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Nitric oxide synthase
Description
Nitric oxide synthase, NOS, catalyzes the production of nitric oxide (NO•), which is a reactive nitrogen species. There are four types of NOS: neuronal NOS (nNOS), endothelial NOS (eNOS), inducible NOS (iNOS) and mitochondrial NOS (mtNOS).
Abbreviation: NOS
MitoPedia topics: Enzyme
mtNOS
The significance of mitochondrial nitric oxide synthase is debated. mtNOS presents two isoforms: a constitutive (c-mtNOS) and an inducible (i-mtNOS) isoform. In normal conditions, both isoforms contribute equally to the production of mitochondrial NO•. However, in an inflammatory process occurs an induction of mtNOS generating high amounts of NO•.
Ghafourifar P (1997) Nitric oxide synthase activity in mitochondria.
