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- Austvold 2024 Front Physiol + (Biological magnetic field sensing that giv โฆ Biological magnetic field sensing that gives rise to physiological responses is of considerable importance in quantum biology. The radical pair mechanism (RPM) is a fundamental quantum process that can explain some of the observed biological magnetic effects. In magnetically sensitive radical pair (RP) reactions, coherent spin dynamics between singlet and triplet pairs are modulated by weak magnetic fields. The resulting singlet and triplet reaction products lead to distinct biological signaling channels and cellular outcomes. A prevalent RP in biology is between flavin semiquinone and superoxide (O<sub>2</sub><sup>โขโ</sup>) in the biological activation of molecular oxygen. This RP can result in a partitioning of reactive oxygen species (ROS) products to form either O<sub>2</sub><sup>โขโ</sup> or hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). Here, we examine magnetic sensing of recombinant human electron transfer flavoenzyme (ETF) reoxidation by selectively measuring O<sub>2</sub><sup>โขโ</sup> and H<sub>2</sub>O<sub>2</sub> product distributions. ROS partitioning was observed between two static magnetic fields at 20ย nT and 50ย ฮผT, with a 13% decrease in H<sub>2</sub>O<sub>2</sub> singlet products and a 10% increase in O<sub>2</sub><sup>โขโ</sup> triplet products relative to 50ย ยตT. RPM product yields were calculated for a realistic flavin/superoxide RP across the range of static magnetic fields, in agreement with experimental results. For a triplet born RP, the RPM also predicts about three times more O<sub>2</sub><sup>โขโ</sup> than H<sub>2</sub>O<sub>2</sub>, with experimental results exhibiting about four time more O<sub>2</sub><sup>โขโ</sup> produced by ETF. The method presented here illustrates the potential of a novel magnetic flavoprotein biological sensor that is directly linked to mitochondria bioenergetics and can be used as a target to study cell physiology.ore O<sub>2</sub><sup>โขโ</sup> produced by ETF. The method presented here illustrates the potential of a novel magnetic flavoprotein biological sensor that is directly linked to mitochondria bioenergetics and can be used as a target to study cell physiology.)