Chowdhury 2018 Oxid Med Cell Longev: Difference between revisions
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|title=Roy Chowdhury S, Banerji V (2018) Targeting mitochondrial bioenergetics as a therapeutic strategy for chronic lymphocytic leukemia. Oxid Med Cell Longev 2018:2426712. doi | |title=Roy Chowdhury S, Banerji V (2018) Targeting mitochondrial bioenergetics as a therapeutic strategy for chronic lymphocytic leukemia. Oxid Med Cell Longev 2018:2426712. https://doi.org/10.1155/2018/2426712 | ||
|info=[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851432/ PMID: 29682155 Open Access] | |info=[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851432/ PMID: 29682155 Open Access] | ||
|authors=Roy Chowdhury S, Banerji V | |authors=Roy Chowdhury S, Banerji V |
Revision as of 11:00, 22 March 2023
Roy Chowdhury S, Banerji V (2018) Targeting mitochondrial bioenergetics as a therapeutic strategy for chronic lymphocytic leukemia. Oxid Med Cell Longev 2018:2426712. https://doi.org/10.1155/2018/2426712 |
Roy Chowdhury S, Banerji V (2018) Oxid Med Cell Longev
Abstract: Altered cellular metabolism is considered a hallmark of cancer and is fast becoming an avenue for therapeutic intervention. Mitochondria have recently been viewed as an important cellular compartment that fuels the metabolic demands of cancer cells. Mitochondria are the major source of ATP and metabolites necessary to fulfill the bioenergetics and biosynthetic demands of cancer cells. Furthermore, mitochondria are central to cell death and the main source for generation of reactive oxygen species (ROS). Overall, the growing evidence now suggests that mitochondrial bioenergetics, biogenesis, ROS production, and adaptation to intrinsic oxidative stress are elevated in chronic lymphocytic leukemia (CLL). Hence, recent studies have shown that mitochondrial metabolism could be targeted for cancer therapy. This review focuses the recent advancements in targeting mitochondrial metabolism for the treatment of CLL.
β’ Bioblast editor: Gnaiger E
Correction: FADH2 and Complex II
- FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).
- Gnaiger E (2024) Complex II ambiguities β FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 - Β»Bioblast linkΒ«
Labels: MiParea: Respiration, Pharmacology;toxicology
Pathology: Cancer