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...kground to reference steady state (Y to Z). Alternatively, ''X'' may be an inhibitor of flux, absent in the reference state but present in the background state |mitopedia topic=Inhibitor, Substrate and metabolite, Uncoupler

|description='''Cyanide''' (usually added as KCN) is a competitive inhibitor of [[Complex_IV| cytochcrome ''c'' oxidase (CIV)]]. Inhibition is reversed {{MitoPedia O2k and high-resolution respirometry|type=Inhibitor ETS

...ylketone completely inhibited caspase activation, while treatment with the inhibitor of calpains- and papain-like cathepsins (2S,3S)-trans-epoxysuccinyl-leucyla

|description='''Sodium azide''' is an inhibitor of [[Complex IV]]/cytochrome ''c'' oxidase (CIV, COX, CcO). |type=Inhibitor ETS

...s of dequalinium (≤10 μM), this swelling is inhibited by cyclosporin A, an inhibitor of the mitochondrial permeability transition pore. At the same time, at hig |topics=Inhibitor, Ion;substrate transport

...ily (MCF). Only mitochondria from the YIL006w deletion mutant exhibited no inhibitor-sensitive pyruvate transport, but otherwise behaved normally. YIL006w encod

...compounds and their potency is related to that of rotenone, the classical inhibitor of complex I. Among commercial products, particular attention is dedicated |keywords=NADH–ubiquinone reductase; Respiratory inhibitor; Ubiquinone

...itochondria: Trx system. Additionally, [[dinitrochlorobenzene]] (DNCB), an inhibitor of glutathione (GSH) can be used to obtain the GSH contribution scavenging ...H, Kim GY, Moon SK, Cheong J, Kim WJ, Yoo YH, Choi YH (2017) Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep

|mitopedia topic=Inhibitor

...cobacterium tuberculosis'' cytochrome ''bcc:aa''3 supercomplex and a novel inhibitor targeting subunit cytochrome ''c''I. Antimicrob Agents Chemother 67:e015312 ...ion via the cIcII head. The successful identification of a new cyt-bcc:aa3 inhibitor demonstrates the potential of a structure-mechanism-based approach for nove

...dase inhibitor diphenyleneiodonium (0.9 +/- 0.1). By contrast, the site IV inhibitor cyanide, as well as inhibitors of xanthine oxidase (allopurinol), nitric ox

...ill make the other more rate limiting and thus will decrease the amount of inhibitor of the other required for half-maximal inhibition. These two types of "coup

...bited by Rot (10-100 nM), but not by piericidin A (PA; 100 nM), another CI inhibitor. At 100 nM, both Rot and PA fully blocked myoblast oxygen consumption. Knoc |topics=Inhibitor

* [[Allows value::Inhibitor]]

...s measured using OROBOROS HRR Oxygraph-2k according to substrate-uncoupler-inhibitor titration (SUIT) protocol. ...d following the addition of complex I inhibitor (rotenone) and complex III inhibitor (antimycin A).

* [[Allows value::Inhibitor]]

...owney B (2016) Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in ...dependent of CypD inhibition. Here we identified a novel, CypD-independent inhibitor of the mPTP. The screening approach and compound described provides a workf

...or EGTA, the inhibitor of Ca²⁺ transport Ruthenium red and the inhibitor of the myosin ATPase vanadate. The caffeine concentration dependency of res

...A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D (2022) A selective inhibitor of cardiac troponin I phosphorylation by delta protein kinase C (δPKC) as ...ylation of cTnI is critical in IR injury, and that a cTnI/δPKC interaction inhibitor should be considered as a therapeutic target to reduce cardiac injury after

...nes in macrophages. It was reported that metformin, mitochondria complex I inhibitor, decreased production of the pro-form of the inflammatory cytokine IL-1β a Stefin B (cystatin B) is an endogenous cysteine cathepsin inhibitor, and the loss-of-function mutations in the stefin B gene were reported in p