Garrido-Perez 2020 Int J Mol Sci: Difference between revisions
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{{Publication | {{Publication | ||
|title=Garrido-Pérez N, Vela-Sebastián A, López-Gallardo E, Emperador S, Iglesias E, Meade P, Jiménez-Mallebrera C, Montoya J, Bayona-Bafaluy MP, Ruiz-Pesini E (2020) Oxidative | |title=Garrido-Pérez N, Vela-Sebastián A, López-Gallardo E, Emperador S, Iglesias E, Meade P, Jiménez-Mallebrera C, Montoya J, Bayona-Bafaluy MP, Ruiz-Pesini E (2020) Oxidative phosphorylation dysfunction modifies the cell secretome. Int J Mol Sci 21:3374. https://doi.org/10.3390/ijms21093374 | ||
|info=[https://pubmed.ncbi.nlm.nih.gov/32397676/ PMID: 32397676 Open Access] | |info=[https://pubmed.ncbi.nlm.nih.gov/32397676/ PMID: 32397676 Open Access] | ||
|authors=Garrido-Perez N, Vela-Sebastian A, Lopez-Gallardo E, Emperador S, Iglesias E, Meade P, Jimenez-Mallebrera C, Montoya J, Bayona-Bafaluy MP, Ruiz-Pesini E | |authors=Garrido-Perez N, Vela-Sebastian A, Lopez-Gallardo E, Emperador S, Iglesias E, Meade P, Jimenez-Mallebrera C, Montoya J, Bayona-Bafaluy MP, Ruiz-Pesini E |
Revision as of 21:08, 8 October 2023
Garrido-Pérez N, Vela-Sebastián A, López-Gallardo E, Emperador S, Iglesias E, Meade P, Jiménez-Mallebrera C, Montoya J, Bayona-Bafaluy MP, Ruiz-Pesini E (2020) Oxidative phosphorylation dysfunction modifies the cell secretome. Int J Mol Sci 21:3374. https://doi.org/10.3390/ijms21093374 |
Garrido-Perez N, Vela-Sebastian A, Lopez-Gallardo E, Emperador S, Iglesias E, Meade P, Jimenez-Mallebrera C, Montoya J, Bayona-Bafaluy MP, Ruiz-Pesini E (2020) Int J Mol Sci
Abstract: Mitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphorylation functioning on the cell's secretome, although it could be a promising approach for the identification and pre-selection of potential circulating biomarkers for mitochondrial diseases. Here, we review the insights obtained from secretome studies with regard to oxidative phosphorylation dysfunction, and the biomarkers that appear, so far, to be promising to identify mitochondrial diseases. We propose two new biomarkers to be taken into account in future diagnostic trials.
• Bioblast editor: Gnaiger E
Correction: FADH2 and Complex II
- FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).
- Gnaiger E (2024) Complex II ambiguities ― FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 - »Bioblast link«