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• Glutamate-aspartate carrier
  ...y [[uncoupling]]. [[Aminooxyacetate]] is an [[inhibitor]] of the glutamate-aspartate carrier.
  623 bytes (82 words) - 14:54, 25 July 2016
• Malate-aspartate shuttle
  |description=The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate^2- for 2 ::::* Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - [[Scaduto 1
  735 bytes (91 words) - 19:30, 1 January 2021
• Malate/aspartate shuttle
  #REDIRECT [[Malate-aspartate shuttle]]
  38 bytes (3 words) - 07:56, 17 December 2018

Page text matches

• Glutamate-aspartate carrier
  ...y [[uncoupling]]. [[Aminooxyacetate]] is an [[inhibitor]] of the glutamate-aspartate carrier.
  623 bytes (82 words) - 14:54, 25 July 2016
• Malate/aspartate shuttle
  #REDIRECT [[Malate-aspartate shuttle]]
  38 bytes (3 words) - 07:56, 17 December 2018
• Malate-aspartate shuttle
  |description=The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate^2- for 2 ::::* Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - [[Scaduto 1
  735 bytes (91 words) - 19:30, 1 January 2021
• Scaduto 1994 Eur J Biochem
  |title=Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. ...timulation of the mitochondrial oxidation of cytosolic NADH via the malate/aspartate cycle.
  2 KB (319 words) - 07:52, 17 December 2018
• Wiesner 1988 Biochim Biophys Acta
  ...eutzer U, Rösen P, Grieshaber MK (1988) Subcellular distribution of malate-aspartate cycle intermediates during normoxia and anoxia in the heart. Biochim Biophy ...itochondria is supported by the glutamate gradient and by a high glutamate/aspartate ratio inside the mitochondria (Glu/Asp = 15) which is maintained by the ene
  2 KB (276 words) - 12:46, 7 May 2019
• Oxoglutarate
  ...as part of the [[malate-aspartate shuttle]]. In the cytosol, oxoglutarate+aspartate are transaminated to form oxaloacetate+glutamate. Cytosolic malate dehydrog
  1 KB (142 words) - 09:38, 11 September 2020
• Altinok 2019 J Cell Physiol
  ...io JL, Stein DE, Bowne WB, Shieh AC, Snyder NW, Orynbayeva Z (2019) Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria. J Cell Physiol 235:25 ...glycolysis and oxidative phosphorylation. We demonstrated that the malate-aspartate shuttle exerts control over NAD⁺/NADH homeostasis to maintain ac
  2 KB (281 words) - 20:36, 7 March 2020
• Gellerich 2009 PLoS One
  ...tochondrial function. This regulation involves the mitochondrial glutamate/aspartate carrier aralar which controls mitochondrial substrate supply according to t |keywords=Glutamate/aspartate carrier aralar, Extramitochondrial Ca (2+), Brain mitochondria
  2 KB (270 words) - 09:28, 7 May 2020
• Profilo 2017 Biochim Biophys Acta
  ...onti B, Palmieri F, Lasorsa FM (2017) Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylasparta ...energetic deficit due to AGC1 impairment is associated with inappropriate aspartate levels to support neuronal proliferation when glutamine is not used as meta
  3 KB (418 words) - 10:02, 8 June 2020
• Digerness 1976 J Mol Cell Cardiol
  |title=Digerness SB, Reddy WJ (1976) The malate-aspartate shuttle in heart mitochondria. J Mol Cell Cardiol 8:779-85.
  310 bytes (39 words) - 17:00, 16 January 2021
• McKenna 1995 Neurochem Res
  ...te, but competitively at high concentrations of malate. Both glutamate and aspartate decreased the activity of mitochondrial malic enzyme, but also increased th ...nzyme, Malate, Astrocyte, Ketoglutarate, Oxoglutarate, Citrate, Glutamate, Aspartate, Anaplerosis
  3 KB (356 words) - 12:23, 27 July 2014
• Gellerich 2012 Biochem J
  ...of isolated brain mitochondria by formation of pyruvate through the malate-aspartate shuttle. Biochem J 443:747-55. ...rmation of pyruvate by lactate dehydrogenase (LDH) is linked to the malate-aspartate shuttle (MAS) with aralar as a central component. A rise of Ca2+cyt in a re
  2 KB (320 words) - 10:46, 13 March 2015
• Valis 2017 Oncotarget
  ...blockade of mitochondrial complex I and II activity by QB and reduction in aspartate and folate metabolism as therapeutic targets in T-ALL cells. Anti-cancer ac
  2 KB (346 words) - 18:31, 31 January 2020
• Oxaloacetate
  ...e, or with [[glutamate]] through transaminase to form [[oxoglutarate]] and aspartate. Oa transport is restricted across the inner [[mitochondrial|mt]]-membrane
  725 bytes (96 words) - 19:31, 1 January 2021
• Jespersen 2017 J Physiol
  ...) Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion. J Phy ...haemic administration of aminooxyacetate (AOA), an inhibitor of the malate-aspartate shuttle (MAS), provides cardioprotection against IR injury, although the un
  3 KB (379 words) - 17:33, 25 February 2020
• Oakey 2019 Wellcome Open Res
  ...ese metabolic consequences. However, the functional relevance of increased aspartate levels after NAD⁺ depletion remains unclear, and requires furthe |keywords=NAD+, NAMPT, NR, Aspartate, Isotopic tracing, Metabolism, Skeletal muscle
  3 KB (431 words) - 15:39, 16 October 2019
• PGM-pathway control state
  ...nd reacts with [[oxaloacetate]] in the [[transaminase]] reaction to form [[aspartate]] and [[oxoglutarate]]. Glutamate as the sole substrate is transported by t
  3 KB (316 words) - 13:14, 2 August 2023
• George 2015 BA Thesis
  ...d that the two shuttles are necessarily interconnected in a lactate-malate-aspartate shuttle. We hypothesized that experimental support for robust mitochondrial
  3 KB (336 words) - 16:41, 7 November 2016
• Molinie 2022 Biochim Biophys Acta Bioenerg
  ...etabolically produced in the cytosol involves redox shuttles as the malate-aspartate shuttle (MAS) and is of paramount importance for cell fate. However, the sp |keywords=Bioenergetics, MDH2, Malate aspartate shuttle, Mitochondria, NADH redox homeostasis, Oxaloacetate, Respirasomes,
  2 KB (325 words) - 18:20, 14 March 2022
• Glutamate
  ...er]] and reacts with [[oxaloacetate]] in the transaminase reaction to form aspartate and [[oxoglutarate]]. Glutamate as the sole substrate is transported by the
  3 KB (352 words) - 09:26, 4 July 2023

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