Chance 1961 J Biol Chem-III: Difference between revisions
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|year=1961 | |year=1961 | ||
|journal=J Biol Chem | |journal=J Biol Chem | ||
|abstract=# A | |abstract=# A specific succinate requirement for energy-linked reduction of mitochondrial pyridine nucleotide is demonstrated in pigeon heart and guinea pig kidney mitochondria. | ||
# The | # The succinate used in this reduction can be generated in the oxidation of malate plus glutamate or of Ξ±-ketoglutarate. Β | ||
# The | # The role of succinate is identified by the specific inhibitory responses of the reaction to malonate, phosphate, and fumarate. Β | ||
# At | # At least two kinds of mitochondrial pyridine nucleotide are shown to be reducible in State 4: (a) about one-third in the absence of added succinate in a malonate-insensitive reaction in the presence of a substrate such as malate plus glutamate and (b) about two-thirds in the presence of added succinate in a malonate-sensitive, energy-linked reaction.Β These two kinds of pyridine nucleotide may be considered to be compartmented. | ||
|keywords= | |keywords=Pyridine nucleotide, Succinate | ||
}} | }} | ||
{{Labeling | {{Labeling |
Revision as of 21:18, 26 January 2013
Chance B, Hollunger G (1961) The interaction of energy and electron transfer reactions in mitochondria III. Substrate requirements for pyridine nucleotide reduction in mitochondria. J Biol Chem 236: 1555-1561. |
Chance B, Hollunger G (1961) J Biol Chem
Abstract:
- A specific succinate requirement for energy-linked reduction of mitochondrial pyridine nucleotide is demonstrated in pigeon heart and guinea pig kidney mitochondria.
- The succinate used in this reduction can be generated in the oxidation of malate plus glutamate or of Ξ±-ketoglutarate.
- The role of succinate is identified by the specific inhibitory responses of the reaction to malonate, phosphate, and fumarate.
- At least two kinds of mitochondrial pyridine nucleotide are shown to be reducible in State 4: (a) about one-third in the absence of added succinate in a malonate-insensitive reaction in the presence of a substrate such as malate plus glutamate and (b) about two-thirds in the presence of added succinate in a malonate-sensitive, energy-linked reaction. These two kinds of pyridine nucleotide may be considered to be compartmented.
β’ Keywords: Pyridine nucleotide, Succinate
Labels:
Organism: Guinea pig, Other Non-Mammal"Other Non-Mammal" is not in the list (Human, Pig, Mouse, Rat, Guinea pig, Bovines, Horse, Dog, Rabbit, Cat, ...) of allowed values for the "Mammal and model" property.
Tissue;cell: Cardiac muscle"Cardiac muscle" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property., Kidney
Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.
Enzyme: Complex II; Succinate Dehydrogenase"Complex II; Succinate Dehydrogenase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property.
Regulation: Substrate; Glucose; TCA Cycle"Substrate; Glucose; TCA Cycle" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
Coupling state: OXPHOS
Made history