Difference between revisions of "Chinopoulos 2013 J Neurosci Res"
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|authors=Chinopoulos C | |authors=Chinopoulos C | ||
|year=2003 | |year=2003 | ||
|journal= | |journal=J Neurosci Res | ||
|abstract=The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the Ξ±-ketoglutarate dehydrogenase complex dictating their directionalities. | |abstract=The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the Ξ±-ketoglutarate dehydrogenase complex dictating their directionalities. | ||
|keywords=TCA cycle | |keywords=TCA cycle |
Revision as of 10:29, 14 March 2022
Chinopoulos C (2003) Which way does the citric acid cycle turn during hypoxia? The critical role of Ξ±-ketoglutarate dehydrogenase complex.. Journal of Neuroscience Research 91(8): 1030-43. |
Β» https://pubmed.ncbi.nlm.nih.gov/23378250/
Chinopoulos C (2003) J Neurosci Res
Abstract: The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the Ξ±-ketoglutarate dehydrogenase complex dictating their directionalities. β’ Keywords: TCA cycle β’ Bioblast editor: Cardoso LHD β’ O2k-Network Lab: HU Budapest Chinopoulos C
Labels:
Stress:Hypoxia