Schofield 2004 Nat Rev Mol Cell Biol
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| Schofield CJ, Ratcliffe P (2004) Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 5:343-54. |
Schofield CJ, Ratcliffe P (2004) Nat Rev Mol Cell Biol
Abstract: The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man. Recent studies have shown that this factor is regulated by an unprecedented signalling mechanism that involves post-translational hydroxylation. This hydroxylation is catalysed by a set of non-haem, Fe2+-dependent enzymes that belong to the 2-oxoglutarate-dependent-oxygenase superfamily. The absolute requirement of these enzymes for molecular oxygen has provided new insights into the way cells sense oxygen.
Cited by
- Komlódi T, Schmitt S, Zdrazilova L, Donnelly C, Zischka H, Gnaiger E. Oxygen dependence of hydrogen peroxide production in isolated mitochondria and permeabilized cells. MitoFit Preprints (in prep).
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