Chinopoulos 2013 J Neurosci Res

Chinopoulos C (2013) Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex. J Neurosci Res 91:1030-43.

» PMID: 23378250 Open Access

Chinopoulos Christos (2013) J Neurosci Res

Abstract: The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the α-ketoglutarate dehydrogenase complex dictating their directionalities. • Keywords: TCA cycle • Bioblast editor: Cardoso LHD • O2k-Network Lab: HU Budapest Chinopoulos C

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Stress:Hypoxia 

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