Template:Correction FADH2 and S-pathway: Difference between revisions

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== Correction: FADH<sub>2</sub> and S-pathway ==
== Correction: FADH<sub>2</sub> and S-pathway ==
:::Β» '''[[Complex II ambiguities]]'''


:::: A commonly found error on FADH<sub>2</sub> in the S-pathway requires correction. For clarification, see page 48 in [[Gnaiger_2020_BEC_MitoPathways |Gnaiger (2020)]]
:::: NADH and FADH<sub>2</sub> are shown as substrates feeding electrons into the [[N-pathway]] and [[S-pathway]], respectively. This requires correction: "Whereas reduced NADH is a substrate of Complex I linked to dehydrogenases of the TCA cycle and mt-matrix upstream of CI,Β  reducedΒ  FADH<sub>2</sub> is a product of Complex II with downstream electron flow from CII to Q" (page 48 in [[Gnaiger_2020_BEC_MitoPathways |Ref [2]]]. For details see Ref [2].
::::* Quote (p 48): "TheΒ  substrateΒ  ofΒ  CIIΒ  isΒ  succinate,Β  whichΒ  isΒ  oxidizedΒ  formingΒ  fumarateΒ  while reducing flavin adenine dinucleotide FAD to FADH<sub>2</sub>, with further electron transfer to the quinone pool. Whereas reduced NADH is a substrate of Complex I linked to dehydrogenases of the TCA cycle and mt-matrix upstream of CI,Β  reducedΒ  FADH<sub>2</sub> is a product of Complex II with downstream electron flow from CII to Q."


:::: Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002
:::# Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002
:::# Gnaiger E (2023) Complex II ambiguities ― FADH<sub>2</sub> in the electron transfer system. MitoFit Preprints 2023.3. https://doi.org/10.26124/mitofit:2023-0003

Revision as of 07:51, 30 March 2023

Correction: FADH2 and S-pathway

NADH and FADH2 are shown as substrates feeding electrons into the N-pathway and S-pathway, respectively. This requires correction: "Whereas reduced NADH is a substrate of Complex I linked to dehydrogenases of the TCA cycle and mt-matrix upstream of CI, reduced FADH2 is a product of Complex II with downstream electron flow from CII to Q" (page 48 in Ref [2]. For details see Ref [2].
  1. Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002
  2. Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. MitoFit Preprints 2023.3. https://doi.org/10.26124/mitofit:2023-0003
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