psychiatric treatment - a short review and current perspective. Transl Psychiatry 10:226.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Burtscher 2020 eNeuro2020Burtscher J, Copin JC, Sandi C, Lashuel HA (2020) Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala. eNeuro 7:ENEURO.0110-20.2020.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Woessner 2020 J Appl Physiol (1985)2020Woessner MN, Neil C, Saner NJ, Goodman CA, McIlvenna LC, Ortiz de Zevallos J, Garnham AP, Levinger I, Allen JD (2020) Effect of inorganic nitrate on exercise capacity, mitochondria respiration and vascular function in heart failure reduced ejection fraction. J Appl Physiol (1985) 128:1355-64.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Visavadiya 2020 Mol Cell Biochem2020Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem 476:23-34.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseLiver
Ledur 2020 Sci Rep2020Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218.LEAK
ROUTINE
ET
ROXIntact cellsHumanNervous system
Owiredu 2020 Toxicol Rep2020Owiredu S, Ranganathan A, Greenwood JC, Piel S, Janowska JI, Eckmann DM, Kelly M, Ehinger JK, Kilbaugh TJ, Jang DH (2020) In vitro comparison of hydroxocobalamin (B12a) and the mitochondrial directed therapy by a succinate prodrug in a cellular model of cyanide poisoning. Toxicol Rep 7:1263-71.ROUTINE
ET
CIV
ROX
Intact cellsHumanBlood cells
Other cell lines
Stankova 2020 Int J Mol Sci2020Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101.LEAK
OXPHOS
F
N
S
Gp
NS
ROX
HomogenateMouseLiver
Fuchs 2020 J Funct Foods2020Fuchs C, Bakuradze T, Steinke R, Grewal R, Eckert GP, Richling E (2020) Polyphenolic composition of extracts from winery by-products and effects on cellular cytotoxicity and mitochondrial functions in HepG2 cells. J Funct Foods 70:103988.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanLiver
Bose 2020 Aging Cell2020Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell 19:e13261.LEAK
OXPHOS
F
N
CIV
NS
ROX
Permeabilized tissueMouseHeart
Vulczak 2020 Cells2020Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:E628.LEAK
OXPHOS
ET
N
ROX
Permeabilized cellsMouseEndothelial;epithelial;mesothelial cell
Jespersen 2020 Sci Rep2020Jespersen NR, Hjortbak MV, Lassen TR, Støttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, Bøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueRatHeart
Rodriguez 2020 J Gerontol A Biol Sci Med Sci2020Rodríguez E, Hakkou M, Hagen TM, Lemieux H, Blier PU (2020) Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves. J Gerontol A Biol Sci Med Sci 76:796-804.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Isolated mitochondriaMolluscs
Maeda 2020 J Cell Mol Med2020Maeda H, Kami D, Maeda R, Murata Y, Jo JI, Kitani T, Tabata Y, Matoba S, Gojo S (2020) TAT-dextran-mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes. J Cell Mol Med 24:5007-20.LEAK
ROUTINE
OXPHOS
ET
N
ROX
Isolated mitochondria
Intact cells
RatHeart
Pajuelo 2020 Cells2020Pajuelo Reguera D, Čunátová K, Vrbacký M, Pecinová A, Houštěk J, Mráček T, Pecina P (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:443.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanHEK
Ulgherait 2020 Nat Commun2020Ulgherait Matt, Chen Anna, McAllister Sophie F, Kim Han X, Delventhal Rebecca, Wayne Charlotte R, Garcia Christian J, Recinos Yocelyn, Oliva Miles, Canman Julie C, Picard Martin, Owusu-Ansah Edward, Shirasu-Hiza Mimi (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaDrosophila
Assis-de-Lemos 2020 Curr Protoc Toxicol2020Assis-de-Lemos G, Ledur PF, Karmirian K, Rehen SK, Galina A (2020) A protocol to study mitochondrial function in human neural progenitors and iPSC-derived astrocytes. Curr Protoc Toxicol 85:e97.LEAK
ROUTINE
ET
ROXIntact cellsHumanNervous system
Gumpp 2020 Proc Natl Acad Sci U S A2020Gumpp AM, Boeck C, Behnke A, Bach AM, Ramo-Fernández L, Welz T, Gündel H, Kolassa IT, Karabatsiakis A (2020) Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Proc Natl Acad Sci U S A 117:24778-84.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Falcao-Tebas 2020 J Physiol2020Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol 598:4251-70.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueRatSkeletal muscle
Fisher 2020 J Physiol2020Fisher JJ, Vanderpeet CL, Bartho LA, McKeating DR, Cuffe JSM, Holland OJ, Perkins AV (2020) Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus. J Physiol 599:1291-305.OXPHOS
ET
N
NS
ROX
Isolated mitochondriaHumanGenital
Wang 2020 J Mol Med (Berl)2020Wang SY, Zhu Siyu, Wu Jian, Zhang Maomao, Xu Yousheng, Xu Wei, Cui Jinjin, Yu Bo, Cao Wei, Liu Jingjin (2020) Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl) 98:245-61.LEAK
OXPHOS
N
ROX
Isolated mitochondriaMouseHeart
Baggio 2020 Neurotoxicology2020Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateZebrafishNervous system
Bianchi 2020 IUBMB Life2020Bianchi SE, Pegues MA, Dias CK, Mascia F, Doneda E, Pittol V, Rao A, Klamt F, Bassani VL (2020) Achyrocline satureioides compounds, achyrobichalcone and 3-O-methylquercetin, induce mitochondrial dysfunction and apoptosis in human breast cancer cell lines. IUBMB Life 72:2133-45.ROUTINEROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Almoiliqy 2020 Acta Pharmacol Sin2020Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin 41:1208-22.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
RatEndothelial;epithelial;mesothelial cell
Magnesa 2020 Thesis2020Magnesa B (2020) Skeletal muscle mitochondrial oxidative phosphorylation plasticity in two studies on humans: exercise training effect in obese subjects and bed rest effect in healthy subjects. PhD Thesis 81.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Aparicio-Trejo 2020 Free Radic Biol Med2020Aparicio-Trejo OE, Avila-Rojas SH, Tapia E, Rojas-Morales P, León-Contreras JC, Martínez-Klimova E, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2020) Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med 154:18-32.LEAK
OXPHOS
F
N
S
ROX
Isolated mitochondriaRatKidney
Dawson 2020 Exp Gerontol2020Dawson NJ, Salmón P (2020) Age-related increase in mitochondrial quantity may mitigate a decline in mitochondrial quality in red blood cells from zebra finches (Taeniopygia guttata). Exp Gerontol 133:110883.LEAK
ROUTINE
ET
ROXIntact cellsBirdsBlood cells
Pham 2020 Eur J Appl Physiol2020Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69.LEAK
OXPHOS
ET
N
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
McLaughlin 2020b Sci Rep2020McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH (2020) Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Sci Rep 10:17599.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Isolated mitochondriaMouseHeart
Liver
Kidney
Fat
Protasoni 2020 EMBO J2020Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E (2020) Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J 39:e102817.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
McCann 2020 Metabolites2020McCann MR, McHugh CE, Kirby M, Jennaro TS, Jones AE, Stringer KA, Puskarich MA (2020) A multivariate metabolomics method for estimating platelet mitochondrial oxygen consumption rates in patients with sepsis. Metabolites 10:E139.LEAK
ROUTINE
ET
ROXIntact cellsHumanPlatelet
Souza da Silva 2020 Mol Neurobiol2020Souza da Silva J, Nonose Y, Rohden F, Lukasewicz Ferreira PC, Fontella FU, Rocha A, Wigner Brochier A, Vieira Apel R, de Lima TM, Seminotti B, Amaral AU, Galina A, Souza DO (2020) Guanosine neuroprotection of presynaptic mitochondrial calcium homeostasis in a mouse study with amyloid-β oligomers. Mol Neurobiol 57:4790-809.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Hijazi 2020 J Cell Sci2020Hijazi I, Knupp J, Chang A (2020) Retrograde signaling mediates an adaptive survival response to endoplasmic reticulum stress. J Cell Sci 133:jcs241539.ROUTINE
ET
ROXIntact cellsSaccharomyces cerevisiae
Lensu 2020 Preprints2020Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Linden J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides targeting Faecalibacterium prausnitzii prevent high fat diet-induced hepatic steatosis in rats. Preprints 2020:2020090241.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatLiver
Janowska 2020 Toxicol In Vitro2020Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK (2020) Mitochondrial respiratory chain Complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug carbamate toxicity and treatment. Toxicol In Vitro 65:104794.LEAK
ROUTINE
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Blood cells
Ayari 2020 Commun Biol2020Ayari Asma, Rosa-Calatrava Manuel, Lancel Steve, Barthelemy Johanna, Pizzorno Andres, Mayeuf-Louchart Alicia, Baron Morgane, Hot David, Deruyter Lucie, Soulard Daphnee, Julien Thomas, Faveeuw Christelle, Molendi-Coste Olivier, Dombrowicz David, Sedano Laura, Sencio Valentin, Le Goffic Ronan, Trottein Francois, Wolowczuk Isabelle (2020) Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Commun Biol 3:237.LEAK
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ET
ROXIntact cellsMouseFat
Cheng 2020 Am J Physiol Heart Circ Physiol2020Cheng TC, Philip JL, Tabima DM, Kumari S, Yakubov B, Frump AL, Hacker TA, Bellofiore A, Li R, Sun X, Goss KN, Lahm T, Chesler N (2020) Estrogen receptor alpha prevents right ventricular diastolic dysfunction and fibrosis in female rats . Am J Physiol Heart Circ Physiol 319:H1459-73.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized tissueRatHeart
Ferreira 2020 PLoS Genet2020Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604.LEAK
OXPHOS
ET
N
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Isolated mitochondriaMouseLiver
Macedo 2020 FASEB J2020Macedo F, Romanatto T, Gomes de Assis C, Buis A, Kowaltowski AJ, Aguilaniu H, Marques da Cunha F (2020) Lifespan-extending interventions enhance lipid-supported mitochondrial respiration in Caenorhabditis elegans. FASEB J 34:9972-81.LEAK
OXPHOS
F
N
CIV
ROX
Intact organism
Isolated mitochondria
Caenorhabditis elegans
Herpich 2020 Exp Gerontol2020Herpich C, Franz K, Klaus S, Müller-Werdan U, Ost M, Norman K (2020) Age-related fatigue is associated with reduced mitochondrial function in peripheral blood mononuclear cells. Exp Gerontol 144:111177.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Mahul-Mellier 2020 Proc Natl Acad Sci U S A2020Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA (2020) The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proc Natl Acad Sci U S A 117:4971-82.LEAK
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OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
MouseNervous system
Gvozdjakova 2020 Diagnostics (Basel)2020Gvozdjáková A, Sumbalová Z, Kucharská J, Komlósi M, Rausová Z, Vančová O, Számošová M, Mojto V (2020) Platelet mitochondrial respiration, endogenous coenzyme Q10 and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:176.LEAK
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OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Heinonen 2020 Sci Rep2020Heinonen I, Sorop O, van Dalen BM, Wüst RCI, van de Wouw J, de Beer VJ, Octavia Y, van Duin RWB, Hoogstrate Y, Blonden L, Alkio M, Anttila K, Stubbs A, van der Velden J, Merkus D, Duncker DJ (2020) Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Sci Rep 10:13173.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissuePigHeart
Chen 2020 Biochim Biophys Acta Mol Basis Dis2020Chen T, Hill JT, Moore TM, Cheung ECK, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, Hansen JM, Thomson DM (2020) Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochim Biophys Acta Mol Basis Dis 1866:165805.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Bhaskaran 2020 Aging Cell2020Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19:e13225.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Avila-Rojas 2020 Food Chem Toxicol2020Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaRatKidney
MitoEAGLE blood cells 12020Åsander Frostner Eleonor*, Aburel Oana M*, Avram Vlad F*, Calabria Elisa, Castelo Rueda Maria Paulina*, Chamkha Imen*, Čižmárová Beata, Danila Maria-Daniela*, Doerrier Carolina*, Eckert Gunter P*, Ehinger Johannes K, Elmer Eskil*, Garcia-Souza Luiz F*, Gnaiger Erich*, Hoppel Florian*, Karabatsiakis Alexander*, Keppner Gloria, Kidere Dita*, Krako Jakovljević Nina, Labieniec-Watala Magdalena*, Lelcu Theia*, Micankova Petra, Michalak Slawomir*, Molina Anthony JA*, Pavlovic Kasja, Pichler Irene*, Piel Sarah, Rousar Tomas, Rybacka-Mossakowska Joanna, Schartner Melanie, Siewiera Karolina*, Silaidos Carmina*, Sjövall Fredrik*, Sobotka Ondrej*, Sumbalova Zuzana*, Swiniuch Daria, Vernerova Andrea*, Volani Chiara*, Vujacic-Mirski Ksenija*, Watala Cezary* (2020) Interlaboratory guide to mitochondrial respiratory studies with peripheral blood mononuclear cells and platelets. - Updated: 2020-03-06 - *ConfirmedLEAK
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OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Peruzzotti-Jametti 2020 bioRxiv2020Peruzzotti-Jametti L, Bernstock JD, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Kittel A, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2020) Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells. bioRxiv doi: https://doi.org/10.1101/2020.01.29.923441 .LEAKN
S
Gp
CIV
ROX
Permeabilized cellsMouseStem cells
Dulac 2020 J Physiol2020Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol 598:3691-710.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Kunz 2020 J Biol Chem2020Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR (2020) Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem 295:17441-59.LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
S
Permeabilized tissue
Intact cells
MouseSkeletal muscle
Pelster 2020 PLoS One2020Pelster B, Wood CM, Campos DF, Val AL (2020) Cellular oxygen consumption, ROS production and ROS defense in two different size-classes of an Amazonian obligate air-breathing fish (Arapaima gigas). PLoS One 15:e0236507.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueFishesKidney
Lung;gill
Purhonen 2020 Nat Commun2020Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseLiver
Kidney
Messner 2020 Thesis2020Messner M (2020) Sorafenib resistance of hepatocellular carcinoma. PhD Thesis 130.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
Jian 2020 Cell Metab2020Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell Metab 31:892-908.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized cellsMouseLiver
Schneider 2020 PLoS One2020Schneider J, Han WH, Matthew R, Sauve Y, Lemieux H (2020) Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat. PLoS One 15:e0228710.LEAK
OXPHOS
F
N
S
CIV
NS
ROX
Permeabilized tissueRatHeart
Fisher 2020 Placenta2020Fisher J, McKeating D, Pennell E, Cuffe J, Holland O, Perkins A (2020) Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast. Placenta 82:1-4.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaHumanGenital
Weger 2020 Sci Rep2020Weger M, Alpern D, Cherix A, Ghosal S, Grosse J, Russeil J, Gruetter R, de Kloet ER, Deplancke B, Sandi C (2020) Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress. Sci Rep 10:18308.OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Roy Chowdhury 2020 Cancers (Basel)2020Roy Chowdhury S, Bouchard EDJ, Saleh R, Nugent Z, Peltier C, Mejia E, Hou S, McFall C, Squires M, Hewitt D, Davidson L, Shen GX, Johnston JB, Doucette C, Hatch GM, Fernyhough P, Marshall A, Gibson SB, Dawe DE, Banerji V (2020) Mitochondrial respiration correlates with prognostic markers in chronic lymphocytic leukemia and Is normalized by ibrutinib treatment. Cancers (Basel) 12:E650.LEAK
ET
ROXIntact cellsHumanLymphocyte
Macasoi 2020 Oncol Rep2020Macașoi I, Pavel IZ, Moacă AE, Avram S, David LV, Coricovac D, Mioc A, Spandidos DA, Tsatsakis A, Șoica C, Dumitrașcu V, Dehelean C (2020) Mechanistic investigations of antitumor activity of a Rhodamine B‑oleanolic acid derivative bioconjugate. Oncol Rep 44:1169-83.LEAK
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OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Pinho 2020 PLoS Negl Trop Dis2020Pinho N, Wiśniewski JR, Dias-Lopes G, Saboia-Vahia L, Bombaça ACS, Mesquita-Rodrigues C, Menna-Barreto R, Cupolillo E, de Jesus JB, Padrón G, Cuervo P (2020) In-depth quantitative proteomics uncovers specie-specific metabolic programs in Leishmania (Viannia) species. PLoS Negl Trop Dis 14:e0008509.ROXIntact cellsProtistsOther cell lines
De-Souza 2020 J Biol Chem2020De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82.LEAK
OXPHOS
N
Gp
NS
ROX
Isolated mitochondria
Intact cells
Caenorhabditis elegans
Saccharomyces cerevisiae
Chandramouleeswaran 2020 PLoS One2020Chandramouleeswaran PM, Guha M, Shimonosono M, Whelan KA, Maekawa H, Sachdeva UM, Ruthel G, Mukherjee S, Engel N, Gonzalez MV, Garifallou J, Ohashi S, Klein-Szanto AJ, Mesaros CA, Blair IA, Pellegrino da Silva R, Hakonarson H, Noguchi E, Baur JA, Nakagawa H (2020) Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes. PLoS One 15:e0239625.ROUTINE
OXPHOS
N
S
CIV
ROX
Permeabilized cells
Intact cells
MouseEndothelial;epithelial;mesothelial cell
Romeiro 2020 bioRxiv2020Romeiro NC, Ferreira CM, Oliveira MF (2020) Assessment of mitochondrial physiology of murine white adipose tissue by mechanical permeabilization and lipid depletion. bioRxiv doi: https://doi.org/10.1101/2020.02.19.956870.LEAK
OXPHOS
ET
S
ROX
Permeabilized tissueMouseFat
Simard 2020b Metabolites2020Simard CJ, Touaibia M, Allain EP, Hebert-Chatelain E, Pichaud N (2020) Role of the mitochondrial pyruvate carrier in the occurrence of metabolic inflexibility in Drosophila melanogaster exposed to dietary sucrose. Metabolites 10:E411.LEAK
OXPHOS
ET
N
Gp
NS
Other combinations
ROX
Permeabilized tissueDrosophila
Jayakumari 2020 J Diabetes2020Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaHumanHeart
Oliveira 2020 Anim Reprod2020Oliveira VS, Castro AJG, Domingues JT, Souza AZP, Scheffer DL, Latini A, Soares CHL, Van Der Kraak G, Silva FRMB (2020) A brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters sertoli cell secretion and mitochondrial activity. Anim Reprod 17:e20190116.LEAK
ROUTINE
ET
ROXIntact cellsRatGenital
Rocha 2020 Sci Adv2020Rocha AL, de Lima TI, de Souza GP, Corrêa RO, Ferrucci DL, Rodrigues B, Lopes-Ramos C, Nilsson D, Knittel TL, Castro PR, Fernandes MF, Dos Santos Martins F, Parmigiani RB, Silveira LR, Carvalho HF, Auwerx J, Vinolo MAR, Boucher J, Mori MA (2020) Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. Sci Adv 6:eabc6250.LEAK
ROUTINE
ET
ROXIntact cellsMouseFat
Burtscher 2020 Int J Mol Sci2020Burtscher J, Di Pardo A, Maglione V, Schwarzer C, Squitieri F (2020) Mitochondrial respiration changes in R6/2 Huntington's Disease model mice during aging in a brain region specific manner. Int J Mol Sci 21:5412.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateMouseNervous system
Burgin 2020 Int J Mol Sci2020Burgin HJ, Lopez Sanchez MIG, Smith CM, Trounce IA, McKenzie M (2020) Pioglitazone and deoxyribonucleoside combination treatment increases mitochondrial respiratory capacity in m.3243A>G MELAS cybrid cells. Int J Mol Sci 21:E2139.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
Larsen 2020 Cardiovasc Drugs Ther2020Larsen AH, Wiggers H, Dollerup OL, Jespersen NR, Hansson NH, Frøkiær J, Brøsen K, Nørrelund H, Bøtker HE, Møller N, Jessen N (2020) Metformin lowers body weight but fails to increase insulin sensitivity in chronic heart failure patients without diabetes: a randomized, double-blind, placebo-controlled study. Cardiovasc Drugs Ther 35:491-503.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis2020Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondria
Intact cells
RatLiver
Nervous system
Zussman 2020 J Autoimmun2020Zussman R, Xu LY, Damani T, Groom KM, Chen Q, Seers B, Viall CA, Chamley LW, Hickey A (2020) Antiphospholipid antibodies can specifically target placental mitochondria and induce ROS production. J Autoimmun 111:102437.LEAK
ET
N
S
Gp
CIV
NS
ROX
Permeabilized tissueHumanGenital
Simard 2020 Metabolites2020Simard C, Lebel A, Allain EP, Touaibia M, Hebert-Chatelain E, Pichaud N (2020) Metabolic characterization and consequences of mitochondrial pyruvate carrier deficiency in Drosophila melanogaster. Metabolites 109:E363.LEAK
OXPHOS
ET
N
S
Gp
NS
ROX
Permeabilized tissueDrosophila
Zulkifli 2020 Nat Commun2020Zulkifli M, Neff JK, Timbalia SA, Garza NM, Chen Y, Watrous JD, Murgia M, Trivedi PP, Anderson SK, Tomar D, Nilsson R, Madesh M, Jain M, Gohil VM (2020) Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism. Nat Commun 11:4866.ROUTINE
ET
ROXIntact cellsSaccharomyces cerevisiae
Groennebaek 2020 Cells2020Groennebaek T, Billeskov TB, Schytz CT, Jespersen NR, Bøtker HE, Olsen RKJ, Eldrup N, Nielsen J, Farup J, De Paoli FV, Vissing K (2020) Mitochondrial structure and function in the metabolic myopathy accompanying patients with critical limb ischemia. Cells 9:E570.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Severo 2020 Life Sci2020Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci 257:117991.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Contreras Mostazo 2020 Cancers (Basel)2020Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, Häupl B, Martín-Sanz P, Brüne B, Serve H, Schwalbe H, Schnütgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Hraoui 2020 J Exp Biol2020Hraoui G, Bettinazzi S, Gendron AD, Boisclair D, Breton S (2020) Mitochondrial thermo-sensitivity in invasive and native freshwater mussels. J Exp Biol 223:jeb215921.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueMolluscsLung;gill
Marrocco 2020 Thesis2020Marrocco A (2020) Alterations of CCSP expression and macrophages metabolism in the development of silica-induced pulmonary inflammation and fibrosis. PhD Thesis 108.LEAK
OXPHOS
ET
S
ROX
Intact cellsMouseMacrophage-derived
Liu 2020 Cell Death Dis2020Liu YF, Zhu Juan-Juan, Yu Tian X, Liu Han, Zhang Tao, Zhang Yun-Peng, Xie Si-An, Zheng Ming, Kong Wei, Yao Wei-Juan, Pang Wei, Zhao Chuan-Rong, Tang Yuan-Jun, Zhou Jing (2020) Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility. Cell Death Dis 11:35.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized tissueMouseEndothelial;epithelial;mesothelial cell
Carvalho 2020 BMC Nutr2020Carvalho E, Adams SH, Borsheim E, Blackburn ML, Ono-Moore KD, Cotter M, Bowlin AK, Yeruva L (2020) Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk. BMC Nutr 6:13.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissuePigLiver
Hosmann 2020 Acta Neurochir (Wien)2020Hosmann A, Milivojev N, Dumitrescu S, Reinprecht A, Weidinger A, Kozlov AV (2020) Cerebral nitric oxide and mitochondrial function in patients suffering aneurysmal subarachnoid hemorrhage-a translational approach. Acta Neurochir (Wien) 163:139-49.OXPHOSN
S
CIV
ROX
HomogenateRatNervous system
Pena 2020 Int J Chronic Dis2020Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
De Souza 2020 Heliyon2020De Souza CEA, Andrade Pires AR, Cardoso CR, Carlos RM, Cadena SMSC, Acco A (2020) Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adenocarcinoma (HeLa) cells. Heliyon 6:e03862.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
HeLa
Woessner 2020 Thesis2020Woessner MN (2020) BEET-HF: The effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. PhD Thesis 198.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Frambach 2020 Biochim Biophys Acta Mol Basis Dis2020Frambach SJCM, van de Wal MAE, van den Broek PHH, Smeitink JAM, Russel FGM, de Haas R, Schirris TJJ (2020) Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165727.LEAK
OXPHOS
F
N
S
Gp
CIV
Other combinations
ROX
Permeabilized tissueMouseSkeletal muscle
Schleier 2020 J Cardiovasc Transl Res2020Schleier Y, Moreno-Loaiza O, López Alarcón MM, Lopes Martins EG, Braga BC, Ramos IP, Galina A, Medei EH (2020) NOD mice recapitulate the cardiac disturbances observed in type 1 diabetes. J Cardiovasc Transl Res 14:271-82.LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseHeart
Risiglione 2020 Int J Mol Sci2020Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP+ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanNeuroblastoma
Gruenig 2020 Biochem Pharmacol2020Grünig D, Szabo L, Marbet M, Krähenbühl S (2020) Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms. Biochem Pharmacol 177:113860.LEAK
OXPHOS
ET
N
S
DQ
CIV
ROX
Isolated mitochondriaMouseLiver
Courtes 2020 Brain Res Bull2020Courtes AA, Gonçalves DF, Hartmann DD, da Rosa PC, Cassol G, Royes LFF, de Carvalho NR, Soares FAA (2020) Guanosine protects against behavioural and mitochondrial bioenergetic alterations after mild traumatic brain injury. Brain Res Bull 163:31-39.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Rodriguez de Yurre 2020 An Acad Bras Cienc2020Rodriguez de Yurre A, Martins EGL, Lopez-Alarcon M, Cabral B, Vera N, Lopes JA, Galina A, Takiya CM, Lindoso RS, Vieyra A, SÁenz OC, Medei E (2020) Type 2 diabetes mellitus alters cardiac mitochondrial content and function in a non-obese mice model. An Acad Bras Cienc 92:e20191340.LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseHeart
Baxter 2020 Elife2020Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateMouseHeart
Hoffmann 2020 J Clin Endocrinol Metab2020Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Juarez-Flores 2020 Antioxidants (Basel)2020Juarez-Flores DL, Ezquerra M, Gonzalez-Casacuberta I, Ormazabal A, Moren C, Tolosa E, Fucho R, Guitart-Mampel M, Casado M, Valldeoriola F, de la Torre-Lara J, Munoz E, Tobias E, Compta Y, Garcia-Garcia FJ, Garcia-Ruiz C, Fernandez-Checa JC, Marti MJ, Grau JM, Cardellach F, Artuch R, Fernandez-Santiago R, Garrabou G (2020) Disrupted mitochondrial and metabolic plasticity underlie comorbidity between age-related and degenerative disorders as Parkinson disease and type 2 diabetes mellitus. Antioxidants (Basel) 9:1063.LEAK
ROUTINE
ET
ROXPermeabilized cells
Intact cells
HumanFibroblast
Dawson 2020 J Exp Biol2020Dawson NJ, Millet C, Selman C, Metcalfe NB (2020) Measurement of mitochondrial respiration in permeabilized fish gills. J Exp Biol 223:jeb216762.LEAK
OXPHOS
N
CIV
NS
ROX
Permeabilized tissueFishesLung;gill
Seitaj 2020 Cells2020Seitaj B, Maull F, Zhang L, Wüllner V, Wolf C, Schippers P, La Rovere R, Distler U, Tenzer S, Parys JB, Bultynck G, Methner A (2020) Transmembrane BAX inhibitor-1 motif containing protein 5 (TMBIM5) sustains mitochondrial structure, shape, and function by impacting the mitochondrial protein synthesis machinery. Cells 9:E2147.LEAK
ROUTINE
ET
ROXIntact cellsHumanKidney
Grewal 2020 Exp Neurol2020Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248.LEAK
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OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanNeuroblastoma
Owiredu 2020 Am J Physiol Cell Physiol2020Owiredu S, Ranganathan A, Eckmann DM, Shofer FS, Hardy K, Lambert DS, Kelly M, Jang DH (2020) Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide poisoned individuals. Am J Physiol Cell Physiol 319:C129-35.LEAK
ROUTINE
ET
S
CIV
ROX
Permeabilized cells
Intact cells
HumanBlood cells
He 2020 Clin Transl Med2020He C, Gao P, Cui Y, Li Q, Li Y, Lu Z, Ma H, Zhao Y, Li L, Sun F, Chen, X, Jia H, Liu D, Yang G, Zheng H, Zhu Z (2020) Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes. Clin Transl Med 10:e205.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaMouseNervous system
Xia 2020 Biomed Res Int2020Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation in vivo. Biomed Res Int 2020:1202189.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Makrecka-Kuka 2020 Sci Rep2020Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. Sci Rep 10:21595.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized cellsMouseEndothelial;epithelial;mesothelial cell
Krajcova 2020 PLOS ONE2020Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142.LEAK
OXPHOS
ET
N
S
NS
ROX
Homogenate
Isolated mitochondria
HumanHeart
Ugarteburu 2020 J Clin Med2020Ugarteburu O, Sánchez-Vilés M, Ramos J, Barcos-Rodríguez T, Garrabou G, García-Villoria J, Ribes A, Tort F (2020) Physiopathological bases of the disease caused by HACE1 mutations: alterations in autophagy, mitophagy and oxidative stress response. J Clin Med 9:E913.LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Tepp 2020 Biochim Biophys Acta Gen Subj2020Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueMouseHeart
Skeletal muscle
Feng 2020 Int J Biol Macromol2020Feng Q, Shao M, Han J, Tang T, Zhang Y, Liu F (2020) TFAM, a potential oxidative stress biomarker used for monitoring environment pollutants in Musca domestica. Int J Biol Macromol 155:524-34.LEAK
OXPHOS
N
S
ROX
Isolated mitochondriaHexapods
Mikulas 2020 Materials2020Mikulás K, Komlódi T, Földes A, Sváb G, Horváth G, Nagy AM, Ambrus A, Gyulai-Gaál Sz, Gera I, Hermann P, Varga G, Tretter L (2020) Bioenergetic Impairment of triethylene glycol dimethacrylate- (TEGDMA-) treated dental pulp stem cells (DPSCs) and isolated brain mitochondria are amended by redox compound methylene blue. Materials (Basel) 13(16):3472.OXPHOS
ET
ROUTINE
N
S
ROX
Isolated mitochondria
Permeabilized cells
Intact cells
Guinea pig
Human
Stem cells
Mouithys-Mickalad 2020 Chem Biol Interact2020Mouithys-Mickalad A, Ceusters J, Charif M, El Moualij B, Schoumacher M, Plyte S, Franck T, Bettendorff L, Pirotte B, Serteyn D, de Tullio P (2020) Modulation of mitochondrial respiration rate and calcium-induced swelling by new cromakalim analogues. Chem Biol Interact 331:109272.LEAK
ROUTINE
ET
ROXIntact cellsRatHeart
MitoEAGLE muscle 12020Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. - Updated: 2020-03-08LEAK
OXPHOS
ET
N
NS
S
ROX
Permeabilized tissueHumanSkeletal muscle
Irion 2020 Stem Cells Int2020Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, Campos de Carvalho AC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 .LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueRatHeart
Charles 2020 Nanomedicine (Lond)2020Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) 15:2917-32.LEAK
OXPHOS
N
S
CIV
ROX
Isolated mitochondriaHumanEndothelial;epithelial;mesothelial cell
Scrima 2020 bioRxiv2020Scrima R, Fugetto S, Capitanio N, Gatti DL (2020) Hemoglobin non-equilibrium oxygen dissociation curve. bioRxiv https://doi.org/10.1101/2020.01.09.900001.LEAKS
ROX
Isolated mitochondriaRatLiver
Tichanek 2020 Sci Rep2020Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateMouseNervous system
Lin 2020 Preprints2020Lin M, Fu T, Hsu C, Huang S, Lin Y, Wang J (2020) Cycling exercise training enhances mitochondrial bioenergetics of platelets in patients with peripheral arterial disease: a randomized controlled trial. Preprints 2020070567.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Evinova 2020 J Membr Biol2020Evinova A, Cizmarova B, Hatokova Z, Racay P (2020) High‑resolution respirometry in assessment of mitochondrial function in neuroblastoma SH‑SY5Y intact cells. J Membr Biol 253:129-36.LEAK
ROUTINE
ET
N
S
ROX
Permeabilized cells
Intact cells
HumanNeuroblastoma
Silaidos 2020 Mitochondrion2020Silaidos C, Grube J, Muley C, Eckert GP (2020) Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers. Mitochondrion 53:21-29.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Pola 2020 Invest New Drugs2020Pola M, Kolarova H, Ruzicka J, Zholobenko A, Modriansky M, Mosinger J, Bajgar R (2020) Effects of zinc porphyrin and zinc phthalocyanine derivatives in photodynamic anticancer therapy under different partial pressures of oxygen in vitro. Invest New Drugs 39:89-97.LEAK
ROUTINE
ET
ROXIntact cellsHumanHeLa
Padilla-Flores 2020 Biochem Biophys Res Commun2020Padilla-Flores T, Lopez-Gonzalez Z, Vaca L, Aparicio-Trejo OE, Briones-Herrera A, Riveros-Rosas H, Pedraza-Chaverri J, Leon-Aparicio D, Salvador C, Sampieri A, Escobar LI (2020) "Funny" channels in cardiac mitochondria modulate membrane potential and oxygen consumption. Biochem Biophys Res Commun 524:1030-36.LEAK
ROUTINE
ROXIntact cellsRatHeart
Madeo 2020 US Patent2020Madeo F, Eisenberg T, Stekovic S (2020) Use of spermidine for the enhancement of mitochondrial respiration. US Patent US20200054579 A1.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaMouseHeart
Keppner 2020 Thesis2020Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Anand 2020 Toxicol In Vitro2020Anand CR, Bhavya B, Jayakumar K, Harikrishnan VS, Gopala S (2020) Inorganic nitrite alters mitochondrial dynamics without overt changes in cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemia. Toxicol In Vitro 70:105048.LEAK
ROUTINE
ET
ROXIntact cellsRatHeart
Yadav 2020 Cell Death Dis2020Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK (2020) MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis 11:186.LEAK
OXPHOS
ET
N
CIV
NS
ROX
Permeabilized cellsHumanHeart
Stem cells
Brum 2020 Mol Neurobiol2020Brum EDS, Fialho MFP, Fischer SPM, Hartmann DD, Gonçalves DF, Scussel R, Machado-de-Ávila RA, Dalla Corte CL, Soares FAA, Oliveira SM (2020) Relevance of mitochondrial dysfunction in the reserpine-induced experimental fibromyalgia model. Mol Neurobiol 57:4202-17.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Nervous system
Mezeiova 2020 Eur J Med Chem2020Mezeiova E, Janockova J, Andrys R, Soukup O, Kobrlova T, Muckova L, Pejchal J, Simunkova M, Handl J, Micankova P, Capek J, Rousar T, Hrabinova M, Nepovimova E, Marco-Contelles JL, Valko M, Korabecny J (2020) 2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease. Eur J Med Chem 211:113112.LEAK
OXPHOS
ET
ROXIntact cellsHumanNeuroblastoma
Kline 2020 Nitric Oxide2020Kline JA, Puskarich MA, Pike JW, Zagorski J, Alves NJ (2020) Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism. Nitric Oxide 96:20-8.LEAK
ET
ROXIntact cellsHumanPlatelet
Blood cells
Bombaca 2020 Free Radic Biol Med2020Bombaça ACS, Brunoro GVF, Dias-Lopes G, Ennes-Vidal V, Carvalho PC, Perales J, d'Avila-Levy CM, Valente RH, Menna-Barreto RFS (2020) Glycolytic profile shift and antioxidant triggering in symbiont-free and H2O2-resistant Strigomonas culicis. Free Radic Biol Med 146:392-401.ROXIntact cellsProtists
Reutzel 2020 Oxid Med Cell Longev2020Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769.LEAK
ET
OXPHOS
N
S
CIV
ROX
Isolated mitochondriaMouseNervous system
Chen 2020 Chem Biol Interact2020Chen HY, Ho YJ, Chou HC, Liao EC, Tsai YT, Wei YS, Lin LH, Lin MW, Wang YS, Ko ML, Chan H (2020) TGF-β1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact 331:109249.LEAK
ROUTINE
ET
ROXIntact cellsMouseNervous system
Chabi 2019 MitoFit Preprint Arch EA2019-10-10Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. https://doi.org/10.26124/mitofit:ea19.MitoEAGLE.0001LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Doerrier 2019 MitoFit Preprint Arch EA2019-07-04Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. https://doi.org/10.26124/mitofit:ea19.MiPSchool.0009LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
MiPNet20.13 Safranin mt-membranepotential2019-06-24
O2k-Protocols
O2k-FluoRespirometry: HRR and simultaneous determination of mt-membrane potential with safranin or TMRM.
LEAK
ET
S
ROX
HomogenateMouseNervous system
Dollerup 2019 J Physiol2019Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT (2019) Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 598:731-54.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Bousseau 2019 FASEB J2019Bousseau S, Marchand M, Soleti R, Vergori L, Hilairet G, Recoquillon S, Le Mao M, Gueguen N, Khiati S, Clarion L, Bakalara N, Martinez MC, Germain S, Lenaers G, Andriantsitohaina R (2019) Phostine 3.1a as a pharmacological compound with antiangiogenic properties against diseases with excess vascularization. FASEB J 33:5864-75.LEAK
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Kunz 2019 Am J Physiol Endocrinol Metab2019Kunz HE, Dasari S, Lanza IR (2019) EPA and DHA elicit distinct transcriptional responses to high-fat feeding in skeletal muscle and liver. Am J Physiol Endocrinol Metab 317:E460-E472.LEAK
OXPHOS
F
N
S
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Liver
Naszai 2019 Sci Rep2019Nászai A, Terhes E, Kaszaki J, Boros M, Juhász L (2019) Ca(2+)N it be measured? Detection of extramitochondrial calcium movement with high-resolution FluoRespirometry. Sci Rep 9:19229.LEAK
OXPHOS
N
S
NS
ROX
Isolated mitochondriaRatLiver
Miranda Mendonca 2019 Neurochem Int2019Miranda Mendonça AP, Hoppe LY, Gaviraghi A, Araújo-Jorge TC, de Oliveira GM, Felippe RM, Oliveira MF, da Silva Fragoso VM (2019) Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex. Neurochem Int 126:210-17.LEAK
OXPHOS
ET
N
CIV
ROX
Permeabilized tissueMouseNervous system
Bouitbir 2019 Toxicology2019Bouitbir J, Alshaikhali A, Panajatovic MV, Abegg VF, Paech F, Krähenbühl S (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib. Toxicology 426:152281.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Rat
Mouse
Heart
Diebold 2019 Nat Metab2019Diebold LP, Gil HJ, Gao P, Martinez CA, Weinberg SE, Chandel NS (2019) Mitochondrial Complex III is necessary for endothelial cell proliferation during angiogenesis. Nat Metab 1:158–71.LEAK
ROUTINE
ROXIntact cellsHumanHUVEC
Gvozdjakova 2019 Bratisl Lek Listy2019Gvozdjakova A, Sumbalova Z, Kucharska J, Chladekova A, Rausova Z, Vancova O, Komlosi M, Ulicna O, Mojto V (2019) Platelet mitochondrial bioenergetic analysis in patients with nephropathies and non-communicable diseases: a new method. Bratisl Lek Listy 120:630-35.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Blood cells
Madlala 2019 Integr Food Nutr Metab2019Madlala HP, Maarman GJ, Ojuka E (2019) Fructose impairs mitochondrial respiration and substrate utilization in hepatocytes via the enzyme, glutamate oxaloacetate transaminase. Integr Food Nutr Metab doi: 10.15761/IFNM.1000228.LEAK
OXPHOS
ET
N
CIV
ROX
Permeabilized cellsHumanLiver
Gregg 2019 J Biol Chem2019Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ (2019) Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at Complex I in pancreatic β-cells. J Biol Chem 294:4656-66.OXPHOS
ET
LEAK
N
S
NS
ROX
Permeabilized tissueMouseIslet cell;pancreas;thymus
Robinson 2019 Am J Physiol Cell Physiol2019Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. Am J Physiol Cell Physiol 317:C339-C347.LEAK
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Permeabilized cellsMouse
Rat
Skeletal muscle
Moretti-Almeida 2019 Fungal Genet Biol2019Moretti-Almeida G, Thomazella DPT, Pereira GAG, Monteiro G (2019) Heterologous expression of an alternative oxidase from Moniliophthora perniciosa in Saccharomyces cerevisiae: antioxidant function and in vivo platform for the study of new drugs against witches' broom disease. Fungal Genet Biol 126:50-55.OXPHOSROXIsolated mitochondriaSaccharomyces cerevisiae
Cardinale 2019 Front Physiol2019Cardinale DA, Larsen FJ, Lännerström J, Manselin T, Södergård O, Mijwel S, Lindholm P, Ekblom B, Boushel R (2019) Influence of hyperoxic-supplemented high-intensity interval training on hemotological and muscle mitochondrial adaptations in trained cyclists. Front Physiol 10:730.LEAK
OXPHOS
ET
F
N
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Simon 2019 J Biol Chem2019Simon MC, Reinbeck AL, Wessel C, Heindirk J, Jelenik T, Kaul K, Arreguin-Cano J, Strom A, Blaut M, Bäckhed F, Burkart V, Roden M (2019) Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in non-obese diabetic mice. J Biol Chem 295:969-80.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Liver
Driescher 2019 Heliyon2019Driescher N, Joseph DE, Human VR, Ojuka E, Cour M, Hadebe N, Bester D, Marnewick JL, Lecour S, Lochner A, Essop MF (2019) The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon 5:e01357.LEAK
OXPHOS
ET
F
N
CIV
ROX
Permeabilized tissueRatHeart
Shuvo 2019 J Bioenerg Biomembr2019Shuvo SR, Wiens LM, Subramaniam S, Treberg JR, Court DA (2019) Increased reactive oxygen species production and maintenance of membrane potential in VDAC-less Neurospora crassa mitochondria. J Bioenerg Biomembr 51:341-54.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaFungi
Hamraz 2019 FASEB J2019Hamraz M, Abolhassani R, Andriamihaja M, Ransy C, Lenoir V, Schwartz L, Bouillaud F (2019) Hypertonic external medium represses cellular respiration and promotes Warburg/Crabtree effect. FASEB J 34:222-36.LEAK
ET
OXPHOS
ROX
N
CIV
Isolated mitochondria
Intact cells
Other mammals
Human
Rat
Endothelial;epithelial;mesothelial cell
Liver
HEK
Neuroblastoma
Aubin 2019 Thesis2019Aubin M (2019) Glucocorticoids and acute lymphoid leukemia: a proteomic approach. Doctoral Dissertation 99.ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanLymphocyte
Ruegsegger 2019 JCI Insight2019Ruegsegger GN, Vanderboom PM, Dasari S, Klaus KA, Kabiraj P, McCarthy CB, Lucchinetti CF, Nair KS (2019) Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain. JCI Insight 4:130681.LEAK
OXPHOS
ET
ROXIsolated mitochondriaMouseNervous system
Detaille 2019 PLoS One2019Detaille D, Pasdois P, Sémont A, Dos Santos P, Diolez P (2019) An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLoS One 14:e0216385.LEAK
OXPHOS
N
S
NS
ROX
Isolated mitochondriaRatHeart
Mueller 2019 Neurochem Int2019Mueller TE, Nunes MEM, Rodrigues NR, Fontana BD, Hartmann DD, Franco JL, Rosemberg DB (2019) Neurochemical mechanisms underlying acute and chronic ethanol-mediated responses in zebrafish: The role of mitochondrial bioenergetics. Neurochem Int 131:104584.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateZebrafishNervous system
Ahn 2019 J Cachexia Sarcopenia Muscle2019Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fiber branching. J Cachexia Sarcopenia Muscle 10:411-28.OXPHOS
LEAK
N
S
CIV
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Long 2019 Methods Mol Biol2019Long Q, Huang L, Huang K, Yang Q (2019) Assessing mitochondrial bioenergetics in isolated mitochondria from mouse heart tissues using Oroboros Oxygraph-2k. Methods Mol Biol 1966:237-46.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMouseHeart
Greenway 2019 J Evol Biol2019Greenway EVG, Cirino LA, Wilner D, Somjee U, Anagnostou ME, Hepple RT, Miller CW (2019) Extreme variation in testes size in an insect is linked to recent mating activity. J Evol Biol 33:142-50.LEAK
OXPHOS
N
CIV
NS
ROX
Permeabilized cellsHexapodsGenital
Hall 2019 Methods Mol Biol2019Hall A, Moghimi SM (2019) Determination of polycation-mediated perturbation of mitochondrial respiration in intact cells by high-resolution respirometry (Oxygraph-2k, OROBOROS). Methods Mol Biol 1943:313-22.LEAK
ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Scavuzzo 2019 J Neurophysiol2019Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol 122:1123-35.LEAK
OXPHOS
N
S
CIV
NS
ROX
HomogenateRatNervous system
Axton 2019 J Nutr2019Axton ER, Beaver LM, St Mary L, Truong L, Logan CR, Spagnoli S, Prater MC, Keller RM, Garcia-Jaramillo M, Ehrlicher SE, Stierwalt HD, Newsom SA, Robinson MM, Tanguay RL, Stevens JF, Hord NG (2019) Treatment with nitrate, but not nitrite, lowers the oxygen cost of exercise and decreases glycolytic intermediates while increasing fatty acid metabolites in exercised zebrafish. J Nutr 00:1–13.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaZebrafishSkeletal muscle
Inigo 2019 Mol Metab2019Inigo MR, Amorese AJ, Tarpey MD, Balestrieri NP, Jones KG, Patteson DJ, Jackson KC, Torres MJ, Lin CT, Smith CD, Heden TD, McMillin SL, Weyrauch LA, Stanley EC, Schmidt CA, Kilburg-Basnyat BB, Reece SW, Psaltis CE, Leinwand LA, Funai K, McClung JM, Gowdy KM, Witczak CA, Lowe DA, Neufer PD, Spangenburg EE (2019) Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation. Mol Metab 34:1-15.LEAK
OXPHOS
F
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Ruegsegger 2019 FASEB J2019Ruegsegger GN, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, Vanderboom PM, Lanza IR, Klaus KA, Nair KS (2019) Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J 33:4458-72.LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseNervous system
Nold 2019 Psychoneuroendocrinology2019Nold V, Sweatman C, Karabatsiakis A, Böck C, Bretschneider T, Lawless N, Fundel-Clemens K, Kolassa IT, Allers KA (2019) Activation of the kynurenine pathway and mitochondrial respiration to face allostatic load in a double-hit model of stress. Psychoneuroendocrinology 107:148-59.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Mishra 2019 Bio Protoc2019Mishra P, Zhang T, Guo M, Chan D (2019) Mitochondrial respiratory measurements in patient-derived fibroblasts. Bio Protoc 9:e3446. doi: 10.21769/BioProtoc.3446LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Noz 2019 J Am Heart Assoc2019Noz MP, Hartman YAW, Hopman MTE, Willems PHGM, Tack CJ, Joosten LAB, Netea MG, Thijssen DHJ, Riksen NP (2019) Sixteen-week physical activity intervention in subjects with increased cardiometabolic risk shifts innate immune function towards a less proinflammatory state. J Am Heart Assoc 8:e013764.LEAK
ET
ROXIntact cellsHumanBlood cells
Poudel 2019 Can J Physiol Pharmacol2019Poudel A, Zhou JY, Mekala N, Welchko R, Rosca MG, Li L (2019) Berberine hydrochloride protects against cytokine-induced inflammation through multiple pathways in undifferentiated C2C12 myoblast cells. Can J Physiol Pharmacol 97:699-707.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseSkeletal muscle
Dechandt 2019 Front Neurol2019Dechandt CRP, Ferrari GD, Dos Santos JR, de Oliveira JAC, da Silva-Jr RMP, Cunha AOS, Garcia-Cairasco N, Alberici LC (2019) Energy metabolism and redox state in brains of wistar audiogenic rats, a genetic model of epilepsy. Front Neurol 10:1007.LEAK
OXPHOS
ET
N
ROX
Permeabilized tissueRatNervous system
Vaka 2019 Am J Physiol Regul Integr Comp Physiol2019Vaka VR, Mcmasters KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca BD (2019) Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in Reduced Uterine Perfusion Pressure (RUPP) rats. Am J Physiol Regul Integr Comp Physiol 316:R441-R447.LEAK
OXPHOS
ET
N
CIV
ROX
Intact cells
Isolated mitochondria
Human
Rat
Endothelial;epithelial;mesothelial cell
Genital
Kopinski 2019 Proc Natl Acad Sci U S A2019Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC (2019) Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci U S A 116:16028-35.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanOther cell lines
Monteiro 2019 J Bioenerg Biomembr2019Monteiro J, Assis-de-Lemos G, de-Souza-Ferreira E, Marques AM, Neves GA, Silveira MS, Galina A (2019) Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis. J Bioenerg Biomembr 52:1-15.LEAK
OXPHOS
N
S
NS
ROX
Isolated mitochondriaMouseNervous system
Krylova 2019 Mitochondrion2019Krylova TD, Sheremet NL, Tabakov VY, Lyamzaev KG, Itkis YS, Tsygankova PG, Andreeva NA, Shmelkova MS, Nevinitsyna TA, Kadyshev VV, Zakharova EY (2019) Three rare pathogenic mtDNA substitutions in LHON patients with low heteroplasmy. Mitochondrion 50:139-144.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Chang 2019 Br J Anaesth2019Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HumanSkeletal muscle
Garnham 2019 J Cachexia Sarcopenia Muscle2019Garnham JO, Roberts LD, Caspi T, Al-Owais MM, Bullock M, Swoboda PP, Koshy A, Gierula J, Paton MF, Cubbon RM, Kearney MT, Bowen TS, Witte KK (2019) Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. J Cachexia Sarcopenia Muscle 11:79-88.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Szibor 2019 Biochim Biophys Acta Bioenerg2019Szibor Marten, Gainutdinov Timur, Fernandez-Vizarra Erika, Dufour Eric, Gizatullina Zemfira, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Viscomi Carlo, Gellerich Frank Norbert, Moore Anthony L (2019) Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: switch from RET and ROS to FET. Biochim Biophys Acta Bioenerg 1861:148137.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaMouseHeart
McBride 2019 Arch Biochem Biophys2019McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48.LEAK
OXPHOS
F
N
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Pedrotti 2019 Sci Adv2019Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cellsMouseFat
McMurray 2019 FASEB J2019McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME (2019) Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. FASEB J 33:13515-26.LEAK
OXPHOS
F
N
S
CIV
ROX
Permeabilized tissueMouseSkeletal muscle
Calabria 2019 Front Neurosci2019Calabria Elisa, Scambi Ilaria, Bonafede Roberta, Schiaffino Lorenzo, Peroni Daniele, Potrich Valentina, Capelli Carlo, Schena Federico, Mariotti Raffaella (2019) ASCs-exosomes recover coupling efficiency and mitochondrial membrane potential in an in vitro model of ALS. Front Neurosci 13:1070.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
MouseNervous system
Malagrino 2019 Oxid Med Cell Longev2019Malagrinò F, Zuhra K, Mascolo L, Mastronicola D, Vicente JB, Forte E, Giuffrè A (2019) Hydrogen sulfide oxidation: adaptive changes in mitochondria of SW480 colorectal cancer cells upon exposure to hypoxia. Oxid Med Cell Longev 2019:8102936.ROUTINEROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Reyes-Fermin 2019 Antioxidants (Basel)2019Reyes-Fermín LM, Avila-Rojas SH, Aparicio-Trejo OE, Tapia E, Rivero I, Pedraza-Chaverri J (2019) The protective effect of alpha-mangostin against cisplatin-induced cell death in LLC-PK1 cells is associated to mitochondrial function preservation. Antioxidants (Basel) 8:E133.LEAK
ROUTINE
ET
CIV
ROX
Intact cellsPigKidney
Pichaud 2019 Front Genet2019Pichaud N, Bérubé R, Côté G, Belzile C, Dufresne F, Morrow G, Tanguay RM, Rand DM, Blier PU (2019) Age dependent dysfunction of mitochondrial and ROS metabolism induced by mitonuclear mismatch. Front Genet 10:130.LEAK
OXPHOS
ET
N
Gp
CIV
ROX
Permeabilized tissueDrosophilaSkeletal muscle
Halling 2019 Am J Physiol Endocrinol Metab2019Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Langley 2019 Biochim Biophys Acta Mol Basis Dis2019Langley MR, Yoon H, Kim HN, Choi CI, Simon W, Kleppe L, Lanza IR, LeBrasseur NK, Matveyenko A, Scarisbrick IA (2019) High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system. Biochim Biophys Acta Mol Basis Dis 1866:165630.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseNervous system
Luevano-Martinez 2019 Fungal Biol2019Luévano-Martínez LA, Caldeira da Silva CC, Nicastro GG, Schumacher RI, Kowaltowski AJ, Gomes SL (2019) Mitochondrial alternative oxidase is determinant for growth and sporulation in the early diverging fungus Blastocladiella emersonii. Fungal Biol 123:59-65.ETROX
CIV
Intact cellsFungi
Gururaja Rao 2019 Cells2019Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BKCa (Slo) channel regulates mitochondrial function and lifespan in Drosophila melanogaster. Cells 8:E945.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaDrosophila
Kluckova 2019 FASEB J2019Kluckova K, Thakker A, Vettore L, Escribano-Gonzalez C, Hindshaw RL, Tearle JLE, Goncalves J, Kaul B, Lavery GG, Favier J, Tennant DA (2019) Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function. FASEB J 34:303-315.LEAK
ROUTINE
OXPHOS
ET
F
N
NS
ROX
Permeabilized cells
Intact cells
MouseNervous system
Laouafa 2019 Acta Physiol (Oxf)2019Laouafa S, Roussel D, Marcouiller F, Soliz J, Gozal D, Bairam A, Joseph V (2019) Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats. Acta Physiol (Oxf) 226:e13255.LEAK
OXPHOS
ET
N
S
NS
ROX
CIV
Permeabilized tissueRatNervous system
Gaviraghi 2019 Anal Biochem2019Gaviraghi A, Oliveira MF (2019) A method for assessing mitochondrial physiology using mechanically permeabilized flight muscle of Aedes aegypti mosquitoes. Anal Biochem 576:33-41.LEAK
OXPHOS
ET
N
Gp
CIV
ROX
Permeabilized tissueHexapodsSkeletal muscle
Oakey 2019 Wellcome Open Res2019Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG (2019) Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion. Wellcome Open Res 3:147.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseSkeletal muscle
Tyrrell 2019 Circ Res2019Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298–314.OXPHOS
ET
N
S
NS
ROX
MouseEndothelial;epithelial;mesothelial cell
Mayer 2019 Lipids2019Mayer K, Sommer N, Hache K, Hecker A, Reiche S, Schneck E, Weissmann N, Seeger W, Hecker M (2019) Resolvin E1 improves mitochondrial function in human alveolar epithelial cells during severe inflammation. Lipids 54:53-65.LEAK
ROUTINE
ET
ROXIntact cellsHumanLung;gill
Endothelial;epithelial;mesothelial cell
Other cell lines
Crescenzo 2019 Mol Neurobiol2019Crescenzo R, Spagnuolo MS, Cancelliere R, Iannotta L, Mazzoli A, Gatto C, Iossa S, Cigliano L (2019) Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain. Mol Neurobiol 56:7651-63.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Wolf 2019 Cells2019Wolf C, Zimmermann R, Thaher O, Bueno D, Wüllner V, Schäfer MKE, Albrecht P, Methner A (2019) The Charcot-Marie tooth disease mutation R94Q in MFN2 decreases ATP production but increases mitochondrial respiration under conditions of mild oxidative stress. Cells 8:E1289.LEAK
ROUTINE
ET
OXPHOS
ROX
N
NS
Intact cells
Permeabilized cells
MouseFibroblast
Spinazzi 2019 Proc Natl Acad Sci U S A2019Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
Isolated mitochondria
MouseNervous system
Desquiret-Dumas 2019 Biochim Biophys Acta Mol Basis Dis2019Desquiret-Dumas V, Leman G, Wetterwald C, Chupin S, Lebert A, Khiati S, Le Mao M, Geffroy G, Kane MS, Chevrollier A, Goudenege D, Gadras C, Tessier L, Barth M, Leruez S, Amati-Bonneau P, Henrion D, Bonneau D, Procaccio V, Reynier P, Lenaers G, Gueguen N (2019) Warburg-like effect is a hallmark of complex I assembly defects. Biochim Biophys Acta Mol Basis Dis 1865:2475-89.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Glombik 2019 Neurotox Res2019Głombik K, Detka J, Góralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res 37:406-24.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaRatNervous system
Gaiser 2019 Adv Ther (Weinh)2019Gaiser A, Hafner S, Schmiech M, Büchele B, Schäfer P, Arnim CA, Calzia, E, Feuring‐Buske M, Buske C, Vick B, Jeremias I, Syrovets T, Simmet T (2019) Gold nanoparticles with selective antileukemic activity in vitro and in vivo target mitochondrial respiration. Adv Ther (Weinh) doi:10.1002/adtp.201800149.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Germain 2019 Int J Med Sci2019Germain N, Dessein AF, Vienne JC, Dobbelaere D, Mention K, Joncquel M, Dekiouk S, Laine W, Kluza J, Marchetti P (2019) First-line screening of OXPHOS deficiencies using microscale oxygraphy in human skin fibroblasts: A preliminary study. Int J Med Sci 16:931-38.LEAK
ET
ROX
N
Intact cellsHumanFibroblast
Kumar 2019 Free Radic Biol Med2019Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99.LEAK
ROUTINE
OXPHOS
ET
F
N
S
DQ
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Intact cells
MouseSkeletal muscle
Kladnicka 2019 Physiol Res2019Kladnická I, Čedíková M, Kripnerová M, Dvořáková J, Kohoutová M, Tůma Z, Müllerová D, Kuncová J (2019) Mitochondrial respiration of adipocytes differentiating from human mesenchymal stem cells derived from adipose tissue. Physiol Res 68:287-96.LEAK
ROUTINE
ET
ROXIntact cellsHumanFat
Stem cells
Zverova 2019 Neuropsychiatr Dis Treat2019Zvěřová M, Hroudová J, Fišar Z, Hansíková H, Kališová L, Kitzlerová E, Lambertová A, Raboch J (2019) Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder. Neuropsychiatr Dis Treat 15:233-40.LEAK
ROUTINE
ET
ROXIntact cellsHumanPlatelet
Blood cells
Halle 2019 Am J Physiol Regul Integr Comp Physiol2019Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol 317:R68-R82.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissue
Intact cells
MouseSkeletal muscle
Liver
Fat
Karusheva 2019 Am J Clin Nutr2019Karusheva Y, Koessler T, Strassburger K, Markgraf D, Mastrototaro L, Jelenik T, Simon MC, Pesta D, Zaharia OP, Bódis K, Bärenz F, Schmoll D, Wolkersdorfer M, Tura A, Pacini G, Burkart V, Müssig K, Szendroedi J, Roden M (2019) Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial. Am J Clin Nutr 110:1098-107.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Thome 2019 Am J Physiol Cell Physiol2019Thome T, Salyers ZR, Kumar RA, Hahn D, Berru FN, Ferreira LF, Scali ST, Ryan TE (2019) Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity. Am J Physiol Cell Physiol 317:C701-13.LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
Isolated mitochondria
Intact cells
MouseSkeletal muscle
Lemieux 2019 bioRxiv2019Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 .LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
MouseBlood cells
Pharaoh 2019 Mol Neurobiol2019Pharaoh G, Owen D, Yeganeh A, Premkumar P, Farley J, Bhaskaran S, Ashpole N, Kinter M, Van Remmen H, Logan S (2019) Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function. Mol Neurobiol 57:1317-31.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
Intact cells
MouseSkeletal muscle
Nervous system
Fat
Thomas 2019 Redox Biol2019Thomas NO, Shay KP, Hagen TM (2019) Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I. Redox Biol 22:101155.LEAK
OXPHOS
ET
N
S
NS
ROX
Intact cellsRatLiver
Sanchez-de-Diego 2019 iScience2019Sánchez-de-Diego C, Artigas N, Pimenta-Lopes C, Valer JA, Torrejon B, Gama-Pérez P, Villena JA, Garcia-Roves PM, Rosa JL, Ventura F (2019) Glucose restriction promotes osteocyte specification by activating a PGC-1α-dependent transcriptional program. iScience 15:79-94.LEAK
ROUTINE
ET
ROXIntact cellsMouseOther cell lines
Zhang 2019 Nephron2019Zhang R, Wang X, Gao Q, Jiang H, Zhang S, Lu M, Liu F, Xue X (2019) Taurine supplementation reverses diabetes-induced podocytes injury via modulation of the CSE/TRPC6 axis and improvement of mitochondrial function. Nephron 144:84-95.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
MouseKidney
Ahmed 2019 Mol Nutr Food Res2019Ahmed N, Tcheng M, Roma A, Buraczynski M, Jayanth P, Rea K, Akhtar TA, Spagnuolo PA (2019) Avocatin B protects against lipotoxicity and improves insulin sensitivity in diet-induced obesity. Mol Nutr Food Res 63:e1900688.LEAK
ROUTINE
ET
N
ROX
Intact cellsMouse
Rat
Skeletal muscle
Islet cell;pancreas;thymus
Wessels 2019 Obesity (Silver Spring)2019Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T (2019) Adipose mitochondrial respiratory capacity in obesity is impaired independently of glycemic status of tissue donors. Obesity (Silver Spring) 27:756-66.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cellsHumanFat
Papadimitriou 2019 Sci Rep2019Papadimitriou ID, Eynon N, Yan X, Munson F, Jacques M, Kuang J, Voisin S, North KN, Bishop DJ (2019) A "human knockout" model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations. Sci Rep 9:12688.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Bettinazzi 2019 Cryobiology2019Bettinazzi S, Gendron AD, Breton S (2019) The effect of cryopreservation on mitochondrial function in freshwater mussel tissue samples (Bivalvia: Unionida). Cryobiology 88:106-109.LEAK
OXPHOS
ET
N
Gp
CIV
NS
ROX
S
Other combinations
Permeabilized tissueMolluscsLung;gill
Cruz-Gregorio 2019 Biomolecules2019Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Coronado-Martinez I, Pedraza-Chaverri J, Lizano M (2019) E6 oncoproteins from high-risk human papillomavirus induce mitochondrial metabolism in a head and neck squamous cell carcinoma model. Biomolecules 9:E351.LEAK
ROUTINE
CIV
ROX
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Anton 2019 Front Physiol2019Anton L, DeVine A, Polyak E, Olarerin-George A, Brown AG, Falk MJ, Elovitz MA (2019) HIF-1α stabilization increases miR-210 eliciting first trimester extravillous trophoblast mitochondrial dysfunction. Front Physiol 10:699.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanGenital
Cesnekova 2019 Thesis2019Cesnekova J (2019) Functional characterization of LACE1 APTase and mitochondrial AAA proteases YME1L and AFG3L2 in mitochondrial protein homeostasis. PhD Thesis 133.OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanHEK
Dlaskova 2019 Biochim Biophys Acta Bioenerg2019Dlasková A, Špaček T, Engstová H, Špačková J, Schröfel A, Holendová B, Smolková K, Plecitá-Hlavatá L, Ježek P (2019) Mitochondrial cristae narrowing upon higher 2-oxoglutarate load. Biochim Biophys Acta Bioenerg 1860:659-78.LEAK
ET
N
ROX
Intact cellsHumanLiver
Shrum 2019 Biomolecules2019Shrum S, Rusch NJ, MacMillan-Crow LA (2019) Specific BK channel activator NS11021 protects rat renal proximal tubular cells from cold storage-induced mitochondrial injury in vitro. Biomolecules 9:E825.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsRatKidney
Fernando 2019 Exp Gerontol2019Fernando R, Drescher C, Deubel S, Jung T, Ost M, Klaus S, Grune T, Castro JP (2019) Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp Gerontol 117:45-52.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Zhang 2019 Biochem Biophys Res Commun2019Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW (2019) Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice. Biochem Biophys Res Commun 514:386-92.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseLiver
Krycer 2019 J Biol Chem2019Krycer JR, Elkington SD, Diaz-Vegas A, Cooke KC, Burchfield JG, Fisher-Wellman KH, Cooney GJ, Fazakerley DJ, James DE (2019) Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes. J Biol Chem 295:99-110.LEAK
ET
ROXIntact cellsRatFat
D'Amico 2019 Mol Cell2019D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J (2019) The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging. Mol Cell 73:775-87.OXPHOSS
NS
ROX
HomogenateMouseSkeletal muscle
Sundstroem 2019 Acta Neuropathol Commun2019Sundstrøm T, Prestegarden L, Azuaje F, Aasen SN, Røsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun 7:55.ET
LEAK
N
S
NS
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Gustafson 2019 PLoS One2019Gustafson MA, McCormick EM, Perera L, Longley MJ, Bai R, Kong J, Dulik M, Shen L, Goldstein AC, McCormack SE, Laskin BL, Leroy BP, Ortiz-Gonzalez XR, Ellington MG, Copeland WC, Falk MJ (2019) Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes. PLoS One 14:e0221829.LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Lymphocyte
Lerchner 2019 Anal Bioanal Chem2019Lerchner J, Sartori MR, Volpe POL, Lander N, Mertens F, Vercesi AE (2019) Direct determination of anaerobe contributions to the energy metabolism of Trypanosoma cruzi by chip calorimetry. Anal Bioanal Chem 411:3763-68.LEAK
OXPHOS
ET
ROXIntact cellsProtists
Moscheni 2019 Cancers (Basel)2019Moscheni C, Malucelli E, Castiglioni S, Procopio A, De Palma C, Sorrentino A, Sartori P, Locatelli L, Pereiro E, Maier JA, Iotti S (2019) 3D quantitative and ultrastructural analysis of mitochondria in a model of doxorubicin sensitive and resistant human colon carcinoma cells. Cancers (Basel) 11:E1254.LEAK
ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Zhao 2019 Pharmacol Res2019Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J (2019) MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1. Pharmacol Res 146:104276.LEAK
ROUTINE
ET
ROXIntact cellsMouseLiver
Other cell lines
Nunes 2019 Oxid Med Cell Longev2019Nunes MEM, Schimith LE, da Costa-Silva DG, Lopes AR, Leandro LP, Martins IK, de Mello RS, Hartmann DD, de Carvalho NR, Carvalho da Rosa P, Trevisan R, Di Giulio RT, Posser T, Franco JL (2019) Acute exposure to permethrin modulates behavioral functions, redox, and bioenergetics parameters and induces DNA damage and cell death in larval zebrafish. Oxid Med Cell Longev 2019:9149203.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
HomogenateZebrafish
Cormier 2019 Sci Rep2019Cormier RPJ, Champigny CM, Simard CJ, St-Coeur PD, Pichaud N (2019) Dynamic mitochondrial responses to a high-fat diet in Drosophila melanogaster. Sci Rep 9:4531.LEAK
OXPHOS
ET
N
Gp
NS
ROX
CIV
Permeabilized tissueDrosophilaSkeletal muscle
Rodinova 2019 Dis Model Mech2019Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019) Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease. Dis Model Mech 12:dmm038737.LEAK
OXPHOS
ET
N
S
CIV
ROX
Isolated mitochondriaPigSkeletal muscle
Isei 2019 Free Radic Biol Med2019Isei MO, Kamunde C (2019) Effects of copper and temperature on heart mitochondrial hydrogen peroxide production. Free Radic Biol Med 147:114-28.N
S
ROX
Isolated mitochondriaFishesHeart
Baekkerud 2019 Cardiovasc Toxicol2019Bækkerud FH, Salerno S, Ceriotti P, Morland C, Storm-Mathisen J, Bergersen LH, Høydal MA, Catalucci D, Stølen TO (2019) High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes. Cardiovasc Toxicol 19:422-31.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseHeart
De Moura Escobar 2019 Toxicol In Vitro2019de Moura Escobar SJ, Simone M, de Oliveira Ribeiro CA, Martinez GR, Winnischofer SMB, Witting PK, Rocha MEM (2019) Cytotoxic effects of 4'-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). Toxicol In Vitro 61:104640.LEAK
OXPHOS
N
S
ROX
Permeabilized cellsHumanNeuroblastoma
Rocco-Machado 2019 Free Radic Biol Med2019Rocco-Machado N, Cosentino-Gomes D, Nascimento MT, Paes-Vieira L, Khan YA, Mittra B, Andrews NW, Meyer-Fernandes JR (2019) Leishmania amazonensis ferric iron reductase (LFR1) is a bifunctional enzyme: Unveiling a NADPH oxidase activity. Free Radic Biol Med 143:341-53.LEAK
ROUTINE
ET
ROXIntact organism
Intact cells
Protists
Veyrat-Durebex 2019 Mol Neurobiol2019Veyrat-Durebex C, Bris C, Codron P, Bocca C, Chupin S, Corcia P, Vourc'h P, Hergesheimer R, Cassereau J, Funalot B, Andres CR, Lenaers G, Couratier P, Reynier P, Blasco H (2019) Metabo-lipidomics of fibroblasts and mitochondrial-endoplasmic reticulum extracts from ALS patients shows alterations in purine, pyrimidine, energetic, and phospholipid metabolisms. Mol Neurobiol 56:5780-91.LEAK
ET
ROUTINE
ROXIntact cellsHumanFibroblast
Hafen 2019 J Appl Physiol (1985)2019Hafen PS, Abbott K, Bowden JA, Lopiano R, Hancock CR, Hyldahl RD (2019) Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. J Appl Physiol (1985) 127:47-57.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Berru 2019 Sci Rep2019Berru FN, Gray SE, Thome T, Kumar RA, Salyers ZR, Coleman M, Dennis Le, O'Malley K, Ferreira LF, Berceli SA, Scali ST, Ryan TE (2019) Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondrial energetics. Sci Rep 9:15547.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Rutai 2019 Shock2019Rutai A, Fejes R, Juhász L, Tallósy SP, Poles MZ, Földesi I, Mészáros AT, Szabó A, Boros M, Kaszaki J (2019) Endothelin A and B receptors: Potential pargets for microcirculatory-mitochondrial therapy in experimental sepsis. Shock 54:87-95.LEAK
OXPHOS
N
S
ROX
HomogenateRatLiver
Jansen 2019 Am J Physiol Heart Circ Physiol2019Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS (2019) Dietary Calanus oil recovers metabolic flexibility and rescues post-ischemic cardiac function in obese female mice. Am J Physiol Heart Circ Physiol 317:H290-H299.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseHeart
Chroeis 2019 Basic Clin Pharmacol Toxicol2019Chroeis KM, Larsen S, Pedersen JS, Rygg MO, Boilsen AEB, Bendtsen F, Dela F (2019) Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue. Basic Clin Pharmacol Toxicol [Epub ahead of print].LEAK
OXPHOS
N
S
ROX
Intact cellsHumanLiver
Doig 2019 bioRxiv2019Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 .LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Rose 2019 Am J Physiol Endocrinol Metab2019Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cells
Permeabilized tissue
Intact cells
HumanSkeletal muscle
Blood cells
Platelet
Tiebe 2019 Sci Rep2019Tiebe M, Lutz M, Senyilmaz Tiebe D, Teleman AA (2019) Crebl2 regulates cell metabolism in muscle and liver cells. Sci Rep 9:19869.LEAK
OXPHOS
ROUTINE
F
N
Gp
ROX
Permeabilized cells
Intact cells
MouseSkeletal muscle
Liver
Chao 2019 J Appl Physiol (1985)2019Chao T, Burmeister DM, Corona BT, Greising SM (2019) Oxidative pathophysiology following volumetric muscle loss injury in a porcine model. J Appl Physiol (1985) 126:1541-49.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissuePigSkeletal muscle
Reda 2019 Sci Rep2019Reda A, Refaat A, Abd-Rabou AA, Mahmoud AM, Adel M, Sabet S, Ali SS (2019) Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells. Sci Rep 9:13748.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Weinstein 2019 bioRxiv2019Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: https://doi.org/10.1101/2019.12.16.878025 .LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanOther cell lines
Lymphocyte
Rawat 2019 J Mol Biol2019Rawat S, Anusha V, Jha M, Sreedurgalakshmi K, Raychaudhuri S (2019) Aggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells. J Mol Biol 431:996-1015.OXPHOS
LEAK
N
S
CIV
ROX
Permeabilized cellsMouseNervous system
Other cell lines
Li 2019 Int Urol Nephrol2019Li Z, Zhou J, Li Y, Yang F, Lian X, Liu W (2019) Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells. Int Urol Nephrol 51:1059-70.ROUTINE
OXPHOS
ET
LEAK
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
Brunetta 2019 J Funct Foods2019Brunetta HS, de Paula GC, Fritzen M, Cecchini MS, dos Santos GJ, Nazari EM, Rafacho A, de Bem AF, Nunes EA (2019) Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice. J Funct Foods 62:103544.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Gonzalez-Mariscal 2019 FASEB J2019González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM (2019) Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB J 33:5850-63.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Teh 2019 Mol Cancer Ther2019Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705.LEAK
ROUTINE
OXPHOS
ET
N
S
DQ
ROX
Intact cells
Permeabilized cells
Permeabilized tissue
Human
Mouse
Other cell lines
Blais-Lecours 2019 Am J Respir Cell Mol Biol2019Blais-Lecours P, Laouafa S, Arias-Reyes C, Santos WL, Joseph V, Burgess JK, Halayko AJ, Soliz J, Marsolais D (2019) Metabolic adaptation of airway smooth muscle cells to a SPHK2 substrate precedes cytostasis. Am J Respir Cell Mol Biol 62:35-42.LEAK
ROUTINE
OXPHOS
ET
ROXIntact cellsHumanOther cell lines
Heden 2019 Sci Adv2019Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K (2019) Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv 5:eaax8352.LEAK
OXPHOS
F
N
S
DQ
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Johansen 2019 Comp Biochem Physiol C Toxicol Pharmacol2019Johansen JL, Esbaugh AJ (2019) Oil-induced responses of cardiac and red muscle mitochondria in red drum (Sciaenops ocellatus). Comp Biochem Physiol C Toxicol Pharmacol 219:35-41.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueFishesHeart
Skeletal muscle
Dannheisig 2019 Cells2019Dannheisig DP, Beck E, Calzia E, Walther P, Behrends C, Pfister AS (2019) Loss of Peter Pan (PPAN) affects mitochondrial homeostasis and autophagic flux. Cells 8:E894.LEAK
ROUTINE
ET
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanHeLa
... further results
Publications in the MiPMap
Abstracts: Residual oxygen consumption
Sort in ascending/descending order by a click on one of the small symbols in squares below.
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Irving 2022 Abstract Bioblast20227.4. «5 min»
Irving Brian
Irving Brian A, Stampley J, Quiriarte H, Wigger Z, Stephens J, Soto P, Allerton TA (2022) Impact of nitric oxide promotors on mitochondrial bioenergetics in a murine model of Alzheimer's disease. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »Watch the presentation«
LEAK
OXPHOS
ET
N
Gp
NS
ROX
Permeabilized tissue
Homogenate
MouseNervous system
Cardoso 2022 Abstract Bioblast20224.3. «10+5»
Luiza Cardoso
Cardoso Luiza HD, Doerrier C, Donnelly C, Komlódi T, Gnaiger E (2022) Redox monitoring and respiration - a new horizon with the NextGen-O2k. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »Watch the presentation«
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Isolated mitochondria
MouseLiver
HEK
Molina 2022 Abstract Bioblast20223.2. «10+5»
Molina Anthony JA
Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina Anthony JA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older women. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001
»Bioenergetics Communications« »Watch the presentation«
OXPHOS
ET
F
N
S
Gp
ROX
Permeabilized cellsHumanBlood cells
Porter 2022 Abstract Bioblast20226.3. «10+5»
Porter Richard K
Karavyraki M, Gnaiger E, Porter Richard K (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001
»MitoFit Preprint« »Watch the presentation«
LEAK
ROUTINE
ET
S
ROX
Permeabilized cellsHuman
Gnaiger 2022 ESCI Bari2022
Erich Gnaiger
Gnaiger E (2022) Bioenergetic cluster analysis – diagnostic evaluation of mitochondrial respiratory control in human fibroblasts. 56th Annual Scientific Meeting of the European Society for Clinical Investigation.
LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Cecatto 2022 EBEC2022
Cristiane Cecatto
Cecatto C, Cardoso LHD, Gnaiger E (2022) Mitochondrial calcium uptake capacity is lower than calcium retention capacity in the presence and absence of cyclosporin A. EBEC 2022.
LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaMouseLiver
Magri 2022 Abstract Bioblast20228.5. «5 min»
Magrì Andrea
Magrì Andrea, Cubisino SAM, De Pinto V, Messina A (2022) Modulation of mitochondrial respiration in ALS cells by hexokinase-based peptides: a novel therapeutic approach to fight neurodegeneration. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »Watch the presentation«
LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanNervous system
Doerrier 2020 PaduaMuscleDays Poster2020Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHuman
Mouse
Skeletal muscle
Dominguez-Amorocho 2019 MiP20192019
MiPsociety
Role of Sirtuin 1/3 in CD4+ T cells activation and differentiation in obese and transplanted animals.
LEAK
ET
OXPHOS
ROXMouseLymphocyte
Van der Ende 2019 MiPschool Coimbra2019
Miranda van der Ende
Mitochondrial respiration in muscle tissue of colon cancer patients.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kramer 2019 Abstract IOC1412019Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02.LEAK
OXPHOS
ET
N
CIV
NS
ROX
HumanSkeletal muscle
Goncalves Debora 2019 MiPschool Coimbra2019
MiPsociety
Aging effects on mitochondrial control factors in Pink1 knockout Drosophila melanogaster.
LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateDrosophila
Sumbalova 2019a MiP20192019
Zuzana Sumbalova
Platelet mitochondrial function, coenzyme Q10, and oxidative stress in patients with chronic kidney diseases.
LEAK
OXPHOS
F
N
S
Gp
CIV
NS
ROX
Intact cellsHumanPlatelet
Betiu 2019 MiP20192019
MiPsociety
Cell-permeable succinate improves amiodarone-induced mitochondrial Complex I and II inhibition in human platelets.
LEAK
ET
ROXPermeabilized cells
Intact cells
HumanPlatelet
Garcia-Roves 2019 MiPschool Coimbra2019
Pablo Garcia-Roves
Generating reference values on mitochondrial respiration in permeabilized muscle fibers.
LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Sumbalova 2019b MiP20192019
Zuzana Sumbalova
The decline of mitochondrial respiration in isolated platelets after short-term storage.
LEAK
OXPHOS
F
N
S
Gp
CIV
NS
ROX
Intact cellsHumanPlatelet
Chabi 2019 MiP20192019
Béatrice Chabi
Generating reference values on mitochondrial respiration in permeabilized muscle fibers.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Timohhina 2019 MiP20192019
Natalja Timohhina
Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells.
LEAK
OXPHOS
ET
ROXHumanEndothelial;epithelial;mesothelial cell
Doerrier 2019 MiP20192019
Carolina Doerrier
Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers.
LEAK
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Lelcu 2019 MiP20192019
Theia Lelcu
Assessment of platelet respiration in blood malignancies: a pilot study in children and adults.
LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cellsHumanPlatelet
Bastos Sant'Anna Silva 2019 Life Sciences Meeting 2019 Innsbruck AT2019Cellular succinate transport and mitochondrial respiratory function in prostate cancer.ROUTINES
ROX
Intact cellsHumanGenital
Cardoso 2019 MiP20192019
Luiza Cardoso
Effects of glucose concentration in cell culture media on hepatocellular carcinoma HuH7 cells evaluated by high-resolution respirometry.
LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
Doerrier 2018 ESCI20182018
Carolina Anneliese Doerrier
High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
ROX
CIV
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Skeletal muscle
Nervous system
Blood cells
HEK
Krajcova 2018 ICO1342018Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateHumanSkeletal muscle
Doerrier 2018 EBEC20182018
Carolina Anneliese Doerrier
Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
Blood cells
HEK
Platelet
Bastos Sant'Anna Silva 2018 MiPschool Tromso C42018
Ana Bastos Sant'Anna
Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.
LEAK
ROUTINE
OXPHOS
ET
S
ROX
Intact cellsHumanGenital
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT2018Cellular succinate transport and mitochondrial respiratory function in prostate cancer.ROUTINE
LEAK
OXPHOS
ET
S
ROX
Permeabilized cells
Intact cells
HumanHEK
Genital
Garipi 2018 MiPschool Tromso E22018Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS productionLEAK
ROUTINE
OXPHOS
ET
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Doerrier 2018 MiP2018a2018
Carolina Anneliese Doerrier
Inter-laboratory harmonization of protocols for mitochondrial function evaluation in permeabilized muscle fibers.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Schoepf 2018 33rd Annual EAU Congress Copenhagen2018Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue.LEAK
OXPHOS
ET
F
N
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
HumanGenital
Krajcova 2018 MiPschool Tromso E22018
Adela Krajcova
High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle.
LEAK
OXPHOS
ET
N
NS
ROX
HomogenateHumanHeart
Doerrier 2018 MiP2018c2018
Carolina Doerrier
Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT2018pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cellsHumanHEK
Kidney
Garcia-Roves 2018 MiP2018b2018
Pablo Garcia-Roves
Generating mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. Working Group 2 report. Garcia-Roves_Presentation
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Gasparrini 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
Anti-inflammatory effects of strawberry and honey extracts in RAW 264.7 macrophages stressed with LPS.
LEAKROXMouseMacrophage-derived
Rybacka-Mossakowska 2017 MiP20172017
MiPsociety
Mitochondrial respiration in intact peripheral blood mononuclear cells in multiple sclerosis patients.
LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Garcia-Souza 2017 MiPschool Obergurgl2017
Luiz Garcia-Souza
Assessment of mitochondrial respiratory function in cryopreserved platelets.
ROUTINE
ET
S
CIV
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Gnaiger 2017 MiPschool C12017
Gnaiger Erich.jpg
Apparent Complex IV excess capacity and biochemical thresholds.
N
S
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Sobotka 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
The effect of 24 weeks of high-fat and high-cholesterol diet on rat liver mitochondria. Sobotka_Presentation
OXPHOS
ET
F
N
S
Gp
ROX
Isolated mitochondriaRatLiver
Giampieri 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
Strawberry extract protects human dermal fibroblasts against oxidative stress and improves mitochondrial functionality.
LEAKROXFibroblast
Karavyraki 2017 MiPschool Obergurgl2017
KaravyrakiMarilena.jpg
Mitochondrial function and morphology linked to metabolic differences in normal, dysplastic and cancerous oral cells.
LEAKROXIntact cellsHuman
Irving 2017 MiP20172017
Brian Irving
Impact of acute exercise on PBMC respiratory function and methodological considerations.
LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
Blood cells
Labieniec-Watala 2017 MiP20172017
Magda Labieniec-Watala
Lack of the effect of low metformin concentrations on the response of breast cancer cell mitochondria to radiotherapy under conditions of the in vitro experimental hyperglycemia. Labieniec-Watala_Presentation
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanGenital
Michalak 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Mitochonrial respiration in intact peripheral blood mononuclear cells in patients with extrapyramidal syndromes.
LEAK
ROUTINE
OXPHOS
ET
ROXIntact cellsHumanBlood cells
Afrin 2017 MiPschool Obergurgl2017
AfrinS.jpg
Induction of mitochondrial dysfunction by Manuka honey as a strategy for prevention of colon cancer in vitro model: a rising role on reactive oxygen species, apoptosis, and cell metabolism.
LEAKROX
Komlodi 2017 MiPschool Obergurgl2017
Timea Komlodi
Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H2O2 production.
LEAK
OXPHOS
N
S
Gp
Other combinations
ROX
Isolated mitochondriaMouseNervous system
Chowdhury 2017 Blood2017Importance of mitochondrial metabolism as a selective therapeutic approach in chronic lymphocytic leukemia patients.LEAKROXIntact cellsHumanLymphocyte
Garcia-Roves 2017 MiP20172017
Pablo Garcia-Roves
Mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. MitoEAGLE WG2 pilot study. Garcia-Roves_Presentation
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Collins 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
The effects of a Mediterranean versus Western diet on nonhuman primate skeletal muscle bioenergetics.
OXPHOSF
N
S
Gp
CIV
NS
ROX
Intact cells
Bento 2017 MITOEAGLE Obergurgl2017
Guida Bento Foto.JPG
Isolation of human urine-derived stem cells for mitochondrial function profile assessment.
LEAK
ET
ROXIntact cellsHumanStem cells
Reboredo-Rodriguez 2017 MiPschool Obergurgl2017
Reboredo-Rodriguez Patricia
Protective effect of a polyphenol-rich strawberry extract on oxidative and endoplasmic reticulum stresses in HepG2 cell line.
LEAK
ET
ROXHumanLiver
Markova 2017 MiP20172017
Michaela Markova
Porcine sepsis and associated myocardial depression.
LEAK
OXPHOS
N
S
CIV
NS
ROX
PigHeart
Markova 2017 MiPschool Obergurgl2017
Michaela Markova
Mitochondrial respiration in the rat left heart ventricle after inhibition of pyruvate dehydrogenase kinase.
LEAK
OXPHOS
N
S
CIV
NS
ROX
HomogenateRatHeart
Gnaiger 2017 MiPschool A12017
Gnaiger Erich.jpg
Elemental steps towards understanding mitochondrial core energy metabolism: coupling control.
LEAK
ROUTINE
OXPHOS
ET
ROXIntact cells
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Hoel 2017 MiPschool Obergurgl2017
Hoel Fredrik
A study on mitochondrial stress responses due to OXPHOS inhibition.
LEAKROXHumanNervous system
Michalak 2017 MiP20172017
MiPsociety
The effect of anticoagulants on mitochondrial respiration in intact peripheral blood mononuclear cells.
LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Nogueras 2017 MiPschool Obergurgl2017
Lara Nogueras.jpg
Mitochondrial dysfunction in peripheral blood mononuclear cells from multiple sclerosis patients.
LEAK
ROUTINE
ET
ROXIntact cellsBlood cells
Gnaiger 2017 MiPschool A42017
Gnaiger Erich.jpg
Respiratory pathway control in mitochondrial core energy metabolism: from bioenergetics to mitochondrial physiology.
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Sumbalova 2016b Abstract MitoFit Science Camp 20162016Human blood cells: isolation and HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Lymphocyte
Platelet
Bezuidenhout 2016b Abstract MitoFit Science Camp 20162016Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers.LEAK
OXPHOS
ET
N
S
ROX
Permeabilized tissueMouseSkeletal muscle
Sobotka 2016 Abstract IOC1162016Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Isolated mitochondriaRatLiver
Lamberti 2016 Abstract MitoFit Science Camp 20162016Development of a reference sample for HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
HumanKidney
HEK
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck2016Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.LEAK
OXPHOS
ET
F
N
S
NS
ROX
MouseNervous system
Krumschnabel 2016a Abstract MitoFit Science Camp 20162016O2k-Protocols: Mitochondrial preparations for HRR.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Homogenate
Isolated mitochondria
MouseHeart
Laner 2016 Abstract Mito Xmas Meeting Innsbruck2016OXPHOS and ET capacity in permeabilized fibers of canine superathletes.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Doerrier 2016 Abstract MitoFit Science Camp 20162016Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Blood cells
HEK
Platelet
Hoppel 2016c Abstract MitoFit Science Camp 20162016Mitochondrial respiration in permeabilized skin fibroblasts.OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck2016Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Isolated mitochondriaMouseHeart
Laner 2016 Abstract MitoFit Science Camp 20162016OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Krumschnabel 2016b Abstract MitoFit Science Camp 20162016O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.LEAK
OXPHOS
ET
N
S
NS
ROX
HumanKidney
HEK
Calzia 2015 Abstract MiP20152015Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise.LEAK
OXPHOS
ET
N
S
ROX
HumanSkeletal muscle
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHuman
Mouse
Skeletal muscle
Karabatsiakis 2015 Abstract MiP20152015Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder.LEAK
ROUTINE
OXPHOS
ET
ROXHumanBlood cells
Van Dyk 2015 Abstract MiPschool Cape Town 20152015Optimization of selected cell lines for use on the Seahorse extracellular flux analyzer.LEAK
ROUTINE
ET
N
ROX
Isolated mitochondriaHumanOther cell lines
Fibroblast
Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueRatHeart
Rohlena 2015 Abstract MiP20152015Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.ROUTINE
OXPHOS
ET
S
ROX
Permeabilized cells
Isolated mitochondria
HumanOther cell lines
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II2015On coupling control of mitochondrial respiration. What is wrong with the RCR?LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Chou 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
F
N
S
NS
ROX
Permeabilized cells
Permeabilized tissue
Blood cells
Lymphocyte
Platelet
Laner 2015 Abstract MiP20152015Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Dyrstad 2015 Abstract MiPschool London 20152015Activation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells.LEAK
ROUTINE
ET
N
ROX
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Galina 2015 Abstract MiP20152015High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles.LEAKN
S
ROX
Permeabilized tissueRatSkeletal muscle
Blecha 2015 Abstract MiP20152015Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells.LEAK
ET
ROX
Doerrier 2014 Abstract SECF2014Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseHeart
Felser 2014 Abstract MiP20142014Assessing mitochondrial dysfunction in fibroblast cells – a comparison between O2k and multiwell respirometry.ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
HeLa
Fibroblast
Jezek 2013 Abstract MiP20132013Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Isolated mitochondria
Intact cells
MouseLung;gill
Islet cell;pancreas;thymus
Pecina 2013 Abstract MiP20132013Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Gp
NS
Other combinations
ROX
Permeabilized cells
Homogenate
HumanBlood cells
Lymphocyte
Slinde 2013 Abstract MiP20132013Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
ROX
Permeabilized tissue
Isolated mitochondria
Other mammals
Fishes
Heart
Liver
Blood cells
Christen 2013 Abstract MiP20132013Christen F, Desrosiers V, Blier PU (2013) Thermal sensitivity of mitochondria from arctic charr heart: Mitochondrial respiration and ROS production. Mitochondr Physiol Network 18.08.OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaOther mammals
Fishes
Heart
Szibor 2013 Abstract MiP20132013Szibor M, Heidler J, Gizatullina Z, Salwig I, Dhandapani PK, Wittig I, Rustin P (2013) Expression of Ciona intestinalis alternative oxidase in mouse. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ROXIsolated mitochondria
Oxidase;biochemical oxidation
MouseHeart
Skeletal muscle
Nervous system
Liver
Lung;gill
Larsen FJ 2013 Abstract MiP20132013Larsen FJ, Schiffer TA, Lundberg JO, Weitzberg E (2013) Human mitochondria has a unique response to ischemia-reperfusion injury compared to mitochondria from rat, mouse and pig . Mitochondr Physiol Network 18.08.OXPHOSROXIsolated mitochondriaHuman
Pig
Mouse
Rat
Votion 2013 Abstract MiP20132013Votion DM, Mouithys-Mickalad A, Ceusters Justine D, Lemieux H, Tosi I, Franck T, Art T, Niesten A, Serteyn D (2013) The challenge of understanding myopathies in horses using permeabilized muscle cells. Mitochondr Physiol Network 18.08.OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHorseSkeletal muscle
Oliveira MF 2013 Abstract MiP20132013Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Intact organism
Intact organ
Permeabilized cells
Permeabilized tissue
Homogenate
Intact cells
Human
Drosophila
Hexapods
Other invertebrates
Skeletal muscle
Neuroblastoma
Cavalcanti de Albuquerque 2013 Abstract MiP20132013Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Intact organism
Permeabilized tissue
RatSkeletal muscle
Pichaud 2013 Abstract MiP20132013Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized tissueDrosophila
Hexapods
Skeletal muscle
Amoedo 2013 Abstract MiP20132013Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Permeabilized cells
Enzyme
Intact cells
MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Krumschnabel 2013 Abstract MiP20132013Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouse
Fishes
Heart
Nervous system
Liver
Rodrigues 2013 Abstract MiP20132013Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
ET
ROXIntact cellsGenital
Watala 2012 Abstract Bioblast2012Watala C, Przygodzki T, Siewiera K, Kassassir H, Talar M, Labieniec-Watala M (2012) Oxygen consumption in resting and activated blood platelets: platelet mitochondria and cyclooxygenases as compounding targets for high-resolution respirometry. Mitochondr Physiol Network 17.12.ROUTINE
ET
NS
ROX
Isolated mitochondria
Enzyme
Intact cells
Human
Rat
Endothelial;epithelial;mesothelial cell
Blood cells
Platelet
Pesta 2011Abstract Mitochondrial Medicine-Training2011Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle



MitoPedia concepts: Respiratory state, Recommended 


MitoPedia topics: EAGLE 


Labels: MiParea: Respiration 





Pathway: ROX  HRR: Theory