Tretter Laszlo

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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Tretter Laszlo

MitoPedia topics: EAGLE

COST: Member COST WG1: WG1

COST WG3: WG3 COST WG4: WG4

Name	Tretter Laszlo, Prof., Dr. Head of Department
Institution	Department of Medical Biochemistry, Semmelweis University, HU
Address	H-Tűzoltó u. 37-47, H-1444
City	Budapest
State/Province
Country	Hungary
Email	[email protected]
Weblink
O2k-Network Lab	HU Budapest Tretter L

Bioenergetics Communications

Laszlo Tretter is Associate Editor of the journal Bioenergetics Communications

Keywords: mitochondria, ROS homeostasis, TCA cycle, oxoglutarate dehydrogenases, neurodegeneration

Participated at

Labels: Field of research: Basic

Publications

	Published	Reference
Horvath 2022 Antioxidants (Basel)	2022	Horváth G, Sváb G, Komlódi T, Ravasz D, Kacsó G, Doczi J, Chinopoulos C, Ambrus A, Tretter L (2022) Reverse and forward electron flow-induced H₂O₂ formation is decreased in α-ketoglutarate dehydrogenase (α-KGDH) subunit (E2 or E3) heterozygote knock out animals. https://doi.org/10.3390/antiox11081487
Komlodi 2022 BEC	2022	Komlódi T, Tretter L (2022) The protonmotive force – not merely membrane potential. Bioenerg Commun 2022.16. https://doi.org/10.26124/bec:2022-0016
Daradics 2022 PLoS One	2022	Daradics N, Horvath G, Tretter L, Paal A, Fulop A, Budai A, Szijarto A (2022) The effect of Cyclophilin D depletion on liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy. https://doi.org/10.1371/journal.pone.0271606
Sváb 2021 Antioxidants (Basel)	2021	Svàb G, Kokas M, Sipos I, Ambrus A, Tretter L (2021) Methylene blue bridges the inhibition and produces unusual respiratory changes in Complex III-inhibited mitochondria. Studies on rats, mice and guinea pigs. Antioxidants (Basel) 10:305.
Mikulas 2020 Materials	2020	Mikulás K, Komlódi T, Földes A, Sváb G, Horváth G, Nagy AM, Ambrus A, Gyulai-Gaál Sz, Gera I, Hermann P, Varga G, Tretter L (2020) Bioenergetic Impairment of triethylene glycol dimethacrylate- (TEGDMA-) treated dental pulp stem cells (DPSCs) and isolated brain mitochondria are amended by redox compound methylene blue. Materials (Basel) 13(16):3472.
BEC 2020.1 doi10.26124bec2020-0001.v1	2020	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
Svab 2019 Neurochem Res	2019	Svab G, Doczi J, Gerencser AA, Ambrus A, Gallyas F, Sümegi B, Tretter L (2019) The mitochondrial targets of neuroprotective drug vinpocetine on primary neuron cultures, brain capillary endothelial cells, synaptosomes, and brain mitochondria. Neurochem Res 44:2435-47.
Budai 2018 Br J Surg	2018	Budai A, Horváth G, Tretter L, Radák Z, Koltai E, Bori Z, Torma F, Lukáts Á, Röhlich P, Szijártó A, Fülöp A (2018) Mitochondrial function after associating liver partition and portal vein ligation for staged hepatectomy in an experimental model. Br J Surg 106:120-31.
Komlodi 2018 J Bioenerg Biomembr	2018	Komlódi T, Geibl FF, Sassani M, Ambrus A, Tretter L (2018) Membrane potential and delta pH dependency of reverse electron transport-associated hydrogen peroxide production in brain and heart mitochondria. J Bioenerg Biomembr 50:355-365
Mikulas 2018 Dent Mater	2018	Mikulás K, Hermann P, Gera I, Komlódi T, Horváth G, Ambrus A, Tretter L (2018) Triethylene glycol dimethacrylate impairs bioenergetic functions and induces oxidative stress in mitochondria via inhibiting respiratory Complex I. Dent Mater 34:e166-e181.
Komlodi 2017 Neuropharmacology	2017	Komlódi T, Tretter L (2017) Methylene blue stimulates substrate-level phosphorylation catalysed by succinyl-CoA ligase in the citric acid cycle. Neuropharmacology 123:287-98.
Koncsos 2016 Am J Physiol Heart Circ Physiol	2016	Koncsos G, Varga ZV, Baranyai T, Boengler K, Rohrbach S, Li L, Schlüter KD, Schreckenberg R, Radovits T, Oláh A, Mátyás C, Lux Á, Al-Khrasani M, Komlódi T, Bukosza N, Máthé D, Deres L, Barteková M, Rajtík T, Adameová A, Szigeti K, Hamar P, Helyes Z, Tretter L, Pacher P, Merkely B, Giricz Z, Schulz R, Ferdinandy P (2016) Diastolic dysfunction in prediabetic male rats: role of mitochondrial oxidative stress. Am J Physiol Heart Circ Physiol 311:H927-43.
Tretter 2016 Biochim Biophys Acta	2016	Tretter L, Patocs A, Chinopoulos C (2016) Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis. https://doi.org/10.1016/j.bbabio.2016.03.012
Yavari 2016 Cell Metab	2016	Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martinez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Toth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H (2016) Chronic activation of γ2 AMPK induces obesity and reduces β cell function. Cell Metab 23:821-36.
Nemeth 2016 FASEB J	2016	Németh B, Doczi J, Csete D, Kacso G, Ravasz D, Adams D, Kiss G, Nagy AM, Horvath G, Tretter L, Mócsai A, Csépányi-Kömi R, Iordanov I, Adam-Vizi V, Chinopoulos C (2016) Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage. FASEB J 30:286-300.
Tretter 2014 Methods Enzymol	2014	Tretter L, Ambrus A (2014) Measurement of ROS homeostasis in isolated mitochondria. Methods Enzymol 547:199-223.
Tretter 2014 Free Radic Biol Med	2014	Tretter L, Horvath G, Hölgyesi A, Essek F, Adam-Vizi V (2014) Enhanced hydrogen peroxide generation accompanies the beneficial bioenergetic effects of methylene blue in isolated brain mitochondria. Free Radic Biol Med 77:317-30.
Tretter 2012 Free Radic Biol Med	2012	Tretter Laszlo, Adam-Vizi Vera (2012) High Ca²⁺ load promotes hydrogen peroxide generation via activation of α-glycerophosphate dehydrogenase in brain mitochondria. Free Radic Biol Med 53:2119-30.
Komary 2010 Biochim Biophys Acta	2010	Komary Z, Tretter L, Adam-Vizi V (2010) Membrane potential-related effect of calcium on reactive oxygen species generation in isolated brain mitochondria. Biochim Biophys Acta 1797:922-8. https://doi.org/10.1016/j.bbabio.2010.03.010
Tretter 2007 Neurochem Res	2007	Tretter L, Adam-Vizi V (2007) Moderate dependence of ROS formation on DeltaPsim in isolated brain mitochondria supported by NADH-linked substrates. Neurochem Res 32:569-75.
Tretter 2007b J Neurochem	2007	Tretter L, Takacs K, Hegedüs V, Adam-Vizi V (2007) Characteristics of alpha-glycerophosphate-evoked H2O2 generation in brain mitochondria. J Neurochem 100:650-63.
Tretter 2007 J Neurochem	2007	Tretter L, Adam-Vizi V (2007) Uncoupling is without an effect on the production of reactive oxygen species by in situ synaptic mitochondria. J Neurochem 103:1864-71.
Sipos 2005 Cell Mol Neurobiol	2005	Sipos I, Törocsik B, Tretter L, Adam-Vizi V (2005) Impaired regulation of pH homeostasis by oxidative stress in rat brain capillary endothelial cells. Cell Mol Neurobiol 25:141-51.
Tretter 2005 Philos Trans R Soc Lond B Biol Sci	2005	Tretter L, Adam-Vizi V (2005) Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress. Philos Trans R Soc Lond B Biol Sci 360:2335-45.

Abstracts

	Published	Reference
Komlodi 2022 Abstract Bioblast	2022	3.1. «10+5» Komlódi Timea, Tretter L (2022) The protonmotive force – not merely membrane potential. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint«
Komlodi 2017 Abstract MITOEAGLE Barcelona	2017	Succinate dehydrogenase regulation via oxaloacetate in brain mitochondria.
Komlodi 2016 Abstract IOC116	2016	Komlodi T, Geibl F, Sassani M, Adam-Vizi V, Tretter L (2016) The effect of ΔΨ_mt and ΔpH on mitochondrial reactive oxygen species production - A comparative study using mitochondria isolated from different mammalian tissues. Mitochondr Physiol Network 21.11
Doerrier 2015 Abstract MiPschool Greenville 2015	2015	"Succinate paradox" study by high resolution respirometry combined with fluorometry and spectrofluorometry: NextGen-O2k.
Doerrier 2015 Abstract MiP2015	2015	Simultaneous measurement of mitochondrial respiration, hydrogen peroxide production, and NADH autofluorescence to assess mitochondrial function.
Meszaros 2014 Abstract MiP2014	2014	Methodological aspects of assessing mitochondrial function in small intestinal mucosal samples of rats and guinea pigs.
Nagy 2014 Abstract MiP2014	2014	Investigation of the energy metabolism of microglial cells.
Tretter 2014 Abstract MiP2014	2014	Cool or heat? Bioenergetic and ROS homeostatic approach to therapeutic hypothermia.
Komlodi 2014 Abstract MiP2014	2014	Methylenblue, an enhancer of mitochondrial substrate-level phosphorylation.
Tretter 2013 Abstract MiP2013	2013	Tretter L, Komlódi T, Ádám-Vizi V (2013) The effects of methylmalonic acid on alpha-ketoglutarate supported oxidation in isolated brain, heart and liver mitochondria. Mitochondr Physiol Network 18.08.
Horvath 2012 Abstract Bioblast	2012	Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12.
Fasching 2011 Abstract Berlin	2011	Fasching M, Harrison DK, Tretter L, Gnaiger E (2011) Combination of high-resolution respirometry and fluorometry for continuous monitoring of hydrogen peroxide production by mitochondria with resolution in the nanomolar range. Abstract Berlin.