Difference between revisions of "Mayer 2019 Lipids"
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<small>© 2019 AOCS.</small> | <small>© 2019 AOCS.</small> | ||
|keywords=Fission, Fusion, Inflammation, Lung, Mitochondria, Resolvin | |keywords=Fission, Fusion, Inflammation, Lung, Mitochondria, Resolvin, Human alveolar epithelial A549 cells | ||
|editor=[[Plangger M]], | |editor=[[Plangger M]], | ||
|mipnetlab=DE Giessen Weissmann N | |mipnetlab=DE Giessen Weissmann N | ||
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|diseases=Other | |diseases=Other | ||
|organism=Human | |organism=Human | ||
|tissues=Lung;gill, Endothelial;epithelial;mesothelial cell | |tissues=Lung;gill, Endothelial;epithelial;mesothelial cell, Other cell lines | ||
|preparations=Intact cells | |preparations=Intact cells | ||
|couplingstates=LEAK, ROUTINE, ET | |couplingstates=LEAK, ROUTINE, ET | ||
|pathways=ROX | |pathways=ROX | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional= | |additional=2019-02, | ||
}} | }} | ||
Latest revision as of 10:18, 25 July 2019
| Mayer K, Sommer N, Hache K, Hecker A, Reiche S, Schneck E, Weissmann N, Seeger W, Hecker M (2019) Resolvin E1 improves mitochondrial function in human alveolar epithelial cells during severe inflammation. Lipids 54:53-65. |
Mayer K, Sommer N, Hache K, Hecker A, Reiche S, Schneck E, Weissmann N, Seeger W, Hecker M (2019) Lipids
Abstract: Severe inflammatory disorders such as sepsis are a major cause of morbidity and mortality worldwide. Mitochondrial dysfunction is regarded as a key feature involved in inflammation pathogenesis. In the present study, we investigated the impact of the omega-3 fatty acid-derived lipid mediator Resolvin E1 (RvE1) on mitochondrial function in experimental pulmonary inflammation. RvE1 was found to exert anti-inflammatory properties in human alveolar epithelial cells during severe inflammation. RvE1 is capable of restoring inflammation-induced mitochondrial dysfunction and the impaired imbalance of mitochondrial fission and fusion. Experimental inhibition of mitochondrial fission with Mdivi-1 in our model is associated with a significantly reduced inflammatory response and improved mitochondrial function. These findings suggest a novel functional mechanism for the beneficial effects of RvE1 in experimental pulmonary inflammatory reactions.
© 2019 AOCS. • Keywords: Fission, Fusion, Inflammation, Lung, Mitochondria, Resolvin, Human alveolar epithelial A549 cells • Bioblast editor: Plangger M • O2k-Network Lab: DE Giessen Weissmann N
Labels: MiParea: Respiration, mt-Structure;fission;fusion, mtDNA;mt-genetics, Pharmacology;toxicology
Pathology: Other
Organism: Human Tissue;cell: Lung;gill, Endothelial;epithelial;mesothelial cell, Other cell lines Preparation: Intact cells
Coupling state: LEAK, ROUTINE, ET
Pathway: ROX
HRR: Oxygraph-2k
2019-02
