Additive effect of convergent electron flow: Difference between revisions
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Electron flow converges at the '''Q-junction''' from respiratory Complexes I and II ([[CI+II e-input]]), [[glycerophosphate dehydrogenase]] and [[electron-transferring flavoprotein]]. Convergent electron flow corresponds to the operation of the [[TCA cycle]] and mitochondrial substrate supply in vivo. | {{MitoPedia | ||
|description=Electron flow converges at the '''Q-junction''' from respiratory Complexes I and II ([[CI+II e-input]]), [[glycerophosphate dehydrogenase]] and [[electron-transferring flavoprotein]]. Convergent electron flow corresponds to the operation of the [[TCA cycle]] and mitochondrial substrate supply in vivo. | |||
==Additive effect== | ==Additive effect== | ||
Convergent electron flow simultaneously through CI+II into the [[Q-junction]] supports higher [[OXPHOS capacity]] and [[ETS capacity]] than separate electron flow through either CI or CII. Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular [[TCA cycle]] function. The convergent CI+II effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with [[mt-preparations]] have underestimated cellular OXPHOS capacities. | Convergent electron flow simultaneously through CI+II into the [[Q-junction]] supports higher [[OXPHOS capacity]] and [[ETS capacity]] than separate electron flow through either CI or CII. Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular [[TCA cycle]] function. The convergent CI+II effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with [[mt-preparations]] have underestimated cellular OXPHOS capacities. | ||
== | |info=MiPNet12.12, Gnaiger_2009_IJCBC | ||
|type=Respiration | |||
}} | |||
{{Labeling | |||
|instruments=Theory | |||
|discipline=Mitochondrial Physiology | |||
|topics=Respiration; OXPHOS; ETS Capacity | |||
}} | |||
*[[MiPNet12.12]] | *[[MiPNet12.12]] | ||
*[[Gnaiger_2009_IntJBiochemCellBiol]] | *[[Gnaiger_2009_IntJBiochemCellBiol]] | ||
{{#set:keyword=Respiration|keyword=Mitochondrial pathways}} | {{#set:keyword=Respiration|keyword=Mitochondrial pathways}} | ||
Revision as of 12:14, 13 September 2010
- high-resolution terminology - matching measurements at high-resolution
Additive effect of convergent electron flow
Description
Electron flow converges at the Q-junction from respiratory Complexes I and II (CI+II e-input), glycerophosphate dehydrogenase and electron-transferring flavoprotein. Convergent electron flow corresponds to the operation of the TCA cycle and mitochondrial substrate supply in vivo.
Additive effect
Convergent electron flow simultaneously through CI+II into the Q-junction supports higher OXPHOS capacity and ETS capacity than separate electron flow through either CI or CII. Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular TCA cycle function. The convergent CI+II effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with mt-preparations have underestimated cellular OXPHOS capacities.
Reference: MiPNet12.12, Gnaiger_2009_IJCBC
Labels:
Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
HRR: Theory
