Zunica 2024 Mol Metab
| Zunica ERM, Axelrod CL, Gilmore LA, Gnaiger E, Kirwan JP (2024) The bioenergetic landscape of cancer. Mol Metab 86:101966. https://doi.org/10.1016/j.molmet.2024.101966 |
Zunica Elizabeth RM, Axelrod Christopher L, Gilmore L Anne, Gnaiger Erich, Kirwan John P (2024) Mol Metab
Abstract: Bioenergetic remodeling of core energy metabolism is essential to the initiation, survival, and progression of cancer cells through exergonic supply of adenosine triphosphate (ATP) and metabolic intermediates, as well as control of redox homeostasis. Mitochondria are evolutionarily conserved organelles that mediate cell survival by conferring energetic plasticity and adaptive potential. Mitochondrial ATP synthesis is coupled to the oxidation of a variety of substrates generated through diverse metabolic pathways. As such, inhibition of the mitochondrial bioenergetic system by restricting metabolite availability, direct inhibition of the respiratory Complexes, altering organelle structure, or coupling efficiency may restrict carcinogenic potential and cancer progression. Here, we review the role of bioenergetics as the principal conductor of energetic functions and carcinogenesis while highlighting the therapeutic potential of targeting mitochondrial functions.
• Bioblast editor: Gnaiger E • O2k-Network Lab: US LA Baton Rouge Noland RC, AT Innsbruck Oroboros
Labels: MiParea: Respiration, mt-Structure;fission;fusion, mtDNA;mt-genetics, mt-Medicine, Pharmacology;toxicology
Pathology: Cancer
Stress:Cell death, Oxidative stress;RONS
Regulation: Aerobic glycolysis, Coupling efficiency;uncoupling, mt-Membrane potential, Fatty acid
Metformin, Warburg effect, Crabtree effect
