Chinopoulos 2013 J Neurosci Res: Difference between revisions
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|abstract=The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the ฮฑ-ketoglutarate dehydrogenase complex dictating their directionalities. | |abstract=The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the ฮฑ-ketoglutarate dehydrogenase complex dictating their directionalities. | ||
|keywords=TCA cycle | |keywords=TCA cycle | ||
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|editor=Cardoso LHD | |editor=Cardoso LHD | ||
|mipnetlab=HU Budapest Chinopoulos C | |mipnetlab=HU Budapest Chinopoulos C | ||
}} | }} | ||
[[File:Chinopoulos 2013 J Neurosci Res CORRECTION.png|left|300px]] | |||
''Comment'': FAD is shown as FAD<sup>+</sup> - possibly by copying from NAD<sup>+</sup>. But FAD is neither charged nor a co-substrate comparable to NAD<sup>+</sup>, but it is a covalently bound prosthetic group in CII ([[Gnaiger 2023 MitoFit CII]]). | |||
{{Labeling | {{Labeling | ||
|injuries=Hypoxia | |injuries=Hypoxia | ||
|additional=MitoFit2022rTCA | |additional=MitoFit2022rTCA | ||
}} | }} | ||
Revision as of 14:49, 4 August 2023
| Chinopoulos C (2013) Which way does the citric acid cycle turn during hypoxia? The critical role of ฮฑ-ketoglutarate dehydrogenase complex. J Neurosci Res 91:1030-43. |
Chinopoulos Christos (2013) J Neurosci Res
Abstract: The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the ฮฑ-ketoglutarate dehydrogenase complex dictating their directionalities.
โข Keywords: TCA cycle
โข Bioblast editor: Cardoso LHD
โข O2k-Network Lab: HU Budapest Chinopoulos C
Comment: FAD is shown as FAD+ - possibly by copying from NAD+. But FAD is neither charged nor a co-substrate comparable to NAD+, but it is a covalently bound prosthetic group in CII (Gnaiger 2023 MitoFit CII).
Labels:
Stress:Hypoxia
MitoFit2022rTCA
