Chinopoulos 2013 J Neurosci Res: Difference between revisions
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|title=Chinopoulos C (2013) Which way does the citric acid cycle turn during hypoxia? The critical role of ฮฑ-ketoglutarate dehydrogenase complex. | |title=Chinopoulos C (2013) Which way does the citric acid cycle turn during hypoxia? The critical role of ฮฑ-ketoglutarate dehydrogenase complex. J Neurosci Res 91:1030-43. | ||
|info= [https://pubmed.ncbi.nlm.nih.gov/23378250/ PMID: 23378250 Open Access] | |info= [https://pubmed.ncbi.nlm.nih.gov/23378250/ PMID: 23378250 Open Access] | ||
|authors=Chinopoulos Christos | |authors=Chinopoulos Christos | ||
Revision as of 07:33, 3 April 2023
| Chinopoulos C (2013) Which way does the citric acid cycle turn during hypoxia? The critical role of ฮฑ-ketoglutarate dehydrogenase complex. J Neurosci Res 91:1030-43. |
Chinopoulos Christos (2013) J Neurosci Res
Abstract: The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the ฮฑ-ketoglutarate dehydrogenase complex dictating their directionalities. โข Keywords: TCA cycle โข Bioblast editor: Cardoso LHD โข O2k-Network Lab: HU Budapest Chinopoulos C
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Stress:Hypoxia
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