Difference between revisions of "O2k-Innovation"
From Bioblast
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* '''Application''': 2015-01-30; '''Granted''': 2015-03-24 (total budget € 350.000). | * '''Application''': 2015-01-30; '''Granted''': 2015-03-24 (total budget € 350.000). | ||
* Funding: '''€ 140,000''' plus a bonus of '''€ 5,000''' for the implementation of gender sensitive actions. | * Funding: '''€ 140,000''' plus a bonus of '''€ 5,000''' for the implementation of gender sensitive actions. | ||
== The fourth dimension of respiratory control == | |||
# On the "line": one dimension is insufficient. | |||
# Substrate and coupling control are two necessarily connected dimensions defining the “area” of respiratory control. | |||
# Adding kinetics (including substrate kinetics of O<sub>2</sub>, CHO, adenylates, P<sub>i</sub>, and flux-force kinetics) is the third dimension bringing “volume” into the picture of classical mitochondrial respiratory control. | |||
# The NextGen-O2k on top of O2k-MultiSensor modules and the [[O2k-Fluorometer]] represent the fourth dimension of respiratory control, by adding analysis of functional variables (such as ROS production, mt-membrane potential, Ca<sup>2+</sup>, proton flux, cytochrome and NADH redox states, ATP production) to the measurement of O<sub>2</sub> and O<sub>2</sub>-flux in the same chamber. | |||
Revision as of 10:11, 28 July 2015
O2k-Innovation
- A project in progress
Tyrolean Government grant
- The project NextGen-O2k is supported by the "Technologieförderungsprogramm - Tiroler Innovationsförderung" of the Tyrolean Government.
- Project duration: 2015-02-01 to 2017-01-31.
- Partners: OROBOROS INSTRUMENTS, WGT Elektronik, software security networks.
- Application: 2015-01-30; Granted: 2015-03-24 (total budget € 350.000).
- Funding: € 140,000 plus a bonus of € 5,000 for the implementation of gender sensitive actions.
The fourth dimension of respiratory control
- On the "line": one dimension is insufficient.
- Substrate and coupling control are two necessarily connected dimensions defining the “area” of respiratory control.
- Adding kinetics (including substrate kinetics of O2, CHO, adenylates, Pi, and flux-force kinetics) is the third dimension bringing “volume” into the picture of classical mitochondrial respiratory control.
- The NextGen-O2k on top of O2k-MultiSensor modules and the O2k-Fluorometer represent the fourth dimension of respiratory control, by adding analysis of functional variables (such as ROS production, mt-membrane potential, Ca2+, proton flux, cytochrome and NADH redox states, ATP production) to the measurement of O2 and O2-flux in the same chamber.
Development of the NextGen-O2k: a look inside
- Different stages of prototype development: The NextGen-O2k is becoming more and more packed with two spectrofluorometers, two spectrophotometers, light guides, Peltier temperatue control with new heat pipes, microelectronics.