Brownlee 2001 Nature
From Bioblast
Revision as of 21:41, 11 April 2022 by Komlodi Timea (talk | contribs)
Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 14:813-20. |
Brownlee M (2001) Nature
Abstract: Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.
Cited by
Labels: