Walker 1994 Curr Opin Struct Biol
From Bioblast
| Walker JE (1994) The regulation of catalysis in ATP synthase. Curr Opin Struct Biol 4:912-8. |
Walker JE (1994) Curr Opin Struct Biol
Abstract: ATP synthase is regulated so as to prevent futile hydrolysis of ATP when the transmembrane proton electrochemical gradient, delta mu H+, falls. Mitochondria and chloroplasts have different mechanisms for inhibition of ATP synthase: by binding an inhibitor protein, and by stabilization of the ADP-inhibited state by making an intramolecular disulphide bond, respectively. The recently determined structure of bovine F1-ATPase is locked in a conformation that probably represents the ADP-inhibited state of the enzyme.
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