MitoKit-CII

                

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MitoKit-CII

Description	Cell permeable compound - MitoKit-CII, 2 vials; 1 vial of NV118 (25 mg) + 1 vial of NV161 (10 mg)
Product ID	60200-01
Type	O2k
Link	MitoPedia: MitoFit-CII
Image

Compounds

The cell permeable compound MitoKit-CII is the first generation of NeuroVive Pharmaceutical AB's succinate/malonate prodrugs and was developed to stimulate and inhibit Complex II of the respiratory electron transfer system in intact cells, and will expand the toolbox for evaluating the role of mitochondria in disease.

Compounds of MitoKit-CII

The MitoKit-CII is composed of equal quantities of the following Compounds:

• Cell permeable compound NV118

Description: Succinate prodrug: C₁₀H₁₄O₈, Molecular weight 262,2g.mol^-1

Aliquots per 25 mg

• Cell permeable compound NV161

Description: Malonate prodrug: C₉H₁₂O₈, Molecular weight 248,2g.mol^-1

Aliquots per 10 mg

• Reference:

Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency. Nat Commun 7:12317. »Bioblast link« - Original publication introducing Mito-CII.

Preparation

• NV118: Dissolved in DMSO for 1M concentration and stored in aliquots at -20.
• NV161: ##.

Expiry date of MitoKit-CII compounds (according to NeuroVive)

Before preparation:

• 3 years in -80° C
• 1 year in -20° C

Prepared:

• In DMSO solution

• at room temperature: 24 hours.
• at -20° C: for weeks

CAS-Numbers:

• NV-118: 1592635-33-0
• NV-161: 1432752-62-9

Labels: MiParea: Instruments;methods 

HRR: O2k-Protocol 

O2k-chemicals and media