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|info=MitoFit Preprints 2022.27. [[File:MitoFit Preprints pdf.png|left|160px|link=https://wiki.oroboros.at/images/8/8f/Cabral-Costa_2022_MitoFit.pdf|MitoFit pdf]] [https://wiki.oroboros.at/images/8/8f/Cabral-Costa_2022_MitoFit.pdf Mitochondrial Ca<sup>2+</sup> handling as a cell signaling hub: lessons from astrocyte function.]<br/> | |info=MitoFit Preprints 2022.27. [[File:MitoFit Preprints pdf.png|left|160px|link=https://wiki.oroboros.at/images/8/8f/Cabral-Costa_2022_MitoFit.pdf|MitoFit pdf]] [https://wiki.oroboros.at/images/8/8f/Cabral-Costa_2022_MitoFit.pdf Mitochondrial Ca<sup>2+</sup> handling as a cell signaling hub: lessons from astrocyte function.]<br/> | ||
|authors=Cabral-Costa Joao Victor , Kowaltowski Alicia J | |authors=Cabral-Costa Joao Victor , Kowaltowski Alicia J | ||
|year=2022 | |year=2022 | ||
|journal=MitoFit Prep | |journal=MitoFit Prep | ||
|abstract=Astrocytes are a heterogenous population of macroglial cells spread throughout the central nervous system with diverse functions, expression signatures, and intricate morphologies. Their subcellular compartments contain a distinct range of mitochondria, with functional microdomains exhibiting widespread activities, such as controlling local metabolism and Ca<sup>2+</sup> signaling. Ca<sup>2+</sup> is an ion of utmost importance, both physiologically and pathologically, and participates in critical central nervous system processes, including synaptic plasticity, neuron-astrocyte integration, excitotoxicity, and mitochondrial physiology and metabolism. The mitochondrial Ca<sup>2+</sup> handling system is formed by the mitochondrial Ca<sup>2+</sup> uniporter complex (MCUc), which mediates Ca<sup>2+</sup> influx, and the mitochondrial Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCLX), responsible for most mitochondrial Ca<sup>2+</sup> efflux, as well as additional components, including the mitochondrial permeability transition pore (mtPTP). Over the last decades, mitochondrial Ca<sup>2+</sup> handling has been shown to be key for brain homeostasis, acting centrally in physiopathological processes such as astrogliosis, astrocyte-neuron activity integration, energy metabolism control, and neurodegeneration. In this review we discuss the current state of knowledge of the mitochondrial Ca<sup>2+</sup> handling system molecular composition, highlighting its impact on astrocytic homeostasis.<br> | |abstract=Astrocytes are a heterogenous population of macroglial cells spread throughout the central nervous system with diverse functions, expression signatures, and intricate morphologies. Their subcellular compartments contain a distinct range of mitochondria, with functional microdomains exhibiting widespread activities, such as controlling local metabolism and Ca<sup>2+</sup> signaling. Ca<sup>2+</sup> is an ion of utmost importance, both physiologically and pathologically, and participates in critical central nervous system processes, including synaptic plasticity, neuron-astrocyte integration, excitotoxicity, and mitochondrial physiology and metabolism. The mitochondrial Ca<sup>2+</sup> handling system is formed by the mitochondrial Ca<sup>2+</sup> uniporter complex (MCUc), which mediates Ca<sup>2+</sup> influx, and the mitochondrial Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCLX), responsible for most mitochondrial Ca<sup>2+</sup> efflux, as well as additional components, including the mitochondrial permeability transition pore (mtPTP). Over the last decades, mitochondrial Ca<sup>2+</sup> handling has been shown to be key for brain homeostasis, acting centrally in physiopathological processes such as astrogliosis, astrocyte-neuron activity integration, energy metabolism control, and neurodegeneration. In this review we discuss the current state of knowledge of the mitochondrial Ca<sup>2+</sup> handling system molecular composition, highlighting its impact on astrocytic homeostasis.<br> | ||
Latest revision as of 11:41, 6 March 2023
| Cabral-Costa JV, Kowaltowski AJ (2022) Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function. https://doi.org/10.26124/mitofit:2022-0027 |
» MitoFit Preprints 2022.27.
Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function.
Cabral-Costa Joao Victor, Kowaltowski Alicia J (2022) MitoFit Prep
Abstract: Astrocytes are a heterogenous population of macroglial cells spread throughout the central nervous system with diverse functions, expression signatures, and intricate morphologies. Their subcellular compartments contain a distinct range of mitochondria, with functional microdomains exhibiting widespread activities, such as controlling local metabolism and Ca2+ signaling. Ca2+ is an ion of utmost importance, both physiologically and pathologically, and participates in critical central nervous system processes, including synaptic plasticity, neuron-astrocyte integration, excitotoxicity, and mitochondrial physiology and metabolism. The mitochondrial Ca2+ handling system is formed by the mitochondrial Ca2+ uniporter complex (MCUc), which mediates Ca2+ influx, and the mitochondrial Na+/Ca2+ exchanger (NCLX), responsible for most mitochondrial Ca2+ efflux, as well as additional components, including the mitochondrial permeability transition pore (mtPTP). Over the last decades, mitochondrial Ca2+ handling has been shown to be key for brain homeostasis, acting centrally in physiopathological processes such as astrogliosis, astrocyte-neuron activity integration, energy metabolism control, and neurodegeneration. In this review we discuss the current state of knowledge of the mitochondrial Ca2+ handling system molecular composition, highlighting its impact on astrocytic homeostasis.
• Keywords: astrocytes; mitochondria; calcium signalling; MCU; NCLX; metabolism
• Bioblast editor: Tindle-Solomon L
• O2k-Network Lab: BR Sao Paulo Kowaltowski AJ
Labels:
Regulation: Calcium
ORCID: 
Cabral-Costa Joao Victor, Kowaltowski Alicia
