Template:SUIT-009 AmR mt D021: Difference between revisions
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| S<sub>''L''</sub> or S_L: Succinate, S-LEAK respiration, S<sub>''L''</sub> | | S<sub>''L''</sub> or S_L: Succinate, S-LEAK respiration, S<sub>''L''</sub> | ||
{{Template:SUIT S}} {{Template:SUIT L n}} | {{Template:SUIT S}} {{Template:SUIT L(n)}} | ||
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Revision as of 08:28, 25 January 2019
Step | State | Pathway | Q-junction | Comment - Events (E) and Marks (M) |
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0DTPA |
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0SOD |
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0HRP |
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0AmR |
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Step | State | Pathway | Q-junction | Comment - Events (E) and Marks (M) |
---|---|---|---|---|
1S | SL | S | CII | SL or S_L: Succinate, S-LEAK respiration, SL
Succinate, S ( type S-pathway to Q). Non-phosphorylating resting state (LEAK state); LEAK respiration L(n) in the absence of ADP, ATP, AMP (no adenylates). |
2D | SP | S | CII | 1S;2D
Succinate, S ( type S-pathway to Q). OXPHOS capacity P (with saturating [ADP]), active OXPHOS state. |
3P | NSP | NS | CI&II | 1S;2D;3P
NADH-linked substrates (type N-pathway to Q). & Succinate, S ( type S-pathway to Q). Respiratory stimulation by simultaneous action of type N substrates & succinate, with convergent electron flow in the NS-pathway for reconstitution of TCA cycle function. OXPHOS capacity P (with saturating [ADP]), active OXPHOS state. |
4Rot | SP | S | CII | 1S;2D;3P;4Rot
Succinate, S ( type S-pathway to Q). OXPHOS capacity P (with saturating [ADP]), active OXPHOS state. Succinate pathway control state (S-pathway) after inhibiting CI with rotenone, which also inhibits the F-pathway.
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6Ama | ROX | Rox is the residual oxygen consumption in the ROX state, due to oxidative side reactions, estimated after addition of antimycin A (inhibitor of CIII). Rox is subtracted from oxygen flux as a baseline for all respiratory states, to obtain mitochondrial respiration (mt). |
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- Coupling control
- Pathway control
- ยป Electron transfer pathway
- ยป Fatty acid oxidation pathway control state, F
- ยป NADH electron transfer-pathway state, N
- ยป Succinate pathway control state, S
- ยป NS-pathway control state, NS
- ยป Glycerophosphate pathway control state, Gp
- ยป Complex IV single step, CIV
- ยป Anaplerotic pathway control state
- Pathway control
- Main fuel substrates
- ยป Glutamate, G
- ยป Glycerophosphate, Gp
- ยป Malate, M
- ยป Octanoylcarnitine, Oct
- ยป Pyruvate, P
- ยป Succinate, S
- Main fuel substrates
- Glossary