Succinate and rotenone: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=S(Rot) | |abbr=S(Rot) | ||
|description=Substrate supply by '''succinate''' (S) is the basis for electron input through Complex II into the [[mETS]]. Inhibition of [[Complex I]] by '''[[rotenone]]''' (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of [[succinate dehydrogenase]]. | |description=Substrate supply by '''succinate''' (S) is the basis for electron input through Complex II into the [[Electron transport system|mETS]]. Inhibition of [[Complex I]] by '''[[rotenone]]''' (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of [[succinate dehydrogenase]]. | ||
|info=[[MiPNet11.09]], [[MiPNet12.11]] | |info=[[MiPNet11.09]], [[MiPNet12.11]] | ||
|type=Substrate ETS | |type=Substrate ETS | ||
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{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Inhibitor, Substrate and metabolite | |mitopedia topic=Inhibitor, Substrate and metabolite | ||
|type=Substrate ETS | |type=Substrate ETS | ||
}} | }} | ||
Revision as of 17:38, 9 March 2011
- high-resolution terminology - matching measurements at high-resolution
Succinate and rotenone
Description
Substrate supply by succinate (S) is the basis for electron input through Complex II into the mETS. Inhibition of Complex I by rotenone (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of succinate dehydrogenase.
Abbreviation: S(Rot)
Reference: MiPNet11.09, MiPNet12.11
MitoPedia topics:
Inhibitor,
Substrate and metabolite
