Q-junction: Difference between revisions

Latest revision as of 19:31, 25 August 2023

high-resolution terminology - matching measurements at high-resolution

Q-junction

Description

The Q-junction is a junction for convergent electron flow in the Electron transfer pathway (ET-pathway) from type N substrates and mt-matrix dehydrogenases through Complex I (CI), from type F substrates and FA oxidation through electron-transferring flavoprotein Complex (CETF), from succinate (S) through Complex II (CII), from glycerophosphate (Gp) through glycerophosphate dehydrogenase Complex (CGpDH), from choline through choline dehydrogenase, from dihydro-orotate through dihydro-orotate dehydrogenase, and other enzyme Complexes into the Q-cycle (ubiquinol/ubiquinone), and further downstream to Complex III (CIII) and Complex IV (CIV). The concept of the Q-junction, with the N-junction and F-junction upstream, provides the rationale for defining Electron-transfer-pathway states and categories of SUIT protocols.

Reference: Gnaiger 2009 Int J Biochem Cell Biol, Gnaiger 2020 BEC MitoPathways

MitoPedia concepts: MiP concept, SUIT concept

MitoPedia methods: Respirometry

MitoPedia topics: Enzyme

Contributed by Gnaiger E 2010-08-15; edited 2016-02-12, 2016-03-28.

Convergent NS-linked electron flow at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single N- and S-input pathways (upper panel: Gnaiger 2009; lower panel: Hatefi 1962 J Biol Chem-XLII). Modified Figure in Gnaiger 2020 BEC MitoPathways.

More details: »Respiratory Complexes - more than five

» O2k-Publications: Q-junction effect

Keywords

Bioblast links: Q - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

Coenzyme Q

» Coenzyme Q

» Quinone, Ubiquinone Q; oxidized

» Quinol, Ubiquinol QH₂; reduced

» Semiquinone

» Coenzyme Q2

» Q-redox state

» Q-pools

Mitochondrial pathways, respiratory Complexes, and Q

» Q-cycle

» Q-junction

» Convergent electron flow

» NS-pathway

» FNS

» FNSGp

» N-pathway

» Reverse electron flow from CII to CI

» CI

» Rotenone

» Amytal

» Piericidin

» S-pathway

» CII

» Malonate

» F-pathway

» CETF, Electron-transferring flavoprotein complex

» Gp-pathway

» CGpDH, Glycerophosphate dehydrogenase complex

» CIII

» Myxothiazol

» Choline dehydrogenase

» Dihydro-orotate dehydrogenase

NextGen-O2k and Q-Module

» NextGen-O2k

» Q-Module

» Q-Sensor

» Cyclic voltammetry

» Three-electrode system

General

» Categories of SUIT protocols

» Electron transfer pathway

» Electron-transfer-pathway state

» F-junction

» N-junction

SUITbrowser question: Q-junction

Several SUIT protocols can be used to answer questions on additivity, or convergence of electron flow to the Q-junction.

The SUITbrowser can be used to find the best SUIT protocols for different research questions, among those:

Q-junction (NS)
Q-junction (FNS)
Q-junction (FNSGp)

@@ Line 1: / Line 1: @@
 {{MitoPedia
 |description=[[File:SUIT-catg FNSGp.jpg|right|300px|Q-junction]]
-The '''Q-junction''' is a junction for [[convergent electron flow]] in the [[Electron transfer pathway]] (ET-pathway) from type N substrates and mt-matix dehydrogenases through [[Complex I]] (CI), from type F substrates and FA oxidation through [[electron-transferring flavoprotein complex]] (CETF),  from succinate (S) through [[Complex II]] (CII), from glycerophosphate (Gp) through [[glycerophosphate dehydrogenase complex]] (CGpDH), from choline through [[choline dehydrogenase]], from dihydro-orotate through [[dihydro-orotate dehydrogenase]], and other enzyme complexes into the Q-cycle (ubiquinol/ubiquinone), and further downstream to [[Complex III]] (CIII) and [[Complex IV]] (CIV). The concept of the Q-junction, with the [[N-junction]] and [[F-junction]] upstream, provides the rationale for defining [[Electron-transfer-pathway state]]s and [[categories of SUIT protocols]].
+The '''Q-junction''' is a junction for [[convergent electron flow]] in the [[Electron transfer pathway]] (ET-pathway) from type N substrates and mt-matrix dehydrogenases through [[Complex I]] (CI), from type F substrates and FA oxidation through [[electron-transferring flavoprotein Complex]] (CETF),  from succinate (S) through [[Complex II]] (CII), from glycerophosphate (Gp) through [[glycerophosphate dehydrogenase Complex]] (CGpDH), from choline through [[choline dehydrogenase]], from dihydro-orotate through [[dihydro-orotate dehydrogenase]], and other enzyme Complexes into the Q-cycle (ubiquinol/ubiquinone), and further downstream to [[Complex III]] (CIII) and [[Complex IV]] (CIV). The concept of the Q-junction, with the [[N-junction]] and [[F-junction]] upstream, provides the rationale for defining [[Electron-transfer-pathway state]]s and [[categories of SUIT protocols]].
-|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2014 MitoPathways]]
+|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2020 BEC MitoPathways]]
 }}
 {{MitoPedia concepts
@@ Line 18: / Line 18: @@
 [[File:Hatefi 1962 NS 2012.jpg|right|500px|Q-junction]]
-:::: Convergent [[NS-linked electron flow]] at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single N- and S-input pathways (upper panel: [[Gnaiger 2009 Int J Biochem Cell Biol |Gnaiger 2009]]; lower panel: [[Hatefi 1962 J Biol Chem-XLII]]). Modified Fig. 1.5 in [[Gnaiger 2014 MitoPathways]].
+:::: Convergent [[NS-linked electron flow]] at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single N- and S-input pathways (upper panel: [[Gnaiger 2009 Int J Biochem Cell Biol |Gnaiger 2009]]; lower panel: [[Hatefi 1962 J Biol Chem-XLII]]). Modified Figure in [[Gnaiger 2020 BEC MitoPathways]].
-:::: ''More details:'' [[Respiratory_complexes#Respiratory_complexes_-_more_than_five |»Respiratory complexes - more than five]]
+:::: ''More details:'' [[Respiratory_Complexes#Respiratory_Complexes_-_more_than_five |»Respiratory Complexes - more than five]]
 ::::» [[O2k-Publications: Q-junction effect]]
 <br /> <br /> <br /> <br /> <br /> <br />
-[[File:Questions.jpg|left|40px]]
+== Keywords ==
-<br />
+{{Template:Keywords: Q}}
-<div class="toccolours mw-collapsible mw-collapsed">
-::: <span style="font-size:105%; color:##424242">'''» Keywords'''</span>
-<div class="mw-collapsible-content">
-::: '''Specific'''
-::::» [[Complex III]]
-::::» [[Convergent electron flow]]
-::: '''General'''
-::::» [[Categories of SUIT protocols]]
-::::» [[Choline dehydrogenase]]
-::::» [[Complex I]]
-::::» [[Complex II]]
-::::» [[Dihydro-orotate dehydrogenase]]
-::::» [[Electron-transferring flavoprotein complex]]
-::::» [[Electron transfer pathway]]
-::::» [[F-junction]]
-::::» [[Glycerophosphate dehydrogenase complex]]
-::::» [[N-junction]]
-::::» [[NS-linked electron flow]]
-::::» [[Electron-transfer-pathway state]]s
-</div>
-</div>
-<br />
-== Related MitoPedia pages ==
-::* '''Electron transfer pathway, ET-pathway'''
-::::» [[Electron transfer pathway]]
-::::» [[Q-junction]]
-::* '''Electron-transfer-pathway state'''
-::::» [[Electron-transfer-pathway state]]
-::* '''Coupling control state ''E'''''
-::::[[File:E.jpg |link=ET-capacity]] [[ET-capacity]]
-::::» [[Noncoupled respiration]]
-::::» [[Uncoupler#Is_respiration_uncoupled_-_noncoupled_-_dyscoupled.3F |Is respiration uncoupled - noncoupled - dyscoupled?]]