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• O2k-Publications: Inhibitor
  ...:[[Category:Publications]] [[Instrument and method::Oxygraph-2k]] [[Topic::Inhibitor]] == O2k-Publications: Inhibitor - Abstracts ==
  1 KB (186 words) - 11:44, 11 November 2016
• Substrate-uncoupler-inhibitor titration
  |description=Mitochondrial '''Substrate-uncoupler-inhibitor titration''' ('''SUIT''') [[MitoPedia: SUIT |protocols]] are used with [[mi {{#ask:[[Additional label::Substrate-uncoupler-inhibitor titration]]
  3 KB (339 words) - 08:57, 27 May 2020
• Substrate-uncoupler-inhibitor-titration
  #REDIRECT [[Substrate-uncoupler-inhibitor titration]]
  53 bytes (3 words) - 22:41, 31 August 2015

Page text matches

• Phenylsuccinate
  |description='''Phenylsuccinate''' is a competitive inhibitor of succinate transport (20 mM). |type=Inhibitor
  227 bytes (24 words) - 15:56, 2 May 2014
• Bongkrekik acid
  |description='''Bongkrekik acid''' is a selective and potent inhibitor of the [[adenine nucleotide translocator]] (ANT). Bka binds to the matrix ( |type=Inhibitor PS
  366 bytes (47 words) - 20:51, 23 August 2015
• Hydroxycinnamate
  ...cription='''Hydroxycinnamate''' (alpha-cyano-4-hydroxycinnamic acid) is an inhibitor of the [[pyruvate carrier]] (0.65 mM). Above 10 mM [[pyruvate]], hydroxyci |type=Inhibitor ETS
  537 bytes (63 words) - 15:53, 2 May 2014
• N-ethylmaleimide
  |type=Inhibitor PS {{MitoPedia methods|type=Inhibitor PS
  409 bytes (52 words) - 12:58, 12 February 2021
• MitoPedia: Inhibitors
  »[[O2k-Publications: Inhibitor]] {{#ask:[[MitoPedia topic::Inhibitor]]
  210 bytes (21 words) - 16:18, 10 February 2015
• Hydroxylamine
  |description='''Hydroxylamine''' is an inhibitor of [[catalase]]. |mitopedia topic=Inhibitor
  2 KB (312 words) - 12:19, 21 April 2021
• Mersalyl
  ...iption='''Mersalyl''' (C₁₃H₁₇HgNO₆) is an inhibitor of the [[Pi symporter]]. |type=Inhibitor
  768 bytes (122 words) - 12:55, 12 February 2021
• Thenoyltrifluoroacetone
  |description='''Thenoyltrifluoroacetone''' TTFA is a noncompetitive inhibitor of CII binding on the quinone-binding (SDHC/SDHD). |mitopedia topic=Inhibitor
  332 bytes (37 words) - 23:25, 2 April 2023
• Amytal
  ...mobarbital; 5-Ethyl-5-isoamylbarbituric acid) is a barbiturate drug and an inhibitor of [[Complex I]]. |type=Inhibitor ETS
  920 bytes (127 words) - 11:53, 22 June 2021
• 2-mercaptoacetate
  ...of [[octanoylcarnitine]] oxidation. 2-mercaptoacetate has been used as an inhibitor of [[fatty acid oxidation]] ([[F-pathway control state]]). In permeabilized |mitopedia topic=Inhibitor
  723 bytes (84 words) - 17:08, 18 January 2022
• Substrate-uncoupler-inhibitor-titration
  #REDIRECT [[Substrate-uncoupler-inhibitor titration]]
  53 bytes (3 words) - 22:41, 31 August 2015
• Tartronic acid
  ...artronic acid (hydroxymalonic acid, C3H4O5; molecular weight 120.06) is an inhibitor of [[malic enzyme]]. |mitopedia topic=Inhibitor
  650 bytes (76 words) - 10:37, 11 September 2020
• Citreoviridin
  ...tor of the [[ATP synthase]] which, differently from the FO subunit binding inhibitor oligmycin, binds to the F1 subunit of the ATP synthase. |mitopedia topic=Inhibitor
  910 bytes (125 words) - 10:15, 11 September 2020
• Atractyloside
  |description='''Atractyloside''' is an inhibitor of the [[Adenine nucleotide translocator|adenine nucleotide translocator (A |type=Inhibitor PS
  1 KB (199 words) - 12:47, 12 February 2021
• O2k-Publications: Inhibitor
  ...:[[Category:Publications]] [[Instrument and method::Oxygraph-2k]] [[Topic::Inhibitor]] == O2k-Publications: Inhibitor - Abstracts ==
  1 KB (186 words) - 11:44, 11 November 2016
• Oxalomalic acid
  |description='''Oxalomalic acid''' is an inhibitor of aconitase (and of cytoplasmic NADP-dependent isocitrate dehydrogenase). |mitopedia topic=Inhibitor
  680 bytes (89 words) - 11:18, 2 June 2016
• Dinitrochlorobenzene
  ...lorobenzene (1-chloro-2,4-dinitrobenzene)''' (DNCB) is a glutathione (GSH) inhibitor. ...cavenging H₂O₂. Additionally, [[auranofin]] (AF), an inhibitor of thioredoxin reductase (TrxR) can be used to quantified the contribution
  2 KB (217 words) - 10:20, 11 September 2020
• Kuznetsov 1997 Biochim Biophys Acta
  ...V, Winkler K, Kirches E, Lins H, Feistner H, Kunz WS (1997) Application of inhibitor titrations for the detection of oxidative phosphorylation defects in saponi ...of flux control was observed. We conclude, therefore, that application of inhibitor titrations and the quantitative description of the titration curve can be a
  2 KB (327 words) - 17:24, 16 January 2021
• Krishnathas 2017 Med Chem Comm
  ...henyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I. Med Chem Comm 8:657-61. ...r results challenge the postulated primary mode-of-action of EVP4593 as an inhibitor of NF-κB pathway activation and/or store-operated calcium influx.
  2 KB (232 words) - 13:49, 4 June 2018
• Metabolic control variable
  ...kground to reference steady state (Y to Z). Alternatively, ''X'' may be an inhibitor of flux, absent in the reference state but present in the background state |mitopedia topic=Inhibitor, Substrate and metabolite, Uncoupler
  858 bytes (123 words) - 18:19, 10 November 2020
• Cyanide
  |description='''Cyanide''' (usually added as KCN) is a competitive inhibitor of [[Complex_IV| cytochcrome ''c'' oxidase (CIV)]]. Inhibition is reversed {{MitoPedia O2k and high-resolution respirometry|type=Inhibitor ETS
  3 KB (360 words) - 09:51, 10 June 2021
• Sun 2012 Front Mol Neurosci
  ...ylketone completely inhibited caspase activation, while treatment with the inhibitor of calpains- and papain-like cathepsins (2S,3S)-trans-epoxysuccinyl-leucyla
  2 KB (278 words) - 13:52, 29 July 2016
• Azide
  |description='''Sodium azide''' is an inhibitor of [[Complex IV]]/cytochrome ''c'' oxidase (CIV, COX, CcO). |type=Inhibitor ETS
  2 KB (337 words) - 17:28, 16 December 2021
• Belosludtsev 2018 Biochemistry (Mosc)
  ...s of dequalinium (≤10 μM), this swelling is inhibited by cyclosporin A, an inhibitor of the mitochondrial permeability transition pore. At the same time, at hig |topics=Inhibitor, Ion;substrate transport
  2 KB (282 words) - 09:04, 5 October 2018
• Hildyard 2003 Biochem J
  ...ily (MCF). Only mitochondria from the YIL006w deletion mutant exhibited no inhibitor-sensitive pyruvate transport, but otherwise behaved normally. YIL006w encod
  1 KB (138 words) - 17:17, 16 January 2021
• Degli Esposti 1998 Biochim Biophys Acta
  ...compounds and their potency is related to that of rotenone, the classical inhibitor of complex I. Among commercial products, particular attention is dedicated |keywords=NADH–ubiquinone reductase; Respiratory inhibitor; Ubiquinone
  1 KB (158 words) - 13:55, 12 March 2021
• Auranofin
  ...itochondria: Trx system. Additionally, [[dinitrochlorobenzene]] (DNCB), an inhibitor of glutathione (GSH) can be used to obtain the GSH contribution scavenging ...H, Kim GY, Moon SK, Cheong J, Kim WJ, Yoo YH, Choi YH (2017) Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep
  2 KB (282 words) - 10:11, 11 September 2020
• Strobilurin
  |mitopedia topic=Inhibitor
  498 bytes (64 words) - 02:46, 23 January 2023
• Mathiyazakan 2023 Antimicrob Agents Chemother
  ...cobacterium tuberculosis'' cytochrome ''bcc:aa''3 supercomplex and a novel inhibitor targeting subunit cytochrome ''c''I. Antimicrob Agents Chemother 67:e015312 ...ion via the cIcII head. The successful identification of a new cyt-bcc:aa3 inhibitor demonstrates the potential of a structure-mechanism-based approach for nove
  2 KB (335 words) - 18:10, 17 September 2023
• Becker 1999 Am J Physiol
  ...dase inhibitor diphenyleneiodonium (0.9 +/- 0.1). By contrast, the site IV inhibitor cyanide, as well as inhibitors of xanthine oxidase (allopurinol), nitric ox
  2 KB (242 words) - 17:49, 13 April 2022
• Stoner 1984 J Bioenerg Biomembr
  ...ill make the other more rate limiting and thus will decrease the amount of inhibitor of the other required for half-maximal inhibition. These two types of "coup
  3 KB (369 words) - 22:45, 16 February 2021
• Grefte 2015 Biochim Biophys Acta
  ...bited by Rot (10-100 nM), but not by piericidin A (PA; 100 nM), another CI inhibitor. At 100 nM, both Rot and PA fully blocked myoblast oxygen consumption. Knoc |topics=Inhibitor
  2 KB (244 words) - 10:43, 9 November 2016
• Razak 2018 RUMeS
  ...s measured using OROBOROS HRR Oxygraph-2k according to substrate-uncoupler-inhibitor titration (SUIT) protocol. ...d following the addition of complex I inhibitor (rotenone) and complex III inhibitor (antimycin A).
  2 KB (322 words) - 11:47, 8 April 2019
• Briston 2016 Sci Rep
  ...owney B (2016) Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in ...dependent of CypD inhibition. Here we identified a novel, CypD-independent inhibitor of the mPTP. The screening approach and compound described provides a workf
  2 KB (331 words) - 14:25, 21 September 2021
• Kunz 1993 FEBS Lett
  ...or EGTA, the inhibitor of Ca²⁺ transport Ruthenium red and the inhibitor of the myosin ATPase vanadate. The caffeine concentration dependency of res
  1 KB (185 words) - 11:00, 27 March 2018
• Qvit 2022 Pharmaceuticals (Basel)
  ...A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D (2022) A selective inhibitor of cardiac troponin I phosphorylation by delta protein kinase C (δPKC) as ...ylation of cTnI is critical in IR injury, and that a cTnI/δPKC interaction inhibitor should be considered as a therapeutic target to reduce cardiac injury after
  2 KB (280 words) - 18:55, 6 December 2022
• Kopitar-Jerala 2017 Abstract MITOEAGLE Barcelona
  ...nes in macrophages. It was reported that metformin, mitochondria complex I inhibitor, decreased production of the pro-form of the inflammatory cytokine IL-1β a Stefin B (cystatin B) is an endogenous cysteine cathepsin inhibitor, and the loss-of-function mutations in the stefin B gene were reported in p
  2 KB (289 words) - 08:17, 21 February 2020
• Gottfried 2013 PLoS One
  ..., diclofenac holds potential as a clinically applicable MYC and glycolysis inhibitor supporting established tumor therapies.
  3 KB (382 words) - 08:54, 21 February 2020
• Vanden Hoek 1998 J Biol Chem
  ...y myxothiazol, but not by diphenyleneiodonium or the nitric-oxide synthase inhibitor L-nitroarginine. We conclude that hypoxia increases mitochondrial superoxid
  2 KB (263 words) - 20:58, 11 April 2022
• Etomoxir
  ...(Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of [[carnitine palmitoyltransferase I]] (CPT-I) on the outer face of the mi |mitopedia topic=Inhibitor
  1 KB (184 words) - 06:35, 20 April 2023
• Palmeira 2019 MiP2019
  ...tion of ischemia/reperfusion injury: effects of a soluble adenylyl cyclase inhibitor LRE1. ...a setting of rodent model of hepatic IR. Therefore, we tested LRE1 (a sAC inhibitor) administration before I/R.
  2 KB (344 words) - 16:01, 7 October 2019
• Lambertucci 2008 J Cell Physiol
  ...tion induced by PA was observed by treatment with diphenylene iodonium, an inhibitor of NADPH oxidase. The participation of this enzyme complex was confirmed th
  2 KB (278 words) - 23:16, 5 July 2021
• 3-Mercaptopropionic acid
  |mitopedia topic=Inhibitor
  521 bytes (61 words) - 08:41, 17 March 2023
• Triethyltin bromide
  |description=Triethyltin bromide (TET) is a lipophilic [1] inhibitor of the mitochondrial [[ATP synthase]] [2] which is used to induce [[LEAK st |mitopedia topic=Inhibitor
  1 KB (195 words) - 10:37, 11 September 2020
• Teplova 2017 Toxicol Lett
  ...its capability of acting as both a protonophore and an unusual complex II inhibitor, which interferes with the mitochondrial respiration by blocking the electr |keywords=Complex II inhibitor, Mitochondria, Q(d)-binding site, Superoxide anion, Triclosan, Uncoupler
  2 KB (297 words) - 08:48, 27 June 2019
• Torres-Quesada 2022 Cancers (Basel)
  ...nveiled mitochondrial dysfunction upon exposure to the FDA-approved kinase inhibitor sunitinib. This seemingly context-dependent side effect of this drug highli ...cells, cell bioenergetics, cell culture media, cell proliferation, kinase inhibitor, mitochondrial function
  2 KB (314 words) - 15:16, 9 December 2022
• Kraft 2004 Thesis Universität Halle-Wittenberg - Germany
  ...cooling was without interruption. The newly established multiple substrate-inhibitor titration provides the possibility to measure complex I dependent functiona ...r technique, respirometry, mitochondria, mitochondrial function, substrate-inhibitor-titration, mitochondrial encephalomyopathy, shipment of samples
  2 KB (197 words) - 17:56, 7 November 2016
• Antal 2013 Planta
  ...of mitochondrial respiration, FCCP, a protonophore, nor propyl gallate, an inhibitor of the plastid terminal oxidase, induced such a strong effect like antimyci
  1 KB (216 words) - 15:00, 8 August 2023
• Hsu 2004 Biochemistry
  ...act=Human mitochondrial malic enzyme is a regulatory enzyme with ATP as an inhibitor. Structural studies reveal that the enzyme has two ATP-binding sites, one a |topics=ATP, Inhibitor
  1 KB (220 words) - 15:40, 1 August 2014
• Galina 2014 Int J Biochem Cell Biol
  |keywords=3-Bromopyruvate, Glycolytic inhibitor, Mitochondrial respiration inhibitor, Alkylation,Tumor cell metabolism
  2 KB (210 words) - 14:06, 12 June 2022
• Larsen 2011 Acta Physiol (Oxf)
  ..., ADP and glutamate (GMO(3) ), + succinate (GMOS(3) ), + uncoupler (U) and inhibitor (rotenone) of complex I respiration. Citrate synthase (CS) activity was mea |keywords=AMPKα2 kinase-dead (KD) mice; substrate-uncoupler-inhibitor-titration (SUIT) protocol
  2 KB (338 words) - 15:43, 5 March 2019
• Takada 2016 Cardiovasc Res
  ...ma S, Yokota T, Tanaka S, Okita K, Tsutsui H (2016) Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart ...igated the effects of the administration of a dipeptidyl peptidase (DPP)-4 inhibitor on the exercise capacity and skeletal muscle abnormalities in an HF mouse m
  3 KB (439 words) - 17:28, 8 March 2021
• Cumero 2012 Br J Pharmacol
  ...d soluble F₁-ATPase. Activity assays and immunodetection of the inhibitor protein IF₁ were used and combined with molecular docking analys ''Key Results'': T1AM is a non-competitive inhibitor of F₀F₁-ATPsynthase whose binding is mutually exclusi
  3 KB (456 words) - 09:10, 27 January 2020
• Pasdois 2007 Am J Physiol Heart Circ Physiol
  ...r), ODQ (a GC inhibitor), PP2 (a src kinase inhibitor), and KT-5823 (a PKG inhibitor) abolished preconditioning by BK and blocked the inotropic response to ouab |topics=Cyt c, Inhibitor, Ion;substrate transport
  3 KB (436 words) - 12:42, 16 February 2018
• Hollis 2003 Biochim Biophys Acta
  ...O(2)(-) generation in control cells, or those treated with the NO synthase inhibitor, when incubated at 21% O(2). However, after 30-min exposure of control cell |topics=Cyt c, Flux control, Inhibitor, Oxygen kinetics, Redox state
  2 KB (314 words) - 14:45, 1 December 2015
• Lu 2018 ACS Infect Dis
  ...Wang Z, Rhee KY, Ding K, Zhang T, Cook GM (2018) A pyrazolo[1,5-a]pyridine inhibitor of the respiratory cytochrome bcc complex for the treatment of drug-resista ...infection. Here, we characterize a putative respiratory complex III (QcrB) inhibitor, TB47: a pyrazolo[1,5-a]pyridine-3-carboxamide. TB47 is active (MIC between
  3 KB (360 words) - 11:03, 11 August 2021
• Ahn 2010 Biochim Biophys Acta
  ...ediated pAkt while increased pAMPK regardless of insulin. Reciprocally, an inhibitor of Akt, triciribine (TCN), decreased cellular ATP contents. Overexpression
  2 KB (293 words) - 17:25, 25 February 2020
• Aroor 2015 Diabetes
  ...) and diacylglycerol (DAG) content was significantly attenuated with DPP-4 inhibitor treatment. In addition, MK0626 significantly reduced mitochondrial incomple ...rds=Lipidomics, NAFLD, Obesity, Hepatic insulin resistance, MK-0626 (DPP-4 inhibitor)
  3 KB (364 words) - 16:16, 19 March 2019
• Laboratory titration sheet
  ...et''' contains the sequential titrations in a specific Substrate-uncoupler-inhibitor titration (SUIT) protocol. The laboratory titration sheets for different SU
  522 bytes (60 words) - 11:54, 25 March 2022
• Bastian 2016 Cancer Lett
  ...GA, Doshi A, Zaware N, Gangjee A, Ihnat MA (2016) AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. Cancer Lett pii: S0 ...nd animals with AG311 and dichloroacetate, a pyruvate dehydrogenase kinase inhibitor that increases oxidative metabolism, resulted in synergistic cell kill and
  2 KB (310 words) - 09:30, 23 December 2016
• Nambu 2019 Eur J Pharmacol
  ...were divided into 2 groups, i.e., with or without treatment with the SGLT2 inhibitor empagliflozin (Empa, 300 mg/kg of food). Consistent with previous studies, ..., Ketone body, Mitochondria, Muscle strength, Myocardial infarction, SGLT2 inhibitor
  3 KB (402 words) - 11:35, 3 March 2020
• Ap5A
  |description='''P1,P5-Di(adenosine-5')pentaphosphate (Ap5A)''' is an inhibitor of [[adenylate kinase]] (ADK), the enzyme which rephosphorylates AMP to ADP |mitopedia topic=Inhibitor
  2 KB (227 words) - 10:25, 21 June 2021
• Hiltunen 1981 Biochim Biophys Acta
  ...hydroxymalonate (an inhibitor of malic enzymes) and mercaptopicolinate (an inhibitor of phosphoenolpyruvate carboxykinase) as tools. Hydroxymalonate inhibited t
  2 KB (209 words) - 17:26, 7 November 2016
• Vamecq 1987 Biochem J
  ...xidase]] was inhibited by micromolar concentrations of [[antimycin A]], an inhibitor of mitochondrial respiration. The inhibition was observed with all three su |topics=Inhibitor
  2 KB (233 words) - 19:05, 16 January 2021
• Jaber 2020 BM Exp Neurol
  ...nd cytochrome c release induced by the anti-apoptotic BCL-2 family protein inhibitor ABT-737.
  2 KB (326 words) - 03:19, 24 August 2021
• Bentebibel 2006 Biochemistry
  ...were within the same range as those observed for etomoxiryl-CoA, a potent inhibitor of CPT I. When a pancreatic INS(823/13), muscle L6E9, or kidney HEK293 cell
  2 KB (349 words) - 10:18, 6 July 2021
• Ganguly 2022 MitoFit
  ...uly U, Bir A, Chakrabarti S (2022) Cytotoxicity of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways. https://doi.org/10.26 ...ages/6/64/Ganguly_2022_MitoFit.pdf Cytotoxicity of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways]<br/>
  4 KB (503 words) - 07:47, 8 January 2023
• Malonyl-CoA synthase
  ...ACSF3) with enzymatic activity in the presence of [[malonate]] (Complex II inhibitor) and methylmalonate.
  593 bytes (71 words) - 17:50, 11 November 2016
• Glutamate-aspartate carrier
  ...oneutal and may be impaired by [[uncoupling]]. [[Aminooxyacetate]] is an [[inhibitor]] of the glutamate-aspartate carrier.
  623 bytes (82 words) - 14:54, 25 July 2016
• Tesori 2015 Sci Rep
  ...nk JN, Maulucci G, Puglisi MA, Pani G, Gasbarrini A (2015) The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for c ...oxicity was dramatically increased by glucose withdrawal or the glycolytic inhibitor 2-DG. Under metabolic stress, activation of the AMP dependent Protein Kinas
  2 KB (326 words) - 16:16, 13 November 2017
• Loomis 1948 J Biol Chem
  |topics=Coupling efficiency;uncoupling, Inhibitor
  645 bytes (76 words) - 17:44, 16 January 2021
• Declercq 1987 J Biol Chem
  ...atory subunit). The hepatic monomer is larger than the muscle enzyme. Each inhibitor interacts via its thioester group at the palmitoyl-CoA binding site of the
  3 KB (384 words) - 10:30, 6 July 2021
• Shim 2022 Cancer Cell Int
  ...JH, Yook JI, Kang SG. (2022) Etomoxir, a carnitine palmitoyltransferase 1 inhibitor, combined with temozolomide reduces stemness and invasiveness in patient-de ...being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor exerts cytotoxic effects in GBM, which involve interrupting the FAO pathway
  2 KB (357 words) - 10:58, 18 January 2023
• Oxaloacetate
  ...the inner [[mitochondrial|mt]]-membrane of various tissues. Oa is a potent inhibitor of [[succinate dehydrogenase]].
  725 bytes (96 words) - 19:31, 1 January 2021
• Piel 2015 Abstract MiPschool London 2015
  |title=The novel Cyclophilin D inhibitor NVP019 reduces mitochondrial permeability transition in isolated rat and hu ...as to assess the potential of NVP019, a novel, non-immunosuppressive Cyp-D inhibitor with minimal off-target effects [3], to inhibit mitochondrial permeability
  3 KB (423 words) - 09:10, 16 June 2015
• Shao 2019 Cardiovasc Diabetol
  ...hao Y, Li G, Liu T (2019) Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-f ...patients are less well-explored. We tested the hypothesis that the SGLT-2 inhibitor, empagliflozin, can prevent atrial remodeling in a diabetic rat model.
  2 KB (340 words) - 14:19, 5 December 2019
• Respiratory state
  ::::* Mitochondrial preparations: specific substrate-inhibitor combinations for selectively stimulating electron entry through Complex I ( ::::* Kinetic inhibitor control: Kinetic studies with variation of a specific inhibitor yield apparent kinetic constants, such as the ''K''_I'.
  3 KB (400 words) - 15:50, 15 August 2021
• Zeng 2019 Toxicol Appl Pharmacol
  ...ective effects of ICA on ROT-treated cells was markedly abolished by SIRT3 inhibitor 3-TYP. Our findings demonstrate that ICA exerts a neuroprotective role thro |topics=Inhibitor
  3 KB (360 words) - 15:22, 15 October 2019
• Ganguly 2022 BEC
  ...uly U, Bir A, Chakrabarti S (2022) Cytotoxicity of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways. Bioenerg Commun 2022. ...iseases including Parkinson’s disease. Because the mitochondrial Complex I inhibitor rotenone is widely used to develop experimental models of Parkinson’s dis
  3 KB (418 words) - 07:00, 8 January 2023
• Worth 2014 J Biol Chem
  |abstract=Rotenone is a naturally occurring mitochondrial complex I inhibitor with a known association with parkinsonian phenotypes in both human populat |topics=Inhibitor
  2 KB (254 words) - 05:33, 22 March 2023
• Substrate-uncoupler-inhibitor titration
  |description=Mitochondrial '''Substrate-uncoupler-inhibitor titration''' ('''SUIT''') [[MitoPedia: SUIT |protocols]] are used with [[mi {{#ask:[[Additional label::Substrate-uncoupler-inhibitor titration]]
  3 KB (339 words) - 08:57, 27 May 2020
• TPP+ inhibitory effect
  |mitopedia topic=Inhibitor
  773 bytes (102 words) - 00:03, 18 February 2020
• Taroni 1987 Biochim Biophys Acta
  ...ce of succinate the Km value for malate was 1.9 mM. ATP was found to be an inhibitor competitive with malate, with a Ki (ATP) of 0.2 mM. This is the first repor
  2 KB (272 words) - 15:10, 27 May 2020
• Myxothiazol
  |description='''Myxothiazol''' Myx is an inhibitor of [[Complex III]] (CIII). CIII also inhibits [[Complex I|CI]]. Myxothiazol ..., Xia D, Yu C-A, Xia J-Z, Kachurin AM, Zhang L, Yu L, Deisenhofer J (1998) Inhibitor binding changes domain mobility in the iron–sulfur protein of the mitocho
  3 KB (443 words) - 18:23, 9 April 2022
• Gellerich 2009 PLoS One
  .../sub>= 360 nM Ca²⁺). This regulation was not affected by RR, an inhibitor of the mitochondrial Ca²⁺ uniporter. Active respiration is regul |topics=Calcium, Inhibitor
  2 KB (270 words) - 09:28, 7 May 2020
• Danylovych 2016 Ukr Biochem J
  ...se in FAD fluorescence in comparison to control. NaN3 (5 mM), a complex IV inhibitor, and CCCP (10 μM), a protonophore, caused decrease in NADH and FAD fluores
  2 KB (300 words) - 13:18, 14 February 2022
• Bociaga-Jasik 2013 Pharmacol Rep
  ...i A, Mach T, Dembińska-Kieć A (2013) Metabolic effects of the HIV protease inhibitor – saquinavir in differentiating human preadipocytes. Pharmacol Rep 65:93 Methods: The aim of the study was to characterize effects of the protease inhibitor (PI) - saquinavir (SQV) on metabolic functions, and gene expression during
  2 KB (262 words) - 21:08, 18 March 2018
• Siebels 2013 Biochim Biophys Acta
  |title=Siebels I, Dröse S (2013) Q-site inhibitor induced ROS production of mitochondrial complex II is attenuated by TCA cyc ...ccupied flavin site. Importantly, the ROS production induced by the Q-site inhibitor atpenin A5 was largely unaffected by the redox state of the Q pool and the
  2 KB (278 words) - 10:39, 27 March 2018
• Moreno-Sanchez 2013 FEBS J
  ...dicating that CII, not CIII, is the ROS-producing site. The complex I (CI) inhibitor rotenone partially reduces the ROS production driven by high succinate leve
  3 KB (404 words) - 14:40, 26 March 2018
• Zeng 2017 J Biol Chem
  ...oxygen species (ROS) metabolism remains unclear. In this study a specific inhibitor for the rate-limiting enzyme involved in peroxisomal FAO, [[acyl-CoA oxidas |topics=Inhibitor
  2 KB (251 words) - 15:38, 28 March 2018
• Bukowska 2019 Eur J Pharmacol
  ...neration, which was effectively prevented by edoxaban, vorapaxar and GB83 (inhibitor of protease-activated receptor 2). Of note, exposure to FXa did not initiat
  3 KB (376 words) - 11:19, 3 March 2020
• Antimycin A
  ...e transfer of electrons from heme ''b''_H to oxidized Q (Qi site inhibitor). High concentrations of antimycin A also inhibit acyl-CoA oxidase and D-am * [[Myxothiazol]] - this CIII inhibitor induces less ROS production but is more expensive than Ama.
  3 KB (462 words) - 13:23, 15 March 2022
• Covi 2007 Physiol Biochem Zool
  ...energy-producing pathways in the developing embryo. However, the V-ATPase inhibitor exhibits a concentration-dependent inhibition of oxygen consumption in aero
  2 KB (283 words) - 09:35, 9 November 2016
• Kuhnt 2007 Neurochem Res
  ...l muscles. For that purpose skinned fiber technique and multiple substrate inhibitor titration were adapted to tumor samples. In our animal tumor model (R1H) fu ...Skinned fiber technique, High-resolution respirometry, Multiple substrate inhibitor titration, Rat rhabdomyosarcoma R1H
  2 KB (259 words) - 10:57, 27 March 2018
• MiPNet09.12 O2k-Titrations
  |topics=ADP, Inhibitor, Substrate, Uncoupler, Amino acid
  974 bytes (128 words) - 22:23, 9 April 2022
• Quiles 2006 Plant Cell Environ
  ...lectron donation by NADPH and ferredoxin to plastoquinone. Antimycin A (an inhibitor of cyclic electron flow) increased the NADH DH activity and preserved the
  2 KB (321 words) - 09:38, 11 September 2021
• Morota 2009 Exp Neurol
  ...ate from direct mPT inhibition. We conclude that a clinically relevant mPT inhibitor should have a mitochondrial target and increase mitochondrial calcium reten
  3 KB (371 words) - 17:34, 25 February 2020
• Ali 2019 MiP2019
  ...s with glycolytic inhibitors. Indeed, iodoacetate (IA), an effective GAPDH inhibitor, caused about 70% drop in MDA-MB-231 cell viability at 20 μM while 40 μM |topics=Inhibitor
  2 KB (285 words) - 15:29, 19 August 2019
• Kopitar-Jerala 2015 Front Cell Neurosci
  ...l loss in the brain of the stefin B-deficient mice, implying a role of the inhibitor at the cross-talk between microglia and cerebellar cells. Detailed analysis
  2 KB (286 words) - 13:40, 27 July 2016
• Dawson 1993 Am J Physiol
  ...greater after azide than after myxothiazol or cyanide. Desferrioxamine, an inhibitor of iron-catalyzed hydroxyl radical formation, delayed cell killing after ea
  2 KB (288 words) - 16:31, 3 February 2022
• Takahashi 2017 Exp Gerontol
  ...OCR in the isolated mitochondria was not inhibited by Mdivi-1, a selective inhibitor of DRP1. Thus, we propose a novel function of OPA1 in regulating the CIV ac
  2 KB (304 words) - 17:37, 25 February 2020
• Krumschnabel 1999 Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
  ...rophenol. Similarly, oxygen consumption sensitive to the protein synthesis inhibitor cycloheximide was transiently increased by A23187, but returned to control
  2 KB (288 words) - 12:05, 23 January 2019
• Scaduto 1994 Eur J Biochem
  ...in both heart and liver mitochondria. In liver, 2-oxoglutarate is a potent inhibitor of oxalacetate transamination to aspartate and activation of this enzyme by |topics=Calcium, Inhibitor, Redox state, Substrate
  2 KB (319 words) - 07:52, 17 December 2018
• Sodium orthovanadate
  ...='''Sodium vanadate (Na₃VO₄)''' is used as an ATPase inhibitor. |mitopedia topic=Inhibitor
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• Rudnicki 2014 United States Patent Application Publication
  ...enting and treating obesity, as well as related diseases, using a microRNA inhibitor.
  814 bytes (104 words) - 15:52, 13 November 2017
• Xue 1996 Plant Physiol
  ...presence of this compound (Trebst, 1980). Glycolaldehyde is a Calvin cycle inhibitor that prevents the regeneration of ribulose-1,5-bisphosphate from triose pho ...iratory pathway to LEDR was examined by the use of the alternative oxidase inhibitor propyl gallate (Weger and Dasgupta, 1993). Addition of propyl gallate, adde
  3 KB (460 words) - 10:47, 3 August 2022
• Ferreira 2019 Nat Commun
  ...isatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D (2019) A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. ...and dysfunctional mitochondria in heart failure. βIIPKC siRNA or a βIIPKC inhibitor mitigates mitochondrial fragmentation and cell death. We confirm that Mfn1-
  2 KB (273 words) - 12:58, 18 March 2019
• O'Connor 2018 Sci Rep
  ...B, Trefely S, Nunez-Cruz S, Blair IA, June CH, Milone MC (2018) The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. |abstract=Etomoxir (ETO) is a widely used small-molecule inhibitor of fatty acid oxidation (FAO) through its irreversible inhibitory effects o
  2 KB (282 words) - 10:09, 6 July 2021
• Kiorpes 2021 J Biol Chem
  ...oxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria. J B ...M (R)-TDGA-CoA). TDGA-CoA was identified as a complexing type irreversible inhibitor (Ki approximately 0.27 microM) by the double reciprocal relationship betwee
  2 KB (269 words) - 22:54, 5 July 2021
• Hyunhee 2015 Abstract MiPschool Greenville 2015
  ...ondrial permeability transition pore inhibitor) and Ca-074 Me (cathepsin B inhibitor) did not. TMRE and mitoSOX experiments revealed that 18 h of CIT and reperf
  3 KB (472 words) - 15:34, 20 July 2015
• Konjar 2010 Immunology
  ...ells and primary antigen-restricted mouse CTLs with the cathepsin L (CatL) inhibitor L1 resulted in a marked inhibition of perforin-dependent target cell death
  2 KB (290 words) - 14:30, 29 July 2016
• Rosenfeld 2010 Abstract IOC60
  ...en bacterium ''Pseudomonas aeruginosa'' is known to produce the Complex IV inhibitor HCN and a blue phenazine pigment, pyocyanin (PCN), which harbors many poten |topics=Aerobic glycolysis, Inhibitor, Oxygen kinetics, Redox state
  2 KB (291 words) - 16:37, 26 March 2018
• Wiedemann 1998 J Neurol Sci
  ...oxidoreductase amytal revealed a higher sensitivity of respiration to this inhibitor indicating an elevated flux control coefficient of this enzyme. (iii) Apply
  2 KB (297 words) - 18:07, 16 January 2021
• Mohazzab 1995 Am J Physiol
  ...g NAD(P)H oxidoreductases, diphenyliodonium (DPI), could be employed as an inhibitor of O2-. production by NADH oxidoreductase, which functions as a selective p
  2 KB (277 words) - 15:32, 11 February 2022
• Chakrabarti 2022 Abstract Bioblast
  ...<u>Chakrabarti Sasanka</u> (2022) Cytotoxicity of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways. Bioblast 2022: BEC In ...early established. We show here that the classical mitochondrial Complex I inhibitor rotenone (0.5 µM) causes death of SH-SY5Y cells (a human neuroblastoma cel
  3 KB (441 words) - 16:23, 20 June 2022
• Gammon 2019 Cells
  ...ca-Worms D (2019) Mechanism-specific pharmacodynamics of a novel Complex-I inhibitor quantified by imaging reversal of consumptive hypoxia with [18F]FAZA PET '' ...itable vulnerability. In this regard, IACS-010759 is a novel high affinity inhibitor of OxPhos targeting mitochondrial complex-I that has recently completed a P
  3 KB (420 words) - 13:09, 14 October 2023
• Maher 2014 J Biol Chem
  ...enhanced IL-1β processing. Pretreatment of macrophages with the cathepsin inhibitor E-64d did not affect secretion of IL-1β, suggesting that the increased cat
  2 KB (292 words) - 15:32, 27 July 2016
• Wang 2010 J Biol Chem
  ...st step of FAO), but was only partially inhibited by rotenone (a complex I inhibitor). Although palmitoyl-CoA and octanoyl-CoA provided reducing equivalents to |topics=Cyt c, Inhibitor
  4 KB (564 words) - 21:45, 10 September 2023
• Niu 2018 Cancer Metab
  ...vity in purified mitochondria. GSK-2837808A, in contrast, is a competitive inhibitor of NAD, which cannot cross the inner mitochondrial membrane. GSK-2837808A d |topics=Inhibitor
  2 KB (329 words) - 11:22, 29 July 2019
• Traufeller 2004 Biochim Biophys Acta
  ...d fibers was inhibited by high concentrations of L-AC, indicating that the inhibitor can be transported via the acyl-carnitine transporter, too. The combined us
  2 KB (350 words) - 10:53, 23 January 2019
• Domenis 2012 Int J Mol Sci
  ...ulated mitochondria adaptation in tumor cells: a focus on ATP synthase and inhibitor factor 1. Int J Mol Sci 13:1933-50. ...tion and a rise in the expression levels of the ATP synthase β subunit and Inhibitor Factor 1 (IF1). Hyperglycemia, on the other hand, led to a markedly decreas
  2 KB (318 words) - 10:14, 13 March 2015
• Dikova 2020 Free Radic Biol Med
  ...e. According to our experiments with the glucose-6-phosphate dehydrogenase inhibitor 6-Aminonicotinamide, this was attributable to the pentose phosphate pathway
  2 KB (337 words) - 10:09, 31 May 2023
• Wei 2019 Biochem Biophys Res Commun
  ...itochondrial biogenesis. The inhibition of CREB activation by its specific inhibitor H89 obscures the induction of PGC-1α, NRF1, and TFAM by aminophylline, and
  2 KB (319 words) - 14:58, 12 January 2022
• Delport 2017 Metab Brain Dis
  ...target for antidepressant action. MB is also recognized as a non-selective inhibitor of nitric oxide synthase (NOS) and guanylate cyclase. Dysfunction of the ni
  2 KB (335 words) - 23:18, 23 April 2023
• Lagoutte 2010 Biochim Biophys Acta
  |abstract=Sulfide (H₂S) is an inhibitor of mitochondrial cytochrome oxidase comparable to cyanide. In this study, p |topics=Inhibitor
  2 KB (343 words) - 13:30, 13 November 2017
• Hawley 2016 Diabetes
  ...EA, Salt IP, Steinberg GR, Hardie DG (2016) The Na+/glucose cotransporter inhibitor canagliflozin activates AMPK by inhibiting mitochondrial function and incre |topics=Inhibitor
  2 KB (311 words) - 15:52, 9 November 2016
• Hegazy 2022 Biomedicines
  ...the nanomolar range that were up to 7-fold more potent than the canonical inhibitor UK-5099. These novel compounds possess drug-like properties and complied wi
  2 KB (319 words) - 13:39, 5 December 2022
• Brown 2008 Am J Physiol Endocrinol Metab
  ...d by incubating human skeletal muscle cell cultures with the mitochondrial inhibitor sodium azide and examining the effects on insulin action. Incubation of hum |topics=Inhibitor
  2 KB (327 words) - 11:08, 27 March 2018
• Johnson 2000 Arthritis Rheum
  ...beta from increasing intracellular ATP and elaboration of PPi, a critical inhibitor of hydroxyapatite deposition. Antimycin and oligomycin also abrogated the a |topics=Inhibitor
  3 KB (333 words) - 16:34, 23 February 2015
• Fink 2022 FASEB Bioadv
  ...and consequently ΔΨ, were perturbed both by GDP, a well-recognized potent inhibitor of UCP1 and by the chemical uncoupler carbonyl cyanide m-chlorophenyl hydra |topics=Inhibitor, mt-Membrane potential
  2 KB (331 words) - 01:29, 3 April 2023
• Martin 2012 Osteoarthritis Cartilage
  ...were treated with rotenone, an ET inhibitor; or oligomycin an ATP synthase inhibitor; or 2-fluoro-2-deoxy-D-glucose, a glycolysis inhibiter; or peroxide, an exo
  2 KB (329 words) - 15:52, 25 November 2015
• Sugimura 2012 J Reprod Dev
  ...coupled to ATP synthesis, as determined by sensitivity to an ATP synthase inhibitor, and the remaining 37% was attributed to proton leak. In contrast, 50% and
  2 KB (345 words) - 16:13, 13 November 2017
• Patyal 2022 Int J Mol Sci
  ...X, Azhar G, Ameer FS, Verma A, Crane J, Kc G, Che Y, Wei JY (2022) Rho/SRF inhibitor modulates mitochondrial functions. https://doi.org/10.3390/ijms231911536 |abstract=CCG-1423 is a Rho A pathway inhibitor that has been reported to inhibit Rho/SRF-mediated transcriptional regulati
  2 KB (309 words) - 16:07, 20 December 2023
• Malic enzyme
  ...heart and skeletal muscle. [[Tartronic acid]] (hydroxymalonic acid) is an inhibitor of ME. ...fumarate and to some extent by succinate as an activator, and by ATP as an inhibitor ([[Sauer 1973 Biochem Biophys Res Commun]]).
  4 KB (531 words) - 20:38, 30 April 2022
• Simonin 2012 Biochem J
  ...much the same way as thenoyltrifluoroacetone (TTFA), a noncompetitive SDH inhibitor. We suggest that NO inhibits SDH in its ubiquinone site or its Fe-S centers
  2 KB (337 words) - 10:17, 9 November 2016
• Gomez 2008 Circulation
  ...usion), the mPTP inhibitor cyclosporine A (CsA; 10 mg/kg IV), or the GSK3β inhibitor SB216763 (SB21; 70 µg/kg IV). Infarct size was assessed by triphenyltetraz
  2 KB (329 words) - 16:45, 26 March 2018
• Carnitine palmitoyltransferase I
  ...different kinetic and regulatory properties. Malonyl-CoA is an endogenous inhibitor of CPT-I.
  946 bytes (123 words) - 16:47, 13 April 2023
• Malagrino 2019 Oxid Med Cell Longev
  |abstract=Hydrogen sulfide (H₂S), a known inhibitor of cytochrome c oxidase (CcOX), plays a key signaling role in human (patho) |topics=Inhibitor
  2 KB (333 words) - 11:18, 21 January 2020
• Fisar 2017 Indian J Biochem Biophys
  ...lonate, oligomycin, rotenone), and uncoupler. Multiple substrate-uncoupler-inhibitor titration (SUIT) protocols were proposed for Complex I-, Complex II-, Compl |topics=ADP, Inhibitor, Substrate
  2 KB (327 words) - 12:38, 29 May 2018
• Wang 2023 Clin Exp Pharmacol Physiol
  ...but numerous challenges remain. 3-nitro-N-methyl salicylamide (3-NNMS), an inhibitor of mitochondrial electron transport chain complex III, can be used to reduc |keywords=3-NNMS, Heart preservation solution, Mitochondrial inhibitor, Myocardial ischaemia-reperfusion injury, Oxidative stress
  2 KB (330 words) - 15:22, 6 December 2023
• Blebbistatin
  ...'Blebbistatin''' is a widely used muscle and non-muscle myosin II-specific inhibitor that block contractile activity. Blebbistatin shows selectivity and high af |mitopedia topic=Inhibitor
  2 KB (338 words) - 10:21, 27 September 2021
• Krumschnabel 2003 J Exp Biol
  ...was insensitive to EIPA, an inhibitor of Na(+)/H(+) exchange, and SITS, an inhibitor of Cl(-)/HCO(3)(-) exchange, but was prevented in Cl(-)-free medium. In hyp
  2 KB (339 words) - 13:28, 21 June 2019
• Walker 1994 Curr Opin Struct Biol
  ...ts have different mechanisms for inhibition of ATP synthase: by binding an inhibitor protein, and by stabilization of the ADP-inhibited state by making an intra
  884 bytes (122 words) - 09:18, 5 April 2022
• Rekuviene 2017 Neurosci Lett
  ...olved in regulation of mPTP opening during ischemia and whether a specific inhibitor of this complex - rotenone can protect against ischemia-induced cell death |topics=Inhibitor
  2 KB (338 words) - 11:46, 11 June 2018
• Flux control efficiency
  ...X''); then ''Y_X'' is the background rate in the presence of the inhibitor. ...'', acts on ''Y_X'' (substrate, activator) or is removed from Y (inhibitor) to yield ''Z_X''. The ''X''-specific (in contrast to general) [[
  8 KB (1,272 words) - 18:27, 1 January 2021
• Zholobenko 2017 PLOS ONE
  ...ered by increased [ADP] and is increased by adenine nucleotide transporter inhibitor, atractyloside, but not bongkrekic acid. Both quercetin and dehydrosilybin |topics=ADP, Coupling efficiency;uncoupling, Inhibitor
  3 KB (381 words) - 13:38, 29 May 2018
• Stepanova 2016 Biochim Biophys Acta
  ...etate (OAA) is an intermediate of the TCA cycle and at the same time is an inhibitor of complex II with high affinity (Kd~10-8M). Whether or not OAA inhibition |topics=Inhibitor
  3 KB (384 words) - 10:02, 24 September 2018
• Piericidin
  |mitopedia topic=Inhibitor
  1 KB (151 words) - 09:28, 2 November 2020
• Salicylhydroxamic acid
  ...HAM; synonym: 2-Hydroxybenzohydroxamic acid N,2-Dihydroxybenzamide) is an inhibitor of the [[alternative oxidase]] (AOX). When AOX is blocked by SHAM, electron |mitopedia topic=Inhibitor
  2 KB (337 words) - 22:29, 9 April 2022
• Pon 2011 Malar J
  ...y the enzyme and evaluate its activity in terms of cofactor dependency and inhibitor preference. |topics=Inhibitor
  3 KB (370 words) - 10:05, 9 November 2016
• Timon-Gomez 2023 GIBB
  ...rrier C, Garcia-Souza LF, Gnaiger E (2023) A reference substrate-uncoupler-inhibitor titration protocol to create a mitochondrial pathway and coupling control d ...diseases. To address these challenges, we developed a substrate-uncoupler-inhibitor titration reference protocol (SUIT-RP) for measuring metabolic fluxes by hi
  3 KB (337 words) - 13:18, 31 May 2023
• Felser 2013 Toxicol Sci
  ...odarone at 20µM. Similar to amiodarone, dronedarone is an uncoupler and an inhibitor of the mitochondrial respiratory chain and of β-oxidation both acutely and |topics=Inhibitor, mt-Membrane potential, Fatty acid
  3 KB (363 words) - 16:28, 7 November 2016
• Davis 2017 Tissue Eng Part C Methods
  ...ial O2k system to measure oxygen consumption. In response to the complex I inhibitor rotenone, myobundle basal respiration decreased dose dependently with an IC |topics=Inhibitor
  3 KB (338 words) - 13:22, 4 June 2018
• Seitaj 2020 Cells
  ...tler U, Tenzer S, Parys JB, Bultynck G, Methner A (2020) Transmembrane BAX inhibitor-1 motif containing protein 5 (TMBIM5) sustains mitochondrial structure, sha |abstract=The Transmembrane Bax Inhibitor-1 motif (TMBIM)-containing protein family is evolutionarily conserved and h
  3 KB (353 words) - 20:58, 1 October 2020
• Kupsch 2009 FEBS J
  inhibitor of IMM-linked K⁺-transport) and tributyltin (an inhibitor of the
  3 KB (378 words) - 10:58, 23 January 2019
• Silva 2019 ESCI2019
  ...iger E (2019) Can fatty acid oxidation be specifically blocked by the CPT1 inhibitor etomoxir? |abstract=Etomoxir is an irreversible inhibitor of the mitochondrial transport of long-chain fatty acids via blockage of ca
  5 KB (697 words) - 19:11, 10 January 2022
• Hedges 2020 Biosci Rep
  ...ey AJR, Shepherd PR, Merry TL (2020) Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does n ...and female mice were fed a diet containing 0.3 g/kg of the p110α-selective inhibitor BYL-719 (BYL) or a vehicle diet (VEH) for 6 weeks. Mice consuming BYL-719 h
  2 KB (352 words) - 14:49, 17 January 2023
• Rouet 2017 US Patent
  ...e for treating a pathophysiological situation, wherein said compound is an inhibitor of the ApoO activity or of the ApoO gene expression.
  1 KB (157 words) - 12:47, 5 February 2018
• Bredholt T 2009 Mol Cancer
  ...ro''. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cel |topics=ADP, Inhibitor
  3 KB (331 words) - 18:19, 31 January 2020
• Grefte 2014 Abstract MiP2014
  ...hibited by high concentrations of [[rotenone]] (Rot; 10 µM), a widely used inhibitor of OXPHOS [[Complex I]] (CI), suggesting that activity of this complex is r ...two CI inhibitors (Rot or piericidin A, PA) or in the presence of the CIII inhibitor [[antimycin A]] (Ama). For all inhibitors, the lowest concentration that fu
  4 KB (565 words) - 16:30, 23 February 2015
• Chicco 2022 MitoFit
  ...rein, we demonstrate inhibitory effects of >1 mM malate or malonate (a CII inhibitor) on ''J''_O₂ supported by pyruvate and/or glutamate, s
  3 KB (372 words) - 07:52, 8 January 2023
• Amaral 2016 J Neurochem
  .... Taken together, our data strongly indicate that 2MCA behaves as a potent inhibitor of glutamate oxidation by inhibiting GDH activity and as a PT inducer, dist |topics=Calcium, Inhibitor
  3 KB (361 words) - 11:22, 3 March 2020
• Chicco 2022 Abstract Bioblast
  ..., Garcia-Roves PM (2022) Elucidating the complexity of substrate-uncoupler-inhibitor titration protocols. '''Bioblast 2022: BEC Inaugural Conference.''' In: htt ...n of succinate exerts a stimulatory effect (NS > N). Then the selective CI inhibitor rotenone is utilized to eliminate the contribution of the N-pathway to NS-p
  4 KB (625 words) - 08:33, 28 July 2022
• Malonate
  |description='''Malonate''' (malonic acid) is a competitive inhibitor of [[succinate dehydrogenase]] ([[Complex II]]). Malonate is a substrate of |mitopedia topic=Inhibitor
  3 KB (357 words) - 11:12, 10 June 2021
• Doucet 2018 Mol Pharmacol
  ...fication of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets. Mol Pharmacol 95:139-50. ...racetylated quercetin (compound 6) as a more selective platelet-type 12-LO inhibitor than baicalein, with no measurable non-targeted effects on the platelet's a
  3 KB (364 words) - 23:46, 29 February 2020
• Gellerich 1995 HRR
  ...eiter R, Sperl W (1995) Hochauflösende Respirometrie und multiple Substrat/Inhibitor-Titration zum funktionellen Nachweis mitochondrialer Defekte in permeabilis
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• Goudie 2017 Abstract IOC122
  ...istically significant result. Thus, systemic administration of a selective inhibitor of mitochondrial fission reduced the severity of disease in two different,
  2 KB (341 words) - 16:46, 27 March 2018
• Fisher-Wellman 2023 Cancers (Basel)
  ...ility in the drug-resistant phenotype, a potential therapeutic avenue. The inhibitor regimen showed efficacy in an ''in vivo'' model and in primary AML cells fr
  3 KB (455 words) - 13:58, 19 July 2023
• Lisak 2015 Cell Death Differ
  ...ms-Quack P, Hahn M, Waisman A, Reed JC, Hövelmeyer N, Methner A (2015) BAX inhibitor-1 is a Ca²⁺ channel critically important for immune cell functio ...in the synthesis and folding of proteins. BAX (BCL2-associated X protein) inhibitor-1 (BI-1) is a Ca²⁺ leak channel also implicated in the response
  2 KB (358 words) - 15:11, 13 November 2017
• Ballot 2010 Apoptosis
  ...potential, swelling and cytochrome c release. Cyclosporin A, a well-known inhibitor of MPT, completely prevents mitochondrial signs of apoptosis. The drug decr |topics=Inhibitor, Substrate
  3 KB (387 words) - 11:49, 22 December 2020
• Hoejeberg 1977 Biochem Biophys Res Commun
  |topics=Inhibitor
  1 KB (148 words) - 12:45, 24 February 2015
• Ale-Agha 2018 PLOS Biol
  ...pendent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endotheli
  3 KB (376 words) - 15:45, 23 August 2018
• 2-Deoxyglucose
  |mitopedia topic=Inhibitor
  990 bytes (130 words) - 11:16, 21 June 2021
• Perry 2011 Biochem J
  ...ulated respiratory kinetics. BLEB ('''blebbistatin'''), a myosin II ATPase inhibitor, blocked contraction under all conditions and yielded high ''K''<sub>m</sub |topics=ADP, Inhibitor, Temperature
  3 KB (378 words) - 16:12, 6 March 2020
• Kosenko 2010 Biology Bull
  ...MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology Bull 37:346-50.
  1 KB (161 words) - 15:50, 26 May 2015
• Woyda-Ploszczyca 2017 IOC124
  ...gical significance and consequently GDP should not be used as a diagnostic inhibitor of UCPs.
  3 KB (355 words) - 13:50, 28 August 2017
• Pless-Petig 2018 Cell Transplant
  ...ed hepatocytes confirmed that impaired energy production-as elicited by an inhibitor of the respiratory chain, antimycin A-can decrease cell attachment without
  3 KB (386 words) - 12:22, 16 March 2018
• Kanner 1976 Biochem Biophys Res Commun
  |abstract=Coupling factor 6 (F6) and mitochondrial ATPase inhibitor were isolated from the rutamycin-sensitive ATPase complex of bovine heart m
  1 KB (150 words) - 13:03, 24 February 2015
• Marshall 1996 Am J Respir Cell Mol Biol
  ...nhibitor diphenyleneiodonium (DPI: 10 microM) but not by the mitochondrial inhibitor myxathiazole (10 microM). The hypoxic superoxide increase was significantly
  3 KB (377 words) - 17:48, 20 April 2022
• Schoeckel 2015 Cancer Metab
  ...evidence that inhibition of mutated BRAF using the specific small molecule inhibitor vemurafenib increased the OXPHOS dependency of BRAF mutant melanoma cells. ...ve phosphorylation (OXPHOS), Reactive oxygen species (ROS), Small molecule inhibitor, Human melanoma SK-MEL-28 cells, Human skin A-375 cells
  3 KB (381 words) - 15:07, 9 November 2016
• Osiki 2016 FASEB J
  ...ith 1mM oxalomalic acid (aconitase inhibitor) or 1mM 2-mercaptoacetate, an inhibitor of MCAD – the rate-limiting enzyme of octanoylcarnitine oxidation. Respir
  3 KB (373 words) - 16:15, 26 March 2018
• Beryllium sulfate
  |mitopedia topic=Inhibitor
  1 KB (136 words) - 12:57, 26 April 2024
• Lim 2011 PloS One
  ...r AG18051 would also confer protection from HA toxicity. We found that the inhibitor conferred only partial protection from HA toxicity indicating distinct path
  3 KB (416 words) - 15:10, 13 November 2017
• Background state
  ...reference state. Alternatively, the metabolic control variable ''X'' is an inhibitor, which is present in the background state Y, but absent in the reference st
  1 KB (177 words) - 18:19, 10 November 2020
• Sodium fluoride
  |mitopedia topic=Inhibitor
  1 KB (140 words) - 12:59, 26 April 2024
• Reference state
  ...in the reference state but absent in the background state. If ''X'' is an inhibitor of flux, it is absent in the reference state but present in the background
  1 KB (179 words) - 18:14, 10 November 2020
• Jaskiewicz 2019 J Clin Med
  ...does not do so in conjunction with caspase-3. It appears that the calpain inhibitor, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal (ALLM), restored the viability th
  3 KB (374 words) - 12:28, 21 June 2019
• Warne 2015 J Biol Chem
  ...We therefore designed and synthesised a new mitochondrially-targeted CypD inhibitor, JW47, using a quinolinium cation tethered to cyclosporine (CsA). X-ray ana |topics=Inhibitor
  3 KB (349 words) - 20:10, 7 March 2020
• Vielhaber 2013 Acta Neuropathol
  ...of active state oxygen consumption to azide, a cytochrome c oxidase (CIV) inhibitor, was increased. The observed dysfunction of the mitochondrial respiratory c |topics=Inhibitor, Threshold;excess capacity
  3 KB (400 words) - 12:18, 8 November 2016
• Nagy 2014 Abstract MiP2014
  ...In the presence of glucose, adding a mitochondrial fatty acid transporter inhibitor further increased the ECAR.
  3 KB (403 words) - 13:04, 23 January 2019
• Cyclosporin A
  ...ransition and from CsA inhibition. Moreover, it is also a is a calcineurin inhibitor and potent immunosuppressive agent used largely as a means of prophylaxis a |mitopedia topic=Inhibitor
  3 KB (370 words) - 11:04, 14 June 2022
• Ouabain
  |mitopedia topic=Inhibitor
  1 KB (157 words) - 13:05, 12 February 2021
• Goo 2012 PLoS One
  ...rdinated regulation by PTEN/Akt. Using LY294002 (a PI3K inhibitor) and Akt inhibitor IV, we showed that the regulation of enzyme activities and protein expressi
  3 KB (426 words) - 14:24, 13 November 2017
• Cockova 2017 Thesis
  ..., we managed to observe increased ROS production in cells treated with FTO inhibitor. |topics=Inhibitor
  3 KB (415 words) - 11:23, 22 January 2018
• Zhang 2017 J Am Heart Assoc
  ...X, Wang X, Tse G, Li G, Liu T (2017) Alogliptin, a dipeptidyl peptidase-4 inhibitor, alleviates atrial remodeling and improves mitochondrial function and bioge ...n. In this study, we explored whether alogliptin, a dipeptidyl peptidase-4 inhibitor, can prevent mitochondrial dysfunction and atrial remodeling in a diabetic
  3 KB (381 words) - 11:58, 27 June 2019
• Ruas 2016 PLOS ONE
  ...red when oxidative phosphorylation was fully inhibited by the ATP synthase inhibitor citreoviridin. Further experiments indicated that oligomycin cannot be repl |topics=Inhibitor, Substrate
  3 KB (421 words) - 12:08, 9 December 2021
• He 2005 Am J Physiol Lung Cell Mol Physiol
  ...crease in DHE fluorescence. This response was blocked by the NADPH oxidase inhibitor diphenyleneiodonium (10 microM). KO neutrophils did not respond; however, a
  3 KB (379 words) - 18:01, 13 April 2022
• Schiller 2022 Pharmaceuticals (Basel)
  ...sources. The structure of complex I is determined at high resolution, and inhibitor binding sites are described in detail. In this review, we summarize the sta
  1 KB (177 words) - 15:58, 22 March 2023
• Kampjut 2020 Science
  ...ys. Quinone binds at three positions along the quinone cavity, as does the inhibitor rotenone that also binds within subunit ND4. Dramatic conformational change
  1 KB (174 words) - 19:49, 6 November 2023
• Parvez 2010 Biochim Biophys Acta
  |topics=Calcium, Inhibitor ...hrome c; FCCP, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; IC50, inhibitor concentration causing 50% inhibition; mtPTP, mitochondrial permeability tra
  3 KB (397 words) - 10:43, 23 January 2019
• Sumbalova 2014 Abstract MiP2014
  ...ger [2], and the effect was attributed to accumulation of oxaloacetate, an inhibitor of succinate dehydrogenase (SDH) and fumarate [1,3]. |topics=Inhibitor, Substrate, Uncoupler
  4 KB (587 words) - 13:46, 5 January 2023
• Krajcova 2016 Abstract MitoFit Science Camp 2016
  ...consumption rate (OCR) was measured at baseline, after addition of ATPase inhibitor and subsequently after incubation in a range of propofol concentrations (fo ...fter addition of ATPase inhibitor, mitochondrial uncoupler and complex III inhibitor. Injection of these agents enabled to calculate baseline OCR, ATP turnover
  5 KB (679 words) - 15:19, 23 January 2019
• Doerrier 2017 MiPschool C2
  |title=[[File:DoerrierC.JPG|left|90px]] Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles. ...monized states differ in terms of the sequence of substrate, uncoupler and inhibitor titrations (Figure 2). RP1 includes respiratory states that can be compared
  5 KB (706 words) - 12:00, 27 May 2019
• Goretzki 2022 Int J Mol Sci
  ...ine IL 1β was unaffected. Interestingly, pretreatment with the glutaminase inhibitor BPTES resulted in an increase in IL-1β, but decreased IL-12p70 secretion w
  3 KB (428 words) - 10:57, 19 January 2023
• George 2015 Abstract MiPschool Greenville 2015
  ...idation was inhibited with addition of oxamate, a membrane impermeable LDH inhibitor. Similar observations were made within rat hippocampal (cornu ammonis 1; CA
  3 KB (403 words) - 16:41, 7 November 2016
• Pereira da Silva Grilo da Silva 2018 MiP2018
  ...d to evaluate mitochondrial fitness in the course of disease. Etomoxir, an inhibitor of carnitine palmitoyltransferase-I, is often used (40-400 μm) in commerci ...lated from mouse liver and brain mitochondria. We used substrate-uncoupler-inhibitor titration (SUIT) protocols to analyze oxidative phosphorylation (OXPHOS) an
  6 KB (816 words) - 19:07, 10 January 2022
• Peleli 2016 Free Radic Biol Med
  ...ed with wt, and this augmented response was abolished by the selective XOR inhibitor febuxostat. Livers from eNOS^-/- displayed higher nitrite reducin
  3 KB (479 words) - 10:52, 2 August 2017
• Hand 2013 Abstract MiP2013
  ...ict that the F1Fo-ATP synthase is blocked during diapause by the F1-ATPase inhibitor protein IF1. This 9.6 kDa protein binds to the ATP synthase at the F1 catal |keywords=Diapause, Inhibitor protein IF1
  4 KB (563 words) - 14:30, 13 November 2017
• S/NS pathway control ratio
  ...nate in the absence of Rot, since [[oxaloacetate]] accumulates as a potent inhibitor of [[succinate dehydrogenase]] (CII).
  1 KB (163 words) - 18:28, 1 January 2021
• McKee 2010 Abstract IOC60
  ...ems. In this regard we have already demonstrated that AZT is a competitive inhibitor of thymidine phosphorylation in mitochondria isolated from heart, liver, an ...Lynx MD, McKee EE (2006) 3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.
  3 KB (469 words) - 14:37, 8 November 2016
• Busanello 2017 Front Pharmacol
  ...(Ca²⁺ chelator), cyclosporin A (MPT inhibitor), ruthenium red (inhibitor of mitochondria Ca²⁺ uptake) and coenzyme Q10 (antioxidant), ind
  3 KB (445 words) - 11:16, 25 June 2019
• Rapamycin
  |description='''Rapamycin''' is an inhibitor of the mammalian/mechanistic target of rapamycin, complex 1 (mTORC1). Rapam
  1 KB (154 words) - 14:10, 24 September 2023
• Yang 2018 Cell Death Dis
  ...asome system as a part of the protective leptin pathway. In addition, GSK3 inhibitor (SB216763) was also involved in the degradation of OMA1. In conclusion, in
  3 KB (433 words) - 00:23, 1 March 2020
• MitoKit-CII/Succinate-nv
  |mitopedia topic=Inhibitor
  1 KB (154 words) - 12:08, 27 July 2021
• Carboxyatractyloside
  |description='''Carboxyatractyloside''' CAT is a highly selective and potent inhibitor of the [[adenine nucleotide translocator]] (ANT). CAT stabilizes the nucleo |mitopedia topic=Inhibitor
  3 KB (491 words) - 14:55, 7 February 2024
• Fandrey 1994 Biochem J
  ...ion of endogenous H2O2 levels by the addition of menadione or the catalase inhibitor, aminotriazole, dose-dependently lowered Epo production. The inhibitory eff
  1 KB (194 words) - 09:29, 12 April 2022
• Koizumi 2023 Front Cardiovasc Med
  |keywords=SGLT2 inhibitor; diabetes; empagliflozin; mitochondria; reactive oxygen species |topics=ADP, Inhibitor, Substrate
  3 KB (454 words) - 14:46, 20 August 2023
• Volska 2013 Abstract MiP2013
  |title=Volska K, Makrecka-Kuka M, Svalbe B, Dambrova M (2013) The inhibitor of L-carnitine biosynthesis protects brain mitochondria against anoxia-reox ...cellular energy metabolism. Recently it has been shown that mildronate, an inhibitor of L-carnitine biosynthesis, improves the neurological outcome after ischem
  3 KB (413 words) - 14:24, 27 March 2018
• Arandarcikaite 2013 Abstract MiP2013
  ...o PKG activation before inducing ischemia in vena cava, we infused the PKG inhibitor KT5823 (1 µM) and NOC-18. ...brain mitochondria. Pre-treatment of brain in the ischemic group with PKG inhibitor and NO donor resulted in no statistically significant differences to contro
  3 KB (436 words) - 11:02, 28 April 2017
• Aspirin
  ...equires dosage adjusted to individual body mass. It is a non-selective COX inhibitor and exerts an effect on long-chain fatty acid transport into mitochondria.
  1 KB (156 words) - 17:19, 24 September 2023
• Porter 2018 MiP2018b
  ...ration, P<0.001). The response to the adenine nucleotide translocase (ANT) inhibitor bongkrekic acid during state 4 respiration was similar in healthy and burne
  3 KB (434 words) - 08:11, 13 September 2018
• Scott 2016 Thesis
  ...d fructose-fed rats was measured in response to different substrate and/or inhibitor combinations using the Oroboros Oxygraph-2K high-resolution respirometry sy ...ased mitochondrial expression of CD36, (iv) the reduced presence of CPT1’s inhibitor malonyl-CoA, (v) the reduced sensitivity of CPT1 to malonyl-CoA, and (vi) t
  3 KB (455 words) - 16:00, 23 January 2019
• Ethanol
  | mitopedia topic=Inhibitor, Substrate and metabolite, Uncoupler, Permeabilization agent
  1 KB (221 words) - 11:29, 27 May 2021
• Oligomycin
  |description='''Oligomycin''' (Omy) is an inhibitor of [[ATP synthase]] by blocking its proton channel (Fo subunit), which is n |mitopedia topic=Inhibitor
  6 KB (917 words) - 12:57, 29 April 2024
• Daura 2021 Neurobiol Dis
  ...the molecular pathogenesis of CSTB deficiency.Cystatin B (CSTB) acts as an inhibitor of cysteine proteases of the cathepsin family and loss-of-function mutation
  3 KB (447 words) - 12:32, 27 March 2023
• Ling 2023 EBioMedicine
  ...; an mTORC1-inhibitor, rapamycin; a SIRT1-activator, resveratrol; or SIRT1-inhibitor, EX-527. Malnutrition enteropathy was induced in enteric organoids through
  3 KB (431 words) - 15:03, 14 November 2023
• Wieser 2001 Biochem J
  ...tion to be functionally related to the concentration of cycloheximide, the inhibitor used. It was found that at 15 mM cycloheximide [three orders of magnitude h |topics=ATP production, Inhibitor, Ion;substrate transport
  4 KB (522 words) - 12:08, 23 January 2019
• Chowdhury 2017 Blood
  ...g NAMPT contributes to the prolonged survival of CLL cells. Idelalisib, an inhibitor of phosphatidylinositol-3-kinase-delta (PI3Kδ) is an approved therapy for ...o each individual drug after 48 hours. Preliminary data with another NAMPT-inhibitor, GMX-1778 at 1nM also showed similar effect to FK866 and in combination wit
  5 KB (673 words) - 18:30, 31 January 2020
• Succinate
  ...nate alone may lead to accumulation of [[oxaloacetate]], which is a potent inhibitor of Complex II (compare [[Succinate and rotenone]]). High activities of mt-[ :::: In the absence of CI-linked substrates, add the CI-inhibitor [[rotenone]] before addition of succinate, to avoid accumulation of [[oxalo
  3 KB (467 words) - 15:06, 17 December 2022
• Campanella 2009 Trends Biochem Sci
  ...limited by the mitochondrial protein IF(1), an endogenous F(1)F(o)-ATPase inhibitor. IF(1), therefore, preserves ATP at the expense of Deltapsi(m). Despite a w
  1 KB (182 words) - 10:37, 3 April 2022
• Timon-Gomez 2023 MiP2023
  ...=[[File:Timon-Gomez A.jpg|left|100px|Timon-Gomez Alba]]Substrate-uncoupler-inhibitor titration protocol for analyzing carbohydrate and fatty acid metabolism ...l defects using high-resolution respirometry [2]. This substrate-uncoupler-inhibitor titration (SUIT) protocol analyzes fatty acid oxidation (FAO) by adding 0.1
  4 KB (456 words) - 16:47, 12 July 2023
• Sundstroem 2019 Acta Neuropathol Commun
  ...hondrial respiration, β-sitosterol represents a promising adjuvant to BRAF inhibitor therapy in patients with, or at risk for, melanoma brain metastases.
  3 KB (453 words) - 06:14, 20 April 2020
• Sauer 1973 Biochem Biophys Res Commun
  ...entration. Succinate was an allosteric activator and ATP was a competitive inhibitor of malate. The second peak showed hyperbolic kinetics in plots of activity
  1 KB (206 words) - 12:44, 29 May 2015
• Groeger 2010 Crit Care
  |abstract='''Introduction:''' Hydrogen sulfide (H₂S) is a potent inhibitor of cytochrome c oxidase (COX) and, thus, of mitochondrial respiration [1]. ...donor Na₂S (1 to 64 μM). In the parallel chamber, the identical inhibitor titration sequence was preceded by the inhibition of the respiratory chain
  3 KB (463 words) - 14:26, 13 November 2017
• Cottingham 1983 Biochim Biophys Acta
  ...fferent activities of the NADH dehydrogenase. In the absence of a specific inhibitor, the turnover of the external NADH dehydrogenase was adjusted using a novel
  2 KB (216 words) - 09:44, 1 April 2021
• Komlodi 2018 Methods Mol Biol
  ...d Buffer Z), and MiRK03 (KCl). Respiration in a simple substrate-uncoupler-inhibitor titration protocol was identical in MiR05, Buffer Z, and MiR07, whereas oxy ...solution respirometry, Oxygraph-2k, Respiration media, Substrate-uncoupler-inhibitor titration, HEK 293T cells, Permeabilized muscle fibers, DTPA, Buffer z
  3 KB (453 words) - 12:33, 25 October 2023
• Giulivi 2008 Biochem J
  ...confirm the involvement of malic enzyme, the effect of tartronic acid, an inhibitor of this enzyme, was tested on malate only or on malate- and pyruvate-supple
  4 KB (555 words) - 18:53, 15 March 2021
• Hoppel 2016c Abstract MitoFit Science Camp 2016
  ...acquire the noncoupled ET capacity; Antimycin A is used as the Complex III inhibitor.
  3 KB (480 words) - 15:32, 23 January 2019
• Galemou Yoga 2021 Front Chem
  |keywords=NADH dehydrogenase, Electron transfer, Inhibitor, Oxidative phosphorylation, Proton pumping, Respiratory chain, Semiquinone
  2 KB (216 words) - 16:15, 22 March 2023
• Nemeth 2016 FASEB J
  ...taconyl-CoA at the expense of ATP (or GTP), and is also a weak competitive inhibitor of complex II. Here, we investigated specific bioenergetic effects of incre |topics=ADP, Inhibitor
  3 KB (443 words) - 13:30, 2 August 2023
• Schaefer 2016 Abstract MitoFit Science Camp 2016
  (HEK APP) ± gamma secretase inhibitor treatment. In the upper panel the whole cells were analysed, the lower pane
  3 KB (494 words) - 15:19, 23 January 2019
• Spurway 1997 FEBS Letters
  |abstract=The effects of etomoxir, an inhibitor of mitochondrial long-chain fatty acid oxidation, on triacylglycerol metabo
  1 KB (183 words) - 23:07, 5 July 2021
• Garcia-Souza 2018 Life Sciences Meeting 2018 Innsbruck AT
  ...ting procedures have to be established. We developed a substrate-uncoupler-inhibitor titration protocol to measure respiratory control in intact cells and cell ...measured before and after addition of pyruvate. Oligomycin (0.05 – 2.5 µM, inhibitor of F-ATPase) was added to obtain LEAK respiration. Electron transfer-capaci
  3 KB (477 words) - 19:10, 10 January 2022
• SUIT reference protocol
  |description=The '''substrate-uncoupler-inhibitor titration ([[SUIT]]) reference protocol''', SUIT RP, provides a common base
  2 KB (204 words) - 10:38, 29 July 2022
• Djafarzadeh 2017 J Vis Exp
  ...stopper with injection ports, which makes it ideal for substrate-uncoupler-inhibitor titrations or detergent titration protocols for determining effective and o
  2 KB (204 words) - 16:28, 27 March 2018
• Hill 2015 Abstract MiPschool London 2015
  |title=A novel inhibitor of the mitochondrial permeability transition pore is beneficial in an exper ...ted mPTP opening. Compounds were compared to cyclosporin A – the canonical inhibitor of pore opening. Two of the compounds inhibited pore opening with significa
  3 KB (455 words) - 20:08, 7 March 2020
• Munro 2016 Free Radic Biol Med
  ...) and/or glutathione (GSH)-dependent enzymatic pathways. The Trx-reductase inhibitor auranofin (2µM), and a pre-treatment of mitochondria with 35µM of 1-chlor |topics=Inhibitor, Substrate
  4 KB (588 words) - 09:35, 8 November 2016
• Gariani 2016 J Hepatol
  ...o do this, we examined the preventive and therapeutic benefits of the PARP inhibitor (PARPi), olaparib, in different models of NAFLD. ...ds=Non-alcoholic fatty liver disease, Poly-ADP ribosylation, Sirtuin, PARP inhibitor
  3 KB (499 words) - 14:08, 2 August 2017
• MitoKit-CII/Malonate-nv
  |mitopedia topic=Inhibitor
  1 KB (174 words) - 12:06, 27 July 2021
• Maher 2014 FEBS Lett
  ...al role in preventing inflammation. Stefin B (cystatin B) is an endogenous inhibitor of cysteine proteinases. In stefin B-deficient bone marrow-derived macropha
  1 KB (183 words) - 16:09, 9 November 2016
• Liao 2021 Biotechniques
  ...awback of using Fluo-4 AM is that it requires an organic anion transporter inhibitor, such as probenecid, to prevent leakage. This can hinder the studies that r
  1 KB (199 words) - 13:25, 9 February 2022
• Aguirre 2012 Mitochondrion
  ...P(50) values than control animals. These effects were prevented by the NOS inhibitor L-NMMA. Our results suggest that mitochondrially derived NO is generated by
  1 KB (197 words) - 15:43, 10 March 2015
• Aasander Frostner 2017 MiP2017
  ...ytoplasm without disrupting the plasma membrane. Malonate is a competitive inhibitor of complex II that binds to the active site of succinate dehydrogenase, thu |topics=Inhibitor, Substrate
  4 KB (532 words) - 17:54, 5 December 2017
• Fox 2018 Thesis
  ...rds=Ovarian cancer, Drug resistance, Microtubule targeting agent, Tubulin, Inhibitor, Destabilizing agent
  2 KB (221 words) - 17:27, 4 February 2019
• Cadenas 2006 Biochim Biophys Acta
  ...pathway, since NO is a membrane-permeant second messenger and competitive inhibitor of COX (1). It is now well established that oxygraphs, with Teflon-coated s |topics=Inhibitor, Oxygen kinetics
  4 KB (517 words) - 12:42, 18 February 2022
• Phillips 2017 Cancer Research
  ...pentose phosphate pathway inhibitor (oxythiamine) or lactate dehydrogenase inhibitor (XF-11) reducing growth by 90% and ~25% at day 5, respectively; the inhibit
  4 KB (487 words) - 08:52, 11 July 2017
• Bernardo 2013 Biol Chem
  ...L maturation and oscillatory Ca2+ waves are prevented by the mitochondrial inhibitor rotenone and restored by PPAR-γ agonists, suggesting that PPAR-γ promotes
  2 KB (195 words) - 04:29, 10 November 2023
• Eberhart 2009 Leukemia
  ...us to investigate whether co-administration of 2-deoxy-glucose (2-DG), an inhibitor of glycolysis, systemic application of which up to a blood concentration of
  2 KB (207 words) - 18:17, 31 January 2020
• GIBB 2023 Riva del Garda IT
  ...imon-Gomez Alba]]: [[Timon-Gomez 2023 GIBB|A reference substrate-uncoupler-inhibitor titration protocol to create a mitochondrial pathway and coupling control d
  2 KB (231 words) - 10:11, 13 June 2023
• Zickermann 2015 Science
  ...ative proton-pumping units. The binding position for a substrate analogous inhibitor and blockage of the predicted ubiquinone binding site provide a model for t
  2 KB (219 words) - 14:06, 28 March 2023
• Mitchell 1968 Eur J Biochem
  Classical inhibitor studies of the overall ATPase reaction catalysed by the mitochondria indica
  2 KB (233 words) - 00:31, 18 February 2022
• Wojtczak 2012 Abstract Bioblast
  ...effect on the release of ROS was exerted by carboxyatractyloside, specific inhibitor of the mitochondrial [[ANT|adenine nucleotide transporter]]. Much lower eff
  4 KB (550 words) - 16:37, 7 November 2016
• Legkun 2014 Abstract IOC 2014-04 Schroecken
  |topics=ADP, Inhibitor, Uncoupler
  2 KB (221 words) - 09:43, 3 June 2020
• Droese 2011 Mol Pharmacol
  ...required for half-maximal inhibition-ranging from nanomolar for the Q site inhibitor atpenin A5 to millimolar for the succinate analog malonate-all inhibitors m
  2 KB (228 words) - 17:05, 19 February 2018
• Preparation of SUIT chemicals
  ...cals''' describes the preparation of chemicals used in Substrate-Uncoupler-Inhibitor Ttitration (SUIT) protocols. ...tock solutions is critical for concentration-dependent substrate-uncoupler-inhibitor kinetic (SUIK) titrations.
  6 KB (916 words) - 08:50, 17 June 2021
• Doerrier 2015 Abstract MiPschool Greenville 2015
  ...events the accumulation of oxaloacetate (Oa) which is a strong competitive inhibitor of CII [1].
  5 KB (714 words) - 18:35, 10 January 2022
• Yu 2023 Antioxidants (Basel)
  ...ntions, dietary supplements, and chemicals, such as mitochondrial division inhibitor-1 (Mdivi-1) and other mitochondrial fission inhibitors, as well as certain
  2 KB (251 words) - 09:54, 24 October 2023
• Walker 2013 Abstract MiP2013
  ...active by a redox mechanism in the hours darkness. Mitochondria contain an inhibitor protein, IF1, that inhibits ATP hydrolysis but not ATP synthesis. Its in vi |topics=Coupling efficiency;uncoupling, Inhibitor
  4 KB (632 words) - 11:00, 17 February 2022
• Keeley 2018 FASEB J
  ...d with 18% O2. This protection was abolished by cotreatment with the SERCA inhibitor cyclopiazonic acid. Taken together, these results demonstrate that culturin
  2 KB (238 words) - 09:16, 28 June 2022
• Gniadecki 2000 J Cell Biochem
  ...nide-p-trifluoromethoxy-phenylhydrazone and oligomycin) and the complex II inhibitor (theonyltrifluoroacetone) prevented H(2)O(2) accumulation after UV. Antimyc
  2 KB (214 words) - 17:01, 16 February 2022
• Madlala 2019 Integr Food Nutr Metab
  |topics=Inhibitor, Substrate
  2 KB (228 words) - 16:01, 30 January 2020
• Spurway 1997 Biochem J
  ...arboxylate (Etomoxir), which is converted to Etomoxir-CoA, an irreversible inhibitor of CPT I. We measured CPT I activity and flux through beta-oxidation at 0.2
  1 KB (209 words) - 23:04, 5 July 2021
• Doerrier 2017 Abstract MitoEAGLE Barcelona
  ...monized states differ in terms of the sequence of substrate, uncoupler and inhibitor titrations (Figure 2). RP1 includes respiratory states that can be compared :::#[[MitoPedia:_SUIT]] - Substrate-uncoupler-inhibitor protocols.
  6 KB (754 words) - 12:00, 27 May 2019
• Galvan 2019 Biochimie
  ...uction of reactive oxygen species. MccJ25 behaves as a dose-dependent weak inhibitor. Intriguingly, MccJ25 is capable of producing a change in the oxidation sta
  2 KB (223 words) - 16:21, 17 February 2022
• Crispim 2019 MitoFit Preprint Arch EA
  ...mulating the effects of atovaquone. 4-nitrobenzoate (4-NB) is a well-known inhibitor of 4HPT (4-hydroxybenzoate polyprenyltransferase), the first enzyme of UQ b
  4 KB (546 words) - 08:28, 8 January 2023
• Kopitar-Jerala 2015 Front Mol Neurosci
  ...Type I cystatin stefin B (cystatin B) is an endogenous cysteine cathepsin inhibitor localized in the cytosol, mitochondria and nucleus. Mutations in the gene o
  2 KB (238 words) - 13:23, 27 July 2016
• Rekuviene 2017 Data Brief
  |topics=Calcium, Inhibitor
  2 KB (232 words) - 11:47, 11 June 2018
• Garcia-Souza 2016 Abstract Mito Xmas Meeting Innsbruck
  ...ors represents a key aspect of bioenergetics research. Substrate-uncoupler-inhibitor titration (SUIT) protocols are applied for determining respiratory capaciti ...ain mt with octanoylcarnitine and malate was inhibited by 50% by malonate (inhibitor of CII). In liver mt, however, FAO-linked respiration was paradoxically inc
  4 KB (493 words) - 18:45, 10 January 2022
• Zoccarato 2011 J Bioenerg Biomembr
  ...depends on the concentration of each metabolite. Acetoacetate is a strong inhibitor of H(2)O(2) release, starting at 10 μM and acting quickly. It potentiates
  2 KB (206 words) - 10:46, 3 April 2022
• Hildebrandt 2008 FEBS J
  |topics=Inhibitor, Substrate
  2 KB (233 words) - 10:53, 27 March 2018
• Winkler-Stuck 2004 J Neurol Sci
  ...itochondrial function of skin fibroblast cultures were evaluated. Applying inhibitor titrations of the mitochondrial respiration to calculate flux control coeff
  2 KB (240 words) - 15:47, 9 November 2016
• Coupling/pathway control diagram
  ...the respiratory '''states''' obtained step-by-step in substrate-uncoupler-inhibitor titrations in a [[SUIT protocol]]. Each step (to the next state) is defined
  2 KB (240 words) - 20:03, 1 January 2021
• Mould 2023 Front Physiol
  ...d that mitochondria in one cuvette stressed by an electron transport chain inhibitor, antimycin, alters the respiration of mitochondria in an adjacent, but chem
  2 KB (244 words) - 23:37, 7 February 2024
• Rotenone
  |description='''Rotenone''' is an inhibitor of [[Complex I]] (CI) and thus inhibits NADH oxidation. It inhibits the tra |mitopedia topic=Inhibitor
  4 KB (569 words) - 10:13, 5 March 2024
• Russell 1991 Am J Physiol
  ...able performance with no fall in the work output. When hydroxymalonate, an inhibitor of NADP(+)-dependent malic enzyme and malate dehydrogenase, was added to th
  2 KB (270 words) - 14:53, 4 March 2015
• Maarman 2015 Abstract MiPschool Cape Town 2015
  inhibitor. When glutamate and malate were used as substrates: MCT rotenone as inhibitor: MCT hearts had a 52% lower RV state 3 (''p''< 0.002),
  3 KB (496 words) - 13:15, 23 January 2019
• Dungel 2008 Arch Biochem Biophys
  |topics=Inhibitor
  2 KB (244 words) - 15:44, 20 March 2015
• Nelson 2015 Master Thesis
  ...y impaired in AGE-treated cells, but not when co-treated with myriocin, an inhibitor of ''de novo'' ceramide biosynthesis. Moreover, we exposed WT and RAGE KO m
  2 KB (240 words) - 15:29, 13 November 2017
• Gong 2005 Am J Physiol Cell Physiol
  ...ot prevented by the antioxidants Trolox and N-acetyl-cysteine. Oligomycin, inhibitor of F(0)F(1)-ATPase, prevented hypoxia-induced HIF-1alpha protein accumulati
  2 KB (255 words) - 16:58, 31 May 2019
• Chen 2016 Nat Chem Biol
  ...m enriched lactate enter the mitochondria. The lactate dehydrogenase (LDH) inhibitor oxamate decreased respiration of isolated mitochondria incubated in lactate
  2 KB (253 words) - 17:19, 9 November 2017
• Murray 2018 MiPschool Tromso E1
  For the mitochondrial physiologist, the substrate-uncoupler-inhibitor titration (SUIT) protocol represents a flexible method for the assessment o
  2 KB (259 words) - 12:16, 17 October 2018
• Komlodi 2017 MiPschool Obergurgl
  ...ce of ADP (LEAK and OXPHOS states), and the absence and presence of the CI inhibitor rotenone, selectively blocking RET. Experiments were carried out on isolate |topics=Flux control, Inhibitor, Q-junction effect, Redox state, Substrate
  5 KB (694 words) - 18:54, 10 January 2022
• Silva Ferraz 2020 Biochem Pharmacol
  ...-RAF (40-60% of cases). Recent studies have shown that vemurafenib (a MAPK inhibitor) promoted disturbance of mitochondrial bioenergetics, although underlying m
  2 KB (234 words) - 21:41, 20 August 2020
• Chance 1962 J Biol Chem
  |topics=Flux control, Inhibitor, Redox state
  2 KB (260 words) - 17:18, 9 November 2017
• Howie 2014 Front Immunol
  ...cell types by TGFβ and the adenosine generated can be shown to be a potent inhibitor of T cell proliferation. This review will focus on mechanisms of nutrient s
  2 KB (267 words) - 16:03, 26 October 2023
• Le Bourvellec 2004 J Agric Food Chem
  |topics=Inhibitor
  2 KB (259 words) - 12:01, 22 November 2017
• Efimova 2017 MiP2017
  ...daptation of the technique of affinity purification through IF₁ inhibitor protein [1,2] in order to isolate individual ATP-synthase subassemblies and ::::#Bason JV, Runswick MJ, Fearnley IM, Walker JE (2011) Binding of the inhibitor protein IF(1) to bovine F(1)-ATPase. J Mol Biol 406:443–53.
  4 KB (598 words) - 14:33, 26 March 2018
• Debska 2002 Biochim Biophys Acta
  ...ed by the antidiabetic sulfonylurea derivative glibenclamide, a well-known inhibitor of ATP-regulated potassium channels (K_atp channels). Since both
  2 KB (265 words) - 15:45, 24 March 2015
• Cizmarova Beata
  ...mize the SUIT protocols with defined substrate combinations, uncoupler and inhibitor titrations, which will be applied for the measurement of respiration of the
  4 KB (586 words) - 13:19, 16 March 2020
• Contreras-Ferrat 2014 Abstract MiP2014
  ...ulin, were decreased in the presence of xestospongin or ruthenium red (MCU inhibitor). This effect suggests a retrograde regulation of insulin signaling by mito
  4 KB (546 words) - 16:12, 15 February 2016
• Kane 2016 Abstract MitoFit Science Camp 2016
  ...tial pre-assay inconsistency might, therefore, be to introduce contraction inhibitor early in the preparation of the sample. ...etermine whether JO₂ in myofibers treated with myosin II ATPase inhibitor blebbistatin (bleb) during the entire sample preparation exhibit different
  6 KB (790 words) - 17:46, 7 November 2016
• Bobba 2015 Apoptosis
  of dichloroacetate, inhibitor of the pyruvate dehydrogenase
  2 KB (270 words) - 13:51, 27 March 2018
• Ponce 2019 Thesis
  ...and ischemic conditions ''in vivo''. Furthermore, pretreatment with a Cdk1 inhibitor followed by ischemia ''in vivo'' results in reduced mitochondrial fission.
  2 KB (264 words) - 18:08, 19 May 2020
• Che 2023 Plant Cell Environ
  ...he recovery of damaged PSII under darkness. By transcriptomic analysis and inhibitor verification experiments, dark hypoxia was shown to inhibit respiration, th
  2 KB (252 words) - 23:44, 16 September 2023
• Gautam 2019 Sci Rep
  ...per se'' induced synthesis of thrombogenic peptides, plasminogen activator inhibitor-1 and hypoxia-inducible factor-2α, from pre-existing mRNAs in enucleate pl
  2 KB (248 words) - 23:45, 29 February 2020
• MiPNet16.04 IOC62
  ...e is complemented by lectures and experiments based on substrate-uncoupler-inhibitor titration ([[SUIT]]) protocols. Short presentations of 'Hot topics in Mitoc ...0 Mitochondrial respiratory physiology: Protocols with substrate-uncoupler-inhibitor titrations for coupling and substrate control.
  4 KB (545 words) - 02:27, 9 October 2019
• Rodriguez-Juarez 2007 Biochem J
  |topics=Inhibitor, Oxygen kinetics
  2 KB (248 words) - 15:49, 9 November 2016
• Barsottini 2020 Commun Biol
  ...ch, aided by an MpAOX structural model, indicates key residues for protein-inhibitor interaction. We also discuss the importance of the correct hydrophobic envi
  2 KB (245 words) - 18:41, 3 June 2020
• Boveris 1999 Methods Enzymol
  |topics=ADP, Inhibitor, Oxygen kinetics
  2 KB (285 words) - 14:36, 1 December 2015
• Dungel 2011 J Biochem Mol Toxicol
  ...y at complex I. Both effects were insensitive to chloral hydrate, an ALDH2 inhibitor. Nitrite, an NG intermediate, had no influence on either mitochondrial resp
  2 KB (239 words) - 08:46, 29 March 2017
• Matallo MiP2010
  |topics=Flux control, Inhibitor, Temperature ...azide (Azd) in 0.2, 0.4, 0.8, 1.6, 3.2, 6.4, 12.8, 25.6 mM-steps as a CIV-inhibitor that does not undergo any metabolism at the mitochondrial level. To quantif
  7 KB (955 words) - 15:31, 24 January 2018
• Copsey 2021 Sci Rep
  ...B, Xu F, Albury MS, Young L, Moore AL (2021) Kinetic characterisation and inhibitor sensitivity of ''Candida albicans'' and ''Candida auris'' recombinant AOX e
  2 KB (255 words) - 09:22, 30 July 2021
• Moreno 2013 Biomed Chromatogr
  ...ctrometry to monitor therapeutic levels of imatinib in plasma, a selective inhibitor of protein tyrosine kinase. After solid-phase extraction of plasma samples,
  2 KB (241 words) - 16:15, 10 October 2016
• Galambo 2022 Curr Res Physiol
  ...ermeabilized mice aorta using high-resolution respirometry and a substrate-inhibitor titration protocol. We found that CL significantly lowers LEAK and maximal
  2 KB (269 words) - 17:07, 3 January 2023
• SUIT-003 O2 ce D039
  ...Depending on the species of microalgae studied [[oligomycin]] or any other inhibitor of the [[ATP synthase]] or of the [[adenine nucleotide translocase]] might
  2 KB (253 words) - 14:47, 23 March 2021
• Garedew 2005 Eur Shock Soc
  ...million cells or <4 mg biopsy (muscle, liver) per assay. Complex substrate/inhibitor titration protocols are used to quantify functional properties of selected
  2 KB (235 words) - 04:16, 23 November 2021
• Sivertsson 2013 Adv Exp Med Biol
  ...ontrol and streptozotocin-induced diabetic rats were treated with the mTOR inhibitor rapamycin (0.2 mg/day) by oral gavage for 14 days, after which mitochondria
  2 KB (269 words) - 17:30, 23 February 2020
• IOC62
  ...0 Mitochondrial respiratory physiology: Protocols with substrate-uncoupler-inhibitor titrations for coupling and substrate control.
  2 KB (213 words) - 23:20, 17 March 2019
• Elustondo 2013 J Biol Chem
  ...t addition of NAD(+) significantly increased JO2, and was abolished by the inhibitor of mitochondrial pyruvate transport, α-cyano-4-hydroxycinnamate. In experi
  2 KB (267 words) - 13:34, 27 April 2015
• Domenis 2011 J Bioenerg Biomembr
  ...tic ATP, thereby sustaining ΔΨm. A higher expression level of ATP synthase Inhibitor Factor 1 (IF1), a higher extent of IF1 bound to ATP synthase and a lower AT
  2 KB (264 words) - 15:09, 3 December 2013
• Dos Santos 2013 J Bioenerg Biomembr
  ...increase in oxygen consumption was not inhibited by GDP, a well-known UCP inhibitor. In phosphorylating mitochondria, palmitate lowered both ADP/O ratio (numbe
  2 KB (260 words) - 17:50, 9 November 2017
• NS-S pathway control efficiency
  ...nate in the absence of Rot, since [[oxaloacetate]] accumulates as a potent inhibitor of [[succinate dehydrogenase]] CII.
  2 KB (288 words) - 18:30, 1 January 2021
• Burney 2018 Thesis
  ...rat myoblasts. High-resolution respirometry and three Substrate-Uncoupler-Inhibitor-Titration (SUIT) protocols were used to examine respiration. Mitochondrial
  2 KB (271 words) - 13:29, 7 March 2020
• Karlsson 2016 Mitochondrion
  ...this, ten pigs received an infusion of rotenone, a mitochondrial complex I inhibitor, or vehicle. Clinical parameters, blood gases, continuous indirect calorime
  2 KB (253 words) - 14:52, 18 October 2018
• Rekuviene 2018 Thesis
  |topics=Inhibitor
  2 KB (292 words) - 14:20, 5 March 2019
• Gutman 1972 FEBS Lett
  |topics=Flux control, Inhibitor, Q-junction effect
  2 KB (280 words) - 13:03, 3 April 2021
• Zhu 2019 Aging Cell
  |keywords=DPP-4 inhibitor, GLP-1, Healthspan, High-fat diet, Longevity
  2 KB (242 words) - 11:50, 9 August 2019
• Misirkic Marjanovic 2019 MiP2019
  ...lization (LMP)-inducing agent N- dodecylimidazole (NDI)[1] with glycolytic inhibitor 2-deoxy-D-glucose (2DG) and in antipsychotic action of atypical antipsychot ...-induced death of glioma cells was partly prevented by lysosomal cathepsin inhibitor E64 and antioxidant tocopherol, suggesting the involvement of LMP and oxida
  4 KB (568 words) - 15:40, 3 October 2019
• Esfandiary 2012 Abstract IOC68
  ...ricles was quantified by high-resolution respirometry. We used a substrate-inhibitor protocol with pyruvate, ADP, malate, octanoylcarnitine, rotenone, succinate
  2 KB (303 words) - 18:51, 18 July 2014
• Skorkowski 1984 Comp Biochem Physiol
  ...te very slowly unless pyruvate was added. Arsenite and hydroxymalonate (an inhibitor of malic enzyme) inhibited the respiration rate of mitochondria isolated fr
  2 KB (312 words) - 09:14, 9 November 2016
• Sharpe 1998 J Biol Chem
  |topics=ADP, Inhibitor, Substrate
  2 KB (294 words) - 10:11, 29 May 2019
• SUIT-006 MgG mt D055
  :::* The [[ATP synthase]] inhibitor [[oligomycin]] (Omy) can also be used, instead of [[carboxyatractyloside]], | Can be substituted for other CIII or CIV inhibitor
  5 KB (755 words) - 10:43, 18 August 2023
• Djafarzadeh 2011 Mitochondrion
  pore-opening inhibitor). Poly-I:C induced activation of NF-κB, and the
  2 KB (248 words) - 04:26, 29 February 2020
• Chang 2017 FASEB J
  ...aric hypoxia chamber. Before and immediately after HE, Substrate-Uncoupler-Inhibitor Titrations (SUIT) protocols and TMRE, a mitochondrial membrane potential fl
  2 KB (280 words) - 14:15, 2 March 2020
• Qin 2018 Biochem Biophys Res Commun
  ...the expression of cytochrome B, which were suppressed by the specific AMPK inhibitor compound C. Indeed, Humanin treatment caused the phosphorylation of AMPK, w
  2 KB (256 words) - 05:24, 1 March 2020
• Xu 1999 Structure
  ...The natural ligand for this second binding site may be ATP, an allosteric inhibitor of the enzyme.
  2 KB (302 words) - 12:45, 30 July 2014
• Gruening 2011 Cell Metab
  ...tion of the PYK substrate phosphoenolpyruvate (PEP). PEP acted as feedback inhibitor of the glycolytic enzyme triosephosphate isomerase (TPI). TPI inhibition st
  2 KB (258 words) - 09:21, 9 November 2016
• MitoPedia: SUIT
  ::: '''MitoPedia: SUIT''' - '''Substrate-uncoupler-inhibitor titration protocols''' '''SUIT: Substrate-uncoupler-inhibitor-titration'''
  9 KB (1,166 words) - 19:56, 11 February 2023
• Silva 2019 MiPschool Coimbra
  Etomoxir is an irreversible inhibitor of the mitochondrial transport of long-chain fatty acids via blockage of ca ...)] in different electron transfer (ET) pathway states. Substrate-uncoupler-inhibitor titration protocol was used to study oxidative phosphorylation (OXPHOS) and
  7 KB (977 words) - 19:13, 10 January 2022
• Piskernik 2008 Biochim Biophys Acta
  |abstract=Here we show that both Antimycin A, a respiratory chain inhibitor inducing apoptosis, and endotoxic shock, a syndrome accompanied by both nec
  2 KB (287 words) - 15:59, 20 March 2015
• Mastronicola 2011 IUBMB Life
  ...impaired, and the FDP undergoes a degradation, prevented by the proteasome-inhibitor MG132. Instead, H₂O₂ does not cause degradation or in
  2 KB (276 words) - 11:20, 21 January 2020
• Van Doan 2023 Abstract IOC162
  In vitro, H9C2 rat cardiomyocytes were treated with FK866, a Nampt inhibitor, to deplete cellular NAD⁺. For ''in vivo'' study, mitochondria w
  2 KB (292 words) - 17:40, 18 September 2023
• Madlala 2015 Abstract MiPschool Cape Town 2015
  10 mM fructose, fructose + 10 mM SB431542 (TGF-β1 receptor inhibitor), fructose + 100 M allopurinol (uric acid inhibitor), fructose + SB431542
  4 KB (531 words) - 13:16, 23 January 2019
• Curtabbi 2023 Redox Biol
  ...ex. In this study, we demonstrate that diphenyleneiodonium (DPI), a N-site inhibitor, uniquely affects the stability of complex I by reacting with its flavin co
  2 KB (279 words) - 15:35, 3 January 2024
• Calderon-Dominguez 2017 Adv Sci (Weinh)
  ...ed the appropriate weight of the explants, the exact concentration of each inhibitor in the reaction, and the specific incubation time to optimize bioenergetics
  2 KB (282 words) - 15:57, 27 March 2018
• SUIT-006 MgG ce-pce D085
  :::* The [[ATP synthase]] inhibitor [[oligomycin]] (Omy) can also be used, instead of [[carboxyatractyloside]], | Can be substituted for other CIII or CIV inhibitor
  5 KB (762 words) - 11:12, 18 August 2023
• IOC16
  ::::* Substrate/inhibitor titration regimes for mitochondrial enzyme complexes.
  2 KB (270 words) - 16:11, 23 January 2019
• Fasching IOC61-TPP group
  ...neously with changes in respiration in the course of [[Substrate-uncoupler-inhibitor titration|SUIT]] protocol. [[Calculation of mitochondrial membrane potentia
  2 KB (320 words) - 11:02, 23 January 2019
• Jayasankar 2022 ACS Omega
  ...derived molecules such as avocatin B (Avo B), a fatty-acid oxidation (FAO) inhibitor, are promising novel therapeutics. The roots of the Curcuma amada plants ha
  2 KB (257 words) - 06:36, 23 October 2023
• Guerrier 2023 MiP2023
  ...ermeabilized adipocytes using high resolution respirometry and a substrate/inhibitor titration approach (Figure) (4,5). Protein accumulation of mitochondrial an ...er 2023 MiP2023 Figure.png|400px|none|thumb|'''Figure. Substrate/Uncoupler/Inhibitor Titration Protocol.''' This protocol is based on the injection of substrate
  5 KB (640 words) - 16:45, 12 July 2023
• Kunz 2000 Ann Neurol
  ...ic focus showed reduced complex I activity only in parahippocampal tissue. Inhibitor titrations of the maximal respiration rate of intact human brain slices rev
  2 KB (273 words) - 16:33, 17 February 2015
• Laner 2016 Abstract Mito Xmas Meeting Innsbruck
  ...(SUIT) protocols in mt-respiration medium MiR06Cr. Two substrate-uncoupler-inhibitor titration protocols were applied (Fig. 1). SUIT1 emphasized pathway control
  4 KB (530 words) - 18:38, 10 January 2022
• Wolff 2013 J Orthop Res
  ...idium (ROS indicator) and a Luciferase-based ATP assay. Electron transport inhibitor rotenone and mitochondrial ROS scavenger MitoQ significantly suppressed mec
  2 KB (274 words) - 14:38, 19 May 2015
• Benani 2009 J Neurosci Methods
  |topics=ADP, Inhibitor, Substrate
  2 KB (291 words) - 16:33, 26 March 2018
• Hards 2018 Proc Natl Acad Sci U S A
  |abstract=Bedaquiline (BDQ), an inhibitor of the mycobacterial F₁F_o-ATP synthase, has revolutio
  2 KB (277 words) - 10:56, 14 August 2018
• Ceru 2010 J Biol Chem
  |abstract=Stefin B (cystatin B) is an endogenous inhibitor of cysteine proteinases localized in the nucleus and the cytosol. Loss-of-f
  2 KB (300 words) - 14:47, 29 July 2016
• Hamann 2022 J Fungi (Basel)
  ...-native PAGE revealed that the pro34 mutant lacks mitochondrial complex I. Inhibitor experiments revealed that pro34 respires via complexes III and IV, but also
  2 KB (285 words) - 12:28, 22 November 2022
• Racker 1967 J Biol Chem
  ...st, submitochondrial particles from yeast were much less sensitive to this inhibitor.
  2 KB (318 words) - 10:57, 20 February 2015
• Carballal 2021 J Biol Chem
  ...enous sources of this signaling molecule, notably from gut microbes. As an inhibitor of complex IV in the electron transport chain, H₂S can have a pr
  2 KB (302 words) - 15:52, 19 October 2021
• Meng 2021 FEBS Open Bio
  |abstract=Sunitinib (Sun), a tyrosine kinase inhibitor of vascular endothelial growth factor receptor (VEGFR), is the standard fir
  2 KB (257 words) - 15:50, 19 October 2021
• Armstrong 2003 J Biol Chem
  ...me ''bc''₁), because (''1'') stigmatellin, a Q_o site inhibitor, blocked ROS production and prevented the mtPT and cell death and (''2'') c
  2 KB (287 words) - 16:59, 11 March 2021
• Corona de la Pena 2017 PLoS One
  ...resveratrol, ATP (calcium-release inhibitors) and PP1 (Tyr-phosphorylation inhibitor) prevented the thrombin-induced platelet activation. These results suggest
  2 KB (286 words) - 19:48, 20 March 2023
• Oroboros Science Scholarship
  ...e conceptual basis of OXPHOS analysis with respiratory substrate-uncoupler-inhibitor titration (SUIT) protocols when working with isolated mitochondria, permeab
  2 KB (287 words) - 15:23, 5 September 2022
• Swenson 2018 Anesthesiology
  ...and brain homogenate experiments that acetazolamide, a carbonic anhydrase inhibitor, reduces intracellular pH. This led him to conclude that hydrogen ion and b
  2 KB (316 words) - 05:56, 5 July 2022
• Nuskova 2010 J Bioenerg Biomembr
  |topics=Flux control, Inhibitor
  2 KB (295 words) - 15:16, 19 March 2015
• Vasington 1962 J Biol Chem
  |topics=ADP, Calcium, Coupling efficiency;uncoupling, Inhibitor, Ion;substrate transport
  3 KB (351 words) - 11:23, 28 May 2015
• Vigueira 2014 Cell Rep
  ...timulated insulin secretion and was corrected by sulfonylurea KATP channel inhibitor administration. Collectively, these data are consistent with a role for MPC
  2 KB (258 words) - 14:20, 18 March 2018
• Franciso 2007 Eur J Pharmacol
  |topics=ADP, Inhibitor, Oxygen kinetics
  2 KB (274 words) - 16:12, 9 November 2016
• Batandier 2006 J Bioenerg Biomembr
  ...ria extracted from liver of rats treated with or without metformin, a mild inhibitor of respiratory chain complex 1 used in type 2 diabetes. A high rate of ROS
  2 KB (266 words) - 11:32, 14 February 2022
• Slater 1953 Biochem J
  # Hypertonic sucrose (0.88 M) is an inhibitor of the succinic oxidase system in the Keilin & Hartree preparation. Its maj
  2 KB (330 words) - 11:06, 26 February 2015
• Alves 2018 MiPschool Tromso E2
  ...th EX527 (SIRT1 inhibitor); YK-3-237 (SIRT1 activator) and Rapamycin (mTOR inhibitor), as well as in a combined treatment of EX527+Rapamycin. In addition to cyt
  5 KB (660 words) - 18:01, 23 February 2020
• Hervouet 2006 Biochem Biophys Res Commun
  |topics=Inhibitor
  2 KB (262 words) - 14:30, 26 March 2018
• Jardim-Messeder 2012 Int J Biochem Cell Biol
  |topics=ADP, Inhibitor
  2 KB (302 words) - 13:09, 26 February 2015
• Hughey 2011 J Vis Exp
  ...gen concentration in the closed chamber declines. Using selected substrate-inhibitor-uncoupler titration protocols, electrons are provided to specific sites of
  2 KB (278 words) - 11:37, 27 February 2013
• Jezek 2010 Physiol Res
  ...rom the inhibition by bromoenol lactone (BEL), a specific iPLA₂ inhibitor. Concomitant uncoupling has been caused by free fatty acids, since it was i
  2 KB (297 words) - 15:25, 26 May 2015
• Hancock 2016 Amino Acids
  ...the addition of DHP and NAC. We found that succinate was an uncompetitive inhibitor of PRODH/POX activity, inhibited ROS generation by PRODH/POX, and alleviate
  2 KB (314 words) - 13:29, 19 February 2019
• Kunz 2000 J Biol Chem
  ...he present work, by titrating cytochrome c oxidase (COX) with the specific inhibitor KCN, the flux control coefficient and the metabolic reserve capacity of COX
  2 KB (282 words) - 17:23, 16 January 2021
• O2k-Webinars
  :::::* Substrate-uncoupler-inhibitor titration (SUIT) protocols </div> </div>
  3 KB (332 words) - 12:27, 28 July 2020
• SUIT protocol library
  |description=The '''Substrate-uncoupler-inhibitor titration (SUIT) protocol library''' contains a sequential list of SUIT pro :::: [[Pathway control state]]s are defined for many substrate-inhibitor combinations in SUIT protocols, particularly: ([[N-pathway control state]],
  5 KB (721 words) - 15:01, 8 June 2020
• Gnaiger 1998 BTK-HRR
  |topics=Inhibitor, Oxygen kinetics, Substrate
  2 KB (250 words) - 04:26, 23 November 2021
• Pike 2011 Biochim Biophys Acta
  ...of fatty acid β-oxidation by etomoxir, a carnitine palmitoyltransferase 1 inhibitor, markedly reduces cellular ATP levels and viability. We also found that inh ...iger E (2019) Can fatty acid oxidation be specifically blocked by the CPT1 inhibitor etomoxir? - [[Silva 2019 ESCI2019 |»Bioblast link«]]
  11 KB (1,581 words) - 12:38, 21 April 2023
• Sidlauskas 2017 Neurosci Lett
  |topics=Inhibitor
  2 KB (280 words) - 15:00, 18 February 2019
• Taleva 2015 Abstract MiP2015
  ...ffer between BS and Dk trypanosomes, the sensitivity of these cells to AAC inhibitor carboxyatractyloside was approximately 40-folds higher for Dk cells compare
  2 KB (310 words) - 14:24, 26 March 2018
• Krumschnabel 1997 Am J Physiol
  ...in of the Ca2+ increase observed in trout cells. Cyclosporin A, a specific inhibitor of the mitochondrial permeability transition pore in mammalian cells, was i
  2 KB (315 words) - 12:05, 23 January 2019
• Ocloo 2017 J Appl Pharmac Sc
  ...at liver mitochondria and permeabilised mouse heart fibers using substrate-inhibitor titrations. The O, O-dimethyl-alpinumisoflavone inhibited State 3 respirati
  2 KB (269 words) - 12:10, 27 March 2018
• Schlaepfer 2014 Mol Cancer Ther
  ...n and lipid synthesis/lipolysis, respectively. Etomoxir is an irreversible inhibitor of the carnitine palmitoyltransferase (CPT1) enzyme that decreases β oxida
  2 KB (288 words) - 23:13, 5 July 2021
• Hand 2012 Abstract Bioblast
  ...ty than that observed through Complex I alone. The nature of the potential inhibitor is unknown at present, but one candidate could be long-chain acyl CoA ester
  5 KB (683 words) - 11:16, 8 June 2020
• Liu 2023 Pharmacol Res
  |abstract=Sorafenib, a multi-targeted tyrosine kinase inhibitor, is a first-line treatment for advanced solid tumors, but it induces many a
  2 KB (303 words) - 15:41, 19 December 2023
• Warnsmann 2018 Mech Ageing Dev
  ...t forms of cell death in various types of cancer. Gossypol acts as a Bcl-2 inhibitor that induces apoptosis in apoptosis-competent cells. In apoptosis-resistant
  2 KB (288 words) - 16:21, 23 March 2018
• Krumschnabel 2016b Abstract MitoFit Science Camp 2016
  ...aph-2k in combination with the O2k-Fluo LED2-Module, a substrate-uncoupler-inhibitor-titration (SUIT) protocol was applied to HEK 293T cells and respiration was
  2 KB (302 words) - 13:05, 7 March 2020
• Cheng 2008 Cell Physiol Biochem
  ...d a reduced Ca(2+)-retention capacity with 100 nM iberiotoxin, a selective inhibitor of BK-channels. We therefore conclude that there is interaction between the
  2 KB (293 words) - 21:12, 18 March 2018
• Zhuge 2017 Redox Biol
  ...ce. These effects were diminished when XOR was blocked using the selective inhibitor febuxostat. Finally, we demonstrate that NDHP, in contrast to glyceryl trin
  2 KB (280 words) - 13:11, 26 June 2019
• Schoenfeld 2016 J Cereb Blood Flow Metab
  ...treatment of rats with methylpalmoxirate (carnitine palmitoyltransferase-1 inhibitor) decreased peroxidation of polyunsaturated fatty acids in brain tissue. Thi
  2 KB (298 words) - 16:23, 9 May 2017
• Doeller 1999 J Exp Biol.
  ...nts performed in the presence and absence of the mitochondrial complex III inhibitor antimycin A to limit endogenous carbon substrate oxidation showed that expo
  2 KB (301 words) - 09:19, 9 November 2016
• Mallick 2015 Cell Calcium
  ...of talin and microparticle release were precluded by calpeptin, a specific inhibitor of calpain. As microparticles are endowed with phosphatidylserine-enriched
  2 KB (275 words) - 16:19, 9 November 2016
• Sharpley 2006 J Biol Chem
  ...ne or proton translocation. Thus, zinc represents a new class of complex I inhibitor clearly distinct from the many ubiquinone site inhibitors. No evidence for
  2 KB (327 words) - 04:53, 15 October 2023
• Mills 2016 Cell
  ...s combination induces a pro-inflammatory gene expression profile, while an inhibitor of succinate oxidation, dimethyl malonate (DMM), promotes an anti-inflammat
  2 KB (280 words) - 13:42, 3 April 2023
• Vicentini 2019 Plant Physiol Biochim
  ...nt to Al-induced cell death. In addition, at 70 μM, Al also appeared as an inhibitor of cell wall invertase. In conclusion, Al tolerance in cultured ''J. curcas
  2 KB (293 words) - 15:34, 8 August 2023
• Waypa 2001 Circ Res
  ...pyrrolidinedithiocarbamate and ebselen and the Cu,Zn superoxide dismutase inhibitor diethyldithiocarbamate were used. These abolished HPV without affecting con
  2 KB (292 words) - 18:00, 13 April 2022
• Lin 2017 FASEB J
  ...irometry Oroboros Oxygraph-2k (O2k). The mitochondrial substrate-uncoupler-inhibitor titration (SUIT) protocol was used to determine mitochondrial oxygen consum
  3 KB (361 words) - 17:32, 25 February 2020
• Mousa 2023 Cell Rep
  ...e, including the transforming growth factor (TGF)-β1 target gene Mss51, an inhibitor of skeletal muscle mitochondrial respiration. Although Mss51 is implicated
  2 KB (293 words) - 10:11, 24 April 2024
• Chu SRS 2011
  ...nalysis was performed on permeabilised liver samples using a substrate and inhibitor titration protocol in conjunction with a high-resolution respirometer (OROB
  2 KB (290 words) - 08:27, 16 June 2015
• Klingenberg 1982 Eur J Biochem
  ...ined by employing a rapid mixing, quenching and sampling apparatus and the inhibitor quench-back exchange method. Thus the exchange is resolved down to 0.1 s. R
  2 KB (319 words) - 16:47, 11 February 2015
• Doerrier 2017 MiP2017 WG2
  ...ygen regimes. It has been reported that blebbistatin (a myosin II-specific inhibitor) allows the study of mitochondrial respiration in pfi at normoxic oxygen le |topics=ADP, Inhibitor, Oxygen kinetics
  5 KB (664 words) - 21:48, 17 March 2019
• Geyer 1951 J Biol Chem
  |topics=Inhibitor
  2 KB (348 words) - 06:07, 22 March 2023
• Jones 2010 Biochim Biophys Acta
  |topics=Inhibitor, Substrate
  2 KB (304 words) - 14:38, 20 March 2015
• Treberg 2018 Comp Biochem Physiol B Biochem Mol Biol
  |topics=Inhibitor
  2 KB (325 words) - 13:30, 7 March 2020
• Tomita 2001 Arthritis Rheum
  |topics=Inhibitor
  2 KB (312 words) - 09:04, 17 June 2015
• Kong 2018 Proteomics
  ...respiration. Further functional experiments using the substrate-uncoupler inhibitor titration approach confirmed that three representative ginsenosides were ab
  2 KB (305 words) - 16:11, 10 July 2018
• King 2009 Biochemistry
  ...itive to inhibitors such as rotenone and piericidin A). Here, we show that inhibitor-insensitive ubiquinone reduction occurs by a ping-pong type mechanism, cata
  2 KB (320 words) - 11:58, 5 November 2023
• Boyle 2015 Abstract MiP2015
  ...ation compared to WT HEK293 cells. PAP-1, a selective, cell permeant Kv1.3 inhibitor, reduced proliferation in both HEK293/Kv1.3 and HSVSMCs. Channel expression
  2 KB (309 words) - 09:14, 1 February 2017
• Pinho 2011 Abstract IOC65
  |topics=Inhibitor, Redox state, Substrate
  2 KB (295 words) - 10:05, 9 November 2016
• Morselli 2011 J Cell Biol
  ...t deacetylase sirtuin 1 (SIRT1). In this paper, we show that the acetylase inhibitor spermidine stimulates autophagy independent of SIRT1 in human and yeast cel
  2 KB (306 words) - 12:32, 19 February 2020
• Ziabreva 2010 Glia
  |topics=Inhibitor, mt-Membrane potential, Substrate
  2 KB (312 words) - 13:14, 19 March 2015
• Parrino 2000 J Exp Biol
  ...concentrations except in the presence of salicylhydroxamic acid (SHAM), an inhibitor of alternative oxidases. Sulfide-stimulated ATP production was 3-5 times gr
  2 KB (305 words) - 10:08, 9 November 2016
• Ma 2020 Sci Rep
  ...k cellular FAO function. Oxfenicine, on the other hand, acted as a partial inhibitor of FAO. As another class of FAO inhibitors that transcriptionally repress F
  2 KB (293 words) - 13:04, 12 September 2023
• Lee 2017 MiPschool Obergurgl
  ...ivation activity (AhRTA) and serum AhRTA correlated with its mitochondrial inhibitor activity (MIA). In this presentation I will show recent data which show the |topics=Inhibitor
  5 KB (649 words) - 16:10, 12 January 2018
• Khuchua 1994 Biochim Biophys Acta
  ...the calcium-induced activation of actomyosin ATPase. (i) Thapsigargin, an inhibitor of the sarcoplasmic reticulum Ca(2+)-ATPase, had no influence. (ii) In myos
  2 KB (302 words) - 11:03, 27 March 2018
• Hanna 2023 Antioxid Redox Signal
  ...sm of action. Studies on the dual impact of H2S as an ETC substrate and an inhibitor have led to the exciting discovery of ETC plasticity and the use of fumarat
  2 KB (324 words) - 23:26, 23 April 2023
• Civiletto 2018 EMBO Mol Med
  |abstract=The mTOR inhibitor rapamycin ameliorates the clinical and biochemical phenotype of mouse, worm
  2 KB (319 words) - 14:46, 20 June 2023
• Gnaiger 2019 NatureConference
  ...ng the quality standards of the Oroboros technology. [[Substrate-uncoupler-inhibitor-titration]]s (SUIT) can be applied for OXPHOS phenotyping of mitochondrial
  5 KB (689 words) - 09:49, 3 March 2020
• Cabrero 1999 Biochem Biophys Res Commun
  ...ure of rat preadipocytes for 24 h with 40 microM etomoxir, an irreversible inhibitor of carnitine palmitoyltransferase I (CPT-I), up-regulated UCP-3 mRNA levels
  2 KB (283 words) - 22:57, 5 July 2021
• Niemann 2022 Biology (Basel)
  ...8 weeks) as matched pairs. The role of AMPK was investigated with an AMPK inhibitor in rats or the use of alpha 2 AMPK knock-out mice.
  2 KB (296 words) - 17:25, 30 November 2022
• Kunz 1999 J Neurochem
  ...e oxidation rates of brain cortex homogenates from Movbr and control mice. Inhibitor titrations were
  2 KB (316 words) - 14:52, 28 March 2018
• Q-redox state
  ...sub> is measured in the presence of CoQ2 and isolated mitochondria. The CI inhibitor rotenone might have to be added to inhibit respiration of endogenous substr
  2 KB (361 words) - 11:49, 10 March 2022
• Wisniewski 1995 Eur J Biochem
  ..., 0.08 2 0.03 (n = 5), 0.01 -+ 0.006 (n = 4) and 0.09 ? 0.03 (n = 3) using inhibitor titrations with the specific inhibitors oligomycin, carboxyatractyloside, m
  2 KB (278 words) - 10:43, 23 January 2019
• Maddalena 2017 Biochem Biophys Res Commun
  ...olished or substantially reduced by treatment with GKT 137831, a selective inhibitor of NADPH oxidase subunits 1 and 4. These data indicate that oxygen levels e
  2 KB (315 words) - 14:31, 11 February 2022
• Chang 2015 Abstract EB2015
  ...ek for 6 weeks. According to a novelistically designed Substrate-Uncoupler-Inhibitor Titrations (SUIT) protocol, various modes of mitochondrial respiratory cont
  2 KB (284 words) - 14:15, 2 March 2020
• Elustondo 2014 Biochim Biophys Acta
  control mitochondria and in mitochondria treated with the PTP inhibitor CSA. We
  2 KB (323 words) - 11:51, 27 October 2023
• Rodrigues 2021 Sci Rep
  ...lanted tissue. All groups were able to respond to the substrates-uncoupler-inhibitor protocol. We found a dramatic decrease in general oxygen consumption in hem
  2 KB (302 words) - 17:20, 9 November 2021
• Shen 2017 Thesis
  ...rotein targets. Cells were then treated with TC-E 5003 (TC-E), a selective inhibitor of PRMT1 in order to specifically examine the enzymes role during myogenic
  2 KB (311 words) - 16:22, 15 January 2018
• Selivanov 2008 J Biol Chem
  ...with intact respiring mitochondria as well as in the presence of complex I inhibitor rotenone, which enhanced reactive oxygen species release. The phenomena rev
  2 KB (317 words) - 00:16, 18 February 2022
• Karlsson 2013 Int J Biochem Cell Biol
  ...omogenates using high-resolution respirometry and a multiple substrate and inhibitor protocol. The animals were divided into four groups; infected injected with
  2 KB (340 words) - 14:50, 13 November 2017
• Ruas 2018 Sci Rep
  ...ot occur when glutamine was the metabolic substrate or when the glycolytic inhibitor 2-deoxyglucose was present. ATP levels were reduced and ADP/ATP ratios incr
  2 KB (332 words) - 14:29, 12 June 2022
• Krumschnabel 2016 Abstract Mito Xmas Meeting Innsbruck
  ..., HEK293T cells, which can be examined using reference substrate-uncoupler-inhibitor titration (SUIT) protocols, and evaluated conditions for cell storage for l
  2 KB (322 words) - 18:43, 10 January 2022
• Hoel 2017 MiPschool Obergurgl
  |topics=Inhibitor
  2 KB (324 words) - 14:40, 27 March 2018
• Ziemer 2015 Dissertation
  ...lin D (CypD) ist mit der Pore assoziiert und ist Targetprotein für den PTP-Inhibitor Cyclosporin A (CsA). Diese Arbeit untersucht mit vergleichenden Experimente
  2 KB (281 words) - 15:33, 7 November 2016
• SUIT-006 O2 ce-pce D029
  ...ver, it is less specific than a similar protocol containing the complex II inhibitor malonic acid, that would allow to analyse the NADH-pathway without any cont
  2 KB (290 words) - 23:58, 12 April 2021
• Carmona 2009 Int J Obes
  |topics=Inhibitor
  2 KB (324 words) - 15:45, 3 June 2015
• Gatza 2011 Sci Transl Med
  ...oxidants, whereas proliferating BM cells did not. Bz-423, a small-molecule inhibitor of the mitochondrial F(1)F(0) adenosine triphosphate synthase (F(1)F(0)-ATP
  2 KB (304 words) - 16:03, 9 November 2016
• Lemmi 1990 Biochem Med Metab Biol
  ::::* Rotenone, an inhibitor of Complex I, and acetoacetate, to divert NADH to the formation of p-hydrox
  2 KB (311 words) - 16:52, 22 March 2023
• MiPNet08.12 IOC22
  |topics=Inhibitor, Oxygen kinetics
  2 KB (333 words) - 12:09, 27 October 2023
• Paech 2018a Toxicology
  |keywords=Apoptosis, Hepatotoxicity, Kinase inhibitor, Mitochondrial fission & mitophagy, Mitochondrial toxicity, Reactive oxygen
  2 KB (330 words) - 14:21, 21 August 2018
• Kakimoto 2021 Redox Biol
  ...on. Furthermore, the mitochondrial antioxidant mitoquinone, or a selective inhibitor of complex I electron leakage (S1QEL) further enhanced palmitate-induced gl
  2 KB (301 words) - 10:21, 5 August 2021
• Schaefer 2016 PLOS ONE
  ...E overexpression. Surprisingly, this could be rescued by a gamma secretase inhibitor, oppositionally indicating an Aβ-mediated mitochondrial toxicity. Analyzin
  2 KB (332 words) - 12:07, 22 November 2017
• Lardy 1953 J Biol Chem
  The thiol inhibitor, p-chloromercuribenzoate, strongly depressed the effect of DNP; iod
  3 KB (356 words) - 15:15, 25 November 2015
• Chang 2018 Biophys J
  knock-in mice were permeabilized and subjected to a substrate-inhibitor titration
  2 KB (339 words) - 17:34, 20 March 2018
• Costa 2013 Cell Death Dis
  |topics=Inhibitor
  3 KB (340 words) - 12:14, 27 March 2018
• Ashok 2023 Mol Cell Biochem
  ...affected with diseases with underlying cardiac complications. As CQ is an inhibitor of the lysosomal pathway, the observed effect could be an outcome of the ac
  2 KB (327 words) - 14:41, 26 April 2023
• Singer 1956 J Biol Chem
  |topics=Inhibitor, Temperature
  2 KB (311 words) - 10:46, 6 July 2022
• Osenbroch 2009 FEBS J
  ...xidant menadione. Inhibitors of mitochondrial complexes and the glycolysis inhibitor 2-deoxyglucose kill csb(m/m) cells more efficiently than wild-type cells, v
  2 KB (329 words) - 15:08, 19 February 2015
• Diaz-Ruiz 2008 J Biol Chem
  |topics=Inhibitor, Substrate
  2 KB (325 words) - 16:07, 27 August 2018
• Niehusmann 2011 Epilepsy Behav
  |topics=Inhibitor
  2 KB (310 words) - 14:50, 23 January 2019
• Angelin 2007 Proc Natl Acad Sci U S A
  ...n VI, and by treatment with cyclosporin A or with the specific cyclophilin inhibitor methylAla(3)ethylVal(4)-cyclosporin, which does not affect calcineurin acti
  2 KB (321 words) - 11:28, 14 March 2013
• Brown 2013 J Exp Biol
  ...dehydrogenase (SDH), which had a greater affinity for oxaloacetate (an SDH inhibitor) during torpor. At 10°C, SDH was not inhibited, suggesting that SDH inhibi
  3 KB (333 words) - 12:06, 8 November 2016
• Varikmaa 2014 Biochim Biophys Acta
  |topics=Inhibitor, PCr;Cr
  2 KB (294 words) - 17:06, 19 October 2017
• Perevoshchikova 2013 Free Radic Biol Med
  |topics=Inhibitor, Fatty acid
  2 KB (345 words) - 22:02, 3 August 2023
• Jensen 2021 Free Radic Biol Med
  ...n sulfide (H₂S), a ubiquitous signaling molecule, is a powerful inhibitor of respiration of liver mitochondria isolated from torpid 13-lined ground s
  2 KB (337 words) - 14:39, 21 July 2021
• Havird 2018 bioRxiv
  |topics=Flux control, Inhibitor
  2 KB (323 words) - 14:02, 13 December 2018
• Guachalla 2009 Aging (Albany NY)
  |topics=Inhibitor, Redox state
  2 KB (332 words) - 09:00, 8 March 2020
• Galambo 2017 Thesis
  ...ned through the use of high-resolution respirometry and selected substrate-inhibitor-uncoupler titration protocols. We found that calponin1 protein expression h
  2 KB (322 words) - 12:19, 30 January 2018
• Moore 1991 Plant Physiol
  ...protein, and fully reduced as that in the presence of a ''bc''₁ inhibitor or upon anaerobiosis." ...an ion-influx channel, because state 2 conditions favor the release of the inhibitor protein IF, from its inhibitory site on F, facilitating increased H<sup>+</
  6 KB (815 words) - 12:41, 3 April 2021
• Bueno 2016 Thesis
  |topics=Inhibitor
  2 KB (357 words) - 09:47, 28 November 2017
• Brecht 2016 Toxicol In Vitro
  ...as compared to the anti-cancer drug, sorafenib, which is a tyrosine kinase inhibitor known for mitochondrial toxic off-target effects (Will et al., 2008). In bo
  2 KB (306 words) - 17:02, 9 November 2017
• Fato 2009 Biochim Biophys Acta
  |keywords=Complex I inhibitor Reactive oxygen species Iron–sulphur cluster 2′,7′-Dichlorodihydroflu
  2 KB (325 words) - 13:22, 30 November 2018
• Nesci 2016 Biochim Biophys Acta
  ...activity is especially responsive to nitrite, which acts as uncompetitive inhibitor and up to 2 mM inhibits the Ca²⁺-activated-ATPase(s), probably b
  2 KB (352 words) - 17:51, 13 April 2016
• Mejia 2019 Reprod Biol Endocrinol
  ...zyme in ceramide biosynthesis, NFAT5, SMIT, AR, caspase 3 and the X-linked inhibitor of apoptosis. Trophoblast cells were treated with insulin or ceramide and a
  2 KB (327 words) - 15:56, 6 November 2019
• Detaille 2019 PLoS One
  ...pecies (ROS/H₂O₂) production by acting as a specific inhibitor of ROS production at the IQ site of complex I of the mitochondrial respirat
  2 KB (315 words) - 13:15, 20 May 2019
• Aya 2022 Eur J Pharmacol
  ...words=Empagliflozin; Energy metabolism; Heart failure; Mitochondria; SGLT2 inhibitor
  2 KB (323 words) - 16:00, 25 August 2022
• Hellgren 2017 MiPschool Obergurgl
  ...l function was assessed in cardiac homogenates using a substrate-uncoupler-inhibitor (SUIT) protocol with an Oroboros O2k coupled with the O2k-Fluo LED2-module.
  2 KB (326 words) - 16:05, 12 January 2018
• Meunier 1995 Biochemistry
  ...urachin C on cytochrome bo were investigated in more detail. The number of inhibitor binding sites on the purified enzyme was determined by titration to be 0.6
  2 KB (368 words) - 12:40, 3 April 2021
• Friederich-Persson 2020 Am J Physiol Renal Physiol
  ...onse was reversed to increased oxygen consumption by nitric oxide synthase inhibitor L-NAME. AT₁ receptor inhibition did not affect the response to A
  3 KB (364 words) - 09:48, 10 March 2022
• Kaambre 2013 Front Physiol
  |topics=ADP, Flux control, Inhibitor, PCr;Cr
  2 KB (318 words) - 11:31, 28 April 2015
• Boardman 2019 Can J Physiol Pharmacol
  ...hemic preconditioning. However, this effect was reversed by probenecid, an inhibitor of cellular uptake of uric acid. In accordance, in intact cardiomyocytes, e
  2 KB (318 words) - 15:30, 7 May 2020
• Pavlovic 2017 MITOEAGLE Obergurgl
  ...great interest. We think that optimizing and applying substrate-uncoupler-inhibitor titration (SUIT) protocol [3] for detailed evaluation of mitochondrial resp ::::#[[SUIT | MitoPedia:_SUIT - Substrate-uncoupler-inhibitor protocols]]
  5 KB (734 words) - 09:37, 19 January 2018
• NADH electron transfer-pathway state
  ...ration in the N-pathway control state can be further suppressed by the CII-inhibitor [[malonic acid]]). In the N-pathway control state [[Electron-transfer-pathw
  3 KB (409 words) - 08:06, 25 November 2023
• Renner 2015 Eur J Immunol
  ...ction demonstrated metabolic flexibility. Administration of the glycolytic inhibitor 2-deoxy-glucose suppressed both glycolysis and respiration and exerted a st
  2 KB (312 words) - 12:28, 16 September 2021
• SUIT-021 Fluo mt D036
  ...olarises the mt-membrane in a concentration-dependent manner. Complex III inhibitor Antimycin (Ama) blocks the respiration. Antimycin A dissipates mt-membrane
  6 KB (834 words) - 14:07, 6 September 2021
• Lukasiak 2010 Abstract IOC60
  ...flow in isolated guinea pig hearts in NO dependent manner (100 µM L-NAME, inhibitor of nitric oxide synthase, partially reversed the effect of NS1619). It seem
  2 KB (346 words) - 14:38, 8 November 2016
• Ruthenium red
  |mitopedia topic=Inhibitor
  2 KB (317 words) - 12:07, 15 June 2021
• Egnatchik 2014 Metabolism
  ...rial activation. To directly limit mitochondrial metabolism, the complex I inhibitor phenformin was added to cells treated with palmitate. Phenformin addition e
  2 KB (325 words) - 23:09, 5 July 2021
• MiPNet16.02 IOC64
  Novel developments are presented on substrate-uncoupler-inhibitor titration ([[SUIT]]) protocols. An overview is given on the [[O2k-MultiSens
  3 KB (359 words) - 12:16, 23 January 2019
• Tokarska-Schlattner 2007 Biochim Biophys Acta
  |topics=ADP, Inhibitor, PCr;Cr
  3 KB (340 words) - 16:35, 26 March 2018
• Clara 2016 Metabolism
  ...espiration and potently stimulated GLP-1 release. The fatty acid oxidation inhibitor etomoxir did neither reduce OA-induced respiration nor affect the OA-induce
  2 KB (337 words) - 15:56, 24 March 2022
• Kuznetsov 2002 Anal Biochem
  ...y in tissue samples of 2–7 mg, for application of a standardized substrate/inhibitor titration protocol in high-resolution respirometry. Specific respirometric
  2 KB (327 words) - 14:05, 27 December 2021
• Larsen 2011 FASEB J
  |topics=Inhibitor, Oxygen kinetics
  2 KB (316 words) - 10:42, 31 March 2022
• Gruenig 2017 Toxicol In Vitro
  |abstract=The catechol-O-methyltransferase inhibitor tolcapone causes hepatotoxicity and mitochondrial damage in animal models.
  3 KB (332 words) - 11:25, 27 June 2019
• Copperi 2022 Commun Biol
  ...7α,25-dihydroxycholesterol/EBI2 signaling pathway as a so far unknown BAT inhibitor. Understanding the inhibitory regulation of BAT might lead to novel pharmac
  2 KB (324 words) - 17:11, 30 November 2022
• Piccoli 2012 Free Radic Biol Med
  ...vity was observed. Treatment of HgCl(2)-exposed keratinocytes with the PKC inhibitor calphostin C and with all-trans retinoic acid resulted in rescue of the mit
  2 KB (328 words) - 17:06, 3 December 2013
• Hafstad 2020 Antioxidants (Basel)
  ...C57BL/6J mice given normal water (DIO) or water supplemented with the NOX2-inhibitor apocynin (DIO_APO). Mitochondrial function and ROS production wer
  2 KB (335 words) - 13:19, 7 March 2020
• Skemiene 2020 Biomolecules
  ...lso prevented by Complex I inhibitors rotenone and amobarbital and by MPTP inhibitor cyclosporine A. The latter two inhibitors were protective in adult brain sl
  3 KB (349 words) - 21:42, 28 October 2020
• Nin 2012 J Biol Chem
  ...utely activate SIRT1 by inducing dissociation of SIRT1 from its endogenous inhibitor DBC1. Our experiments provide new insight on the ''in vivo'' mechanism of S
  2 KB (363 words) - 12:17, 8 November 2016
• Duicu 2012 Rev Med Chir Soc Med Nat Iasi
  ...+/- 50.16 (CII dependent OXPHOS state obtained after the addition of a CI inhibitor rotenone, with the subsequent entry of electrons from CII only into the Q j
  2 KB (325 words) - 11:42, 23 January 2019
• Dieter 2022 Int J Mol Sci
  ...4 h with different concentrations of ALA and with or without the complex I inhibitor rotenone.
  2 KB (337 words) - 18:47, 8 November 2022
• Yu 2023 Biochim Biophys Acta Bioenerg
  ...ion in muscle but had little effect in IBAT mitochondria. The transaminase inhibitor, aminooxyacetic acid, increased OAA concentrations and impaired succinate-e
  3 KB (357 words) - 07:22, 28 February 2023
• Pambianco 2016 Cell Rep
  ...hondrial biogenesis or fatty acid oxidation[FAO]). The histone deacetylase inhibitor Trichostatin A (TSA) changed chromatin assembly at the PGC-1α promoter, re
  2 KB (296 words) - 14:38, 15 November 2017
• Moore 2016 Abstract IOC116
  ...bic regions. Yellow spheres refer to diirons. Figure shows an AOX specific inhibitor bound within the catalystic site.
  2 KB (330 words) - 12:18, 7 March 2020
• Treberg 2018 Redox Biol
  |topics=Inhibitor
  3 KB (396 words) - 13:35, 7 March 2020
• Musiol 2018 MiPschool Tromso C4
  ...y modulate the activity of complex IV. In standardized substrate-uncoupler-inhibitor-titration protocols, complex IV activity is usually influenced by changes i
  2 KB (343 words) - 16:54, 16 October 2018
• Pinho 2023 Eur J Clin Invest
  ...R), oxygen flux was measured, in WS and NWS, using two substrate-uncoupler-inhibitor titration protocols, at baseline (day 0), day 3 and 10 post-wounding, in ST
  2 KB (342 words) - 15:50, 21 November 2023

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