Glycerophosphate pathway control state

high-resolution terminology - matching measurements at high-resolution

Glycerophosphate pathway control state

Description

[[Description::

The glycerophosphate pathway control state (Gp) is an ET-pathway level 3 control state, supported by the fuel substrate glycerophosphate and electron transfer through glycerophosphate dehydrogenase complex into the Q-junction. The glycerolphosphate shuttle represents an important pathway, particularly in liver and blood cells, of making cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophos-phate dehydrogenase. On the outer face of the inner mitochondrial membrane, mitochondrial glycerophosphate dehydrogenase oxidises glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein donates its reducing equivalents to the electron transfer-pathway at the level of CoQ.]]

Abbreviation: Has abbr::Gp

Reference: [[Info::Electron transfer-pathway state, Gnaiger 2020 MitoPathways]]

MitoPedia concepts: Respiratory state, SUIT state, Recommended 

MitoPedia topics: MitoPedia topic::EAGLE 

Communicated by Gnaiger E 2016-01-25, edited 2016-11-19.

Details

Glycerophosphate oxidation is 10-fold higher in rabbit gracilis mitochondria (fast-twitch white muscle; 99% type IIb) compared to soleus (slow-twitch red muscle; 98% type I). Activity is comparatively low in human vastus lateralis. Glycerophosphate is an important substrate for respiration in brown adipose tissue mitochondria.

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{{#ask: Pathways::Gp |?Was published in year=Year |?Has title=Reference |?Coupling states=Coupling |?Pathways=Pathway |?Preparation=Preparation |?Mammal and model=Organism |?Tissue and cell=Tissue;cell |format=broadtable |limit=5000 |offset=0 |sort=Was published in year |order=descending }}

»Abstracts: Gp-pathway control state

Abstracts: Gp-pathway control state

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{{#ask: Pathways::Gp |?Was submitted in year=Year |?Has title=Reference |?Coupling states=Coupling |?Pathways=Pathway |?Preparation=Preparation |?Mammal and model=Organism |?Tissue and cell=Tissue;cell |format=broadtable |limit=5000 |offset=0 |sort=Was submitted in year |order=descending }}