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A list of all pages that have property "Has abstract" with value "Pioglitazone (Pio) is known to improve insulin sensitivity in skeletal muscle. However, the role of Pio on skeletal muscle lipid metabolism and skeletal muscle oxidative capacity is not clear. The purpose of this study was to determine the effects of 12 weeks of pioglitazone treatment on insulin sensitivity measured by hyperinsulinemic euglycemic clamp, intramyocellular lipid content (IMCL) measured by proton magnetic resonance spectroscopy, metabolic flexibility measured by calculating delta RQ during the steady state of the clamp and muscle maximal ATP synthesis capacity (ATPmax) measured by 31P Magnetic Resonance Spectroscopy. Twenty-four participants with type 2 diabetes (13M/11F 53.38 2.1 years; BMI 36.471.1) were randomized to either a placebo (n=8) or a Pio (n=16) group. After 12 weeks of Pio treatment, there was an increase in insulin sensitivity (Placebo 2.2% vs. Pio 90.1% increase; ''p''=< 0.05) and an increase in metabolic flexibility (delta RQ; Placebo 0.0630.01 to 0.0330.01; ''p''=0.02 vs. Pio 0.0610.01 to 0.0880.02; ''p''=0.03). Pio treatment decreased plasma free fatty acids (Placebo vs. Pio 16% increase vs. -7.7% decrease; ''p''=0.04) and IMCL content in ''Gastrocnemius'' (Placebo -1.1% vs. Pio -56.5% decrease, ''p''=0.005), ''Soleus'' (Placebo -0.4% vs. Pio -21.8% decrease, ''p''<0.05) and ''Tibialis anterior'' muscle (Placebo -1.1% vs. Pio -39.5% decrease, ''p''=0.003). There was no change in ATPmax after Pio treatment (Placebo 15.8% vs. Pio 6.1%, ''p''=0.6). These results suggest that 12 weeks of pioglitazone treatment improves insulin sensitivity, metabolic flexibility and lipid utilization independent of any improvement in maximal ATP synthesis capacity in skeletal muscle.". Since there have been only a few results, also nearby values are displayed.

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Bajpeyi 2015 Abstract MiPschool Cape Town 2015 + (Pioglitazone (Pio) is known to improve ins … Pioglitazone (Pio) is known to improve insulin sensitivity in skeletal muscle. However, the role of Pio on skeletal muscle lipid metabolism and skeletal muscle oxidative capacity is not clear. </br></br>The purpose of this study was to determine the effects of 12 weeks of pioglitazone treatment on insulin sensitivity measured by hyperinsulinemic euglycemic clamp, intramyocellular lipid content (IMCL) measured by proton magnetic resonance spectroscopy, metabolic flexibility measured by calculating delta RQ during the steady state of the clamp and muscle maximal ATP synthesis capacity (ATPmax) measured by 31P Magnetic Resonance Spectroscopy. Twenty-four participants with type 2 diabetes (13M/11F 53.38 2.1 years; BMI 36.471.1) were randomized to either a placebo (n=8) or a Pio (n=16) group. After 12 weeks of Pio treatment, there was an increase in insulin sensitivity (Placebo 2.2% vs. Pio 90.1% increase; ''p''=< 0.05) and an increase in metabolic flexibility (delta RQ; Placebo 0.0630.01 to 0.0330.01; ''p''=0.02 vs. Pio 0.0610.01 to 0.0880.02; ''p''=0.03). Pio treatment decreased plasma free fatty acids (Placebo vs. Pio 16% increase vs. -7.7% decrease; ''p''=0.04) and IMCL content in ''Gastrocnemius'' (Placebo -1.1% vs. Pio -56.5% decrease, ''p''=0.005), ''Soleus'' (Placebo -0.4% vs. Pio -21.8% decrease, ''p''<0.05) and ''Tibialis anterior'' muscle (Placebo -1.1% vs. Pio -39.5% decrease, ''p''=0.003). There was no change in ATPmax after Pio treatment (Placebo 15.8% vs. Pio 6.1%, ''p''=0.6). These results suggest that 12 weeks of pioglitazone treatment improves insulin sensitivity, metabolic flexibility and lipid utilization independent of any improvement in maximal ATP synthesis capacity in skeletal muscle.ximal ATP synthesis capacity in skeletal muscle.)

Bajpeyi 2015 Abstract MiPschool Cape Town 2015 +