Gnaiger 2015 Scand J Med Sci Sports: Difference between revisions

Revision as of 16:08, 4 September 2016

[[Has title::Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34.]]

» [[Has info::PMID: 26589126 Open Access]]

Was written by::Gnaiger E, Was written by::Boushel R, Was written by::Søndergaard H, Was written by::Munch-Andersen T, Was written by::Damsgaard R, Was written by::Hagen C, Was written by::Díez-Sánchez C, Was written by::Ara I, Was written by::Wright-Paradis C, Was written by::Schrauwen P, Was written by::Hesselink M, Was written by::Calbet JA, Was written by::Christiansen M, Was written by::Helge JW, Was written by::Saltin B (Was published in year::2015) Was published in journal::Scand J Med Sci Sports

Abstract: [[has abstract::

File:NFS 1OctM 2D 3G 4S 5Rot 6Omy 7U 8c.jpg

During evolution, mtDNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fibre type and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from V_O2max and maximum capacities of oxidative phosphorylation.

» SUIT protocol: SUIT FNS(GM)01]]

• O2k-Network Lab: Was published by MiPNetLab::AT Innsbruck Gnaiger E, Was published by MiPNetLab::AT Innsbruck OROBOROS, Was published by MiPNetLab::CA Vancouver Boushel RC, Was published by MiPNetLab::NL Maastricht Schrauwen P, Was published by MiPNetLab::DK Copenhagen Christiansen M, Was published by MiPNetLab::ES CN Las Palmas Calbet JA

Labels: MiParea: MiP area::Respiration, MiP area::mt-Biogenesis;mt-density, MiP area::mtDNA;mt-genetics, MiP area::Comparative MiP;environmental MiP, MiP area::Gender, MiP area::Exercise physiology;nutrition;life style

Stress:Injury and adaptation::Temperature Organism: Organism::Human Tissue;cell: tissue and cell::Skeletal muscle Preparation: Preparation::Permeabilized tissue Enzyme: Enzyme::Marker enzyme, Enzyme::TCA cycle and matrix dehydrogenases Regulation: Topic::Coupling efficiency;uncoupling, Topic::Cyt c Coupling state: Coupling states::LEAK, Coupling states::OXPHOS, Coupling states::ETS

HRR: Instrument and method::Oxygraph-2k

additional label::MitoFitPublication, additional label::MitoFit news, additional label::BMI, additional label::VO2max

Greenland expedition CMRC: science and adventure

» Greenland Expedition CMRC

» The Saltin Symposium: Exercise and Integrative Physiology (2015)

MitoFit news 2015#18

2015-11-25: Performance tests on skeletal muscle mitochondria of the Inuit haplogroup reveal fitness information beyond the uncoupling hypothesis for adaptations to the arctic climate. » MitoFit news - a contribution to K-Regio MitoFit.

Bengt Saltin - a Gentle Scientist

Additional references

Marconi C, Marzorati M, Cerretelli P (2006) Work capacity of permanent residents of high altitude. High Alt Med Biol 7:105-115. - »Bioblast link«
Tam E, Bruseghini P, Calabria E, Sacco LD, Doria C, Grassi B, Pietrangelo T, Pogliaghi S, Reggiani C, Salvadego D, Schena F, Toniolo L, Verratti V, Vernillo G, Capelli C (2015) Gokyo Khumbu/Ama Dablam Trek 2012: effects of physical training and high-altitude exposure on oxidative metabolism, muscle composition, and metabolic cost of walking in women. Eur J Appl Physiol [Epub ahead of print]. - »Bioblast link«

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 |year=2015
 |journal=Scand J Med Sci Sports
-|abstract=[[File:NFS_1OctM 2D 3G 4S 5Rot 6Omy 7U 8c 9Ama.jpg|right|300px|link=SUIT FNS(GM)01]]
+|abstract=[[File:NFS_1OctM 2D 3G 4S 5Rot 6Omy 7U 8c.jpg|right|300px|link=SUIT FNS(GM)01]]
 During evolution, mtDNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fibre type and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from ''V''<sub>O2max</sub> and maximum capacities of oxidative phosphorylation.