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- Andriessen 2018 IOC130 + (Modern life is characterized by a 24-hours … Modern life is characterized by a 24-hours mentality in which people’s eating and sleeping behavior does not necessarily depend on the natural day and night rhythm (circadian rhythm). Both epidemiological- and intervention studies suggest that a disturbed circadian rhythm impairs metabolic health [1,2]. Indeed, a previous study showed that skeletal muscle oxidative phosphorylation in young lean males follows a circadian pattern [3]. However, it is currently not known if this pattern is disturbed in people with compromised metabolic health.</br></br>Overweight (BMI 25 – 35 kg/m<sup>2</sup>), prediabetic males, aged 40 – 70 years with a normal sleep-wake rhythm will be recruited for this observational study (n = 14). Participants will stay at the research unit for 44 hours, with standardized meals and sleeping time. Several measurements will be performed during this stay, including five muscle biopsies, indirect calorimetry using the ventilated hood, and several blood draws. Muscle biopsies will be used to assess skeletal muscle oxidative phosphorylation using high-resolution respirometry.ve phosphorylation using high-resolution respirometry.)
