Complex I-linked substrate state: Difference between revisions

Latest revision as of 10:14, 2 November 2023

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Complex I-linked substrate state

Description

See N-pathway control state (previous: CI-linked) versus Complex I

Abbreviation: N

MitoPedia concepts: Respiratory state, SUIT state, Find

MitoPedia topics: EAGLE

SUITbrowser question: CI threshold

When studies indicate changes in complex I enzymatic activity, SUIT protocols can be applied to answer whether these changes in enzymatic activity reach the threshold of leading to alterations in the NADH electron transfer-pathway state (N).

The SUITbrowser can be used to find SUIT protocols for testing CI threshold, among other research questions.

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 {{MitoPedia
-|abbr=CI-linked
+|abbr=N
-|description=The '''Complex I-linked substrate state''' is induced in mt-preparations by addition of [[NADH]]-generating substrates individually or in combination: [[pyruvate]], [[glutamate]], [[malate]], [[oxoglutarate]], [[citrate]], [[hydroxybutyrate]]. These CI-linked substrates are (indirectly) linked to [[Complex I]] by the corresponding dehydrogenase-catalyzed reactions reducing NAD<sup>+</sup> to NADH+H<sup>+</sup>. In mt-preparations, CII may be largely substrate-limited in CI-linked respiration, due to metabolite depletion into the incubation medium.
+|description=''See'' '''[[N-pathway control state]]''' (previous: CI-linked) versus '''[[Complex I]]'''
-|info=[[Gnaiger 2014 MitoPathways]]
+}}
+{{MitoPedia concepts
+|mitopedia concept=Respiratory state, SUIT state, Find
 }}
-{{MitoPedia methods}}
 {{MitoPedia topics
-|mitopedia topic=Respiratory state, Respiratory substrate-coupling state, Substrate and metabolite
+|mitopedia topic=EAGLE
-}}
-= List of publications: CI-linked substrate state =
-{{#ask:[[Category:Publications]] [[Substrate states::CI]]
-|?Was published in year=Year
-|?Has title=Reference
-|?Mammal and model
-|?Tissue and cell
-|?Stress
-|?Diseases
-|format=broadtable
-|limit=5000
-|offset=0
-|sort=Was published in year
-|order=descending
 }}
+__TOC__
+== [[SUITbrowser]] question: CI threshold ==
+:::: When studies indicate changes in complex I enzymatic activity, [[SUIT]] protocols can be applied to answer whether these changes in enzymatic activity reach the threshold of leading to alterations in the NADH electron transfer-pathway state (N).
+:::: The [https://suitbrowser.oroboros.at/ SUITbrowser] can be used to find SUIT protocols for testing CI threshold, among other research questions.