DeLuca 1961 Proc Natl Acad Sci USA: Difference between revisions
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{{Publication | {{Publication | ||
|title=DeLuca HF, Engstrom GW (1961) Calcium uptake by rat kidney mitochondria. Proc Natl Acad Sci USA 47: 1744- | |title=DeLuca HF, Engstrom GW (1961) Calcium uptake by rat kidney mitochondria. Proc Natl Acad Sci USA 47:1744-50. | ||
|info=[http://www.ncbi.nlm.nih.gov/ | |info=[http://www.ncbi.nlm.nih.gov/pubmed/13885269 PMID: 13885269 Open Access] | ||
|authors=DeLuca HF, Engstrom GW | |authors=DeLuca HF, Engstrom GW | ||
|year=1961 | |year=1961 | ||
|journal=Proc Natl Acad Sci USA | |journal=Proc Natl Acad Sci USA | ||
|abstract=Rat kidney mitochondria take up large quantities of calcium by a process requiring ATP, magnesium ions, and an oxidizable substrate. Although the process requires ATP, it is not directly dependent upon oxidative phosphorylation or upon the operation of the entire electron transport chain. The rate of calcium uptake is not enhanced by vitamin D. It is inhibited strongly by dicumarol, antimycin A and 2,3-dimercaptopropanol and less strongly by phloridzin and p-chloromercuribenzoate, but not by dinitrophenol, azide, cyanide, oligomycin, and iodoacetate at the concentrations tested. The mitochondria apparently can bind about 15 calcium ions per molecule of ATP utilized. | |abstract=Rat kidney mitochondria take up large quantities of calcium by a process requiring ATP, magnesium ions, and an oxidizable substrate. Although the process requires ATP, it is not directly dependent upon oxidative phosphorylation or upon the operation of the entire electron transport chain. The rate of calcium uptake is not enhanced by vitamin D. It is inhibited strongly by dicumarol, antimycin A and 2,3-dimercaptopropanol and less strongly by phloridzin and p-chloromercuribenzoate, but not by dinitrophenol, azide, cyanide, oligomycin, and iodoacetate at the concentrations tested. The mitochondria apparently can bind about 15 calcium ions per molecule of ATP utilized. | ||
|keywords= | |keywords=Calcium, Mitochondria | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|organism= | |organism=Rat | ||
|tissues=Kidney | |tissues=Kidney | ||
|preparations=Isolated | |preparations=Isolated mitochondria | ||
|topics=Ion | |topics=ATP, Ion;substrate transport | ||
|additional=Made history | |additional=Made history | ||
}} | }} |
Latest revision as of 17:39, 23 November 2015
DeLuca HF, Engstrom GW (1961) Calcium uptake by rat kidney mitochondria. Proc Natl Acad Sci USA 47:1744-50. |
DeLuca HF, Engstrom GW (1961) Proc Natl Acad Sci USA
Abstract: Rat kidney mitochondria take up large quantities of calcium by a process requiring ATP, magnesium ions, and an oxidizable substrate. Although the process requires ATP, it is not directly dependent upon oxidative phosphorylation or upon the operation of the entire electron transport chain. The rate of calcium uptake is not enhanced by vitamin D. It is inhibited strongly by dicumarol, antimycin A and 2,3-dimercaptopropanol and less strongly by phloridzin and p-chloromercuribenzoate, but not by dinitrophenol, azide, cyanide, oligomycin, and iodoacetate at the concentrations tested. The mitochondria apparently can bind about 15 calcium ions per molecule of ATP utilized. โข Keywords: Calcium, Mitochondria
Labels:
Organism: Rat
Tissue;cell: Kidney
Preparation: Isolated mitochondria
Regulation: ATP, Ion;substrate transport
Made history