E-R control efficiency

high-resolution terminology - matching measurements at high-resolution

E-R control efficiency

Description

The apparent ET-reserve control efficiency (E-R control efficiency), j_E-R = (E-R)/E = 1-R/E, is an expression of the relative scope of increasing ROUTINE respiration in living cells by uncoupling. j_E-R = 0.0 for zero excess capacity when R=E; j_E-R = 1.0 for the maximum limit when R=0. The ROUTINE state of living cells is stimulated to electron transfer pathway by uncoupler titration, which yields the ET-reserve capacity E-R. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by cell ergometry), j_E-R is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve) for uncoupling respiration. Similarly, the apparent ET-excess capacity E-P is not a respiratory reserve in the sense of oxidative phosphorylation.

Abbreviation: j_E-R

Reference: Flux control efficiency

Compare

» ROUTINE-control ratio R/E

» ET-excess coupling efficiency E-P, j_E-P = (E-P)/E = 1-P/E

» ET-coupling efficiency E-L, j_E-L = 1-L/E

MitoPedia concepts: Respiratory control ratio