Letts 2015 Curr Opin Struct Biol
| Letts JA, Sazanov LA (2015) Gaining mass: the structure of respiratory complex I-from bacterial towards mitochondrial versions. Curr Opin Struct Biol 33:135-45. doi: 10.1016/j.sbi.2015.08.008 |
Letts JA, Sazanov Leonid A (2015) Curr Opin Struct Biol
Abstract: The 1MDa, 45-subunit proton-pumping NADH-ubiquinone oxidoreductase (complex I) is the largest complex of the mitochondrial electron transport chain. The molecular mechanism of complex I is central to the metabolism of cells, but has yet to be fully characterized. The last two years have seen steady progress towards this goal with the first atomic-resolution structure of the entire bacterial complex I, a 5 Å cryo-electron microscopy map of bovine mitochondrial complex I and a ∼3.8 Å resolution X-ray crystallographic study of mitochondrial complex I from yeast Yarrowia lipotytica. In this review we will discuss what we have learned from these studies and what remains to be elucidated.
• Bioblast editor: Gnaiger E
Labels:
Organism: Bovines, Eubacteria
Enzyme: Complex I
