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• Glutamate-aspartate carrier
  ...y [[uncoupling]]. [[Aminooxyacetate]] is an [[inhibitor]] of the glutamate-aspartate carrier.
  623 bytes (82 words) - 14:54, 25 July 2016
• Malate-aspartate shuttle
  |description=The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate^2- for 2 ::::* Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - [[Scaduto 1
  735 bytes (91 words) - 19:30, 1 January 2021
• Malate/aspartate shuttle
  #REDIRECT [[Malate-aspartate shuttle]]
  38 bytes (3 words) - 07:56, 17 December 2018

Page text matches

• Glutamate-aspartate carrier
  ...y [[uncoupling]]. [[Aminooxyacetate]] is an [[inhibitor]] of the glutamate-aspartate carrier.
  623 bytes (82 words) - 14:54, 25 July 2016
• Malate/aspartate shuttle
  #REDIRECT [[Malate-aspartate shuttle]]
  38 bytes (3 words) - 07:56, 17 December 2018
• Malate-aspartate shuttle
  |description=The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate^2- for 2 ::::* Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - [[Scaduto 1
  735 bytes (91 words) - 19:30, 1 January 2021
• Scaduto 1994 Eur J Biochem
  |title=Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. ...timulation of the mitochondrial oxidation of cytosolic NADH via the malate/aspartate cycle.
  2 KB (319 words) - 07:52, 17 December 2018
• Wiesner 1988 Biochim Biophys Acta
  ...eutzer U, Rösen P, Grieshaber MK (1988) Subcellular distribution of malate-aspartate cycle intermediates during normoxia and anoxia in the heart. Biochim Biophy ...itochondria is supported by the glutamate gradient and by a high glutamate/aspartate ratio inside the mitochondria (Glu/Asp = 15) which is maintained by the ene
  2 KB (276 words) - 12:46, 7 May 2019
• Oxoglutarate
  ...as part of the [[malate-aspartate shuttle]]. In the cytosol, oxoglutarate+aspartate are transaminated to form oxaloacetate+glutamate. Cytosolic malate dehydrog
  1 KB (142 words) - 09:38, 11 September 2020
• Altinok 2019 J Cell Physiol
  ...io JL, Stein DE, Bowne WB, Shieh AC, Snyder NW, Orynbayeva Z (2019) Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria. J Cell Physiol 235:25 ...glycolysis and oxidative phosphorylation. We demonstrated that the malate-aspartate shuttle exerts control over NAD⁺/NADH homeostasis to maintain ac
  2 KB (281 words) - 20:36, 7 March 2020
• Gellerich 2009 PLoS One
  ...tochondrial function. This regulation involves the mitochondrial glutamate/aspartate carrier aralar which controls mitochondrial substrate supply according to t |keywords=Glutamate/aspartate carrier aralar, Extramitochondrial Ca (2+), Brain mitochondria
  2 KB (270 words) - 09:28, 7 May 2020
• Profilo 2017 Biochim Biophys Acta
  ...onti B, Palmieri F, Lasorsa FM (2017) Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylasparta ...energetic deficit due to AGC1 impairment is associated with inappropriate aspartate levels to support neuronal proliferation when glutamine is not used as meta
  3 KB (418 words) - 16:44, 3 May 2024
• Digerness 1976 J Mol Cell Cardiol
  |title=Digerness SB, Reddy WJ (1976) The malate-aspartate shuttle in heart mitochondria. J Mol Cell Cardiol 8:779-85.
  310 bytes (39 words) - 17:00, 16 January 2021
• McKenna 1995 Neurochem Res
  ...te, but competitively at high concentrations of malate. Both glutamate and aspartate decreased the activity of mitochondrial malic enzyme, but also increased th ...nzyme, Malate, Astrocyte, Ketoglutarate, Oxoglutarate, Citrate, Glutamate, Aspartate, Anaplerosis
  3 KB (356 words) - 12:23, 27 July 2014
• Gellerich 2012 Biochem J
  ...of isolated brain mitochondria by formation of pyruvate through the malate-aspartate shuttle. Biochem J 443:747-55. ...rmation of pyruvate by lactate dehydrogenase (LDH) is linked to the malate-aspartate shuttle (MAS) with aralar as a central component. A rise of Ca2+cyt in a re
  2 KB (320 words) - 10:46, 13 March 2015
• Valis 2017 Oncotarget
  ...blockade of mitochondrial complex I and II activity by QB and reduction in aspartate and folate metabolism as therapeutic targets in T-ALL cells. Anti-cancer ac
  2 KB (346 words) - 18:31, 31 January 2020
• Oxaloacetate
  ...e, or with [[glutamate]] through transaminase to form [[oxoglutarate]] and aspartate. Oa transport is restricted across the inner [[mitochondrial|mt]]-membrane
  725 bytes (96 words) - 19:31, 1 January 2021
• Jespersen 2017 J Physiol
  ...) Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion. J Phy ...haemic administration of aminooxyacetate (AOA), an inhibitor of the malate-aspartate shuttle (MAS), provides cardioprotection against IR injury, although the un
  3 KB (379 words) - 17:33, 25 February 2020
• Oakey 2019 Wellcome Open Res
  ...ese metabolic consequences. However, the functional relevance of increased aspartate levels after NAD⁺ depletion remains unclear, and requires furthe |keywords=NAD+, NAMPT, NR, Aspartate, Isotopic tracing, Metabolism, Skeletal muscle
  3 KB (431 words) - 15:39, 16 October 2019
• PGM-pathway control state
  ...nd reacts with [[oxaloacetate]] in the [[transaminase]] reaction to form [[aspartate]] and [[oxoglutarate]]. Glutamate as the sole substrate is transported by t
  3 KB (316 words) - 13:14, 2 August 2023
• George 2015 BA Thesis
  ...d that the two shuttles are necessarily interconnected in a lactate-malate-aspartate shuttle. We hypothesized that experimental support for robust mitochondrial
  3 KB (336 words) - 16:41, 7 November 2016
• Molinie 2022 Biochim Biophys Acta Bioenerg
  ...etabolically produced in the cytosol involves redox shuttles as the malate-aspartate shuttle (MAS) and is of paramount importance for cell fate. However, the sp |keywords=Bioenergetics, MDH2, Malate aspartate shuttle, Mitochondria, NADH redox homeostasis, Oxaloacetate, Respirasomes,
  2 KB (325 words) - 18:20, 14 March 2022
• Glutamate
  ...er]] and reacts with [[oxaloacetate]] in the transaminase reaction to form aspartate and [[oxoglutarate]]. Glutamate as the sole substrate is transported by the
  3 KB (352 words) - 09:26, 4 July 2023
• Wang H 2019 J Biol Chem
  ...hrough the bottom portion of the TCA cycle while accumulating pyruvate and aspartate that rescue their redox defects.
  3 KB (397 words) - 18:52, 7 September 2023
• Gellerich 2010 Biochim Biophys Acta
  ...ings of Satrustegui and Palmieri showing that aralar as part of the malate-aspartate shuttle is involved in the Ca²⁺-dependent transport of reducing
  3 KB (427 words) - 09:29, 7 May 2020
• Herbst 2016 Appl Physiol Nutr Metab
  ...oxidation is enhanced with acute exercise through activation of the malate-aspartate shuttle.
  1 KB (173 words) - 17:24, 7 November 2016
• Szibor 2020 J Biol Chem
  ...from the cytosol to the mitochondria. Here, we studied the role of malate aspartate shuttle (MAS)-dependent substrate supply on OXPHOS responses to changing Ca |keywords=Bioenergetics, Calcium, Malate-aspartate shuttle, Mitochondria, Mitochondrial calcium uniporter, Mouse, Respiratory
  3 KB (459 words) - 10:11, 8 June 2020
• Rej 1993 Arch Pathol Lab Med
  ...e. Multivariate display techniques are applied to the specific examples of aspartate aminotransferase, alpha-amylase, and alkaline phosphatase to judge the comm
  2 KB (254 words) - 11:53, 26 January 2021
• Russell 1991 Am J Physiol
  ...ing acetoacetate alone. Measurements of the specific activities of malate, aspartate, and citrate confirm inhibition of both pyruvate carboxylation and malate o
  2 KB (270 words) - 14:53, 4 March 2015
• Schnaitman 1968 J Cell Biol
  ...rogenase, NAD- and NADH-isocitrate dehydrogenase, glutamate dehydrogenase, aspartate aminotransferase, and ornithine transcarbamoylase were found in the inner m
  2 KB (280 words) - 12:17, 28 May 2015
• Wahrheit 2015 Eng Life Sci
  ...n of pyruvate metabolization was accomplished by feeding both pyruvate and aspartate simultaneously. The presented high-throughput respiration screening provide
  2 KB (282 words) - 16:57, 7 November 2016
• Juhasz 2017 MiPschool Obergurgl
  |title=[[File:Juhasz L.jpg|left|90px]] Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in ...ondrial dysfunction and depleted energy supplies [1]. Recently, N-methyl-D-aspartate receptor (NMDA-R)-mediated increase in intracellular calcium (Ca^{2+</su
  4 KB (555 words) - 13:33, 28 March 2018
• Trumbeckaite 2013 Mitochondrion
  ...the immunosuppressive CsA analogue [D-Ser](8)CsA, and MK 801, a N-methyl-D-aspartate (NMDA) receptor antagonist. OGD/reperfusion reduced the glutamate/malate de
  2 KB (256 words) - 16:19, 13 November 2017
• Lemasters 1984 J Biol Chem
  ...s malate is then accounted for by proton translocation linked to glutamate/aspartate exchange. The data suggest a new 13-proton scheme of chemiosmotic coupling
  2 KB (286 words) - 14:54, 7 February 2022
• Dias 2016 Neurobiol Aging
  ...(•)NO concentration dynamics revealed a significant increase in N-methyl-D-aspartate type receptor-evoked peak (•)NO in the 3xTgAD model at an early age. Agin
  2 KB (289 words) - 18:05, 12 July 2019
• Du 2015 J Biol Chem
  ...regulation of the activities of alpha-ketoglutarate dehydrogenase and the aspartate-glutamate carrier 1. In addition, a comprehensive analysis of the retinal m
  2 KB (294 words) - 13:17, 10 March 2020
• Gellerich 2013 Abstract MiP2013
  ...p>2+}_cyt we detected that pyruvate formation by the malate aspartate shuttle (MAS) is tightly controlled by Ca²⁺_cyt [6,7]. ...of isolated brain mitochondria by formation of pyruvate through the malate-aspartate shuttle. Biochem J 443: 747-755.
  7 KB (1,002 words) - 11:12, 28 April 2017
• Kumar 2021 J Biol Chem
  ...everse. Under these conditions, the purine nucleotide cycle and the malate aspartate shuttle furnish fumarate, which supports complex II reversal and leads to s
  2 KB (358 words) - 23:32, 23 April 2023
• Yu 2023 Biochim Biophys Acta Bioenerg
  ...rown adipose tissue (IBAT) directed at the effect of OAA transamination to aspartate (catalyzed by the mitochondrial form of glutamic-oxaloacetic transaminase,
  3 KB (357 words) - 07:22, 28 February 2023
• Sridharan 2008 Am J Physiol Cell Physiol
  ...ctive. The source of fumarate for this unusual respiration is derived from aspartate via the purine nucleotide cycle. In sum, these studies show that the O<sub>
  3 KB (357 words) - 23:36, 13 February 2022
• Cardoso 2022 MitoFit rTCA
  ...and simultaneous utilization of several fermentable substrates ― including aspartate and glutamate (Hochachka, Somero 1984) ― exert profound implications on t
  2 KB (349 words) - 10:00, 26 February 2022
• Agil 2015 J Pineal Res
  ...ic function was evaluated by measurement of serum alanine transaminase and aspartate transaminase levels, liver histopathology and electron microscopy, and hepa
  3 KB (337 words) - 08:04, 21 February 2020
• Jezek 2018 Antioxid Redox Signal
  ...lay a major role in cell physiology and pathology. Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter meta
  3 KB (346 words) - 18:40, 16 January 2021
• Fink 2021 Pharmacol Res Perspect
  ...vels but did not improve liver function as marked by circulating levels of aspartate and alanine aminotransferase (ALT). In summary, our results for HF-fed rats
  2 KB (363 words) - 22:21, 12 February 2021
• Adant 2022 Mol Metab
  ...ked to an NAD+/NADH imbalance including depletion of TCA intermediates and aspartate, and increased levels of glycerol-3-phosphate. Supplementation with pyruvat
  3 KB (368 words) - 16:14, 10 August 2022
• Kucera 2011 Int J Exp Pathol
  ...eoxyuridine [BrdU] incorporation). Activities of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase and concentration of serum biliru
  2 KB (365 words) - 10:34, 18 March 2020
• Tartaro 2015 Transplant Proc
  In groups CG and IG, aspartate aminotransferase and alanine aminotransferase enzymes were elevated in comp
  3 KB (361 words) - 15:06, 25 February 2019
• Halbrook 2022 Nat Cancer
  ...s asparagine during limited respiration indirectly supports maintenance of aspartate pools, a rate-limiting biosynthetic precursor. Conversely, depletion of ext
  2 KB (358 words) - 19:14, 24 November 2022
• Diana 2015 Surg Innov
  ...ntly after 1 hour (ROI 1 vs ROI 3ab). Seven metabolites (lactate, glucose, aspartate, choline, creatine, taurine, and tyrosine) expressed significantly differen
  2 KB (351 words) - 20:26, 7 March 2020
• Weidinger 2013 Front Physiol
  ...resulting in the release of alanine aminotransferase (ALT). The leakage of aspartate aminotransferase (AST) was observed only during the hypoxic phase in the HO
  3 KB (402 words) - 16:54, 7 November 2016
• Weidinger 2015 Antioxid Redox Signal
  ...s in blood and plasma, and markers of organ damage (lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase). In cultured hepatocytes, t
  3 KB (385 words) - 16:31, 13 November 2017
• Yan 2019 Int Immunopharmacol
  ...ival rate, liver histopathologic score, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, respiration control ratio (RCR), and FUDNC1,
  3 KB (394 words) - 15:09, 21 March 2019
• Gellerich 2008 J Biol Chem
  ...up>2+</sup> binding sites on the mitochondrial surface, e.g. the glutamate/aspartate carrier (aralar), mediate this regulation. Interactions between htt51Q and
  3 KB (427 words) - 14:58, 8 June 2015

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