Coupling-control ratio: Difference between revisions
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Revision as of 13:19, 17 May 2020
Description
Coupling control ratios, CCR, are flux control ratios, FCR, at a constant mitochondrial pathway control state. In mitochondrial preparations, there are three well-defined coupling states of respiration, L, P, E (LEAK, OXPHOS, ET-pathway). In intact cells, state P cannot be induced, but a ROUTINE state of respiration, R, can be measured. The reference state, Jref, is defined by taking Jref as the maximum flux, i.e. flux in the ET state, E, such that the lower and upper limits of the CCR are defined as 0.0 and 1.0. Then there are two mitochondrial CCR, L/E and P/E, and two CCR for intact cells, L/E and R/E.
Abbreviation: CCR
Reference: Flux control ratio
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- Free OXPHOS capacity, โP = P-L
- OXPHOS coupling efficiency, jโP = โP/P = 1-L/P
- Free ROUTINE activity, โR = R-L
- ROUTINE coupling efficiency, jโR = โR/R = 1-L/R
- LEAK control ratio, L/E
- Free ET-capacity, โE = E-L
- ET-coupling efficiency, jโE = โE/E = 1-L/E
- netOXPHOS control ratio, โP/E=(P-L)/E
- Free OXPHOS capacity, โP = P-L
- netROUTINE control ratio, โR/E=(R-L)/E
- Free ROUTINE activity, โR = R-L
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- More details ยป ET-coupling efficiency
- OXPHOS control ratio, P/E
- Excess E-P capacity, ExP = E-P
- Excess E-P capacity factor, jExP = ExP/E = 1-P/E
- Excess E-R capacity, ExR = E-R
- Excess E-R capacity factor, jExR = ExR/E = 1-R/E
Compare
- ยป Coupling control factor, CCF = 1-CCR
- ยป Respiratory acceptor control ratio, RCR
References
MitoPedia concepts: Respiratory control ratio
MitoPedia methods:
Respirometry