Difference between revisions of "Coupling-control ratio"
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:::* [[L/P coupling control ratio |''L/P'' coupling control ratio]], ''L/P'' | :::* [[L/P coupling control ratio |''L/P'' coupling control ratio]], ''L/P'' | ||
:::: [[Free OXPHOS capacity]], ''≈P = P-L'' | :::: [[Free OXPHOS capacity]], ''≈P = P-L'' | ||
:::: [[OXPHOS coupling efficiency]], ''j<sub>≈P</sub>'' = ''≈P''/''P'' = 1-''L/P'' | :::: [[OXPHOS-coupling efficiency]], ''j<sub>≈P</sub>'' = ''≈P''/''P'' = 1-''L/P'' | ||
:::* [[L/R coupling control ratio |''L/R'' coupling control ratio]], ''L/R'' | :::* [[L/R coupling control ratio |''L/R'' coupling control ratio]], ''L/R'' | ||
:::: [[Free ROUTINE activity]], ''≈R = R-L'' | :::: [[Free ROUTINE activity]], ''≈R = R-L'' | ||
:::: [[ROUTINE coupling efficiency]], ''j<sub>≈R</sub>'' = ''≈R''/''R'' = 1-''L/R'' | :::: [[ROUTINE-coupling efficiency]], ''j<sub>≈R</sub>'' = ''≈R''/''R'' = 1-''L/R'' | ||
:::* [[LEAK control ratio]], ''L/E'' | :::* [[LEAK-control ratio]], ''L/E'' | ||
:::: [[Free ET | :::: [[Free ET capacity]], ''≈E = E-L'' | ||
:::: [[ET-coupling efficiency]], ''j<sub>≈E</sub>'' = ''≈E''/''E'' = 1-''L/E'' | :::: [[ET-coupling efficiency]], ''j<sub>≈E</sub>'' = ''≈E''/''E'' = 1-''L/E'' | ||
:::* [[netOXPHOS control ratio]], ''≈P/E''=(''P-L'')/''E'' | :::* [[netOXPHOS-control ratio]], ''≈P/E''=(''P-L'')/''E'' | ||
:::: [[Free OXPHOS capacity]], ''≈P = P-L'' | :::: [[Free OXPHOS capacity]], ''≈P = P-L'' | ||
:::* [[netROUTINE control ratio]], ''≈R/E''=(''R-L'')/''E'' | :::* [[netROUTINE-control ratio]], ''≈R/E''=(''R-L'')/''E'' | ||
:::: [[Free ROUTINE activity]], ''≈R = R-L'' | :::: [[Free ROUTINE activity]], ''≈R = R-L'' | ||
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== References == | == References == | ||
{{#ask:[[Additional label::Coupling control ratio]] | {{#ask:[[Additional label::Coupling-control ratio]] | ||
| mainlabel=Bioblast link | | mainlabel=Bioblast link | ||
|?Has title=Reference | |?Has title=Reference |
Revision as of 10:19, 3 June 2020
Description
Coupling-control ratios, CCR, are flux control ratios, FCR, at a constant mitochondrial pathway-control state. In mitochondrial preparations, there are three well-defined coupling states of respiration, L, P, E (LEAK, OXPHOS, Electron transfer pathway). In living cells, the OXPHOS state cannot be induced, but a ROUTINE state of respiration, R, can be measured. The reference state, Jref, is defined by taking Jref as the maximum flux, i.e. flux in the ET state, E, such that the lower and upper limits of the CCR are defined as 0.0 and 1.0. Then there are two mitochondrial CCR, L/E and P/E, and two CCR for living cells, L/E and R/E.
Abbreviation: CCR
Reference: Flux control ratio
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- Free OXPHOS capacity, ≈P = P-L
- OXPHOS-coupling efficiency, j≈P = ≈P/P = 1-L/P
- Free ROUTINE activity, ≈R = R-L
- ROUTINE-coupling efficiency, j≈R = ≈R/R = 1-L/R
- LEAK-control ratio, L/E
- Free ET capacity, ≈E = E-L
- ET-coupling efficiency, j≈E = ≈E/E = 1-L/E
- netOXPHOS-control ratio, ≈P/E=(P-L)/E
- Free OXPHOS capacity, ≈P = P-L
- netROUTINE-control ratio, ≈R/E=(R-L)/E
- Free ROUTINE activity, ≈R = R-L
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- More details » ET-coupling efficiency
- OXPHOS-control ratio, P/E
- Excess E-P capacity, ExP = E-P
- Excess E-P capacity factor, jExP = ExP/E = 1-P/E
- Excess E-R capacity, ExR = E-R
- Excess E-R capacity factor, jExR = ExR/E = 1-R/E
Compare
- » Coupling control factor, CCF = 1-CCR
- » Respiratory acceptor control ratio, RCR
References
Bioblast link | Reference | Year |
---|---|---|
Gnaiger 2020 BEC MitoPathways | Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002 | 2020 |
BEC 2020.1 doi10.26124bec2020-0001.v1 | Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1 | 2020 |
- Bioblast links: Normalization - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Quantities for normalization
- » Count in contrast to Number
- » Mitochondrial marker
- » O2k-Protocols: mitochondrial and marker-enzymes
- » Citrate synthase activity
- Quantities for normalization
- General
- Related keyword lists
MitoPedia concepts:
Respiratory control ratio
MitoPedia methods:
Respirometry