Gnaiger 2015 Scand J Med Sci Sports

[[Has title::Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. https://doi.org/10.1111/sms.12612]]

» [[Has info::Scand J Med Sci Sports 25 (Suppl 4):126–34. PMID: 26589126 Open Access »]]

Was written by::Gnaiger Erich, Was written by::Boushel R, Was written by::Soendergaard H, Was written by::Munch-Andersen T, Was written by::Damsgaard R, Was written by::Hagen C, Was written by::Diez-Sanchez C, Was written by::Ara I, Was written by::Wright-Paradis C, Was written by::Schrauwen P, Was written by::Hesselink M, Was written by::Calbet Jose AL, Was written by::Christiansen M, Was written by::Helge JW, Was written by::Saltin Bengt (Was published in year::2015) Was published in journal::Scand J Med Sci Sports

Abstract: [[has abstract::O2k-in brief

During evolution, mtDNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fibre type and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from V_O2max and maximum capacities of oxidative phosphorylation.

]] • Keywords: has publicationkeywords::BMI, has publicationkeywords::VO2max • Bioblast editor: [[has editor::Gnaiger E]] • O2k-Network Lab: Was published by MiPNetLab::AT Innsbruck Gnaiger E, Was published by MiPNetLab::AT Innsbruck Oroboros, Was published by MiPNetLab::CA Vancouver Boushel RC, Was published by MiPNetLab::NL Maastricht Schrauwen P, Was published by MiPNetLab::DK Copenhagen Christiansen M, Was published by MiPNetLab::ES CN Las Palmas Calbet JAL

SUIT protocol

• • • • 1OctM;2D;3G;4S;5Rot;6Omy;7U-

Greenland expedition CMRC: science and adventure

» Greenland Expedition CMRC

» The Saltin Symposium: Exercise and Integrative Physiology (2015)

MitoEAGLE V_O2max/BME database

• Human vastus lateralis
• 8 females & 8 males
• 31 years
• Active; Danes, baseline control in Copenhagen
• H = 1.75 m
• M = 74.5 kg
• BME = 0.19
• BMI = 24.3 kg·m^-2
• V_O2max/M = 48.0 mL·min^-1·kg^-1
• Permeabilized muscle fibres; 30 °C; GMS_P; m_w; conversions: Gnaiger 2009 Int J Biochem Cell Biol
• J_O2,P(NS) = 90.5 µmol·s^-1·kg^-1 wet muscle mass (37 °C)

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Bengt Saltin - a Gentle Scientist

Additional references

• Marconi C, Marzorati M, Cerretelli P (2006) Work capacity of permanent residents of high altitude. High Alt Med Biol 7:105-115. - »Bioblast link«
• Tam E, Bruseghini P, Calabria E, Sacco LD, Doria C, Grassi B, Pietrangelo T, Pogliaghi S, Reggiani C, Salvadego D, Schena F, Toniolo L, Verratti V, Vernillo G, Capelli C (2015) Gokyo Khumbu/Ama Dablam Trek 2012: effects of physical training and high-altitude exposure on oxidative metabolism, muscle composition, and metabolic cost of walking in women. Eur J Appl Physiol. - »Bioblast link«

O2k-brief

» List of O2k-Publications presented as O2k-brief

MitoFit news 2015#18

• 2015-11-25: Performance tests on skeletal muscle mitochondria of the Inuit haplogroup reveal fitness information beyond the uncoupling hypothesis for adaptations to the arctic climate. » MitoFit news - a contribution to K-Regio MitoFit.

References: BME and VO2max

» VO2max

{{#ask: Additional label::BME Additional label::VO2max |?Has title=Reference |format=broadtable |limit=5000 |offset=0 |order=ascending }}

MitoPedia: BME and mitObesity

» Body mass excess and mitObesity | BME and mitObesity news | Summary | {{#ask:Additional label::MitoPedia:BME | mainlabel=Term |?Has abbr=Abbreviation |?Description=Description |format=broadtable |limit=5000 |order=ascending }}

Cited by

• 13 articles in PubMed (2021-12-27) https://pubmed.ncbi.nlm.nih.gov/26589126/

Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5^th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002

Labels: MiParea: MiP area::Respiration, MiP area::mt-Biogenesis;mt-density, MiP area::mtDNA;mt-genetics, MiP area::Comparative MiP;environmental MiP, MiP area::Gender, MiP area::Exercise physiology;nutrition;life style 

Stress:Injury and adaptation::Temperature  Organism: Organism::Human  Tissue;cell: tissue and cell::Skeletal muscle  Preparation: Preparation::Permeabilized tissue  Enzyme: Enzyme::Marker enzyme, Enzyme::TCA cycle and matrix dehydrogenases  Regulation: Topic::Coupling efficiency;uncoupling, Topic::Cyt c  Coupling state: Coupling states::LEAK, Coupling states::OXPHOS, Coupling states::ET  Pathway: Pathways::F, Pathways::N, Pathways::S, Pathways::ROX  HRR: Instrument and method::Oxygraph-2k, Instrument and method::O2k-Protocol 

additional label::MitoFitPublication, additional label::VO2max, additional label::BMI, additional label::BME, additional label::1OctM;2D;3G;4S;5Rot;6Omy;7U-, additional label::SUIT-016, additional label::SUIT-016 O2 pfi D044, additional label::MitoEAGLE BME, additional label::O2k-brief, additional label::BEC 2020.2