Lemminger 2022 Antioxidants (Basel): Difference between revisions

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|title=Lemminger AK, Fiorenza M, Eibye K, Bangsbo J, Hostrup M (2022) High-intensity exercise training alters the effect of N-acetylcysteine on exercise-related muscle ionic shifts in men. https://doi.org/10.3390/antiox12010053
|title=Lemminger AK, Fiorenza M, Eibye K, Bangsbo J, Hostrup M (2022) High-intensity exercise training alters the effect of N-acetylcysteine on exercise-related muscle ionic shifts in men. https://doi.org/10.3390/antiox12010053
|info=Antioxidants (Basel) 12:53. [https://pubmed.ncbi.nlm.nih.gov/36670915 PMID: 36670915 Open Access]
|info=Antioxidants (Basel) 12:53. [https://pubmed.ncbi.nlm.nih.gov/36670915 PMID: 36670915 Open Access]
|authors=Lemminger AK, Fiorenza M, Eibye K, Bangsbo J, Hostrup M
|authors=Lemminger Anders K, Fiorenza Matteo, Eibye Kasper, Bangsbo Jens, Hostrup Morten
|year=2022
|year=2022
|journal=Antioxidants (Basel)
|journal=Antioxidants (Basel)
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{{Labeling
{{Labeling
|area=Respiration, Exercise physiology;nutrition;life style
|area=Respiration, Exercise physiology;nutrition;life style
|organism=Human
|tissues=Skeletal muscle
|preparations=Permeabilized tissue
|couplingstates=LEAK, OXPHOS, ET
|pathways=F, N, S, NS, ROX
|instruments=Oxygraph-2k
|instruments=Oxygraph-2k
|additional=2023-01
|additional=2023-01
}}
}}

Latest revision as of 13:23, 31 January 2023

Publications in the MiPMap
Lemminger AK, Fiorenza M, Eibye K, Bangsbo J, Hostrup M (2022) High-intensity exercise training alters the effect of N-acetylcysteine on exercise-related muscle ionic shifts in men. https://doi.org/10.3390/antiox12010053

ยป Antioxidants (Basel) 12:53. PMID: 36670915 Open Access

Lemminger Anders K, Fiorenza Matteo, Eibye Kasper, Bangsbo Jens, Hostrup Morten (2022) Antioxidants (Basel)

Abstract: This study investigated whether high-intensity exercise training alters the effect of N-acetylcysteine (a precursor of antioxidant glutathione) on exercise-related muscle ionic shifts. We assigned 20 recreationally-active men to 6 weeks of high-intensity exercise training, comprising three weekly sessions of 4-10 ร— 20-s all-out bouts interspersed by 2 min recovery (SET, n = 10), or habitual lifestyle maintenance (n = 10). Before and after SET, we measured ionic shifts across the working muscle, using leg arteriovenous balance technique, during one-legged knee-extensor exercise to exhaustion with and without N-acetylcysteine infusion. Furthermore, we sampled vastus lateralis muscle biopsies for analyses of metabolites, mitochondrial respiratory function, and proteins regulating ion transport and antioxidant defense. SET lowered exercise-related H+, K+, lactate-, and Na+ shifts and enhanced exercise performance by โ‰ˆ45%. While N-acetylcysteine did not affect exercise-related ionic shifts before SET, it lowered H+, HCO3-, and Na+ shifts after SET. SET enhanced muscle mitochondrial respiratory capacity and augmented the abundance of Na+/K+-ATPase subunits (ฮฑ1 and ฮฒ1), ATP-sensitive K+ channel subunit (Kir6.2), and monocarboxylate transporter-1, as well as superoxide dismutase-2 and glutathione peroxidase-1. Collectively, these findings demonstrate that high-intensity exercise training not only induces multiple adaptations that enhance the ability to counter exercise-related ionic shifts but also potentiates the effect of N-acetylcysteine on ionic shifts during exercise. โ€ข Keywords: NAC, ROS, Antioxidant, High-intensity training, Lactate, Oxygen species, pH, Performance, Potassium, Scavengers โ€ข Bioblast editor: Plangger M


Labels: MiParea: Respiration, Exercise physiology;nutrition;life style 


Organism: Human  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue 


Coupling state: LEAK, OXPHOS, ET  Pathway: F, N, S, NS, ROX  HRR: Oxygraph-2k 

2023-01 

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