Difference between revisions of "Greggio 2017 Cell Metab"
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{{Publication | {{Publication | ||
|title=Greggio C, Jha P, Kulkarni SS, Lagarrigue S, Broskey NT, Boutant M, Wang X, | |title=Greggio C, Jha P, Kulkarni SS, Lagarrigue S, Broskey NT, Boutant M, Wang X, Alonso SC, Ofori E, Auwerx J, Cantó C, Amati F (2017) Enhanced respiratory chain supercomplex formation in response to exercise in human skeletal muscle. Cell Metab 25:301-11. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/27916530 PMID: 27916530 Open Access]»[[File:O2k-brief.png|36px|link=http://wiki.oroboros.at/images/c/c1/Greggio_2017_Cell_Metabolism_O2k-brief.pdf |O2k-brief]] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/27916530 PMID: 27916530 Open Access]»[[File:O2k-brief.png|36px|link=http://wiki.oroboros.at/images/c/c1/Greggio_2017_Cell_Metabolism_O2k-brief.pdf |O2k-brief]] | ||
|authors=Greggio | |authors=Greggio Chiara, Jha Pooja, Kulkarni Sameer S, Lagarrigue Sylviane, Broskey Nicholas T, Boutant Marie, Wang Xu, Alonso Sonia Conde, Ofori Emmanuel, Auwerx Johan, Canto Alvarez Carles, Amati Francesca | ||
|year=2017 | |year=2017 | ||
|journal=Cell Metab | |journal=Cell Metab | ||
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|keywords=Aging, Electron transport chain, Endurance training, Exercise intervention, Human, Mitochondria, Pre-/post-design, Respiratory complex, Skeletal muscle, Supercomplex | |keywords=Aging, Electron transport chain, Endurance training, Exercise intervention, Human, Mitochondria, Pre-/post-design, Respiratory complex, Skeletal muscle, Supercomplex | ||
|editor=[[Kandolf G]] | |editor=[[Kandolf G]] | ||
|mipnetlab= | |mipnetlab=CH Lausanne Auwerx J, CH Lausanne Canto C | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
Revision as of 04:07, 1 March 2020
| Greggio C, Jha P, Kulkarni SS, Lagarrigue S, Broskey NT, Boutant M, Wang X, Alonso SC, Ofori E, Auwerx J, Cantó C, Amati F (2017) Enhanced respiratory chain supercomplex formation in response to exercise in human skeletal muscle. Cell Metab 25:301-11. |
Greggio Chiara, Jha Pooja, Kulkarni Sameer S, Lagarrigue Sylviane, Broskey Nicholas T, Boutant Marie, Wang Xu, Alonso Sonia Conde, Ofori Emmanuel, Auwerx Johan, Canto Alvarez Carles, Amati Francesca (2017) Cell Metab
Abstract: Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiovascular complications. Here, we investigated the effect of 4 months of exercise training on skeletal muscle mitochondria electron transport chain complexes and supercomplexes in 26 healthy, sedentary older adults. Exercise differentially modulated respiratory complexes. Complex I was the most upregulated complex and not stoichiometrically associated to the other complexes. In contrast to the other complexes, complex I was almost exclusively found assembled in supercomplexes in muscle mitochondria. Overall, supercomplex content was increased after exercise. In particular, complexes I, III, and IV were redistributed to supercomplexes in the form of I+III2+IV. Taken together, our results provide the first evidence that exercise affects the stoichiometry of supercomplex formation in humans and thus reveal a novel adaptive mechanism for increased energy demand.
Copyright © 2017 Elsevier Inc. All rights reserved. • Keywords: Aging, Electron transport chain, Endurance training, Exercise intervention, Human, Mitochondria, Pre-/post-design, Respiratory complex, Skeletal muscle, Supercomplex • Bioblast editor: Kandolf G • O2k-Network Lab: CH Lausanne Auwerx J, CH Lausanne Canto C
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style
Organism: Human
Tissue;cell: Skeletal muscle
Preparation: Permeabilized tissue
Enzyme: Complex I, Complex III, Complex IV;cytochrome c oxidase, Supercomplex
Coupling state: LEAK, OXPHOS, ET Pathway: N, NS, ROX HRR: Oxygraph-2k
Labels, 2017-10, BMI, VO2max
